ES479271A1 - Un procedimiento para la preparacion de compuestos derivados de acido tioetianico. - Google Patents
Un procedimiento para la preparacion de compuestos derivados de acido tioetianico.Info
- Publication number
- ES479271A1 ES479271A1 ES479271A ES479271A ES479271A1 ES 479271 A1 ES479271 A1 ES 479271A1 ES 479271 A ES479271 A ES 479271A ES 479271 A ES479271 A ES 479271A ES 479271 A1 ES479271 A1 ES 479271A1
- Authority
- ES
- Spain
- Prior art keywords
- thio
- preparation
- acid derivatives
- pharmaceutical use
- etianic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Thio etianic acid derivatives Chemical class 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nuevos derivados de 3- oxoandrost-4-eno-17 beta -tiocarboxilatos de alquilo, fenilo o bencilo y los androsta-.1,4-dienos correspondientes que son activos agentes anti-inflamatorios en los mamíferos. El invento se refiere también a composiciones farmacéuticamente activas que comprenden un 17beta-tiocarboxilato del invento en combinación con un excipiente aceptable en farmacia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/893,388 US4188385A (en) | 1978-04-05 | 1978-04-05 | Thioetianic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479271A1 true ES479271A1 (es) | 1980-01-16 |
Family
ID=25401484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479271A Expired ES479271A1 (es) | 1978-04-05 | 1979-04-04 | Un procedimiento para la preparacion de compuestos derivados de acido tioetianico. |
Country Status (28)
Country | Link |
---|---|
US (1) | US4188385A (es) |
EP (1) | EP0004741B1 (es) |
JP (2) | JPS54141758A (es) |
AR (1) | AR226035A1 (es) |
AT (1) | AT368168B (es) |
AU (1) | AU526025B2 (es) |
CA (1) | CA1134345A (es) |
CS (1) | CS203956B2 (es) |
DE (2) | DE2912331A1 (es) |
DK (1) | DK147735C (es) |
ES (1) | ES479271A1 (es) |
FI (1) | FI66393C (es) |
FR (1) | FR2421912A1 (es) |
GB (1) | GB2018256B (es) |
GR (1) | GR67275B (es) |
HK (1) | HK41284A (es) |
HU (1) | HU179314B (es) |
IL (1) | IL56972A0 (es) |
IT (1) | IT1120954B (es) |
MY (1) | MY8500575A (es) |
NO (1) | NO152935C (es) |
NZ (1) | NZ190076A (es) |
PL (1) | PL121469B1 (es) |
PT (1) | PT69409A (es) |
SG (1) | SG6786G (es) |
SU (1) | SU1052161A3 (es) |
YU (1) | YU40929B (es) |
ZA (1) | ZA791635B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4263289A (en) * | 1978-04-05 | 1981-04-21 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
US4261984A (en) * | 1978-04-05 | 1981-04-14 | Syntex (U.S.A.) Inc. | 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes |
US4310466A (en) * | 1979-08-31 | 1982-01-12 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
BE887518A (fr) * | 1980-02-15 | 1981-08-13 | Glaxo Group Ltd | Cartothioates d'androstanes |
GB2137206B (en) * | 1980-02-15 | 1985-04-03 | Glaxo Group Ltd | Androstane 17-carbothioc acid derivatives |
PT72502B (en) * | 1980-02-15 | 1982-02-05 | Glaxo Group Ltd | Androstane carbothioates |
US4578221A (en) * | 1980-04-23 | 1986-03-25 | Glaxo Group Limited | Androstane carbothioic acids |
SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
IL78144A0 (en) * | 1985-04-04 | 1986-07-31 | Draco Ab | Novel androstane-17beta-carboxylic acid esters |
GB9225923D0 (en) * | 1992-12-11 | 1993-02-03 | Rhone Poulenc Rorer Ltd | New compositions of matter |
DK0675897T3 (da) * | 1992-12-24 | 1998-01-26 | Rhone Poulenc Rorer Ltd | Nye steroider |
CA2241728A1 (en) * | 1995-12-29 | 1997-07-10 | Panayiotis Alexandrou Procopiou | Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives |
US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
US20020133032A1 (en) * | 2000-02-25 | 2002-09-19 | Jufang Barkalow | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods |
GB0017988D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Novel process |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
AU2001276497B2 (en) * | 2000-08-05 | 2005-04-07 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
GB0019172D0 (en) * | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
US6777400B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6750210B2 (en) * | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6858593B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6787532B2 (en) * | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
UA77656C2 (en) * | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
DE60229372D1 (de) * | 2001-04-30 | 2008-11-27 | Glaxo Group Ltd | Antiphlogistische 7.beta.-carbothioate esterderivate von androstan mit einer 17.alpha.-zyklischen estergruppe |
EP1395604B1 (en) * | 2001-06-12 | 2008-06-25 | Glaxo Group Limited | Novel anti inflammatory 17.alpha.-heterocyclic-esters of 17.beta.-carbothioate androstane derivatives |
US20050175545A1 (en) * | 2002-02-04 | 2005-08-11 | Keith Biggadike | Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist |
GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
IL150654A (en) | 2002-07-09 | 2006-12-10 | Ori Lerman | Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate |
JP2006522028A (ja) * | 2003-04-04 | 2006-09-28 | アルファーマ エーピーエス | ステロイド性カルボチオ酸誘導体の製造方法および中間体 |
GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
AR059216A1 (es) * | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
GB0615108D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
AR069804A1 (es) * | 2007-12-21 | 2010-02-17 | Schering Corp | Agonistas del receptor glucocorticoide c20- c21 sustituido |
AR077101A1 (es) | 2009-06-16 | 2011-08-03 | Schering Corp | Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2509171A (en) * | 1946-02-06 | 1950-05-23 | Ciba Ltd | Primary alcohols from thiocarboxylic acids and esters |
US3636010A (en) * | 1968-12-23 | 1972-01-18 | Ciba Geigy Corp | Esters of steroid-17-carboxylic acids |
US3989686A (en) * | 1972-06-15 | 1976-11-02 | Glaxo Laboratories Limited | Anaesthetic steroids of the androstane series and process for preparing same |
GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
CH628355A5 (de) * | 1976-02-24 | 1982-02-26 | Ciba Geigy Ag | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
-
1978
- 1978-04-05 US US05/893,388 patent/US4188385A/en not_active Expired - Lifetime
-
1979
- 1979-03-28 EP EP79300500A patent/EP0004741B1/en not_active Expired
- 1979-03-28 DE DE19792912331 patent/DE2912331A1/de not_active Ceased
- 1979-03-28 GB GB7910862A patent/GB2018256B/en not_active Expired
- 1979-03-28 IT IT67652/79A patent/IT1120954B/it active
- 1979-03-28 DE DE7979300500T patent/DE2960096D1/de not_active Expired
- 1979-03-28 FR FR7907823A patent/FR2421912A1/fr active Granted
- 1979-03-29 IL IL56972A patent/IL56972A0/xx not_active IP Right Cessation
- 1979-03-29 AU AU45583/79A patent/AU526025B2/en not_active Ceased
- 1979-03-29 CS CS792107A patent/CS203956B2/cs unknown
- 1979-03-30 PT PT69409A patent/PT69409A/pt unknown
- 1979-03-30 CA CA000324557A patent/CA1134345A/en not_active Expired
- 1979-03-30 AR AR276014A patent/AR226035A1/es active
- 1979-03-31 GR GR58748A patent/GR67275B/el unknown
- 1979-04-02 NZ NZ190076A patent/NZ190076A/en unknown
- 1979-04-02 FI FI791081A patent/FI66393C/fi not_active IP Right Cessation
- 1979-04-03 HU HU79SI1682A patent/HU179314B/hu not_active IP Right Cessation
- 1979-04-03 DK DK136579A patent/DK147735C/da not_active IP Right Cessation
- 1979-04-04 NO NO791140A patent/NO152935C/no unknown
- 1979-04-04 YU YU803/79A patent/YU40929B/xx unknown
- 1979-04-04 PL PL1979214676A patent/PL121469B1/pl unknown
- 1979-04-04 AT AT0251979A patent/AT368168B/de not_active IP Right Cessation
- 1979-04-04 SU SU792787402A patent/SU1052161A3/ru active
- 1979-04-04 ES ES479271A patent/ES479271A1/es not_active Expired
- 1979-04-05 JP JP4041479A patent/JPS54141758A/ja active Granted
- 1979-04-05 ZA ZA791635A patent/ZA791635B/xx unknown
-
1984
- 1984-05-10 HK HK412/80A patent/HK41284A/xx unknown
- 1984-07-27 JP JP59155726A patent/JPS6069019A/ja active Granted
-
1985
- 1985-12-30 MY MY575/85A patent/MY8500575A/xx unknown
-
1986
- 1986-01-22 SG SG67/86A patent/SG6786G/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES479271A1 (es) | Un procedimiento para la preparacion de compuestos derivados de acido tioetianico. | |
IT8024820A0 (it) | Composizioni germicide a base di iodio dotate di maggiore stabilita'. | |
DE2965284D1 (en) | Pharmaceutical compositions for topical administration containing prostaglandins | |
IT7947847A0 (it) | Derivati dell'imidazolo relativo procedimento di produzione e composizioni farmaceutiche che li contengono come ingrediente attivo | |
NZ189574A (en) | Dehydrocyclicimino acid derivatives pharmaceutical compositions | |
IT7928417A0 (it) | Composizioni farmaceutiche con esaltazione dell'attivita'terapeutica di cortisonici. | |
AU536920B2 (en) | Hydroxypropyl-triazole derivatives and their use as antimycotic agents | |
OA07525A (fr) | Dérivés d'acides-animés, leur préparation et utilisation ainsi que les compositions contenant ces dérivés. | |
IT1193847B (it) | Composizione farmaceutica contenente 3,4-di-idro-3-osso-2-chinossaline | |
IT8323898A0 (it) | Composizione anti-acne contenent,come composto attivo, un derivato dell'isotiazolo-(5,4b) piridinone-3. | |
IT7949064A0 (it) | Perfezionamento nelle composizioni farmaceutiche contenenti prostaglandina | |
NZ190810A (en) | 1-aminoalkyl-3-phenoxy-propan-2-ol derivatives pharmaceutical compositions | |
IT7948449A0 (it) | Derivati di 3,3-dicloro-2-azetidino ne ad attivita' anti-infiammatoria | |
FR2434804A1 (fr) | Derives de la n-phenyl-indoline, leur preparation et leur application comme medicaments | |
IT1161974B (it) | Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono | |
IL58621A0 (en) | Pharmaceutical compositions comprising aryltrifluoroethanol derivatives | |
IT1112581B (it) | Derivati dell'isochinolina,loro preparazione,e composizioni farmaceutiche che li contengono | |
FI792303A (fi) | Farmaceutisk komposition foer rektal administration av kefalosporin | |
SE7602128L (sv) | Legerinskompositioner | |
LV10917A (lv) | Bambuterina pielietojums lipidu saturu pazeminosu farmaceitisku kompoziciju pagatavosanai | |
NZ190958A (en) | 2-phenylamino-2-imidazoline derivatives pharmaceutical compositions | |
IT7949944A0 (it) | Derivati di dossorubicina dotati di attivita' antitumorale procedimento per la loro preparazione e composizioni che li contengono | |
IT8125874A0 (it) | Composizioni terapeutiche adattivita' coleretica contenenti come principio attivo derivati dall'acido colanico. | |
IT8026521A0 (it) | Derivati dell'acido carbotioico di mercaptoacilamminoacidi. | |
IT8025251A0 (it) | Derivati dell'acido ossayohimban-carbossilico. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |