ES8702439A1 - Procedimiento de preparacion de nuevos derivados gonadoniberinos y sus sales complejas de acion acida terapeuticamente utilizables. - Google Patents

Procedimiento de preparacion de nuevos derivados gonadoniberinos y sus sales complejas de acion acida terapeuticamente utilizables.

Info

Publication number
ES8702439A1
ES8702439A1 ES550009A ES550009A ES8702439A1 ES 8702439 A1 ES8702439 A1 ES 8702439A1 ES 550009 A ES550009 A ES 550009A ES 550009 A ES550009 A ES 550009A ES 8702439 A1 ES8702439 A1 ES 8702439A1
Authority
ES
Spain
Prior art keywords
group
amino acid
amide
acid group
glycyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550009A
Other languages
English (en)
Other versions
ES550009A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOEZPONTI VALTO HITELBANK
Original Assignee
KOEZPONTI VALTO HITELBANK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOEZPONTI VALTO HITELBANK filed Critical KOEZPONTI VALTO HITELBANK
Publication of ES550009A0 publication Critical patent/ES550009A0/es
Publication of ES8702439A1 publication Critical patent/ES8702439A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE GONADOLIBERINOS Y SUS SALES Y COMPLEJOS DE AIDICION ACIDA. CONSISTENTE EN CONDENSAR DISTINTAS AZIDAS Y PEPTIDOS, DE LA FORMA: A) CONDENSAR UNA AZIDA PENTAPEPTIDA DE FORMULA (II) CON UN TETRAPEPTIDO O PENTAPEPTIDO X1-X2-X3-PRO-X4; B) CONDENSAR UNA AZIDA HEXAPEPTIDA DE FORMULA (IV) CON UN TRIPEPTIDO O TETRAPEPTIDO DE FORMULA X2-X3-PRO-X4; O C) CONDENSAR UNA AZIDA HEPTAPEPTIDA DE FORMULA (IV) CON UN DIPEPTIDO O TRIPEPTIDO DE FORMULA X3-PRO-X4; D) TRATAR EL COMPUESTO RESULTANTE DE FORMULA (I), DE FORMA OPCIONAL, CON ACIDO FARMACEUTICAMENTE ADECUADO Y CONVERTIR EN SU SAL ACIDA. SIENDO: X1, UN GRUPO GLICILO O D-ISOMERO DE GAS NATURAL; X2, GRUPO L-AMINOACIDO CON CADENA LATERAL DE 1-4 CARBONOS; X3, GRUPOS L-AMINO CON CADENA LINEAL ALQUILICA O ALCANOIL-AMIDA; Y X4, UN GRUPO GLICIL-AMIDA. APLICACION ZOOTECNICA COMO HORMONA GONADOLIBERINA.
ES550009A 1983-12-23 1985-12-16 Procedimiento de preparacion de nuevos derivados gonadoniberinos y sus sales complejas de acion acida terapeuticamente utilizables. Expired ES8702439A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU445883 1983-12-23

Publications (2)

Publication Number Publication Date
ES550009A0 ES550009A0 (es) 1987-01-01
ES8702439A1 true ES8702439A1 (es) 1987-01-01

Family

ID=10968024

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538988A Expired ES8607992A1 (es) 1983-12-23 1984-12-21 Procedimiento de preparacion de nuevos derivados gonadoliberinos y sus sales y complejos de adicion acida terapeuticamente utilizables
ES550009A Expired ES8702439A1 (es) 1983-12-23 1985-12-16 Procedimiento de preparacion de nuevos derivados gonadoniberinos y sus sales complejas de acion acida terapeuticamente utilizables.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538988A Expired ES8607992A1 (es) 1983-12-23 1984-12-21 Procedimiento de preparacion de nuevos derivados gonadoliberinos y sus sales y complejos de adicion acida terapeuticamente utilizables

Country Status (24)

Country Link
US (1) US4647553A (es)
JP (1) JPS60226898A (es)
AT (1) AT394727B (es)
AU (1) AU583803B2 (es)
BE (1) BE901307A (es)
CA (1) CA1268897A (es)
CH (1) CH664968A5 (es)
CZ (1) CZ1021084A3 (es)
DD (1) DD255164A5 (es)
DE (1) DE3446997A1 (es)
DK (1) DK164875C (es)
ES (2) ES8607992A1 (es)
FI (1) FI82255C (es)
FR (1) FR2557114B1 (es)
GB (1) GB2152059B (es)
GR (1) GR82556B (es)
IL (1) IL73902A (es)
IT (1) IT1178775B (es)
LU (1) LU85710A1 (es)
NL (1) NL8403888A (es)
NO (1) NO166449C (es)
SE (1) SE469032B (es)
SU (1) SU1396970A3 (es)
ZA (1) ZA849985B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193607B (en) * 1985-07-18 1987-11-30 Innofinance Altalanos Innovaci Process for production of sexual products applyable for natural or artificial insemination for mammates
HU194913B (en) * 1986-01-03 1988-03-28 Innofinance Altalanos Innovaci Process for producing novel gonadoliberin derivatives containing in the sixth position aromatic amino carboxylic acid and medical preparations containing these compounds
HU199694B (en) * 1988-05-10 1990-03-28 Innofinance Altalanos Innovaci Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives
CA2257381C (en) * 1996-06-21 2007-08-21 Takeda Chemical Industries, Ltd. Method for producing peptides
DE19813849A1 (de) 1998-03-27 1999-09-30 Degussa Verfahren zur einstufigen Umsalzung und Aufreinigung von Oligopeptiden
US6323179B1 (en) * 1999-10-15 2001-11-27 Theresa Siler-Khodr Chicken GNRH analogs and uses thereof in regulation of fertility and pregnancy
US6635739B2 (en) * 1999-10-15 2003-10-21 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
DE10050831A1 (de) * 2000-10-05 2002-05-02 Veyx Pharma Gmbh Verfahren zum Zyklusstart bei weiblichen Zuchttieren
WO2003016331A2 (en) * 2001-08-17 2003-02-27 Siler-Khodr Theresa M Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy
CN114805542A (zh) * 2022-04-29 2022-07-29 江苏尤里卡生物科技有限公司 一种基于尿液中促性腺激素的纯化方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2211101A1 (de) * 1972-03-08 1973-09-13 Hoechst Ag Neues dekapeptid mit hormon-wirkung
AT347054B (de) * 1973-09-29 1978-12-11 Takeda Chemical Industries Ltd Verfahren zur herstellung von neuen nonapeptidamid-derivaten
US4083967A (en) * 1973-11-01 1978-04-11 Burroughs Wellcome Co. Nona- and decapeptides
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
US4213895A (en) * 1979-03-26 1980-07-22 American Home Products Corporation N-[N-[N-[N-[N-(5-Oxo-L-prolyl)-L-histidyl]-L-tryptophyl]-L-seryl]-L-tyrosyl]glycine azide, an intermediate of the releasing agent of luteinizing hormone (LW) and of follicle stimulating hormone (FSH)
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
US4443368A (en) * 1982-11-01 1984-04-17 The Salk Institute For Biological Studies Peptides affecting gonadal function
JPS59501985A (ja) * 1982-11-01 1984-11-29 ザ・サルク・インステチュ−ト・フォ−・バイオロジカル・スタディ−ズ 生殖腺機能に影響を及ぼすペプチド類
US4410514A (en) * 1982-12-06 1983-10-18 The Salk Institute For Biological Studies GnRH Agonists
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist

Also Published As

Publication number Publication date
DK164875B (da) 1992-08-31
BE901307A (fr) 1985-06-19
LU85710A1 (fr) 1986-07-17
IT1178775B (it) 1987-09-16
ES8607992A1 (es) 1986-06-01
FI845051L (fi) 1985-06-24
ZA849985B (en) 1986-04-30
NO166449C (no) 1991-07-24
SE8406554L (sv) 1985-06-24
NO166449B (no) 1991-04-15
SE469032B (sv) 1993-05-03
ES550009A0 (es) 1987-01-01
ATA404284A (de) 1991-11-15
FR2557114A1 (fr) 1985-06-28
DE3446997C2 (es) 1989-12-07
AU3709884A (en) 1985-07-04
US4647553A (en) 1987-03-03
AU583803B2 (en) 1989-05-11
DK625084A (da) 1985-06-24
ES538988A0 (es) 1986-06-01
FI845051A0 (fi) 1984-12-20
AT394727B (de) 1992-06-10
NL8403888A (nl) 1985-07-16
IT8424183A1 (it) 1985-08-21
IT8424183A0 (it) 1984-12-21
DK625084D0 (da) 1984-12-21
FI82255C (fi) 1991-02-11
FR2557114B1 (fr) 1989-04-14
CA1268897A (en) 1990-05-08
DK164875C (da) 1993-01-11
DD255164A5 (de) 1988-03-23
IL73902A (en) 1988-08-31
IL73902A0 (en) 1985-03-31
GB8432495D0 (en) 1985-02-06
SE8406554D0 (sv) 1984-12-21
GR82556B (en) 1985-04-23
NO845193L (no) 1985-06-24
GB2152059B (en) 1987-04-08
JPS60226898A (ja) 1985-11-12
DE3446997A1 (de) 1985-07-11
CZ1021084A3 (en) 1994-02-16
FI82255B (fi) 1990-10-31
CH664968A5 (de) 1988-04-15
SU1396970A3 (ru) 1988-05-15
GB2152059A (en) 1985-07-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303