FI911882A7 - Menetelmä vierasproteiinien valmistamiseksi streptomykeeteissä - Google Patents

Menetelmä vierasproteiinien valmistamiseksi streptomykeeteissä Download PDF

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Publication number
FI911882A7
FI911882A7 FI911882A FI911882A FI911882A7 FI 911882 A7 FI911882 A7 FI 911882A7 FI 911882 A FI911882 A FI 911882A FI 911882 A FI911882 A FI 911882A FI 911882 A7 FI911882 A7 FI 911882A7
Authority
FI
Finland
Prior art keywords
streptomycetes
foreign proteins
producing foreign
producing
proteins
Prior art date
Application number
FI911882A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI911882L (fi
FI911882A0 (fi
Inventor
Klaus-Peter Koller
GüNTHER RIESS
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI911882A0 publication Critical patent/FI911882A0/fi
Publication of FI911882L publication Critical patent/FI911882L/fi
Publication of FI911882A7 publication Critical patent/FI911882A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
FI911882A 1990-04-21 1991-04-18 Menetelmä vierasproteiinien valmistamiseksi streptomykeeteissä FI911882A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4012818A DE4012818A1 (de) 1990-04-21 1990-04-21 Verfahren zur herstellung von fremdproteinen in streptomyceten

Publications (3)

Publication Number Publication Date
FI911882A0 FI911882A0 (fi) 1991-04-18
FI911882L FI911882L (fi) 1991-10-22
FI911882A7 true FI911882A7 (fi) 1991-10-22

Family

ID=6404857

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911882A FI911882A7 (fi) 1990-04-21 1991-04-18 Menetelmä vierasproteiinien valmistamiseksi streptomykeeteissä

Country Status (29)

Country Link
EP (1) EP0453969B1 (enExample)
JP (1) JP3319605B2 (enExample)
KR (1) KR0168669B1 (enExample)
CN (1) CN1049248C (enExample)
AT (1) ATE142263T1 (enExample)
AU (1) AU630287B2 (enExample)
BR (1) BR9101587A (enExample)
CA (1) CA2040810C (enExample)
CZ (1) CZ285440B6 (enExample)
DE (2) DE4012818A1 (enExample)
DK (1) DK0453969T3 (enExample)
ES (1) ES2093043T3 (enExample)
FI (1) FI911882A7 (enExample)
GR (1) GR3021040T3 (enExample)
HR (1) HRP940770A2 (enExample)
HU (1) HU210358B (enExample)
IE (1) IE911322A1 (enExample)
IL (1) IL97903A0 (enExample)
LT (1) LT3686B (enExample)
LV (1) LV10494B (enExample)
NO (1) NO911557L (enExample)
NZ (1) NZ237882A (enExample)
PL (2) PL169596B1 (enExample)
PT (1) PT97427B (enExample)
RU (1) RU2055892C1 (enExample)
SK (1) SK110191A3 (enExample)
TW (1) TW213487B (enExample)
YU (1) YU48435B (enExample)
ZA (1) ZA912937B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI103805B (fi) * 1990-09-05 1999-09-30 Hoechst Ag Menetelmä preproinsuliinien hydroloimiseksi
SG46612A1 (en) 1992-12-02 1998-02-20 Hoechst Ag Process for obtaining proinsulin in processing correctly linked cystine bridges
DE59409816D1 (de) * 1993-04-27 2001-09-13 Hoechst Ag Amorphe monosphärische Formen von Insulinderivaten
DE4405179A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
CN1061375C (zh) * 1996-07-19 2001-01-31 中国科学院上海生物工程研究中心 利用异源启动子在链霉菌中表达透明颤菌血红蛋白
EP0821006B1 (de) 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Insulinderivate mit erhöhter Zinkbindung
RU2122581C1 (ru) * 1997-11-27 1998-11-27 Закрытое акционерное общество "Фосфосорб" Штамм escherichia coli xli-blue/pinsr - продуцент препроинсулина
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
RU2162102C1 (ru) * 1999-09-08 2001-01-20 Головков Алексей Леонардович Рекомбинантная плазмида, кодирующая гибридный белок с проинсулином человека (варианты)
CN1298742C (zh) * 2003-06-03 2007-02-07 上海新药研究开发中心 一种适合于高效表达的融合蛋白及其生产方法
RU2395296C1 (ru) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Способ получения препарата проинсулина для перорального применения
CN104818291A (zh) * 2015-05-08 2015-08-05 江南大学 一种链霉菌重组表达载体的构建及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE3418274A1 (de) 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt Signalpeptid fuer die exkretion von peptiden in streptomyceten
DE3707150A1 (de) * 1987-03-06 1988-09-15 Hoechst Ag Tendamistat-derivate
DE3714866A1 (de) * 1987-05-05 1988-11-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE3715033A1 (de) 1987-05-06 1988-11-17 Hoechst Ag Verfahren zur isolierung von fusionsproteinen
DE3716722A1 (de) 1987-05-19 1988-12-01 Hoechst Ag Gentechnologisches verfahren zur herstellung von angiogeninen
DE3843713A1 (de) * 1988-04-25 1989-11-02 Henkel Kgaa Verwendung von calcinierten hydrotalciten als katalysatoren fuer die ethoxylierung bzw. propoxylierung
ATE132531T1 (de) * 1988-11-03 1996-01-15 Hoechst Ag Verfahren zur herstellung eines insulin- vorprodukts in streptomyceten

Also Published As

Publication number Publication date
FI911882L (fi) 1991-10-22
CN1055952A (zh) 1991-11-06
HRP940770A2 (en) 1997-06-30
IL97903A0 (en) 1992-06-21
CA2040810A1 (en) 1991-10-22
NZ237882A (en) 1993-12-23
IE911322A1 (en) 1991-10-23
CN1049248C (zh) 2000-02-09
DE59108128D1 (de) 1996-10-10
JP3319605B2 (ja) 2002-09-03
FI911882A0 (fi) 1991-04-18
RU2055892C1 (ru) 1996-03-10
BR9101587A (pt) 1991-12-10
CA2040810C (en) 2001-07-24
PT97427B (pt) 1998-08-31
NO911557L (no) 1991-10-22
LV10494A (lv) 1995-02-20
EP0453969B1 (de) 1996-09-04
LT3686B (en) 1996-01-25
ZA912937B (en) 1991-12-24
HU911302D0 (en) 1991-10-28
JPH04228086A (ja) 1992-08-18
EP0453969A1 (de) 1991-10-30
YU69691A (sh) 1995-12-04
KR910018551A (ko) 1991-11-30
CZ110191A3 (en) 1993-08-11
ES2093043T3 (es) 1996-12-16
HU210358B (en) 1995-04-28
ATE142263T1 (de) 1996-09-15
PL169178B1 (pl) 1996-06-28
PT97427A (pt) 1992-01-31
PL289953A1 (en) 1991-11-04
HUT57268A (en) 1991-11-28
SK110191A3 (en) 1995-07-11
LTIP1523A (en) 1995-06-26
CZ285440B6 (cs) 1999-08-11
LV10494B (en) 1996-02-20
YU48435B (sh) 1998-07-10
KR0168669B1 (ko) 1999-01-15
PL169596B1 (pl) 1996-08-30
AU630287B2 (en) 1992-10-22
DE4012818A1 (de) 1991-10-24
NO911557D0 (no) 1991-04-19
GR3021040T3 (en) 1996-12-31
TW213487B (enExample) 1993-09-21
AU7515491A (en) 1991-10-24
DK0453969T3 (enExample) 1997-02-10

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