ES8603489A1 - Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas - Google Patents
Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinasInfo
- Publication number
- ES8603489A1 ES8603489A1 ES543115A ES543115A ES8603489A1 ES 8603489 A1 ES8603489 A1 ES 8603489A1 ES 543115 A ES543115 A ES 543115A ES 543115 A ES543115 A ES 543115A ES 8603489 A1 ES8603489 A1 ES 8603489A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- opt
- refamycins
- pyrido
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- RAFHKEAPVIWLJC-OQQFTUDCSA-N Rifamycin O Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC5(OCC(=O)O5)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C RAFHKEAPVIWLJC-OQQFTUDCSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229960003292 rifamycin Drugs 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- RAFHKEAPVIWLJC-TWYIRNIGSA-N z67lem9p1w Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)N2)C)OC)C(C(=C3O)C)=C1C1=C3C(=O)C2=C[C@]11OCC(=O)O1 RAFHKEAPVIWLJC-TWYIRNIGSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT03463/84A IT1199374B (it) | 1984-05-15 | 1984-05-15 | Processo per la preparazione di pirido-imidazo-rifamicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES543115A0 ES543115A0 (es) | 1986-01-01 |
| ES8603489A1 true ES8603489A1 (es) | 1986-01-01 |
Family
ID=11107845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543115A Expired ES8603489A1 (es) | 1984-05-15 | 1985-05-14 | Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4557866A (en:Method) |
| EP (1) | EP0161534B1 (en:Method) |
| JP (1) | JPS60252483A (en:Method) |
| AR (1) | AR241913A1 (en:Method) |
| AT (1) | ATE46512T1 (en:Method) |
| AU (1) | AU568934B2 (en:Method) |
| CA (1) | CA1215708A (en:Method) |
| DE (1) | DE3573120D1 (en:Method) |
| DK (1) | DK162647C (en:Method) |
| ES (1) | ES8603489A1 (en:Method) |
| FI (1) | FI81101C (en:Method) |
| GR (1) | GR851144B (en:Method) |
| IE (1) | IE58392B1 (en:Method) |
| IT (1) | IT1199374B (en:Method) |
| NO (1) | NO164242C (en:Method) |
| PH (1) | PH22007A (en:Method) |
| PT (1) | PT80446B (en:Method) |
| ZA (1) | ZA852971B (en:Method) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7078399B2 (en) * | 2001-12-13 | 2006-07-18 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US7923553B2 (en) | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
| US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
| US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
| US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
| US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
| US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
| US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
| PT1698630E (pt) * | 2005-03-03 | 2014-09-15 | Alfa Wassermann Spa | Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais |
| ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
| CN103263668A (zh) | 2006-03-09 | 2013-08-28 | 萨利克斯药品公司 | 利福昔明抗直肠功能障碍制剂 |
| DK2054066T3 (en) | 2006-08-02 | 2015-06-08 | Salix Pharmaceuticals Inc | METHODS OF TREATMENT OF RADIATE ENTERITIS |
| ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
| CA2663776C (en) * | 2006-09-22 | 2016-01-26 | Cipla Limited | Rifaximin in an amorphous form |
| US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
| US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
| ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
| US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| CN102015725B (zh) | 2008-02-25 | 2014-10-22 | 萨利克斯药品有限公司 | 利福昔明的多种形式及其用途 |
| US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| US8309569B2 (en) | 2008-02-26 | 2012-11-13 | Salix Pharmaceuticals, Ltd. | Methods for treating diarrhea-associated irritable bowel syndrome |
| US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
| PL2294012T3 (pl) | 2008-05-07 | 2014-12-31 | Salix Pharmaceuticals Inc | Podawanie środka czyszczącego jelito i antybiotyku w leczeniu choroby jelit |
| CN101585843B (zh) * | 2008-05-21 | 2011-07-06 | 重庆赛诺生物药业股份有限公司 | 一种利福昔明的制备工艺 |
| US12285414B2 (en) | 2008-10-02 | 2025-04-29 | Salix Pharmaceuticals, Inc. | Methods of treating hepatic encephalopathy |
| US20110035232A1 (en) * | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
| DK3628319T3 (da) | 2008-10-02 | 2024-03-04 | Salix Pharmaceuticals Ltd | Behandling af hepatisk encefalopati ved anvendelse af rifaximin |
| US7928115B2 (en) * | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| US8916193B2 (en) | 2008-12-10 | 2014-12-23 | Cipla Limited | Rifaximin complexes |
| IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
| MX2011012829A (es) | 2009-06-02 | 2012-02-28 | Salix Pharmaceuticals Ltd | Metodos para tratar encefalopatia hepatica. |
| MX2012002895A (es) | 2009-09-13 | 2012-05-22 | Salix Pharmaceuticals Ltd | Metodos para tratar el sindrome de intestino irritado (ibs). |
| MX2012005883A (es) | 2009-11-23 | 2012-10-09 | Cipla Ltd | Composicion topica en espuma. |
| EP2401282B2 (en) | 2009-12-28 | 2017-01-04 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
| CA2789929C (en) | 2010-02-18 | 2019-11-26 | Salix Pharmaceuticals, Ltd. | Methods for treating infection |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| US8883795B2 (en) * | 2010-06-16 | 2014-11-11 | Apotex Pharmachem Inc. | Polymorphic forms of Rifaximin |
| ES2801678T3 (es) | 2010-07-12 | 2021-01-12 | Salix Pharmaceuticals Inc | Formulaciones de rifaximina y sus usos |
| US8759513B2 (en) | 2010-09-13 | 2014-06-24 | Sequent Scientific Limited | Polymorphic form of rifaximin and process for its preparation |
| WO2012109605A2 (en) | 2011-02-11 | 2012-08-16 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
| EP2705042A1 (en) | 2011-05-02 | 2014-03-12 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
| WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
| ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
| WO2013067394A1 (en) | 2011-11-02 | 2013-05-10 | Salix Pharmaceuticals, Ltd | Methods for treating irritable bowel syndrome (ibs) and infections |
| WO2013185211A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| KR20150129691A (ko) | 2013-03-15 | 2015-11-20 | 알파 와셔만 에스.피.아. | 질 감염증의 치료에 사용하기 위한 리팍시민 |
| WO2014140995A2 (en) | 2013-03-15 | 2014-09-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
| JP6433980B2 (ja) | 2013-04-12 | 2018-12-05 | アルファシグマ ソシエタ ペル アチオニ | Ｎｓａｉｄ投与並びに関連する組成物、方法及びシステム |
| US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
| ITMI20131307A1 (it) | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
| CN103509038B (zh) * | 2013-09-30 | 2016-01-20 | 浙江思贤制药有限公司 | 一种新晶型利福昔明ζ及其制备方法 |
| ES2621557T3 (es) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
| CA2947962C (en) | 2014-05-04 | 2024-01-16 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
| EP3546464B1 (en) | 2014-05-12 | 2020-06-17 | Alfasigma S.p.A. | Preparation and use of crystalline form tau of rifaximin solvated with degme |
| EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
| US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
| KR20230023043A (ko) | 2016-09-30 | 2023-02-16 | 샐릭스 파마슈티컬스 인코포레이티드 | 리팍시민의 고체 분산물 형태 |
| CN110770244A (zh) * | 2017-06-26 | 2020-02-07 | 倍尔福股份公司 | 吡啶并咪唑利福霉素衍生物的抗菌剂 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1154655B (it) | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
-
1984
- 1984-05-15 IT IT03463/84A patent/IT1199374B/it active
-
1985
- 1985-04-19 ZA ZA852971A patent/ZA852971B/xx unknown
- 1985-04-19 AT AT85104790T patent/ATE46512T1/de not_active IP Right Cessation
- 1985-04-19 EP EP85104790A patent/EP0161534B1/en not_active Expired
- 1985-04-19 DE DE8585104790T patent/DE3573120D1/de not_active Expired
- 1985-04-25 PH PH32186A patent/PH22007A/en unknown
- 1985-04-26 US US06/727,521 patent/US4557866A/en not_active Expired - Lifetime
- 1985-04-29 CA CA000480321A patent/CA1215708A/en not_active Expired
- 1985-05-13 PT PT80446A patent/PT80446B/pt unknown
- 1985-05-13 GR GR851144A patent/GR851144B/el unknown
- 1985-05-14 DK DK214685A patent/DK162647C/da not_active IP Right Cessation
- 1985-05-14 ES ES543115A patent/ES8603489A1/es not_active Expired
- 1985-05-14 IE IE119185A patent/IE58392B1/en not_active IP Right Cessation
- 1985-05-14 JP JP60102528A patent/JPS60252483A/ja active Granted
- 1985-05-14 FI FI851907A patent/FI81101C/fi not_active IP Right Cessation
- 1985-05-14 NO NO851921A patent/NO164242C/no not_active IP Right Cessation
- 1985-05-15 AR AR85300385A patent/AR241913A1/es active
- 1985-05-15 AU AU42515/85A patent/AU568934B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI851907A0 (fi) | 1985-05-14 |
| DK214685D0 (da) | 1985-05-14 |
| DK162647B (da) | 1991-11-25 |
| FI81101B (fi) | 1990-05-31 |
| ATE46512T1 (de) | 1989-10-15 |
| DE3573120D1 (en) | 1989-10-26 |
| IT8403463A0 (it) | 1984-05-15 |
| FI81101C (fi) | 1990-09-10 |
| IE851191L (en) | 1985-11-15 |
| ZA852971B (en) | 1985-12-24 |
| US4557866A (en) | 1985-12-10 |
| AR241913A1 (es) | 1993-01-29 |
| AU4251585A (en) | 1985-11-21 |
| PT80446A (en) | 1985-06-01 |
| ES543115A0 (es) | 1986-01-01 |
| EP0161534A2 (en) | 1985-11-21 |
| EP0161534B1 (en) | 1989-09-20 |
| PT80446B (pt) | 1987-11-11 |
| CA1215708A (en) | 1986-12-23 |
| NO164242C (no) | 1990-09-12 |
| GR851144B (en:Method) | 1985-11-25 |
| NO851921L (no) | 1985-11-18 |
| JPH0469634B2 (en:Method) | 1992-11-06 |
| AU568934B2 (en) | 1988-01-14 |
| FI851907L (fi) | 1985-11-16 |
| JPS60252483A (ja) | 1985-12-13 |
| DK162647C (da) | 1992-04-13 |
| IT1199374B (it) | 1988-12-30 |
| DK214685A (da) | 1985-11-16 |
| EP0161534A3 (en) | 1987-03-04 |
| NO164242B (no) | 1990-06-05 |
| IE58392B1 (en) | 1993-09-08 |
| PH22007A (en) | 1988-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8603489A1 (es) | Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas | |
| EP0226225A3 (en) | Process for the preparation of (2,2)-paracyclophane and derivatives thereof | |
| GB1412130A (en) | 3-substituted-morphinan derivatives | |
| GB1247370A (en) | Glyoxals and production thereof | |
| SE7409577L (en:Method) | ||
| GB1477945A (en) | Method of protecting polyurethane resins from degradation by ultra violet radiation | |
| GR3002689T3 (en) | Process for producing 2-methyl-1,4-naphthoquinone | |
| GB1481859A (en) | Halogen-substituted benzimidazolone compounds and a process for their manufacture | |
| AU7055087A (en) | Process for the preparation of hydroxyamines | |
| ES2112433T3 (es) | Sintesis de derivados del acido n-acetil neuraminico. | |
| ES8302733A1 (es) | Un procedimiento para preparar nuevos derivados de antraci- clina | |
| NO173829C (no) | Fremgangsmaate for fremstilling av polyoksyalkylenforbindelser | |
| JPS6485953A (en) | Production of 7-amino-6-demethyl-6-deoxytetracycline | |
| FI932126A0 (fi) | Foerfarande foer framstaellning av 2-klor-5-klormetylpyridin | |
| GR3031922T3 (en) | Novel process. | |
| ES481264A1 (es) | Procedimiento para fabricar derivados del acido arilacetico. | |
| GB1464067A (en) | Process for preparing hydroxyphenol ethers | |
| ES8306021A1 (es) | Un metodo mejorado para concentrar una solucion de antibiotico de beta-lactama por medio de una membrana permeable. | |
| HUT58268A (en) | Process for producing benzaldehydes | |
| NO932952D0 (no) | Natriumhydrosulfittfremstilling med hoeyt utbytte | |
| HU9802495D0 (en) | Process for producing of formyl-imidazole-derivatives | |
| ES8307236A1 (es) | Un procedimiento para la preparacion de ranitidina. | |
| TW275061B (en:Method) | ||
| IE820659L (en) | Penicillinate compounds | |
| GB1502275A (en) | Naphthoquinone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051003 |