FI93546C - Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi Download PDF

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Publication number
FI93546C
FI93546C FI890286A FI890286A FI93546C FI 93546 C FI93546 C FI 93546C FI 890286 A FI890286 A FI 890286A FI 890286 A FI890286 A FI 890286A FI 93546 C FI93546 C FI 93546C
Authority
FI
Finland
Prior art keywords
formula
compound
process according
purin
acid
Prior art date
Application number
FI890286A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI93546B (fi
FI890286A (fi
FI890286A0 (fi
Inventor
Richard Storer
Robert Vince
Mei Hua
Peter Leslie Myers
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/146,252 external-priority patent/US4916224A/en
Priority claimed from GB888821011A external-priority patent/GB8821011D0/en
Priority claimed from US07/278,652 external-priority patent/US4931559A/en
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of FI890286A0 publication Critical patent/FI890286A0/fi
Publication of FI890286A publication Critical patent/FI890286A/fi
Publication of FI93546B publication Critical patent/FI93546B/fi
Application granted granted Critical
Publication of FI93546C publication Critical patent/FI93546C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI890286A 1988-01-20 1989-01-19 Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi FI93546C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14625288 1988-01-20
US07/146,252 US4916224A (en) 1988-01-20 1988-01-20 Dideoxycarbocyclic nucleosides
GB8821011 1988-09-07
GB888821011A GB8821011D0 (en) 1988-09-07 1988-09-07 Chemical compounds
US07/278,652 US4931559A (en) 1988-01-20 1988-12-05 Optically-active isomers of dideoxycarbocyclic nucleosides
US27865288 1988-12-05

Publications (4)

Publication Number Publication Date
FI890286A0 FI890286A0 (fi) 1989-01-19
FI890286A FI890286A (fi) 1989-07-21
FI93546B FI93546B (fi) 1995-01-13
FI93546C true FI93546C (fi) 1995-04-25

Family

ID=27264063

Family Applications (1)

Application Number Title Priority Date Filing Date
FI890286A FI93546C (fi) 1988-01-20 1989-01-19 Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi

Country Status (29)

Country Link
JP (1) JP2793825B2 (de)
KR (1) KR0127137B1 (de)
AT (1) AT397801B (de)
AU (2) AU626278B2 (de)
BE (1) BE1003815A4 (de)
CA (1) CA1339896C (de)
CH (1) CH679152A5 (de)
DE (1) DE3901502C2 (de)
DK (1) DK175131B1 (de)
ES (1) ES2010091A6 (de)
FI (1) FI93546C (de)
FR (1) FR2626002B1 (de)
GB (1) GB2217320B (de)
GR (1) GR890100033A (de)
HU (1) HU203755B (de)
IE (1) IE62275B1 (de)
IL (1) IL88999A (de)
IT (1) IT1229531B (de)
LU (1) LU87437A1 (de)
MY (1) MY103801A (de)
NL (1) NL8900122A (de)
NO (1) NO169123C (de)
NZ (1) NZ227663A (de)
OA (1) OA09031A (de)
PL (1) PL163814B1 (de)
PT (1) PT89482B (de)
RU (1) RU2114846C1 (de)
SE (1) SE505213C2 (de)
YU (1) YU47791B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215339B (it) * 1987-01-14 1990-02-08 Co Pharma Corp Srl Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
US5631370A (en) 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US4939252A (en) * 1989-04-20 1990-07-03 Hoffmann-La Roche Inc. Novel intermediates for the preparation of Carbovir
DE69033252T2 (de) * 1989-06-27 1999-12-09 The Wellcome Foundation Ltd., Greenford Therapeutische nukleoside
GB8916477D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916479D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916478D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
GB8916480D0 (en) * 1989-07-19 1989-09-06 Glaxo Group Ltd Chemical process
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
US5241069A (en) * 1990-04-06 1993-08-31 Glaxo Inc. Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
US5144034A (en) * 1990-04-06 1992-09-01 Glaxo Inc. Process for the synthesis of cyclopentene derivatives of purines
US5057630A (en) * 1990-04-06 1991-10-15 Glaxo Inc. Synthesis of cyclopentene derivatives
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
AU677732B2 (en) * 1993-11-12 1997-05-01 Merrell Pharmaceuticals Inc. 6-oxo-nucleosides useful as immunosuppressants
GB9721780D0 (en) * 1997-10-14 1997-12-10 Glaxo Group Ltd Process for the synthesis of chloropurine intermediates
HU227559B1 (en) * 1998-10-30 2011-08-29 Lonza Ag Method for producing 4-[(2',5'-diamino-6'-halopyrimidine-4'-yl)amino]-cyclopent-2-enylmethanols
US6433170B1 (en) 1998-10-30 2002-08-13 Lonza Group Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
TW202019942A (zh) 2018-07-27 2020-06-01 日商富士軟片股份有限公司 環戊烯嘌呤衍生物或其鹽
JP2023519882A (ja) 2020-03-27 2023-05-15 ソム、イノベーション、バイオテック、ソシエダッド、アノニマ シヌクレイノパチーの治療に有用な化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
JPS62177234A (ja) * 1986-01-30 1987-08-04 Mitsubishi Heavy Ind Ltd 遠心紡糸によるカ−ボン繊維の製造装置
IN164556B (de) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.

Also Published As

Publication number Publication date
KR0127137B1 (ko) 1997-12-29
NO169123B (no) 1992-02-03
MY103801A (en) 1993-09-30
SE8900192D0 (sv) 1989-01-19
AU2867189A (en) 1989-07-20
SE8900192L (sv) 1989-07-21
PT89482B (pt) 1994-02-28
DK23489A (da) 1989-07-21
FI93546B (fi) 1995-01-13
FI890286A (fi) 1989-07-21
GB2217320A (en) 1989-10-25
GB2217320B (en) 1992-04-08
AT397801B (de) 1994-07-25
FR2626002B1 (fr) 1994-01-28
OA09031A (en) 1991-03-31
PL163814B1 (en) 1994-05-31
IE890153L (en) 1989-07-20
HUT48887A (en) 1989-07-28
IE62275B1 (en) 1995-01-25
PL277261A1 (en) 1989-09-18
CA1339896C (en) 1998-06-02
DK23489D0 (da) 1989-01-19
CH679152A5 (de) 1991-12-31
DE3901502C2 (de) 2002-06-13
LU87437A1 (fr) 1989-08-30
NO890253D0 (no) 1989-01-19
ATA10689A (de) 1993-11-15
AU637015B2 (en) 1993-05-13
KR890011902A (ko) 1989-08-23
IL88999A0 (en) 1989-08-15
NO169123C (no) 1992-05-13
DK175131B1 (da) 2004-06-14
IT8947546A0 (it) 1989-01-19
FI890286A0 (fi) 1989-01-19
FR2626002A1 (fr) 1989-07-21
GB8901187D0 (en) 1989-03-15
JPH02196788A (ja) 1990-08-03
HU203755B (en) 1991-09-30
RU2114846C1 (ru) 1998-07-10
AU626278B2 (en) 1992-07-30
BE1003815A4 (fr) 1992-06-23
GR890100033A (el) 1994-03-31
YU12389A (en) 1991-10-31
YU47791B (sr) 1996-01-09
AU1018092A (en) 1992-03-12
NL8900122A (nl) 1989-08-16
DE3901502A1 (de) 1989-07-27
JP2793825B2 (ja) 1998-09-03
SE505213C2 (sv) 1997-07-14
NO890253L (no) 1989-07-21
IT1229531B (it) 1991-09-04
IL88999A (en) 1994-12-29
NZ227663A (en) 1990-09-26
PT89482A (pt) 1989-10-04
ES2010091A6 (es) 1989-10-16

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BB Publication of examined application
FG Patent granted

Owner name: REGENTS OF THE UNIVERSITY OF MINNESOTA

MA Patent expired