FI82255B - Foerfarande foer framstaellning av nya gonadoliberinderivat som paoverkar djurens foeroekningsprocesser. - Google Patents
Foerfarande foer framstaellning av nya gonadoliberinderivat som paoverkar djurens foeroekningsprocesser. Download PDFInfo
- Publication number
- FI82255B FI82255B FI845051A FI845051A FI82255B FI 82255 B FI82255 B FI 82255B FI 845051 A FI845051 A FI 845051A FI 845051 A FI845051 A FI 845051A FI 82255 B FI82255 B FI 82255B
- Authority
- FI
- Finland
- Prior art keywords
- peptide
- pro
- trp
- gln
- mmol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Claims (4)
1. Förfarande för framställning av nya gonadoliberinderivat, sora päverkar djurens förökningsprocesser och som uppvisar den allmänna formeln (I) Glp-His-Trp-Ser-Tyr-Xi-Leu-Gln-Pro-X4 (I) samt terapeutiskt användbara syraadditionssalter och komplex därav, varvid i formel (I) Xl är en D-aminosyragrupp, som innehäller en aromatisk sidokedja, och X4 är en glycinamid- eller Ci_4-alkylamidgrupp, kännetecknat av att a) genom användning av förfarandet för peptidsyntes i fast fas kopplas lämpligt skyddade aminosyror i den erforderliga ordningen tili en fast polymerbärare med hjälp av karbodi-imid eller en aktiv ester och, i ett bestärat fall, avskiljs den färdiga peptiden frän bäraren medelst syra eller amino-lys och, om sä önskas, avlägsnas aminosyrornas skyddsgrupper frän peptiden samtidigt som, före eller efter det att peptiden avskilts frän polymerbäraren eller b) den erforderliga slutsprodukten byggs upp av de lämpli-ga skyddade aminosyrorna genom användning av en lämplig kombination av fragmentkondensering och stegvis syntes be-roende pä de varierande aminosyrakomponenternas kemiska karaktär.
2. Förfarande enligt patentkrav 1/a, kännetecknat av att man använder benshydrylamin eller Boc-prolin-harts som fast bärare.
3. Förfarande enligt patentkrav 1/a, kännetecknat av att den skyddade peptiden avlägsnas frlin hartset genom behandling med vätefluorid och/eller etylammonolys.
4. Förfarande enligt patentkrav 1/b, kännetecknat av att en pentapeptidatsid med formel (II) II 27 82255 Glp-His-Trp-Ser-Tyr-N3 (II) kondenseras med en tetra- eller pentapeptid med den allmänna formeln (III), Xl~Leu-Gln-Pro-X4 (III) i vilka formler X^ och X4 har samma betydelse som i patent-krav 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU445883 | 1983-12-23 | ||
| HU445883 | 1983-12-23 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI845051A0 FI845051A0 (fi) | 1984-12-20 |
| FI845051L FI845051L (fi) | 1985-06-24 |
| FI82255B true FI82255B (fi) | 1990-10-31 |
| FI82255C FI82255C (sv) | 1991-02-11 |
Family
ID=10968024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI845051A FI82255C (sv) | 1983-12-23 | 1984-12-20 | Förfarande för framställning av nya gonadoliberinderivat som påverkar djurens förökningsprocesser |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4647553A (sv) |
| JP (1) | JPS60226898A (sv) |
| AT (1) | AT394727B (sv) |
| AU (1) | AU583803B2 (sv) |
| BE (1) | BE901307A (sv) |
| CA (1) | CA1268897A (sv) |
| CH (1) | CH664968A5 (sv) |
| CZ (1) | CZ1021084A3 (sv) |
| DD (1) | DD255164A5 (sv) |
| DE (1) | DE3446997A1 (sv) |
| DK (1) | DK164875C (sv) |
| ES (2) | ES8607992A1 (sv) |
| FI (1) | FI82255C (sv) |
| FR (1) | FR2557114B1 (sv) |
| GB (1) | GB2152059B (sv) |
| GR (1) | GR82556B (sv) |
| IL (1) | IL73902A (sv) |
| IT (1) | IT1178775B (sv) |
| LU (1) | LU85710A1 (sv) |
| NL (1) | NL8403888A (sv) |
| NO (1) | NO166449C (sv) |
| SE (1) | SE469032B (sv) |
| SU (1) | SU1396970A3 (sv) |
| ZA (1) | ZA849985B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU193607B (en) * | 1985-07-18 | 1987-11-30 | Innofinance Altalanos Innovaci | Process for production of sexual products applyable for natural or artificial insemination for mammates |
| HU194913B (en) * | 1986-01-03 | 1988-03-28 | Innofinance Altalanos Innovaci | Process for producing novel gonadoliberin derivatives containing in the sixth position aromatic amino carboxylic acid and medical preparations containing these compounds |
| HU199694B (en) * | 1988-05-10 | 1990-03-28 | Innofinance Altalanos Innovaci | Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives |
| ATE224912T1 (de) * | 1996-06-21 | 2002-10-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von peptiden |
| DE19813849A1 (de) | 1998-03-27 | 1999-09-30 | Degussa | Verfahren zur einstufigen Umsalzung und Aufreinigung von Oligopeptiden |
| US6635739B2 (en) * | 1999-10-15 | 2003-10-21 | Theresa Siler-Khodr | Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy |
| US6323179B1 (en) * | 1999-10-15 | 2001-11-27 | Theresa Siler-Khodr | Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy |
| DE10050831A1 (de) * | 2000-10-05 | 2002-05-02 | Veyx Pharma Gmbh | Verfahren zum Zyklusstart bei weiblichen Zuchttieren |
| WO2003016331A2 (en) * | 2001-08-17 | 2003-02-27 | Siler-Khodr Theresa M | Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy |
| CN114805542A (zh) * | 2022-04-29 | 2022-07-29 | 江苏尤里卡生物科技有限公司 | 一种基于尿液中促性腺激素的纯化方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2211101A1 (de) * | 1972-03-08 | 1973-09-13 | Hoechst Ag | Neues dekapeptid mit hormon-wirkung |
| AT347054B (de) * | 1973-09-29 | 1978-12-11 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von neuen nonapeptidamid-derivaten |
| US4083967A (en) * | 1973-11-01 | 1978-04-11 | Burroughs Wellcome Co. | Nona- and decapeptides |
| DE2617646C2 (de) * | 1976-04-22 | 1986-07-31 | Hoechst Ag, 6230 Frankfurt | Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| US4213895A (en) * | 1979-03-26 | 1980-07-22 | American Home Products Corporation | N-[N-[N-[N-[N-(5-Oxo-L-prolyl)-L-histidyl]-L-tryptophyl]-L-seryl]-L-tyrosyl]glycine azide, an intermediate of the releasing agent of luteinizing hormone (LW) and of follicle stimulating hormone (FSH) |
| US4377515A (en) * | 1979-10-01 | 1983-03-22 | Merck & Co., Inc. | Long lasting agonists and antagonists of LH-RH |
| HU185535B (en) * | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
| US4443368A (en) * | 1982-11-01 | 1984-04-17 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
| JPS59501985A (ja) * | 1982-11-01 | 1984-11-29 | ザ・サルク・インステチュ−ト・フォ−・バイオロジカル・スタディ−ズ | 生殖腺機能に影響を及ぼすペプチド類 |
| US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
| US4530920A (en) * | 1983-11-07 | 1985-07-23 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist |
-
1984
- 1984-02-21 IT IT8424183A patent/IT1178775B/it active
- 1984-12-19 BE BE1/11159A patent/BE901307A/fr not_active IP Right Cessation
- 1984-12-20 FI FI845051A patent/FI82255C/sv not_active IP Right Cessation
- 1984-12-20 AT AT0404284A patent/AT394727B/de not_active IP Right Cessation
- 1984-12-20 CH CH6073/84A patent/CH664968A5/de not_active IP Right Cessation
- 1984-12-20 US US06/684,065 patent/US4647553A/en not_active Expired - Fee Related
- 1984-12-21 ES ES538988A patent/ES8607992A1/es not_active Expired
- 1984-12-21 CZ CS8410210A patent/CZ1021084A3/cs unknown
- 1984-12-21 CA CA000470789A patent/CA1268897A/en not_active Expired - Fee Related
- 1984-12-21 NO NO845193A patent/NO166449C/no unknown
- 1984-12-21 SE SE8406554A patent/SE469032B/sv unknown
- 1984-12-21 IL IL73902A patent/IL73902A/xx unknown
- 1984-12-21 DD DD84271457A patent/DD255164A5/de not_active IP Right Cessation
- 1984-12-21 GB GB08432495A patent/GB2152059B/en not_active Expired
- 1984-12-21 DE DE3446997A patent/DE3446997A1/de active Granted
- 1984-12-21 GR GR82556A patent/GR82556B/el unknown
- 1984-12-21 AU AU37098/84A patent/AU583803B2/en not_active Ceased
- 1984-12-21 ZA ZA849985A patent/ZA849985B/xx unknown
- 1984-12-21 LU LU85710A patent/LU85710A1/fr unknown
- 1984-12-21 JP JP59268720A patent/JPS60226898A/ja active Pending
- 1984-12-21 SU SU843827701A patent/SU1396970A3/ru active
- 1984-12-21 NL NL8403888A patent/NL8403888A/nl not_active Application Discontinuation
- 1984-12-21 FR FR848419639A patent/FR2557114B1/fr not_active Expired
- 1984-12-21 DK DK625084A patent/DK164875C/da active
-
1985
- 1985-12-16 ES ES550009A patent/ES8702439A1/es not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: KOEZPONTI VALTO- ES HITELBANK |