FI81101C - Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner. - Google Patents

Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner. Download PDF

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Publication number
FI81101C
FI81101C FI851907A FI851907A FI81101C FI 81101 C FI81101 C FI 81101C FI 851907 A FI851907 A FI 851907A FI 851907 A FI851907 A FI 851907A FI 81101 C FI81101 C FI 81101C
Authority
FI
Finland
Prior art keywords
rifamycin
formula
alkyl
iodine
solvent
Prior art date
Application number
FI851907A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI81101B (fi
FI851907A0 (fi
FI851907L (fi
Inventor
Vincenzo Cannata
Silvano Piani
Egidio Marchi
Gian Franco Tamagnone
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of FI851907A0 publication Critical patent/FI851907A0/fi
Publication of FI851907L publication Critical patent/FI851907L/fi
Application granted granted Critical
Publication of FI81101B publication Critical patent/FI81101B/fi
Publication of FI81101C publication Critical patent/FI81101C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI851907A 1984-05-15 1985-05-14 Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner. FI81101C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT346384 1984-05-15
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (4)

Publication Number Publication Date
FI851907A0 FI851907A0 (fi) 1985-05-14
FI851907L FI851907L (fi) 1985-11-16
FI81101B FI81101B (fi) 1990-05-31
FI81101C true FI81101C (fi) 1990-09-10

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851907A FI81101C (fi) 1984-05-15 1985-05-14 Nytt foerfarande foer syntetisering av pyridoimidazorifamyciner.

Country Status (18)

Country Link
US (1) US4557866A (en:Method)
EP (1) EP0161534B1 (en:Method)
JP (1) JPS60252483A (en:Method)
AR (1) AR241913A1 (en:Method)
AT (1) ATE46512T1 (en:Method)
AU (1) AU568934B2 (en:Method)
CA (1) CA1215708A (en:Method)
DE (1) DE3573120D1 (en:Method)
DK (1) DK162647C (en:Method)
ES (1) ES543115A0 (en:Method)
FI (1) FI81101C (en:Method)
GR (1) GR851144B (en:Method)
IE (1) IE58392B1 (en:Method)
IT (1) IT1199374B (en:Method)
NO (1) NO164242C (en:Method)
PH (1) PH22007A (en:Method)
PT (1) PT80446B (en:Method)
ZA (1) ZA852971B (en:Method)

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US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
EP1698630B1 (en) * 2005-03-03 2014-09-03 ALFA WASSERMANN S.p.A. New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
CA2643364C (en) 2006-03-09 2017-06-06 Salix Pharmaceuticals, Inc. Rifaximin anti-rectal dysfunction preparation
CN104382900A (zh) 2006-08-02 2015-03-04 萨利克斯药品公司 治疗放射性肠炎的组合物和方法
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
WO2008035109A1 (en) * 2006-09-22 2008-03-27 Cipla Limited Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
US8067429B2 (en) 2008-02-25 2011-11-29 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
CN101959412A (zh) 2008-02-26 2011-01-26 萨利克斯药品有限公司 治疗肠病的方法
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
JP5752032B2 (ja) 2008-05-07 2015-07-22 サリックス ファーマシューティカルズ リミテッド 腸洗浄剤および抗生物質の投与により腸疾患を治療する方法
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US7928115B2 (en) * 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
EP3628319B1 (en) 2008-10-02 2024-02-14 Salix Pharmaceuticals, Ltd. Treatment of hepatic encephalopathy using rifaximin
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
EP2355805B1 (en) 2008-12-10 2019-02-13 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
BRPI1010028A2 (pt) 2009-06-02 2019-02-12 Salix Pharmaceuticals, Ltd. métodos de tratamento de encefalopatia hepática
NZ598671A (en) 2009-09-13 2014-02-28 Salix Pharmaceuticals Ltd Methods for treating irritable bowel syndrome (ibs)
BR112012012316A2 (pt) 2009-11-23 2016-04-26 Cipla Ltd composição farmacêutica para administração retal tópica na forma de espuma, uso de uma composição farmacêutica, método para tratamento, prevenção ou alívio de um dustúrbio no reto, cólon, íleo terminal ou ânus, processo para fabricação de uma composição farmacêutica contendo rifaximina, uso de um silicone e dispensador para composição farmacêutica
EP2401282B2 (en) 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
EP2536282A4 (en) 2010-02-18 2013-07-03 Salix Pharmaceuticals Ltd METHOD FOR THE TREATMENT OF INFECTIONS
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2011156897A2 (en) * 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
LT2593463T (lt) 2010-07-12 2020-08-25 Salix Pharmaceuticals, Inc. Rifaksimino kompozicijos ir jų panaudojimas
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
EA201391171A1 (ru) 2011-02-11 2014-11-28 Сэликс Фармасьютиклз, Лтд. Формы рифаксимина и их применение
CA2834829A1 (en) 2011-05-02 2012-11-08 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
WO2013067394A1 (en) 2011-11-02 2013-05-10 Salix Pharmaceuticals, Ltd Methods for treating irritable bowel syndrome (ibs) and infections
CA2876737A1 (en) 2012-06-13 2013-12-19 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
JP2016516988A (ja) 2013-03-15 2016-06-09 アルファ ワッセルマン ソシエタ ペル アチオニＡｌｆａ Ｗａｓｓｅｒｍａｎｎ Ｓ．Ｐ．Ａ． 膣感染症を診断するための方法
EA201591267A1 (ru) 2013-03-15 2016-03-31 Альфа Вассерманн С.П.А. Рифаксимин для применения в лечении вагинальных инфекций
EP2983647B1 (en) 2013-04-12 2020-09-09 Alfasigma S.p.A. Nsaid administration and related compositions, methods and systems
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
MX375805B (es) 2014-05-04 2025-03-07 Salix Pharmaceuticals Inc Microbiota ibs y sus usos.
HUE050054T2 (hu) 2014-05-12 2020-11-30 Alfasigma Spa DEGME-vel szolvatált rifaximin tau kristályos formájának elõállítása és alkalmazása
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
EP3518924B1 (en) 2016-09-30 2022-08-10 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
MX386622B (es) * 2017-06-26 2025-03-19 Biofer Spa Derivados de pirido-imidazo rifamicina como agente antibacteriano

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) * 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
US4557866A (en) 1985-12-10
EP0161534A3 (en) 1987-03-04
JPS60252483A (ja) 1985-12-13
ES8603489A1 (es) 1986-01-01
NO851921L (no) 1985-11-18
GR851144B (en:Method) 1985-11-25
AU568934B2 (en) 1988-01-14
FI81101B (fi) 1990-05-31
CA1215708A (en) 1986-12-23
ES543115A0 (es) 1986-01-01
IT8403463A0 (it) 1984-05-15
DK214685D0 (da) 1985-05-14
EP0161534B1 (en) 1989-09-20
NO164242B (no) 1990-06-05
NO164242C (no) 1990-09-12
PT80446B (pt) 1987-11-11
ZA852971B (en) 1985-12-24
AR241913A1 (es) 1993-01-29
DK162647B (da) 1991-11-25
PH22007A (en) 1988-05-02
JPH0469634B2 (en:Method) 1992-11-06
DK162647C (da) 1992-04-13
PT80446A (en) 1985-06-01
EP0161534A2 (en) 1985-11-21
IT1199374B (it) 1988-12-30
AU4251585A (en) 1985-11-21
FI851907A0 (fi) 1985-05-14
IE851191L (en) 1985-11-15
ATE46512T1 (de) 1989-10-15
IE58392B1 (en) 1993-09-08
DE3573120D1 (en) 1989-10-26
DK214685A (da) 1985-11-16
FI851907L (fi) 1985-11-16

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: ALFA FARMACEUTICI S.P.A.

MA Patent expired