FR12C0008I1 - - Google Patents

Info

Publication number
FR12C0008I1
FR12C0008I1 FR12C0008C FR12C0008I1 FR 12C0008 I1 FR12C0008 I1 FR 12C0008I1 FR 12C0008 C FR12C0008 C FR 12C0008C FR 12C0008 I1 FR12C0008 I1 FR 12C0008I1
Authority
FR
France
Prior art keywords
transthyretin
misfolding
diseases
treatment
effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32685364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR12C0008(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR12C0008I1 publication Critical patent/FR12C0008I1/fr
Application granted granted Critical
Publication of FR12C0008I2 publication Critical patent/FR12C0008I2/fr
Active legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
FR12C0008C 2002-12-19 2012-02-22 Compositions et methodes permettant de stabiliser la transthyretine et d'inhiber un mauvais repliement de la transthyretine Active FR12C0008I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43507902P 2002-12-19 2002-12-19
US46543503P 2003-04-24 2003-04-24
PCT/US2003/040567 WO2004056315A2 (fr) 2002-12-19 2003-12-19 Compositions et methodes permettant de stabiliser la transthyretine et d'inhiber un mauvais repliement de la transthyretine

Publications (2)

Publication Number Publication Date
FR12C0008I1 true FR12C0008I1 (fr) 2012-03-30
FR12C0008I2 FR12C0008I2 (fr) 2013-01-11

Family

ID=32685364

Family Applications (1)

Application Number Title Priority Date Filing Date
FR12C0008C Active FR12C0008I2 (fr) 2002-12-19 2012-02-22 Compositions et methodes permettant de stabiliser la transthyretine et d'inhiber un mauvais repliement de la transthyretine

Country Status (19)

Country Link
US (6) US7214695B2 (fr)
EP (3) EP1988397B8 (fr)
JP (3) JP4665076B2 (fr)
KR (1) KR101089904B1 (fr)
CN (2) CN101413143B (fr)
AT (2) ATE524741T1 (fr)
AU (2) AU2003303196C1 (fr)
BE (1) BE2012C008I2 (fr)
BR (1) BRPI0317463B8 (fr)
CA (2) CA2510455C (fr)
CY (2) CY1108467T1 (fr)
DE (2) DE60323155D1 (fr)
DK (2) DK1587821T3 (fr)
ES (3) ES2373639T3 (fr)
FR (1) FR12C0008I2 (fr)
LU (1) LU91935I2 (fr)
PT (2) PT1587821E (fr)
SI (1) SI1587821T1 (fr)
WO (1) WO2004056315A2 (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06105459B2 (ja) * 1988-08-11 1994-12-21 日本電気株式会社 ベクトル処理装置
EP1988397B8 (fr) 2002-12-19 2012-02-15 The Scripps Research Institute Compositions et utilisations pour stabiliser la transthyretine et pour inhiber un mauvais repliement de la transthyretine
US7279457B2 (en) * 2004-03-12 2007-10-09 Biodel, Inc. Rapid acting drug delivery compositions
WO2005112913A1 (fr) 2004-05-20 2005-12-01 The Scripps Research Institute Stabilisation de la transthyretine
DK1819354T3 (da) * 2004-08-26 2011-09-12 Biocrine Ab Fremgangsmåder og forbindelser til behandling af diabetes
WO2007022138A2 (fr) * 2005-08-11 2007-02-22 The Scripps Research Institute Inhibition de l'amylose de la transthyretine par la genisteine
WO2008034016A2 (fr) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Dosages pour détecter des protéines à l'état natif et identifier des composés qui modulent la stabilité desdites protéines
WO2010054127A1 (fr) * 2008-11-05 2010-05-14 Elan Pharmaceuticals, Inc. Méthodes et agents pour stabiliser des polypeptides amyloïdogènes non pathologiques
JOP20190230A1 (ar) * 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
CA2751679C (fr) 2009-02-06 2018-02-27 Women & Infants' Hospital Of Rhode Island Compositions destinees au traitement de troubles de la grossesse de type preeclampsie renfermant de la transthyretine
WO2011116123A1 (fr) * 2010-03-19 2011-09-22 Irm Llc Tafamidis pour le traitement de troubles ophtalmiques
BR112012026803A2 (pt) 2010-04-21 2016-07-12 Chiesi Farma Spa composto
EP2566333A4 (fr) 2010-05-07 2014-04-02 Univ Leland Stanford Junior Identification de stabilisants de protéines multimériques
WO2014037832A2 (fr) 2012-09-06 2014-03-13 Mahesh Kandula Compositions et méthodes de traitement de l'épilepsie et de maladies neurologiques
JP5869677B2 (ja) * 2011-09-16 2016-02-24 ファイザー・インク トランスサイレチン解離阻害剤の固体形態
EP2847169A4 (fr) 2012-05-07 2015-09-30 Cellix Bio Private Ltd Compositions et méthodes de traitement de troubles neurologiques
US9399634B2 (en) 2012-05-07 2016-07-26 Cellix Bio Private Limited Compositions and methods for the treatment of depression
CN104603096A (zh) 2012-05-07 2015-05-06 塞利克斯比奥私人有限公司 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法
US9403826B2 (en) 2012-05-08 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory disorders
WO2013168023A1 (fr) 2012-05-08 2013-11-14 Mahesh Kandula Compositions et méthodes pour le traitement de la maladie de parkinson
WO2013167991A1 (fr) 2012-05-08 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de troubles métaboliques
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
WO2013168016A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome métabolique
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013167999A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement d'affections neurologiques
WO2013168000A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur sévère
WO2013168015A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes pour le traitement de l'asthme et de l'allergie
WO2013168012A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de troubles respiratoires
US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
WO2013168002A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement d'affections neurologiques
WO2013168011A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur chronique
WO2013167997A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome métabolique
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
SG11201407319YA (en) 2012-05-23 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of inflammatory bowel disease
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
JP2015518855A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 粘膜炎の治療のための組成物および方法
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9227974B2 (en) 2012-05-23 2016-01-05 Cellex Bio Private Limited Compositions and methods for the treatment of respiratory disorders
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (fr) 2012-08-03 2014-02-06 Mahesh Kandula Compositions et méthodes pour le traitement de la migraine et de maladies neurologiques
WO2014037833A2 (fr) 2012-09-06 2014-03-13 Mahesh Kandula Compositions et méthodes de traitement d'une inflammation et de troubles lipidiques
JP2015529218A (ja) 2012-09-08 2015-10-05 セリックスビオ プライヴェート リミテッド 炎症と脂質障害の治療のための組成物及び方法
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
WO2014124334A2 (fr) 2013-02-08 2014-08-14 Misfolding Diagnostics, Inc. Anticorps anti-transthyrétine et leurs utilisations
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2014195961A1 (fr) 2013-06-04 2014-12-11 Mahesh Kandula Compositions et procédés de traitement du diabète et du pré-diabète
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
WO2016025129A1 (fr) 2014-08-14 2016-02-18 Alhamadsheh Mamoun M Conjugaison d'agents pharmaceutiquement actifs avec des ligands de transthyrétine par des liants réglables pour augmenter la demi-vie de sérum
NZ766084A (en) * 2014-09-08 2023-12-22 Pfizer Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole
CA2976314C (fr) 2014-09-26 2021-02-23 Cellix Bio Private Limited Compositions et methodes de traitement de l'epilepsie et de troubles neurologiques
CN107207403A (zh) 2014-09-29 2017-09-26 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的组合物和方法
CA2965449C (fr) 2014-10-27 2020-11-10 Cellix Bio Private Limited Sels ternaires d'ester monomethylique d'acide fumarique associes a la piperazine ou a l'ethylenediamine pour le traitement de la sclerose en plaques
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
DK3242869T3 (da) 2015-01-06 2022-01-31 Cellix Bio Private Ltd Sammensætninger og fremgangsmåder til behanding af inflammation og smerte
CN107344927A (zh) 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
CN106496014A (zh) * 2016-10-17 2017-03-15 河北美星化工有限公司 一种二氟尼柳的制备方法
WO2018215831A2 (fr) 2017-05-22 2018-11-29 National Hellenic Research Foundation Modulateurs macrocycliques de mauvais repliement et d'agrégation de protéines associés à une maladie
GB2571950A (en) 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
CN108558599B (zh) * 2018-03-29 2021-01-29 浦拉司科技（上海）有限责任公司 2-联苯基甲醇的合成工艺
US20220071965A1 (en) 2018-12-20 2022-03-10 Pfizer Inc. Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent
US20220144787A1 (en) 2019-04-11 2022-05-12 Inke, S.A. Process for Preparing 1-deoxy-1-methylamino-D-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate
WO2020232325A1 (fr) 2019-05-16 2020-11-19 Teva Pharmaceuticals International Gmbh Formes solides de tafamidis et sels associés
CN110215740B (zh) * 2019-07-15 2021-05-04 大连医科大学 一种两性离子亲水前处理硅胶材料的制备方法
WO2021019448A1 (fr) * 2019-08-01 2021-02-04 Honour (R&D) Procédé de préparation d'un inhibiteur de la dissociation de la transthyrétine
WO2021093809A1 (fr) 2019-11-15 2021-05-20 苏州科睿思制药有限公司 Forme cristalline de tafamidis ainsi que son procédé de préparation et son utilisation
KR20220114626A (ko) * 2019-12-20 2022-08-17 화이자 아일랜드 파마슈티컬즈 6-카르복시 벤족사졸 유도체의 효율적인 제조 방법
WO2021152623A1 (fr) * 2020-01-27 2021-08-05 Dr. Reddy’S Laboratories Limited Procédés améliorés pour la préparation de tafamidis et de son sel de méglumine
CA3166429A1 (fr) 2020-01-28 2021-08-05 Bradley Dean Tait Composes, compositions et procedes de stabilisation de la transthyretine et d'inhibition du mauvais repliement de la transthyretine
WO2022112919A1 (fr) 2020-11-25 2022-06-02 Pfizer Inc. Composés de pyrazole substitués par (aza)benzothiazolyle
CN112683844A (zh) * 2020-12-07 2021-04-20 东华理工大学 一种振动对吲哚美辛-糖精共晶形成影响的研究方法
CN112858690B (zh) * 2021-01-21 2023-11-10 宁波职业技术学院 一种尿白蛋白/尿肌酐复合质控品及其制备方法
CN114907283A (zh) * 2021-02-07 2022-08-16 南京正大天晴制药有限公司 一种2-(3，5-二氯苯基)-苯并噁唑-6-羧酸的制备方法
EP4083027A1 (fr) 2021-04-26 2022-11-02 Química Sintética, S.A. Forme de tafamidis à l'état solide et son procédé de préparation
CN113372290A (zh) * 2021-05-21 2021-09-10 遵义医科大学 一种药物Tafamidis的合成方法
CN113321627B (zh) * 2021-06-06 2022-05-24 湖南第一师范学院 一种Tafamidis衍生物及其合成方法
AR126070A1 (es) 2021-06-08 2023-09-06 Alnylam Pharmaceuticals Inc Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
WO2023020762A1 (fr) 2021-08-16 2023-02-23 Synthon B.V. Formes cristallines d'un produit d'addition de tafamidis nicotinamide
WO2023091534A1 (fr) 2021-11-17 2023-05-25 Teva Pharmaceuticals International Gmbh Forme à l'état solide de tafamidis
WO2024023710A1 (fr) 2022-07-28 2024-02-01 Pfizer Inc. Compositions pharmaceutiques de tafamidis

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US435079A (en) 1890-08-26 Lock-nut for axles
DE602336C (de) 1933-03-09 1934-09-06 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von Kuepenfarbstoffen der Anthrachinonreihe
US3551433A (en) * 1967-06-21 1970-12-29 Us Army Preparation of 4-phenyl-4-acyloxypiperidine
US3551443A (en) * 1968-10-30 1970-12-29 Ciba Ltd 2-phenylbenzoxazole derivatives
USRE29608E (en) * 1972-05-18 1978-04-11 Lilly Industries Limited Benzoxazole derivatives
DE2314238A1 (de) 1973-03-22 1974-09-26 Henkel & Cie Gmbh Neue 2-(tetrazol-5'-yl)-benzoxazole, deren herstellung sowie verwendung als entzuendungshemmer in kosmetischen praeparationen
US4025637A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2,5 OR 2,6 Disubstituted benzoxazoles
US4025636A (en) * 1973-10-23 1977-05-24 Lilly Industries, Ltd. 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles
DE2619547A1 (de) * 1976-05-04 1977-11-24 Dynamit Nobel Ag Verfahren zur herstellung von 2-aryl- benzoxazolen und 2-aryl-benzthiazolen
US4416892A (en) * 1981-04-23 1983-11-22 Lilly Industries Limited Method of treating hypersensitivity disease with benzoxazole derivatives
DE4011106A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5254692A (en) * 1990-04-06 1993-10-19 Bayer Aktiengesellschaft 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
CA2051518A1 (fr) 1990-10-01 1992-04-02 Robert J. Perry Synthese de composes heterocycliques
JP3021028B2 (ja) 1990-11-19 2000-03-15 株式会社日本化学工業所 アゾール型カチオン染料
CH681806A5 (fr) 1991-03-19 1993-05-28 Ciba Geigy Ag
JPH0517458A (ja) 1991-07-04 1993-01-26 Idemitsu Kosan Co Ltd 芳香族化合物とその製造方法
US5354759A (en) * 1991-09-12 1994-10-11 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic compounds
JPH0673051A (ja) 1992-08-26 1994-03-15 Asahi Glass Co Ltd ベンズアゾール誘導体
JPH0673050A (ja) 1992-08-26 1994-03-15 Asahi Glass Co Ltd ヘテロ環化合物
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
DE4304650A1 (de) 1993-02-16 1994-08-18 Thomae Gmbh Dr K Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH06239849A (ja) 1993-02-16 1994-08-30 Canon Inc 光学活性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法及び表示装置
JP3243887B2 (ja) 1993-05-28 2002-01-07 三菱化学株式会社 有機電界発光素子
JPH0797379A (ja) 1993-09-06 1995-04-11 Canon Inc 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
US5441946A (en) * 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
US5837390A (en) * 1995-05-10 1998-11-17 Sony Corporation Metal complex, method for producing the same and optical device
JP3861930B2 (ja) 1995-12-15 2006-12-27 ソニー株式会社 金属複核錯体、その製造方法及び光学的素子
JPH09227576A (ja) 1996-02-23 1997-09-02 Sony Corp 金属複核錯体、その製造方法及び光学的素子
JP3760508B2 (ja) 1996-06-10 2006-03-29 東洋インキ製造株式会社 有機エレクトロルミネッセンス素子材料およびそれを用いた有機エレクトロルミネッセンス素子
AU3390297A (en) 1996-06-14 1998-01-07 Aaron Diamond Aids Research Center, The Uses of a chemokine receptor for inhibiting hiv-1 infection
WO1998027972A2 (fr) 1996-12-23 1998-07-02 Texas A & M University Agents anti-amyloidogenes
FR2767527B1 (fr) * 1997-08-25 1999-11-12 Pf Medicament Derives de piperazines indoliques, utiles comme medicaments et procede de preparation
GB9725782D0 (en) * 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
US6156763A (en) * 1998-02-04 2000-12-05 Board Of Regents, The University Of Texas System Inhibition of human telomerase by a g-quadruplex-interaction compound
US6107491A (en) * 1998-07-20 2000-08-22 Ciba Specialty Chemicals Corporation Polymerizable diketopyrrolopyrroles
GB9816654D0 (en) * 1998-07-30 1998-09-30 Zeneca Ltd Chemical compounds
JP2000100569A (ja) 1998-09-22 2000-04-07 Toray Ind Inc 発光素子
JP2001055332A (ja) 1999-06-07 2001-02-27 Saitama Daiichi Seiyaku Kk 芳香族アミジン誘導体類含有のイオントフォレ−シス用製剤
BR0012291A (pt) 1999-06-18 2002-03-26 Bayer Ag Fenoxifluorpirimidinas
JP2001064166A (ja) 1999-06-25 2001-03-13 Dai Ichi Seiyaku Co Ltd 貼付剤
JP2001064205A (ja) 1999-06-25 2001-03-13 Dai Ichi Seiyaku Co Ltd 製剤組成物
WO2001012183A1 (fr) * 1999-08-16 2001-02-22 Merck & Co., Inc. Amides heterocycles comme inhibiteurs de l'adhesion cellulaire
GB9919673D0 (en) 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
JP2001226358A (ja) 1999-10-12 2001-08-21 Japan Tobacco Inc Ｌｐｌ活性増強剤
JP2001242165A (ja) 2000-02-25 2001-09-07 Dai Ichi Seiyaku Co Ltd 採血用試薬
CN1241909C (zh) 2000-03-16 2006-02-15 弗·哈夫曼-拉罗切有限公司 用作ip拮抗剂的羧酸衍生物
GB0007934D0 (en) 2000-03-31 2000-05-17 Darwin Discovery Ltd Chemical compounds
JP3945123B2 (ja) 2000-04-10 2007-07-18 三菱化学株式会社 有機電界発光素子
JP2001301329A (ja) 2000-04-20 2001-10-31 Mitsubishi Chemicals Corp 光学記録媒体
JP2002003368A (ja) 2000-06-23 2002-01-09 Saitama Daiichi Seiyaku Kk 経皮吸収又は経粘膜吸収用の製剤
HU230375B1 (hu) 2000-08-24 2016-03-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében
MXPA03003829A (es) 2000-11-04 2003-07-28 Aventis Pharma Ltd Acidos alcanoicos substituidos.
US20070004713A1 (en) 2000-12-07 2007-01-04 Bernard Barlaam Therapeutic benimidazole compounds
WO2002051821A1 (fr) 2000-12-22 2002-07-04 Astrazeneca Ab Composes therapeutiques
GB0118357D0 (en) 2001-07-27 2001-09-19 Syngenta Ltd Chemical compounds
AU2002334355A1 (en) 2001-09-06 2003-03-18 Prochon Biotech Ltd. Protein tyrosine kinase inhibitors
US6602619B2 (en) * 2001-10-19 2003-08-05 Lightronik Technology Inc. Organic EL device
JP4634037B2 (ja) * 2001-11-16 2011-02-16 日本ケミファ株式会社 キサンチンオキシダーゼ阻害剤
AU2002353739A1 (en) 2001-11-28 2003-06-10 Astrazeneca Ab Therapeutic compounds
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
CN1596240A (zh) 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
US7202247B2 (en) 2001-12-19 2007-04-10 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
GB0205256D0 (en) 2002-03-06 2002-04-17 Oxford Glycosciences Uk Ltd Novel compounds
BR0308537A (pt) 2002-03-20 2005-02-09 Metabolex Inc Composto, composição, e métodos para tratar diabetes tipo 2 e hiperuricemia, para modular resistência a insulina e para aliviar hiperlipidemia em um indivìduo e agente de prodroga
UA79755C2 (en) 2002-04-16 2007-07-25 Bayer Pharmaceuticals Corp Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
GB0226822D0 (en) 2002-11-16 2002-12-24 Oxford Glycosciences Uk Ltd Novel compounds
EP1988397B8 (fr) 2002-12-19 2012-02-15 The Scripps Research Institute Compositions et utilisations pour stabiliser la transthyretine et pour inhiber un mauvais repliement de la transthyretine
EP1587798A4 (fr) 2003-01-14 2007-06-27 Merck & Co Inc Derives de nsaid a disubstitution geminale servant d'agents reducteurs de abeta 42
JP2004250411A (ja) 2003-02-21 2004-09-09 Bf Kenkyusho:Kk アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物
CA2438032C (fr) 2003-03-14 2013-05-07 University Of Pittsburgh Derives de benzothiazole et compositions et utilisations connexes
MY142651A (en) 2003-03-18 2010-12-15 Merck Sharp & Dohme Biaryl substituted triazoles as sodium channel blockers
EP1608622A4 (fr) 2003-03-24 2009-04-01 Merck & Co Inc Heterocycles a 6 elements a substitution biaryle en tant que bloqueurs des canaux sodiques
JP2004302049A (ja) 2003-03-31 2004-10-28 Hodogaya Chem Co Ltd 感光性樹脂組成物
CN101333192A (zh) 2003-04-03 2008-12-31 默克公司 作为钠通道阻滞剂的联芳基取代吡唑
US20070060584A1 (en) 2003-04-18 2007-03-15 Chakravarty Prasun K Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
EP1620413A2 (fr) 2003-04-30 2006-02-01 Cytokinetics, Inc. Composes, compositions et procedes
WO2005112913A1 (fr) * 2004-05-20 2005-12-01 The Scripps Research Institute Stabilisation de la transthyretine

Also Published As

Publication number Publication date
JP2013256521A (ja) 2013-12-26
CA2510455A1 (fr) 2004-07-08
ATE405840T1 (de) 2008-09-15
ATE524741T1 (de) 2011-09-15
US20120065237A1 (en) 2012-03-15
DK1988397T3 (da) 2011-12-12
BRPI0317463B1 (pt) 2017-04-18
US7214695B2 (en) 2007-05-08
EP2325651A3 (fr) 2011-09-21
US7214696B2 (en) 2007-05-08
BE2012C008I2 (fr) 2023-03-07
DE122012000007I1 (de) 2012-04-12
JP4665076B2 (ja) 2011-04-06
JP5756151B2 (ja) 2015-07-29
CN101413143B (zh) 2013-09-18
AU2010201263B8 (en) 2013-04-18
CY1108467T1 (el) 2014-04-09
CN100448852C (zh) 2009-01-07
AU2003303196C1 (en) 2021-03-25
AU2010201263A1 (en) 2010-04-22
US20040152140A1 (en) 2004-08-05
CN1747965A (zh) 2006-03-15
CY2012005I1 (el) 2015-10-07
AU2003303196A1 (en) 2004-07-14
PT1988397E (pt) 2011-12-02
EP1988397A1 (fr) 2008-11-05
US8653119B2 (en) 2014-02-18
ES2373639T3 (es) 2012-02-07
BR0317463A (pt) 2005-11-16
ES2312857T3 (es) 2009-03-01
CY2012005I2 (el) 2015-10-07
EP2325651B1 (fr) 2014-10-08
CA2510455C (fr) 2013-03-12
US20100120919A1 (en) 2010-05-13
EP1587821A2 (fr) 2005-10-26
JP2010270134A (ja) 2010-12-02
EP1988397B1 (fr) 2011-09-14
DK1587821T3 (da) 2008-11-10
FR12C0008I2 (fr) 2013-01-11
AU2003303196B2 (en) 2010-03-25
US7560488B2 (en) 2009-07-14
LU91935I2 (fr) 2012-03-26
CA2800237A1 (fr) 2004-07-08
PT1587821E (pt) 2008-09-23
US20140134753A1 (en) 2014-05-15
WO2004056315A3 (fr) 2005-08-11
EP1587821B1 (fr) 2008-08-20
US20070078186A1 (en) 2007-04-05
JP2006511612A (ja) 2006-04-06
BRPI0317463B8 (pt) 2021-05-25
KR20050090410A (ko) 2005-09-13
US20060057644A1 (en) 2006-03-16
AU2010201263A8 (en) 2013-04-18
KR101089904B1 (ko) 2011-12-05
EP2325651A2 (fr) 2011-05-25
WO2004056315A8 (fr) 2005-12-08
WO2004056315A2 (fr) 2004-07-08
CA2800237C (fr) 2016-05-17
EP1988397B8 (fr) 2012-02-15
EP1587821A4 (fr) 2007-05-09
DE60323155D1 (de) 2008-10-02
LU91935I9 (fr) 2019-01-04
SI1587821T1 (sl) 2009-02-28
US8168663B2 (en) 2012-05-01
CN101413143A (zh) 2009-04-22
ES2524803T3 (es) 2014-12-12
AU2010201263B2 (en) 2012-12-20

Similar Documents

Publication Publication Date Title
BE2012C008I2 (fr)
MXPA05012323A (es) Sulfonamidas ciclicas para la inhibicion de gama-secretasa.
GB0117326D0 (en) Napthoquinone-type inhibitors of protein aggregation
IL174210A0 (en) 1,4 disubstituted isoquinilone derivatives as raf-kinase inhibitors useful for the treatment of proliferative diseases
GB0318447D0 (en) Therapeutic agents
GB0206711D0 (en) HIF Inhibitor
EA200601555A1 (ru) Замещенные индазол-о-глюкозиды
EA200601554A1 (ru) Замещенные индол-о-глюкозиды
TW200510334A (en) Preraration and use of aryl alkyl acid derivatives for the treatment of obesity
UA86599C2 (en) Substituted benzimidazole-, benztriazole- and benzimidazolone-о-glucosides
MXPA02007099A (es) Compuestos de tiazola, imidazola y oxazola y tratamientos de desordenes asociados con la maduracion de la proteina.
EA200501834A1 (ru) Фунгицидные смеси для борьбы с патогенами риса
EA200600078A1 (ru) Способы и композиции для лечения амилоидных заболеваний
EA200500856A1 (ru) Новые химические соединения
MY141528A (en) Anilinopyrazole derivatives useful for the treatment of diabetes
MXPA05013251A (es) Composiciones para estado de oxigeno mejorado en animales de compania.
ATE336996T1 (de) Verwendung von flavonoid-derivaten zur behandlung von atopischem ekzem
DE60219495D1 (de) Verwendung von Interleukin-18 zur Behandlung von UV-assoziierten Hautkrankheiten
AU2003260723A1 (en) Use of vinca alkaloyds, taxane, cryptophycine, ephitoline or eleutherobine for treating alzheimer
BR0214244A (pt) Uso de uma ascomicina
WO2004071433A3 (fr) Procedes de traitement de maladie
MY135225A (en) Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders
EA200600702A1 (ru) Фунгицидные смеси, в частности, для борьбы с патогенами риса