DK167921B1 - 4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte - Google Patents

4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte Download PDF

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Publication number
DK167921B1
DK167921B1 DK021588A DK21588A DK167921B1 DK 167921 B1 DK167921 B1 DK 167921B1 DK 021588 A DK021588 A DK 021588A DK 21588 A DK21588 A DK 21588A DK 167921 B1 DK167921 B1 DK 167921B1
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DK
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Prior art keywords
acid
morpholinyl
preparations
preparation
prepared
Prior art date
Application number
DK021588A
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Danish (da)
English (en)
Other versions
DK21588D0 (da
DK21588A (da
Inventor
Ambra Thomas Edward D
Malcolm Rice Bell
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of DK21588D0 publication Critical patent/DK21588D0/da
Publication of DK21588A publication Critical patent/DK21588A/da
Application granted granted Critical
Publication of DK167921B1 publication Critical patent/DK167921B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK021588A 1987-02-11 1988-01-19 4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte DK167921B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/013,313 US4840950A (en) 1987-02-11 1987-02-11 4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
US1331387 1987-02-11

Publications (3)

Publication Number Publication Date
DK21588D0 DK21588D0 (da) 1988-01-19
DK21588A DK21588A (da) 1988-08-12
DK167921B1 true DK167921B1 (da) 1994-01-03

Family

ID=21759325

Family Applications (1)

Application Number Title Priority Date Filing Date
DK021588A DK167921B1 (da) 1987-02-11 1988-01-19 4-arylcarbonyl-1-oe(4-morpholinyl)-lavere alkylaa-1h-indoler, fremgangsmaade til fremstilling heraf, analgetiske praeparater indeholdende saadanne forbindelser og anvendelsen af disse forbindelser til fremstilling af farmaceutiske praeparater mod smerte

Country Status (21)

Country Link
US (1) US4840950A (es)
EP (1) EP0278265B1 (es)
JP (1) JP2561939B2 (es)
KR (1) KR960007523B1 (es)
AR (1) AR243184A1 (es)
AT (1) ATE80386T1 (es)
AU (1) AU596494B2 (es)
CA (1) CA1299180C (es)
DE (1) DE3874361T2 (es)
DK (1) DK167921B1 (es)
ES (1) ES2052608T3 (es)
FI (1) FI88152C (es)
GR (1) GR3005855T3 (es)
IE (1) IE63264B1 (es)
IL (1) IL84922A (es)
MX (1) MX174421B (es)
NO (1) NO169713C (es)
NZ (1) NZ223146A (es)
PH (1) PH25902A (es)
PT (1) PT86527B (es)
ZA (1) ZA879723B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081122A (en) * 1990-03-05 1992-01-14 Sterling Drug Inc. Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof
CA2651732C (en) 2006-05-18 2014-10-14 Mannkind Corporation Intracellular kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3215699A (en) * 1961-06-27 1965-11-02 Warner Lambert Pharmaceutical Substituted acetylphenyl hydrazones of 2,3-piperidine diones
US3494920A (en) * 1967-12-18 1970-02-10 American Home Prod 1-di(lower)alkylamino(lower)alkyl-3-(2-substituted ethyl) indoles
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof

Also Published As

Publication number Publication date
DK21588D0 (da) 1988-01-19
US4840950A (en) 1989-06-20
NO880206D0 (no) 1988-01-19
FI880117A (fi) 1988-08-12
AR243184A1 (es) 1993-07-30
EP0278265B1 (en) 1992-09-09
ATE80386T1 (de) 1992-09-15
FI880117A0 (fi) 1988-01-12
ES2052608T3 (es) 1994-07-16
NZ223146A (en) 1990-01-29
KR880009962A (ko) 1988-10-06
KR960007523B1 (ko) 1996-06-05
NO169713C (no) 1992-07-29
MX10085A (es) 1993-09-01
IL84922A0 (en) 1988-06-30
JPS63216865A (ja) 1988-09-09
NO880206L (no) 1988-08-12
NO169713B (no) 1992-04-21
AU1038788A (en) 1988-08-18
DE3874361T2 (de) 1993-03-25
DE3874361D1 (de) 1992-10-15
JP2561939B2 (ja) 1996-12-11
PT86527B (pt) 1991-12-31
ZA879723B (en) 1988-06-23
AU596494B2 (en) 1990-05-03
CA1299180C (en) 1992-04-21
DK21588A (da) 1988-08-12
FI88152B (fi) 1992-12-31
PT86527A (en) 1988-02-01
IL84922A (en) 1992-03-29
MX174421B (es) 1994-05-16
IE880047L (en) 1988-08-11
GR3005855T3 (es) 1993-06-07
IE63264B1 (en) 1995-04-05
FI88152C (fi) 1993-04-13
EP0278265A1 (en) 1988-08-17
PH25902A (en) 1991-12-19

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired