FR2421912A1 - Derives d'acide thio-etianique, leur procede de production et medicament les contenant - Google Patents

Derives d'acide thio-etianique, leur procede de production et medicament les contenant

Info

Publication number
FR2421912A1
FR2421912A1 FR7907823A FR7907823A FR2421912A1 FR 2421912 A1 FR2421912 A1 FR 2421912A1 FR 7907823 A FR7907823 A FR 7907823A FR 7907823 A FR7907823 A FR 7907823A FR 2421912 A1 FR2421912 A1 FR 2421912A1
Authority
FR
France
Prior art keywords
radical
alpha
beta
chloro
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7907823A
Other languages
English (en)
French (fr)
Other versions
FR2421912B1 (https=
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of FR2421912A1 publication Critical patent/FR2421912A1/fr
Application granted granted Critical
Publication of FR2421912B1 publication Critical patent/FR2421912B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7907823A 1978-04-05 1979-03-28 Derives d'acide thio-etianique, leur procede de production et medicament les contenant Granted FR2421912A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,388 US4188385A (en) 1978-04-05 1978-04-05 Thioetianic acid derivatives

Publications (2)

Publication Number Publication Date
FR2421912A1 true FR2421912A1 (fr) 1979-11-02
FR2421912B1 FR2421912B1 (https=) 1981-03-20

Family

ID=25401484

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7907823A Granted FR2421912A1 (fr) 1978-04-05 1979-03-28 Derives d'acide thio-etianique, leur procede de production et medicament les contenant

Country Status (28)

Country Link
US (1) US4188385A (https=)
EP (1) EP0004741B1 (https=)
JP (2) JPS54141758A (https=)
AR (1) AR226035A1 (https=)
AT (1) AT368168B (https=)
AU (1) AU526025B2 (https=)
CA (1) CA1134345A (https=)
CS (1) CS203956B2 (https=)
DE (2) DE2960096D1 (https=)
DK (1) DK147735C (https=)
ES (1) ES479271A1 (https=)
FI (1) FI66393C (https=)
FR (1) FR2421912A1 (https=)
GB (1) GB2018256B (https=)
GR (1) GR67275B (https=)
HK (1) HK41284A (https=)
HU (1) HU179314B (https=)
IL (1) IL56972A0 (https=)
IT (1) IT1120954B (https=)
MY (1) MY8500575A (https=)
NO (1) NO152935C (https=)
NZ (1) NZ190076A (https=)
PL (1) PL121469B1 (https=)
PT (1) PT69409A (https=)
SG (1) SG6786G (https=)
SU (1) SU1052161A3 (https=)
YU (1) YU40929B (https=)
ZA (1) ZA791635B (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
JPS56138200A (en) * 1980-02-15 1981-10-28 Glaxo Group Ltd Androstane carbothioate compound
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
KR850000969B1 (ko) * 1980-02-15 1985-07-02 글락소 그룹 리미티드 안드로스탄 카보티오에이트의 제조방법
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) * 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
ES2107806T3 (es) * 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd Nuevos esteroides.
DE69609199T2 (de) 1995-12-29 2001-03-01 Glaxo Group Ltd., Greenford Lacton derivate von 17.beta.-carboxy, carbothio und amide androstanverbindungen
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
WO2002012266A1 (en) * 2000-08-05 2002-02-14 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6759398B2 (en) * 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
PT1383786E (pt) * 2001-04-30 2008-12-30 Glaxo Group Ltd Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
US20040248867A1 (en) * 2001-06-12 2004-12-09 Keith Biggadike Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
WO2004087731A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
CA2710149A1 (en) * 2007-12-21 2009-07-09 John C. Anthes C20-c21 substituted glucocorticoid receptor agonists
JP2012530140A (ja) 2009-06-16 2012-11-29 メルク・シャープ・アンド・ドーム・コーポレーション グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509171A (en) * 1946-02-06 1950-05-23 Ciba Ltd Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Also Published As

Publication number Publication date
DK147735B (da) 1984-11-26
GR67275B (https=) 1981-06-26
FI66393C (fi) 1984-10-10
FI791081A7 (fi) 1979-10-06
EP0004741A3 (en) 1979-11-14
AU526025B2 (en) 1982-12-16
AR226035A1 (es) 1982-05-31
NO791140L (no) 1979-10-08
PL214676A1 (https=) 1980-01-02
ATA251979A (de) 1982-01-15
DE2912331A1 (de) 1979-10-18
DE2960096D1 (en) 1981-03-19
NO152935B (no) 1985-09-09
YU40929B (en) 1986-08-31
JPS6140648B2 (https=) 1986-09-10
GB2018256A (en) 1979-10-17
JPS611038B2 (https=) 1986-01-13
YU80379A (en) 1983-04-30
SG6786G (en) 1986-08-01
EP0004741A2 (en) 1979-10-17
HK41284A (en) 1984-05-18
HU179314B (en) 1982-09-28
US4188385A (en) 1980-02-12
NO152935C (no) 1985-12-18
CA1134345A (en) 1982-10-26
DK136579A (da) 1979-10-06
IT1120954B (it) 1986-03-26
AT368168B (de) 1982-09-27
PL121469B1 (en) 1982-05-31
NZ190076A (en) 1984-07-31
ES479271A1 (es) 1980-01-16
AU4558379A (en) 1979-10-18
IT7967652A0 (it) 1979-03-28
IL56972A0 (en) 1979-05-31
SU1052161A3 (ru) 1983-10-30
MY8500575A (en) 1985-12-31
GB2018256B (en) 1983-02-02
DK147735C (da) 1985-08-19
EP0004741B1 (en) 1981-01-28
JPS54141758A (en) 1979-11-05
FR2421912B1 (https=) 1981-03-20
ZA791635B (en) 1980-11-26
JPS6069019A (ja) 1985-04-19
FI66393B (fi) 1984-06-29
PT69409A (en) 1979-04-01
CS203956B2 (en) 1981-03-31

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Legal Events

Date Code Title Description
ST Notification of lapse