ES2052608T3 - 1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion. - Google Patents

1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion.

Info

Publication number
ES2052608T3
ES2052608T3 ES88100694T ES88100694T ES2052608T3 ES 2052608 T3 ES2052608 T3 ES 2052608T3 ES 88100694 T ES88100694 T ES 88100694T ES 88100694 T ES88100694 T ES 88100694T ES 2052608 T3 ES2052608 T3 ES 2052608T3
Authority
ES
Spain
Prior art keywords
alkyl
morfolinil
analgesics
preparation
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88100694T
Other languages
English (en)
Inventor
Ambra Thomas Edward D
Malcolm Rice Bell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Application granted granted Critical
Publication of ES2052608T3 publication Critical patent/ES2052608T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PREPARAN 4-ARILCARBONIL-1-[(4-MORFOLINIL)-ALQUILO DE CADENA CORTA]-1H-INDOLES, UTILES COMO AGENTES ANALGESICOS DE UN 3-ARILCARBONIL-2-METILNITROBENCENO CON DIMETILACETAL DE DMF; CICLACION REDUSTORA DEL PRODUCTO FORMADO CON HIDROGENO, SOBRE UN CATALIZADOR, Y N-ALQUILACION DEL 4-ARILCARBONILINDOL RESULTANTE CON UNA 4-(HALO-ALQUIL DE CADENA CORTA) MORFOLINA EN PRESENCIA DE UNA BASE FUERTE.
ES88100694T 1987-02-11 1988-01-19 1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion. Expired - Lifetime ES2052608T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/013,313 US4840950A (en) 1987-02-11 1987-02-11 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles

Publications (1)

Publication Number Publication Date
ES2052608T3 true ES2052608T3 (es) 1994-07-16

Family

ID=21759325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88100694T Expired - Lifetime ES2052608T3 (es) 1987-02-11 1988-01-19 1-((4-morfolinil)alquil)-1h-indoles utiles como analgesicos y su preparacion.

Country Status (21)

Country Link
US (1) US4840950A (es)
EP (1) EP0278265B1 (es)
JP (1) JP2561939B2 (es)
KR (1) KR960007523B1 (es)
AR (1) AR243184A1 (es)
AT (1) ATE80386T1 (es)
AU (1) AU596494B2 (es)
CA (1) CA1299180C (es)
DE (1) DE3874361T2 (es)
DK (1) DK167921B1 (es)
ES (1) ES2052608T3 (es)
FI (1) FI88152C (es)
GR (1) GR3005855T3 (es)
IE (1) IE63264B1 (es)
IL (1) IL84922A (es)
MX (1) MX174421B (es)
NO (1) NO169713C (es)
NZ (1) NZ223146A (es)
PH (1) PH25902A (es)
PT (1) PT86527B (es)
ZA (1) ZA879723B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081122A (en) * 1990-03-05 1992-01-14 Sterling Drug Inc. Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3215699A (en) * 1961-06-27 1965-11-02 Warner Lambert Pharmaceutical Substituted acetylphenyl hydrazones of 2,3-piperidine diones
US3494920A (en) * 1967-12-18 1970-02-10 American Home Prod 1-di(lower)alkylamino(lower)alkyl-3-(2-substituted ethyl) indoles
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

Also Published As

Publication number Publication date
DK21588D0 (da) 1988-01-19
US4840950A (en) 1989-06-20
NO880206D0 (no) 1988-01-19
FI880117A (fi) 1988-08-12
AR243184A1 (es) 1993-07-30
EP0278265B1 (en) 1992-09-09
ATE80386T1 (de) 1992-09-15
FI880117A0 (fi) 1988-01-12
NZ223146A (en) 1990-01-29
KR880009962A (ko) 1988-10-06
KR960007523B1 (ko) 1996-06-05
NO169713C (no) 1992-07-29
MX10085A (es) 1993-09-01
IL84922A0 (en) 1988-06-30
JPS63216865A (ja) 1988-09-09
NO880206L (no) 1988-08-12
NO169713B (no) 1992-04-21
AU1038788A (en) 1988-08-18
DE3874361T2 (de) 1993-03-25
DE3874361D1 (de) 1992-10-15
JP2561939B2 (ja) 1996-12-11
PT86527B (pt) 1991-12-31
DK167921B1 (da) 1994-01-03
ZA879723B (en) 1988-06-23
AU596494B2 (en) 1990-05-03
CA1299180C (en) 1992-04-21
DK21588A (da) 1988-08-12
FI88152B (fi) 1992-12-31
PT86527A (en) 1988-02-01
IL84922A (en) 1992-03-29
MX174421B (es) 1994-05-16
IE880047L (en) 1988-08-11
GR3005855T3 (es) 1993-06-07
IE63264B1 (en) 1995-04-05
FI88152C (fi) 1993-04-13
EP0278265A1 (en) 1988-08-17
PH25902A (en) 1991-12-19

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