FR10C0026I1 - Procede ameliore de production en serie d'antigene viral - Google Patents

Procede ameliore de production en serie d'antigene viral

Info

Publication number
FR10C0026I1
FR10C0026I1 FR10C0026C FR10C0026C FR10C0026I1 FR 10C0026 I1 FR10C0026 I1 FR 10C0026I1 FR 10C0026 C FR10C0026 C FR 10C0026C FR 10C0026 C FR10C0026 C FR 10C0026C FR 10C0026 I1 FR10C0026 I1 FR 10C0026I1
Authority
FR
France
Prior art keywords
improved process
viral antigen
serial production
cell culture
serial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR10C0026C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Original Assignee
Baxter Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21723079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR10C0026(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA filed Critical Baxter Healthcare SA
Publication of FR10C0026I1 publication Critical patent/FR10C0026I1/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR10C0026C 2001-12-10 2010-04-16 Procede ameliore de production en serie d'antigene viral Active FR10C0026I1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/006,881 US6951752B2 (en) 2001-12-10 2001-12-10 Method for large scale production of virus antigen
PCT/EP2002/014011 WO2003054174A1 (en) 2001-12-10 2002-12-10 Method for large scale production of virus antigen

Publications (1)

Publication Number Publication Date
FR10C0026I1 true FR10C0026I1 (fr) 2011-01-14

Family

ID=21723079

Family Applications (1)

Application Number Title Priority Date Filing Date
FR10C0026C Active FR10C0026I1 (fr) 2001-12-10 2010-04-16 Procede ameliore de production en serie d'antigene viral

Country Status (18)

Country Link
US (2) US6951752B2 (ru)
EP (3) EP2330189B1 (ru)
JP (2) JP4370511B2 (ru)
CN (2) CN101100657B (ru)
AT (1) ATE447010T2 (ru)
AU (1) AU2002358662B2 (ru)
CA (1) CA2469644C (ru)
DE (2) DE122010000025I1 (ru)
DK (2) DK1453956T3 (ru)
ES (2) ES2335395T5 (ru)
FR (1) FR10C0026I1 (ru)
HK (2) HK1115609A1 (ru)
HU (1) HU225791B1 (ru)
MX (1) MXPA04005644A (ru)
NO (1) NO20042910L (ru)
PL (1) PL208232B1 (ru)
RU (1) RU2314344C2 (ru)
WO (1) WO2003054174A1 (ru)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7445924B2 (en) 2000-11-23 2008-11-04 Bavarian Nordic A/S Modified Vaccinia Ankara virus variant and cultivation method
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
CN1289663C (zh) * 2001-12-20 2006-12-13 巴法里安诺迪克有限公司 从感染细胞中回收和纯化痘病毒的方法
DK1434858T4 (en) 2002-09-05 2019-04-01 Bavarian Nordic As PROCEDURE FOR AMPLIFICATION OF A POXVIRUS UNDER SERUM-FREE CONDITIONS
US7541164B2 (en) * 2002-12-23 2009-06-02 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CN1898379A (zh) * 2003-12-23 2007-01-17 先灵公司 生产在无血清的培养基悬浮培养中稳定的a549细胞系的方法
EP1718738A2 (en) 2004-02-23 2006-11-08 Crucell Holland B.V. Virus purification methods
EP1739167B1 (en) * 2004-04-19 2015-08-12 DENKA SEIKEN Co., Ltd. Method of producing virus
JP2007537760A (ja) * 2004-05-20 2007-12-27 アイディー バイオメディカル コーポレイション インフルエンザワクチンを製造するためのプロセス
AU2005322353B2 (en) * 2004-12-23 2011-09-01 Medimmune, Llc Non-tumorigenic MDCK cell line for propagating viruses
US7344839B2 (en) * 2004-12-23 2008-03-18 Aurx, Inc. Virus preparations and methods
EP2010557B1 (en) 2006-03-31 2014-02-26 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
RU2487935C2 (ru) 2006-09-15 2013-07-20 Медиммун, Ллк. Линии клеток почки собаки майдин-дэрби (mdck), поддерживающие рост вирусов до высоких титров, и способ применения этих клеток в биореакторе
JP5084214B2 (ja) * 2006-09-29 2012-11-28 一般財団法人日本ポリオ研究所 Ｉｐｖワクチン
JP5352578B2 (ja) * 2007-05-04 2013-11-27 バクスター・インターナショナル・インコーポレイテッド ウイルスの増殖のための二段階温度プロフィール
US9474798B2 (en) 2007-06-18 2016-10-25 Wisconsin Alumni Research Foundation Influenza M2 protein mutant viruses as live influenza attenuated vaccines
WO2009114693A1 (en) * 2008-03-12 2009-09-17 Wyeth Method for identifying cells suitable for large-scale production of recombinant proteins
WO2010012045A1 (en) * 2008-08-01 2010-02-04 Gamma Vaccines Pty Limited Influenza vaccines
EP2344634A4 (en) * 2008-09-24 2012-08-29 Medimmune Llc METHODS OF CELL CULTURE, AND PROPAGATION AND PURIFICATION OF VIRUSES
CN102215865B (zh) 2008-09-24 2013-10-30 米迪缪尼有限公司 病毒纯化方法
EP2459709B1 (en) 2009-07-31 2014-09-03 GE Healthcare Bio-Sciences Corp. High yield yellow fever virus strain with increased propagation in cells
ES2813347T3 (es) 2009-10-26 2021-03-23 Wisconsin Alumni Res Found Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero
BR112012015596B1 (pt) * 2009-12-23 2021-06-01 Sanofi Pasteur Processo de cultura de células aderentes
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US9644187B2 (en) 2010-04-14 2017-05-09 Emd Millipore Corporation Methods of producing high titer, high purity virus stocks and methods of use thereof
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
CN101979517B (zh) * 2010-10-15 2011-12-28 普莱柯生物工程股份有限公司 一种利用生物反应器大规模生产流感病毒的方法
AU2012211043B2 (en) 2011-01-27 2017-04-06 Gamma Vaccines Pty Limited Combination vaccines
CN102492659A (zh) * 2011-11-14 2012-06-13 成都康华生物制品有限公司 一种疫苗生产用甲肝病毒的生产方法
JP2016524915A (ja) 2013-07-15 2016-08-22 ウィスコンシン アルムニ リサーチ ファンデイション Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
CN103387958B (zh) * 2013-08-16 2016-04-06 北京科兴中维生物技术有限公司 人胚肺成纤维细胞sv-7在病毒培养中的应用
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2016121768A1 (ja) 2015-01-26 2016-08-04 宇部興産株式会社 物質の産生方法
BR112017012335A2 (pt) 2015-01-26 2018-02-27 Ube Industries, Ltd. método, dispositivo e kit para a cultura em massa de células usando uma membrana de poli-imida porosa
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CN109477074B (zh) 2016-02-19 2023-01-24 威斯康星旧生研究基金会 用于疫苗开发的改进的乙型流感病毒复制
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
AU2017303598A1 (en) 2016-07-25 2019-02-21 Ube Industries, Ltd. Cell culture module
CN109477056A (zh) 2016-07-25 2019-03-15 宇部兴产株式会社 虹吸式培养法
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
SG11202005528PA (en) * 2018-01-18 2020-07-29 Yisheng Biopharma Singapore Pte Ltd Method for adapting influenza viruses to vero cells
SG11202007503WA (en) * 2018-02-07 2020-09-29 Bharat Biotech Int Ltd A process for enterovirus purification and inactivation and vaccine compositions obtained thereof
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
KR102228267B1 (ko) * 2019-01-25 2021-03-17 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
WO2020153619A1 (ko) * 2019-01-25 2020-07-30 바이로큐어 주식회사 Bhk-21 세포를 이용한 바이러스 생산방법
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
EP3924469A4 (en) * 2019-02-15 2022-12-14 Ology Bioservices, Inc. VIRUS PRODUCTION METHOD
WO2020223699A1 (en) 2019-05-01 2020-11-05 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
TW202122572A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 胞外體的產生方法
TW202122569A (zh) 2019-08-09 2021-06-16 日商宇部興產股份有限公司 應用小片多孔膜的細胞培養法
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
CN111850169B (zh) * 2020-07-16 2022-09-27 华农（肇庆）生物产业技术研究院有限公司 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法
JP2024511064A (ja) 2021-03-23 2024-03-12 テルモ ビーシーティー、インコーポレーテッド 細胞捕獲及び増殖

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525349A (en) 1981-12-29 1985-06-25 Societe Anonyme Dite: Institut Merueux Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine
AT393356B (de) 1989-12-22 1991-10-10 Immuno Ag Verfahren zur herstellung von fsme-virus-antigen
US5719051A (en) * 1989-12-22 1998-02-17 Immuno Aktiengesellschaft Perfusion system and a method for the large scale production of virus or virus antigen
FR2723740B1 (fr) 1994-08-16 1996-11-08 Pasteur Merieux Serums Vacc Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications
US5824536A (en) * 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
ATE542891T1 (de) 1994-11-10 2012-02-15 Baxter Healthcare Sa Verfahren zur herstellung von biologischen produkten in protein-freier kultur
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
GB2319413B (en) * 1996-11-12 2001-06-06 Lsi Logic Corp Driver circuits
DE69835813T2 (de) * 1997-01-31 2007-09-13 Schering Corp. Verfahren zur kultivierung von zellen und zur vermehrung von viren
US6168944B1 (en) * 1997-01-31 2001-01-02 Schering Corporation Methods for cultivating cells and propagating viruses
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US5994134A (en) * 1998-05-04 1999-11-30 Canji, Inc. Viral production process
US6951752B2 (en) * 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus

Also Published As

Publication number Publication date
JP2005512564A (ja) 2005-05-12
EP1453956A1 (en) 2004-09-08
HK1115609A1 (en) 2008-12-05
DK2330189T3 (da) 2014-06-16
EP1894998A8 (en) 2008-04-23
RU2314344C2 (ru) 2008-01-10
ES2335395T5 (es) 2017-08-31
EP2330189B1 (en) 2014-05-21
AU2002358662B2 (en) 2008-05-15
JP5021000B2 (ja) 2012-09-05
HUP0402415A2 (hu) 2005-02-28
EP1894998A1 (en) 2008-03-05
DE122010000025I1 (de) 2010-08-12
HUP0402415A3 (en) 2005-07-28
CA2469644A1 (en) 2003-07-03
US7524676B2 (en) 2009-04-28
AU2002358662A1 (en) 2003-07-09
JP2009261410A (ja) 2009-11-12
HU225791B1 (en) 2007-09-28
ES2335395T3 (es) 2010-03-26
NO20042910L (no) 2004-07-09
ATE447010T2 (de) 2009-11-15
CN101100657B (zh) 2012-05-30
PL373487A1 (en) 2005-09-05
EP1453956B8 (en) 2010-02-10
JP4370511B2 (ja) 2009-11-25
WO2003054174A1 (en) 2003-07-03
US6951752B2 (en) 2005-10-04
RU2004121178A (ru) 2005-10-10
US20030108860A1 (en) 2003-06-12
DE60234211D1 (de) 2009-12-10
EP2330189A1 (en) 2011-06-08
ES2488818T3 (es) 2014-08-29
EP1453956B1 (en) 2009-10-28
MXPA04005644A (es) 2005-04-19
CN100335619C (zh) 2007-09-05
US20050181495A1 (en) 2005-08-18
CN1617924A (zh) 2005-05-18
CA2469644C (en) 2013-07-23
CN101100657A (zh) 2008-01-09
HK1158691A1 (en) 2012-07-20
DK1453956T3 (da) 2010-01-11
EP1453956B2 (en) 2017-01-18
PL208232B1 (pl) 2011-04-29

Similar Documents

Publication Publication Date Title
FR10C0026I1 (fr) Procede ameliore de production en serie d'antigene viral
WO2003067213A3 (en) Modulation of sulfate permease for photosynthetic hydrogen production
BR0010806A (pt) Métodos e materiais para a sìntese de produtos orgânicos
DE69329154D1 (de) Erhöhte produktion von taxol und taxanen mittels -taxus-spezifische zellkulturen
ATE442453T1 (de) Verfahren zur herstellung von l-aminosäure oder nucleinsäure unter verwendung von mikroorganismen
HRP20060398A2 (en) Method and fermenter for the anaerobic fermentation of biological waste
NZ597334A (en) Cell culture improvements
ATE452181T1 (de) Verfahren und vorrichtung zur haltung und expansion von hematopoietischen stammzellen und/oder vorläuferzellen
NO20014150L (no) Fotobioreaktor med forbedret lystilförsel ved overflateforstörrelse, bölgelengdeskiftere eller lystransport
AU2002212275A1 (en) Bio-reactor for the cultivation of micro-organisms and method for the production thereof
BR0008772B1 (pt) vetor de expressão, célula bacteriana ou fúngica cultivada, processos para expandir in vitro células hematopoiéticas e progenitores de células hematopoiéticas, e para detectar a presença de rna de ligando zalfa11 e de ligando zalfa 11 in vitro em uma amostra biológica.
ATE231729T1 (de) Verfahren zur industriellen herstellung eines japanischen enkephalitis impfstoffes, und so erhaltener impfstoff
DE60134163D1 (de) Nicht-pathogene mikroorganismen
DE60029232D1 (de) Verbessertes fermentationsverfahren
ATE336567T1 (de) Zellkulturmedium
GB9913979D0 (en) Spheroid preparation
ATE530657T1 (de) Verfahren zur herstellung von zellinien mit latentem immunschwächevirus
BR0011672A (pt) Bactéria corineforme, processo para produzir l-lisina, e, dna
Gotovtsev et al. Synthetic biology as a bridge to integration of bio objects into Internet of Things
ATE327318T1 (de) Fermentationsverfahren mit kontinuierlicher massenkultivierung von ciliaten (protozoa) zur produktion biogener wertstoffe
DE602004029789D1 (de) Keratinozyten-kulturverfahren und verwendung davon
DE69905218D1 (de) Verfahren zur Herstellung von L-Allysin Acetal
DE59809842D1 (de) Antikörper 67D2 gegen CD164
WO2002064811A3 (fr) Procede pour produire des proteines recombinantes, marquees par au moins un isotope
ATE288476T1 (de) Herstellung von proteinen