MX174421B - Procedimiento para la preparacion de 4-arilcarbonil-1-[(4-morfolinil)-alquilo-inferior]-1h-indoles y producto obtenido - Google Patents

Procedimiento para la preparacion de 4-arilcarbonil-1-[(4-morfolinil)-alquilo-inferior]-1h-indoles y producto obtenido

Info

Publication number
MX174421B
MX174421B MX010085A MX1008588A MX174421B MX 174421 B MX174421 B MX 174421B MX 010085 A MX010085 A MX 010085A MX 1008588 A MX1008588 A MX 1008588A MX 174421 B MX174421 B MX 174421B
Authority
MX
Mexico
Prior art keywords
indoles
arylcarbonyl
morpholinyl
alkyl
procedure
Prior art date
Application number
MX010085A
Other languages
English (en)
Other versions
MX10085A (es
Inventor
Thomas Edward D Ambra
Malcolm Rice Bell
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of MX10085A publication Critical patent/MX10085A/es
Publication of MX174421B publication Critical patent/MX174421B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto caracterizado porque tiene la fórmula:en la que Ar es alcoxifenilo inferior de l a 3 átomos de carbono o 1-naftilo y Alk es alquilo inferior que contiene desde dos hasta cuatro átomos de carbono; o una sal de adición de ácido farmacéuticamente aceptable del mismo.
MX010085A 1987-02-11 1988-01-13 Procedimiento para la preparacion de 4-arilcarbonil-1-[(4-morfolinil)-alquilo-inferior]-1h-indoles y producto obtenido MX174421B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/013,313 US4840950A (en) 1987-02-11 1987-02-11 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles

Publications (2)

Publication Number Publication Date
MX10085A MX10085A (es) 1993-09-01
MX174421B true MX174421B (es) 1994-05-16

Family

ID=21759325

Family Applications (1)

Application Number Title Priority Date Filing Date
MX010085A MX174421B (es) 1987-02-11 1988-01-13 Procedimiento para la preparacion de 4-arilcarbonil-1-[(4-morfolinil)-alquilo-inferior]-1h-indoles y producto obtenido

Country Status (21)

Country Link
US (1) US4840950A (es)
EP (1) EP0278265B1 (es)
JP (1) JP2561939B2 (es)
KR (1) KR960007523B1 (es)
AR (1) AR243184A1 (es)
AT (1) ATE80386T1 (es)
AU (1) AU596494B2 (es)
CA (1) CA1299180C (es)
DE (1) DE3874361T2 (es)
DK (1) DK167921B1 (es)
ES (1) ES2052608T3 (es)
FI (1) FI88152C (es)
GR (1) GR3005855T3 (es)
IE (1) IE63264B1 (es)
IL (1) IL84922A (es)
MX (1) MX174421B (es)
NO (1) NO169713C (es)
NZ (1) NZ223146A (es)
PH (1) PH25902A (es)
PT (1) PT86527B (es)
ZA (1) ZA879723B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081122A (en) * 1990-03-05 1992-01-14 Sterling Drug Inc. Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3215699A (en) * 1961-06-27 1965-11-02 Warner Lambert Pharmaceutical Substituted acetylphenyl hydrazones of 2,3-piperidine diones
US3494920A (en) * 1967-12-18 1970-02-10 American Home Prod 1-di(lower)alkylamino(lower)alkyl-3-(2-substituted ethyl) indoles
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

Also Published As

Publication number Publication date
DK21588D0 (da) 1988-01-19
US4840950A (en) 1989-06-20
NO880206D0 (no) 1988-01-19
FI880117A (fi) 1988-08-12
AR243184A1 (es) 1993-07-30
EP0278265B1 (en) 1992-09-09
ATE80386T1 (de) 1992-09-15
FI880117A0 (fi) 1988-01-12
ES2052608T3 (es) 1994-07-16
NZ223146A (en) 1990-01-29
KR880009962A (ko) 1988-10-06
KR960007523B1 (ko) 1996-06-05
NO169713C (no) 1992-07-29
MX10085A (es) 1993-09-01
IL84922A0 (en) 1988-06-30
JPS63216865A (ja) 1988-09-09
NO880206L (no) 1988-08-12
NO169713B (no) 1992-04-21
AU1038788A (en) 1988-08-18
DE3874361T2 (de) 1993-03-25
DE3874361D1 (de) 1992-10-15
JP2561939B2 (ja) 1996-12-11
PT86527B (pt) 1991-12-31
DK167921B1 (da) 1994-01-03
ZA879723B (en) 1988-06-23
AU596494B2 (en) 1990-05-03
CA1299180C (en) 1992-04-21
DK21588A (da) 1988-08-12
FI88152B (fi) 1992-12-31
PT86527A (en) 1988-02-01
IL84922A (en) 1992-03-29
IE880047L (en) 1988-08-11
GR3005855T3 (es) 1993-06-07
IE63264B1 (en) 1995-04-05
FI88152C (fi) 1993-04-13
EP0278265A1 (en) 1988-08-17
PH25902A (en) 1991-12-19

Similar Documents

Publication Publication Date Title
HUT65278A (en) Process for producing pyrido-, pyrrolo-, thiazino-, oxazino- and pyrazino-benzazepine derivatives and pharmaceutical preparations containing them
AU7844791A (en) New peptide compounds, process for preparing these and pharmaceutical compositions containing them
NZ240230A (en) Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
IL102759A0 (en) Hydantoin derivatives,their preparation and pharmaceutical compositions containing them
GR3001889T3 (en) Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
ZA817696B (en) N-substituted omega-(2-oxo-4-imidazolin-1-yl)alcanoic acids,salts and esters thereof,process for producing the same and these active agents containing pharmaceutical compounds
ZA904495B (en) Peptide derivatives,process for preparing them and pharmaceutical compositions containing them
NO932517L (no) 5,10-metylentetrahydrofolsyre-syklo-dekstrin-inkulusjonsforbindels er
SE8204640L (sv) Aminosyraderivat
HUT55034A (en) Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
DE3363105D1 (en) (omega-(diethylamino)-alkoxy)-alpha-(ethyl)-benzhydrol derivatives, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds
AU558261B2 (en) Dialkylaminoalkyoxybenzylalcohol derivatives
MX174421B (es) Procedimiento para la preparacion de 4-arilcarbonil-1-[(4-morfolinil)-alquilo-inferior]-1h-indoles y producto obtenido
ES8801811A1 (es) Procedimiento para preparar acidos hexenoicos
ZA84261B (en) Bicyclo(4.2.0)1,3,5-octatriene derivatives,a process for their preparation and pharmaceutical compositions containing them
ES8504112A1 (es) Procedimiento para la obtencion de derivados de la benzamidina de actividad antimicrobiana
ES435361A1 (es) Un metodo para la preparacion de nuevos esteres alcohilicosde aminoacidos.
DE3160821D1 (en) Alkyl and cycloalkyl substituted 2-(2-(2-hydroxy-3-tert.-butylamino-propoxy)-5-acylaminophenyl)-1,3,4-oxadiazoles, their preparation and pharmaceutical preparations containing them
AU2742288A (en) Novel compound effective as cerebral insufficiency improver
GB2014995A (en) (Cycloalkyl)-alkylbenzamides
IT1248558B (it) Derivati della fisovenina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1248068B (it) Derivati dell'eseridina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1249062B (it) Derivati dell'eserolina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizuini farmaceutiche che li contengono.
IT1247921B (it) Composti ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono