FR2358159A1 - Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant - Google Patents

Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant

Info

Publication number
FR2358159A1
FR2358159A1 FR7621889A FR7621889A FR2358159A1 FR 2358159 A1 FR2358159 A1 FR 2358159A1 FR 7621889 A FR7621889 A FR 7621889A FR 7621889 A FR7621889 A FR 7621889A FR 2358159 A1 FR2358159 A1 FR 2358159A1
Authority
FR
France
Prior art keywords
glucopyranosyl
alanyl
acetamido
deoxy
propionyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7621889A
Other languages
English (en)
Other versions
FR2358159B1 (fr
Inventor
Francoise Audibert
Louis Chedid
Pierre Lefrancier
Jean Choay
Edgard Lederer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7621889A priority Critical patent/FR2358159A1/fr
Priority to US05/815,811 priority patent/US4220637A/en
Publication of FR2358159A1 publication Critical patent/FR2358159A1/fr
Application granted granted Critical
Publication of FR2358159B1 publication Critical patent/FR2358159B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention est relative à un nouvel agent soluble dans l'eau, efficace comme agent adjuvant immunologique. L'agent adjuvant est le diamide de l'acide 2-(2-acétamido-2 -déoxy- 3 -O-D-glucopyranosyl) - D-propionyl-L-alanyl-D-glutamique. Cet agent sert à préparer des compositions médicamenteuses adjuvantes, utilisées pour accroître l'efficacité des vaccins.
FR7621889A 1976-07-16 1976-07-16 Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant Granted FR2358159A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7621889A FR2358159A1 (fr) 1976-07-16 1976-07-16 Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant
US05/815,811 US4220637A (en) 1976-07-16 1977-07-15 Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7621889A FR2358159A1 (fr) 1976-07-16 1976-07-16 Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant

Publications (2)

Publication Number Publication Date
FR2358159A1 true FR2358159A1 (fr) 1978-02-10
FR2358159B1 FR2358159B1 (fr) 1978-12-22

Family

ID=9175836

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7621889A Granted FR2358159A1 (fr) 1976-07-16 1976-07-16 Le diamide de l'acide 2-(2-acetamido-2-deoxy-3 - o-d-glucopyranosyl) - d-propionyl-l-alanyl-d-glutamique et medicaments le contenant

Country Status (2)

Country Link
US (1) US4220637A (fr)
FR (1) FR2358159A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005682A1 (fr) * 1978-05-18 1979-11-28 Ciba-Geigy Ag Dérivés sililés de glucosamine, leur procédé de préparation et médicaments les contenant
EP0006068A2 (fr) * 1978-06-05 1979-12-12 ANVAR Agence Nationale de Valorisation de la Recherche Composés du type muramyl-peptide et médicaments les contenant
US4323559A (en) * 1973-10-23 1982-04-06 Agencie Nationale De Valorisation De La Recherche (Anvar) Compounds derived from N-acetyl-nor-muramyl-L-alanyl-D-isoglutamic acid and other compounds and biologically active compositions containing such compounds
EP0050703A2 (fr) * 1978-02-24 1982-05-05 Ciba-Geigy Ag Dérivés du glucose et méthode pour leur préparation
US4401659A (en) * 1979-01-12 1983-08-30 Agence National De Valorisation De La Recherche (Anvar) Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them
US4446128A (en) * 1978-02-24 1984-05-01 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4574058A (en) * 1978-02-24 1986-03-04 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
JPS5618996A (en) * 1979-06-21 1981-02-23 Dai Ichi Seiyaku Co Ltd Muramyldipeptide derivative
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4933179A (en) * 1983-08-22 1990-06-12 Syntex (U.S.A.) Inc. Feline leukemia virus antigen vaccines
WO2016138286A1 (fr) 2015-02-26 2016-09-01 Stc.Unm Irgm et commandes de l'autophagie de précision contre des maladies bactériennes et inflammatoires et procédés de détection de l'autophagie

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2292486A1 (fr) * 1974-07-01 1976-06-25 Anvar Adjuvants immunologiques solubles dans l'eau, notamment pour vaccins, obtenus a partir de microbacteries et autres micro-organismes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082736A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof
US4082735A (en) * 1976-04-26 1978-04-04 Syntex (U.S.A.) Inc. Novel immunological adjuvant compounds and methods of preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2292486A1 (fr) * 1974-07-01 1976-06-25 Anvar Adjuvants immunologiques solubles dans l'eau, notamment pour vaccins, obtenus a partir de microbacteries et autres micro-organismes

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323559A (en) * 1973-10-23 1982-04-06 Agencie Nationale De Valorisation De La Recherche (Anvar) Compounds derived from N-acetyl-nor-muramyl-L-alanyl-D-isoglutamic acid and other compounds and biologically active compositions containing such compounds
US4327085A (en) * 1973-10-23 1982-04-27 Agence National De Valorisation De La Recherache (Anvar) Biologically active compositions and methods of use
EP0050703A2 (fr) * 1978-02-24 1982-05-05 Ciba-Geigy Ag Dérivés du glucose et méthode pour leur préparation
EP0050703A3 (en) * 1978-02-24 1982-06-02 Ciba-Geigy Ag Glucose derivatives, method for their preparation and their use
US4446128A (en) * 1978-02-24 1984-05-01 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
EP0005682A1 (fr) * 1978-05-18 1979-11-28 Ciba-Geigy Ag Dérivés sililés de glucosamine, leur procédé de préparation et médicaments les contenant
WO1979001088A1 (fr) * 1978-05-18 1979-12-13 Ciba Geigy Ag Nouveaux derives de la glucosamine silylee et leur procede de preparation
EP0006068A2 (fr) * 1978-06-05 1979-12-12 ANVAR Agence Nationale de Valorisation de la Recherche Composés du type muramyl-peptide et médicaments les contenant
FR2428051A1 (fr) * 1978-06-05 1980-01-04 Anvar Nouveaux composes du type muramyl-peptide et medicaments les contenant
EP0006068A3 (en) * 1978-06-05 1980-01-09 Anvar Agence Nationale De Valorisation De La Recherche Compounds of the muramyl-peptide type and medicines containing them
US4401659A (en) * 1979-01-12 1983-08-30 Agence National De Valorisation De La Recherche (Anvar) Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US4220637A (en) 1980-09-02
FR2358159B1 (fr) 1978-12-22

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