ES8200645A1 - Un procedimiento para la preparacion de un muramildipeptido. - Google Patents

Un procedimiento para la preparacion de un muramildipeptido.

Info

Publication number
ES8200645A1
ES8200645A1 ES492664A ES492664A ES8200645A1 ES 8200645 A1 ES8200645 A1 ES 8200645A1 ES 492664 A ES492664 A ES 492664A ES 492664 A ES492664 A ES 492664A ES 8200645 A1 ES8200645 A1 ES 8200645A1
Authority
ES
Spain
Prior art keywords
compounds
group
carbon atoms
preparing
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492664A
Other languages
English (en)
Other versions
ES492664A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of ES492664A0 publication Critical patent/ES492664A0/es
Publication of ES8200645A1 publication Critical patent/ES8200645A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN MURAMILDIPEPTIDO DE FORMULA (I), EN LA QUE X ES UN RESTO AMINOACIDO DE L-ALANINA, L-SERINA, L-VALINA O GLICINA, E Y ES UN RADICAL -NH-A O NHCH(R1)(CH2)N-NHCO-A, PUDIENDO SER R1 Y A VARIOS TIPOS DE RADICALES, EL VALOR DE N DE 1 A 6, Y ACILO ES UN RADICAL ACILO ALIFATICO C2-6. CONSISTE EN LA REACCION DE CONDENSACION DE UN DIPEPTIDO DE ACIDO MURAMIDO DE FORMULA (II), CON UN COMPUESTO DE FORMULA A-W'', EN LAS QUE X, ACILO Y A TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); W ES -OH O -NH-CH(R1)-(CH2)N-NH2, Y W'' ES UN RADICAL -COOM, SIENDO M UNO DE VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN DISOLUCION O EN SUSPENSION EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA IMIDA, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 60C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD COADYUVANTE Y/O CONTRA LAS INFECCIONES MICROBIANAS.
ES492664A 1979-06-21 1980-06-20 Un procedimiento para la preparacion de un muramildipeptido. Expired ES8200645A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7831779A JPS5618996A (en) 1979-06-21 1979-06-21 Muramyldipeptide derivative

Publications (2)

Publication Number Publication Date
ES492664A0 ES492664A0 (es) 1981-11-16
ES8200645A1 true ES8200645A1 (es) 1981-11-16

Family

ID=13658554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492664A Expired ES8200645A1 (es) 1979-06-21 1980-06-20 Un procedimiento para la preparacion de un muramildipeptido.

Country Status (11)

Country Link
US (1) US4317771A (es)
EP (1) EP0021367B1 (es)
JP (1) JPS5618996A (es)
AT (1) ATE2958T1 (es)
AU (1) AU534233B2 (es)
CA (1) CA1183128A (es)
DE (1) DE3062609D1 (es)
ES (1) ES8200645A1 (es)
PH (1) PH15892A (es)
SU (1) SU1190990A3 (es)
ZA (1) ZA803483B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482959A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux tripeptides, leur preparation et les medicaments qui les contiennent
GR78246B (es) * 1981-01-23 1984-09-26 Ciba Geigy Ag
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS5920297A (ja) * 1982-07-27 1984-02-01 Dai Ichi Seiyaku Co Ltd ムラミルジペプチド誘導体
JPS59172497A (ja) * 1983-03-22 1984-09-29 Dai Ichi Seiyaku Co Ltd 新規ムラミルペプチド誘導体
FR2546756B1 (fr) * 1983-06-03 1985-11-29 Centre Nat Rech Scient Nouveaux derives immunostimulants, leur preparation et leur application comme medicament
US4474693A (en) * 1983-10-31 1984-10-02 E. R. Squibb & Sons, Inc. ACE inhibitors produced from Nocardia orientalis
JPS6157597A (ja) * 1984-08-29 1986-03-24 Toshiyuki Hamaoka ムラミルペプチド活性エステル誘導体
JPS6393724A (ja) * 1986-10-09 1988-04-25 Dai Ichi Seiyaku Co Ltd ムラミルジペプチド誘導体含有鎮痛消炎剤
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
CN100522995C (zh) * 2003-10-22 2009-08-05 中国医学科学院药物研究所 胞壁酰-丙氨酰-d-异谷氨酰胺衍生物、制法和其药物组合物与用途
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
EP3239139B1 (en) 2010-05-27 2020-10-28 Ningbo Combireg Pharmaceutical Technology Co. Ltd Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate
CN102219834A (zh) * 2011-04-14 2011-10-19 北京市丰硕维康技术开发有限责任公司 一种制备罗莫肽的方法
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
WO2016049061A1 (en) 2014-09-22 2016-03-31 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems
WO2016138286A1 (en) 2015-02-26 2016-09-01 Stc.Unm Irgm and precision autophagy controls for antimicrobial and inflammatory disease states and methods of detection of autophagy
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
WO2018204421A2 (en) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Momp telonanoparticles, and related compositions, methods and systems
JP2024511067A (ja) 2021-03-19 2024-03-12 トレインド セラピューティクス ディスカバリー，インコーポレーテッド 訓練された免疫を調節するための化合物およびその使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
FR2358159A1 (fr) * 1976-07-16 1978-02-10 Anvar Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant
EP0003833B2 (de) * 1978-02-24 1990-12-19 Ciba-Geigy Ag Antigenderivate, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate
FR2442241A2 (fr) * 1978-03-20 1980-06-20 Anvar Nouveaux composes esters de muramyl-peptide, leur preparation et les compositions pharmaceutiques les contenant, notamment sous forme de liposomes
FR2428050A1 (fr) * 1978-06-05 1980-01-04 Anvar Oligomeres de composes du type muramyl-peptide et medicaments les contenant
US4256735A (en) * 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation

Also Published As

Publication number Publication date
JPS6227079B2 (es) 1987-06-12
EP0021367B1 (en) 1983-04-06
SU1190990A3 (ru) 1985-11-07
ATE2958T1 (de) 1983-04-15
AU5910180A (en) 1981-01-08
ES492664A0 (es) 1981-11-16
JPS5618996A (en) 1981-02-23
AU534233B2 (en) 1984-01-12
DE3062609D1 (en) 1983-05-11
US4317771A (en) 1982-03-02
CA1183128A (en) 1985-02-26
EP0021367A1 (en) 1981-01-07
PH15892A (en) 1983-04-14
ZA803483B (en) 1981-06-24

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