FR2407204A1 - Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments - Google Patents

Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments

Info

Publication number
FR2407204A1
FR2407204A1 FR7829752A FR7829752A FR2407204A1 FR 2407204 A1 FR2407204 A1 FR 2407204A1 FR 7829752 A FR7829752 A FR 7829752A FR 7829752 A FR7829752 A FR 7829752A FR 2407204 A1 FR2407204 A1 FR 2407204A1
Authority
FR
France
Prior art keywords
preparation
amino acid
cyclic amino
group
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7829752A
Other languages
English (en)
Inventor
Erik Wiskott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2407204A1 publication Critical patent/FR2407204A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX AMIDES D'AMINO-ACIDES CYCLIQUES ET LEUR PREPARATION. LES COMPOSES DE L'INVENTION REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE, UN GROUPE CYCLOALKYLE, UN GROUPE ALKYLE SUBSTITUE, UN GROUPE PHENYLE OU PHENYL-ALKYLE SUBSTITUES OU UN RESTE HETEROCYCLIQUE, R ET R SIGNIFIENT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE ALKYLE, A REPRESENTE UN GROUPE METHYLENE OU TRIMETHYLENE OU UN GROUPE ETHYLENE EVENTUELLEMENT SUBSTITUE ET N SIGNIFIE 0, 1 OU 2. CES COMPOSES PEUVENT ETRE UTILISES EN THERAPEUTIQUE A TITRE DE SUBSTANCES ACTIVES DE MEDICAMENTS.
FR7829752A 1977-10-28 1978-10-19 Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments Withdrawn FR2407204A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1315377 1977-10-28

Publications (1)

Publication Number Publication Date
FR2407204A1 true FR2407204A1 (fr) 1979-05-25

Family

ID=4389793

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7829752A Withdrawn FR2407204A1 (fr) 1977-10-28 1978-10-19 Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments

Country Status (16)

Country Link
US (1) US4261895A (fr)
JP (1) JPS5481266A (fr)
AU (1) AU4113878A (fr)
BE (1) BE871574A (fr)
DE (1) DE2845499A1 (fr)
DK (1) DK467378A (fr)
ES (1) ES474562A1 (fr)
FI (1) FI783189A (fr)
FR (1) FR2407204A1 (fr)
GB (1) GB2006781A (fr)
IL (1) IL55801A0 (fr)
IT (1) IT7851510A0 (fr)
NL (1) NL7810595A (fr)
PT (1) PT68707A (fr)
SE (1) SE7810893L (fr)
ZA (1) ZA786081B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
FR2444669A1 (fr) * 1978-12-22 1980-07-18 Squibb & Sons Inc Acetals et thioacetals de mercap
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0060668A1 (fr) * 1981-03-12 1982-09-22 Beecham Group Plc Dérivés N-carboxyalcoyldipeptidiques et leurs compositions pharmaceutiques
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
US4745124A (en) * 1978-09-11 1988-05-17 University Of Miami Orally effective anti-hypertensive agents

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4565819A (en) * 1979-12-07 1986-01-21 Adir Substituted imino diacids, their preparation and pharmaceutical compositions which contain them
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
IT1226796B (it) * 1988-07-15 1991-02-19 Simes Composizione farmaceutica utile per il trattamento di malattie cardiovascolari.
US5166361A (en) * 1988-09-13 1992-11-24 Sepracor, Inc. Methods for preparing captopril and its analogues
IL91581A (en) * 1988-09-13 1993-07-08 Sepracor Inc Methods for preparing optically active captopril and its analogues
IT1241415B (it) * 1990-03-05 1994-01-14 Yason Srl Derivato dell'acido s-(2-tenoil)-tiolattico ad attivita' farmacologica
US20020042377A1 (en) * 1995-06-07 2002-04-11 Steiner Joseph P. Rotamase enzyme activity inhibitors
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383171A1 (fr) * 1977-03-11 1978-10-06 Squibb & Sons Inc Derives de thiopropanoylaminoacides utiles comme hypotenseurs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
US4217458A (en) * 1978-12-08 1980-08-12 E. R. Squibb & Sons, Inc. Acylmercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383171A1 (fr) * 1977-03-11 1978-10-06 Squibb & Sons Inc Derives de thiopropanoylaminoacides utiles comme hypotenseurs

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745124A (en) * 1978-09-11 1988-05-17 University Of Miami Orally effective anti-hypertensive agents
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
FR2444669A1 (fr) * 1978-12-22 1980-07-18 Squibb & Sons Inc Acetals et thioacetals de mercap
FR2462428A1 (fr) * 1979-07-30 1981-02-13 Squibb & Sons Inc Derives d'acide dithioacyldihydropyrazole carboxylique, derives de dithioacylproline, et composes apparentes, a action antihypertensive
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
FR2467845A1 (fr) * 1979-10-22 1981-04-30 Squibb & Sons Inc Nouveaux derives mercapto-acyles de prolines 4,4-disubstituees et de dehydroprolines 4-substituees, utiles notamment comme medicaments hypotenseurs, compositions therapeutiques et formes pharmaceutiques les contenant, et intermediaires utiles pour leur synthese
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
EP0060668A1 (fr) * 1981-03-12 1982-09-22 Beecham Group Plc Dérivés N-carboxyalcoyldipeptidiques et leurs compositions pharmaceutiques

Also Published As

Publication number Publication date
DK467378A (da) 1979-04-29
GB2006781A (en) 1979-05-10
AU4113878A (en) 1980-05-01
DE2845499A1 (de) 1979-05-03
ZA786081B (en) 1980-06-25
US4261895A (en) 1981-04-14
SE7810893L (sv) 1979-04-29
FI783189A (fi) 1979-04-29
ES474562A1 (es) 1979-10-16
IL55801A0 (en) 1978-12-17
IT7851510A0 (it) 1978-10-16
PT68707A (fr) 1978-11-01
NL7810595A (nl) 1979-05-02
JPS5481266A (en) 1979-06-28
BE871574A (fr) 1979-04-26

Similar Documents

Publication Publication Date Title
FR2407204A1 (fr) Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments
FR2439182A1 (fr) Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
DE19875010I2 (de) Acetamidderivate Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
FR2542312B1 (fr) Composes de sulfonium, leur preparation et compositions pharmaceutiques contenant ces composes
ZA792284B (en) Structural analogs of natural phosphatides processes for their preparation,and pharmaceutical preparations thereof
DE2861318D1 (en) New derivatives of 4-phenyl-2-(2',2',2-trichlorethoxycarboxamido)-thiazole useful as medicaments, pharmaceutical compositions containing them and process for the preparation of these compounds
LU79294A1 (fr) Procede pour la preparation de nouveaux derives de la morphine et application a titre de medicament
FR2456104A1 (fr) Nouvelles pyrazinobenzodiazepines, leur preparation et leur application comme medicaments
FR2455048A1 (fr) Nouvelles 14-methoxymorphinane-6-ones, leur procede de production et medicament les contenant
ZA848141B (en) New cyclic benzensulfonamides,process for their preparation and their use as active substance of pharmaceutical compositions
NO873923L (no) Fremgangsmaate for fremstilling av et medisinsk hudpreparat
FR2636630B1 (fr) Nouveaux composes benzofuranniques, leur procede de preparation, compositions pharmaceutiques et cosmetique les contenant et utilisation de ces compositions
AT354635B (de) Verfahren zur herstellung klarer , stabiler, waesseriger oder waesserig-alkoholischer loesungen fettloeslicher parfuemoele oder fettloeslicher arzneimittelwirkstoffe
BE885393A (fr) Nouveaux amino-2 benzoyl-3 phenylacetamides et leurs homologues cycliques utiles comme medicaments et compositions therapeutiques et formes pharmaceutiques les contenant
FR2347048A2 (fr) Compositions constituees par des composes du type plasminogene, notamment d'origine placentaire, procede d'obtention des ces compositions, et medicaments contenant ces compositions
BR8009059A (pt) Administracao de substancia medicas ativas
FR2351078A1 (fr) Composes nouveaux derivant de la cyclopentanone et leur utilisation a titre d'ingredients parfumants et/ou aromatisants
BE858781A (fr) Nouveaux derives 1,4-dihydropyridiques de sucres, leur procede de preparation et medicament les contenant
JPS53139714A (en) Method for separating interferon active substance from medical preparation containing said substace and purifying same * purified substance and utilizing same as medicine
FR2434150A1 (fr) Derives d'acides hydroxamiques et medicaments qui en contiennent
HUT47558A (en) Process for production of 12-halogene-forscoline derivatives and medical compositions containing them as active substance
FR2438656A1 (fr)
BE873259A (fr) Acides acylhydrocarbylaminoalkancarboxyliques leur preparation et leur utilisation, ainsi que medicaments contenant ces composes
FR2621912B1 (fr) Nouveaux derives du norbornane, leur procede de preparation et compositions cosmetique et medicamenteuse les contenant
FR2432316A1 (fr) Nouveaux medicaments contenant, a titre de substance active, des composes de type benzenesulfone, nouveaux composes de ce type et procede pour leur preparation

Legal Events

Date Code Title Description
RE Withdrawal of published application