DE2960096D1 - Thio etianic acid derivatives, their preparation and pharmaceutical use - Google Patents

Thio etianic acid derivatives, their preparation and pharmaceutical use

Info

Publication number
DE2960096D1
DE2960096D1 DE7979300500T DE2960096T DE2960096D1 DE 2960096 D1 DE2960096 D1 DE 2960096D1 DE 7979300500 T DE7979300500 T DE 7979300500T DE 2960096 T DE2960096 T DE 2960096T DE 2960096 D1 DE2960096 D1 DE 2960096D1
Authority
DE
Germany
Prior art keywords
thio
preparation
acid derivatives
pharmaceutical use
etianic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979300500T
Other languages
English (en)
Inventor
John A Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE2960096D1 publication Critical patent/DE2960096D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE7979300500T 1978-04-05 1979-03-28 Thio etianic acid derivatives, their preparation and pharmaceutical use Expired DE2960096D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/893,388 US4188385A (en) 1978-04-05 1978-04-05 Thioetianic acid derivatives

Publications (1)

Publication Number Publication Date
DE2960096D1 true DE2960096D1 (en) 1981-03-19

Family

ID=25401484

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19792912331 Ceased DE2912331A1 (de) 1978-04-05 1979-03-28 Neue 17 beta -thiocarboxylate von 3-oxo-androst-4-en- bzw. -androsta-1,4-dienderivaten, ihre herstellung und diese enthaltende arzneimittel
DE7979300500T Expired DE2960096D1 (en) 1978-04-05 1979-03-28 Thio etianic acid derivatives, their preparation and pharmaceutical use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19792912331 Ceased DE2912331A1 (de) 1978-04-05 1979-03-28 Neue 17 beta -thiocarboxylate von 3-oxo-androst-4-en- bzw. -androsta-1,4-dienderivaten, ihre herstellung und diese enthaltende arzneimittel

Country Status (28)

Country Link
US (1) US4188385A (de)
EP (1) EP0004741B1 (de)
JP (2) JPS54141758A (de)
AR (1) AR226035A1 (de)
AT (1) AT368168B (de)
AU (1) AU526025B2 (de)
CA (1) CA1134345A (de)
CS (1) CS203956B2 (de)
DE (2) DE2912331A1 (de)
DK (1) DK147735C (de)
ES (1) ES479271A1 (de)
FI (1) FI66393C (de)
FR (1) FR2421912A1 (de)
GB (1) GB2018256B (de)
GR (1) GR67275B (de)
HK (1) HK41284A (de)
HU (1) HU179314B (de)
IL (1) IL56972A0 (de)
IT (1) IT1120954B (de)
MY (1) MY8500575A (de)
NO (1) NO152935C (de)
NZ (1) NZ190076A (de)
PL (1) PL121469B1 (de)
PT (1) PT69409A (de)
SG (1) SG6786G (de)
SU (1) SU1052161A3 (de)
YU (1) YU40929B (de)
ZA (1) ZA791635B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
US4261984A (en) * 1978-04-05 1981-04-14 Syntex (U.S.A.) Inc. 17β-thiocarboxylic acid esters of 3-oxo-4-halo-16β-methylandrost-4-enes
US4310466A (en) * 1979-08-31 1982-01-12 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
BE887518A (fr) * 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
PT72502B (en) * 1980-02-15 1982-02-05 Glaxo Group Ltd Androstane carbothioates
US4578221A (en) * 1980-04-23 1986-03-25 Glaxo Group Limited Androstane carbothioic acids
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
GB9225923D0 (en) * 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
DK0675897T3 (da) * 1992-12-24 1998-01-26 Rhone Poulenc Rorer Ltd Nye steroider
CA2241728A1 (en) * 1995-12-29 1997-07-10 Panayiotis Alexandrou Procopiou Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
GB0017988D0 (en) * 2000-07-21 2000-09-13 Glaxo Group Ltd Novel process
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
AU2001276497B2 (en) * 2000-08-05 2005-04-07 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
GB0019172D0 (en) * 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6750210B2 (en) * 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858596B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858593B2 (en) * 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) * 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
UA77656C2 (en) * 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
DE60229372D1 (de) * 2001-04-30 2008-11-27 Glaxo Group Ltd Antiphlogistische 7.beta.-carbothioate esterderivate von androstan mit einer 17.alpha.-zyklischen estergruppe
EP1395604B1 (de) * 2001-06-12 2008-06-25 Glaxo Group Limited Neue anti inflammatorische 17.alpha.-heterozyklische ester von 17.beta.-carbothioat androstan derivativen
US20050175545A1 (en) * 2002-02-04 2005-08-11 Keith Biggadike Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) * 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
JP2006522028A (ja) * 2003-04-04 2006-09-28 アルファーマ エーピーエス ステロイド性カルボチオ酸誘導体の製造方法および中間体
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AR059216A1 (es) * 2006-01-27 2008-03-19 Sun Pharmaceutical Ind Ltd 11b-hidroxiandrosta-4-eno-3-onas
GB0615108D0 (en) * 2006-07-28 2006-09-06 Glaxo Group Ltd Novel formulations
AR069804A1 (es) * 2007-12-21 2010-02-17 Schering Corp Agonistas del receptor glucocorticoide c20- c21 sustituido
AR077101A1 (es) 2009-06-16 2011-08-03 Schering Corp Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2509171A (en) * 1946-02-06 1950-05-23 Ciba Ltd Primary alcohols from thiocarboxylic acids and esters
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
US3989686A (en) * 1972-06-15 1976-11-02 Glaxo Laboratories Limited Anaesthetic steroids of the androstane series and process for preparing same
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
CH628355A5 (de) * 1976-02-24 1982-02-26 Ciba Geigy Ag Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze.

Also Published As

Publication number Publication date
FI791081A (fi) 1979-10-06
AT368168B (de) 1982-09-27
DK136579A (da) 1979-10-06
NO152935C (no) 1985-12-18
NO152935B (no) 1985-09-09
IT1120954B (it) 1986-03-26
AU4558379A (en) 1979-10-18
JPS6069019A (ja) 1985-04-19
SG6786G (en) 1986-08-01
IL56972A0 (en) 1979-05-31
GR67275B (de) 1981-06-26
CA1134345A (en) 1982-10-26
AU526025B2 (en) 1982-12-16
DK147735C (da) 1985-08-19
SU1052161A3 (ru) 1983-10-30
PL121469B1 (en) 1982-05-31
DK147735B (da) 1984-11-26
NO791140L (no) 1979-10-08
IT7967652A0 (it) 1979-03-28
CS203956B2 (en) 1981-03-31
JPS6140648B2 (de) 1986-09-10
FR2421912B1 (de) 1981-03-20
US4188385A (en) 1980-02-12
YU80379A (en) 1983-04-30
GB2018256A (en) 1979-10-17
NZ190076A (en) 1984-07-31
ES479271A1 (es) 1980-01-16
JPS611038B2 (de) 1986-01-13
FR2421912A1 (fr) 1979-11-02
EP0004741A3 (en) 1979-11-14
ZA791635B (en) 1980-11-26
PT69409A (en) 1979-04-01
FI66393B (fi) 1984-06-29
EP0004741B1 (de) 1981-01-28
FI66393C (fi) 1984-10-10
DE2912331A1 (de) 1979-10-18
EP0004741A2 (de) 1979-10-17
ATA251979A (de) 1982-01-15
JPS54141758A (en) 1979-11-05
GB2018256B (en) 1983-02-02
AR226035A1 (es) 1982-05-31
HU179314B (en) 1982-09-28
HK41284A (en) 1984-05-18
MY8500575A (en) 1985-12-31
YU40929B (en) 1986-08-31
PL214676A1 (de) 1980-01-02

Similar Documents

Publication Publication Date Title
DE2960096D1 (en) Thio etianic acid derivatives, their preparation and pharmaceutical use
DE3069559D1 (en) Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use
IL56557A0 (en) 6-substituted 2-penem-3-carboxylic acid derivatives, theirproduction and pharmaceutical compositions containing them
IL57708A0 (en) Aminopropoxyindole derivatives,their preparation and pharmaceutical compositions containing them
ZA802155B (en) Penem-3-carboxylic acid derivatives, their preparation and use
DE2965443D1 (en) Novel anti-hypertensive mercaptoacylamino acid derivatives, their preparation and use
IL56421A (en) 4-pyridone-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE2862404D1 (en) Hydantoin derivatives, their preparation and pharmaceutical compositions containing them
IL57297A (en) 4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
DE2966364D1 (en) Phenyl-alkanoic acid derivatives, the preparation thereof and pharmaceutical compositions containing them
IL58620A (en) Aryltrifluoroethanol derivatives,their preparation and pharmaceutical compositions containing them
IL56816A0 (en) N-phenylaniline derivatives,their preparation and pharmaceutical compositions containing them
DE2962834D1 (en) 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions
IL57219A (en) 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them
IL56913A (en) Sprio-steroid-oxazolidinone derivatives,their preparation and pharmaceutical compositions containing them
IL56890A0 (en) 2-amino-carbazole derivatives,their preparation and pharmaceutical compositions containing them
IL56461A0 (en) 1-naphthyl-acetic acid derivatives, their preparation and pharmaceutical compositions containing them
DE2963868D1 (en) Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them
IL56075A (en) Tautomeric 1-cycloalkenoyl-2-anilino-imidazoline derivatives,their preparation and pharmaceutical compositions containing them
IL57735A (en) 7beta-aminothiazolyl-acetamido-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IL56349A0 (en) 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
ZA811567B (en) 2-penem-3-carboxylic acid derivatives, their preparation and use
GB2025394B (en) Benzoylphenoxyalkanoic acid derivatives their use and preparation
IL56529A0 (en) Azathianaphthalene derivatives, their manufacture and pharmaceutical compositions containing them
DE3062022D1 (en) Dihydronicotinic acid derivatives, their preparation and use

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee