ES8603489A1 - Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas - Google Patents
Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinasInfo
- Publication number
- ES8603489A1 ES8603489A1 ES543115A ES543115A ES8603489A1 ES 8603489 A1 ES8603489 A1 ES 8603489A1 ES 543115 A ES543115 A ES 543115A ES 543115 A ES543115 A ES 543115A ES 8603489 A1 ES8603489 A1 ES 8603489A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- opt
- refamycins
- pyrido
- imidazo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 229930189077 Rifamycin Natural products 0.000 abstract 1
- RAFHKEAPVIWLJC-OQQFTUDCSA-N Rifamycin O Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC5(OCC(=O)O5)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C RAFHKEAPVIWLJC-OQQFTUDCSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229960003292 rifamycin Drugs 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical compound OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- RAFHKEAPVIWLJC-TWYIRNIGSA-N z67lem9p1w Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)N2)C)OC)C(C(=C3O)C)=C1C1=C3C(=O)C2=C[C@]11OCC(=O)O1 RAFHKEAPVIWLJC-TWYIRNIGSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT03463/84A IT1199374B (it) | 1984-05-15 | 1984-05-15 | Processo per la preparazione di pirido-imidazo-rifamicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES543115A0 ES543115A0 (es) | 1986-01-01 |
| ES8603489A1 true ES8603489A1 (es) | 1986-01-01 |
Family
ID=11107845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES543115A Expired ES8603489A1 (es) | 1984-05-15 | 1985-05-14 | Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4557866A (en:Method) |
| EP (1) | EP0161534B1 (en:Method) |
| JP (1) | JPS60252483A (en:Method) |
| AR (1) | AR241913A1 (en:Method) |
| AT (1) | ATE46512T1 (en:Method) |
| AU (1) | AU568934B2 (en:Method) |
| CA (1) | CA1215708A (en:Method) |
| DE (1) | DE3573120D1 (en:Method) |
| DK (1) | DK162647C (en:Method) |
| ES (1) | ES8603489A1 (en:Method) |
| FI (1) | FI81101C (en:Method) |
| GR (1) | GR851144B (en:Method) |
| IE (1) | IE58392B1 (en:Method) |
| IT (1) | IT1199374B (en:Method) |
| NO (1) | NO164242C (en:Method) |
| PH (1) | PH22007A (en:Method) |
| PT (1) | PT80446B (en:Method) |
| ZA (1) | ZA852971B (en:Method) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| AU2002364162A1 (en) * | 2001-12-13 | 2003-06-30 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
| US7906542B2 (en) | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
| US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
| US7902206B2 (en) | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US7923553B2 (en) | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
| US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
| US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
| US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
| PL1698630T3 (pl) | 2005-03-03 | 2014-12-31 | Alfasigma Spa | Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych |
| ITBO20050123A1 (it) | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
| BRPI0708561A2 (pt) | 2006-03-09 | 2011-06-07 | Salix Pharmaceuticals Inc | preparação farmacêutica, e métodos de tratamento de um indivìduo que sofre de um distúrbio anal, e de avaliação da eficácia de um tratamento de distúrbio anal em um indivìduo, monitoramento do progresso de um indivìduo sendo tratado para um distúrbio anal, ou um método de seleção de um indivìduo para o tratamento de distúrbio anal |
| EP2054066B1 (en) | 2006-08-02 | 2015-04-15 | Salix Pharmaceuticals, Inc. | Methods for treatment of radiation enteritis |
| ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
| NZ575550A (en) * | 2006-09-22 | 2011-12-22 | Cipla Ltd | Rifaximin |
| US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
| US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
| ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
| US7709634B2 (en) | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| JP5706693B2 (ja) | 2008-02-25 | 2015-04-22 | サリックス ファーマシューティカルズ リミテッド | リファキシミンの型およびその使用 |
| US8486956B2 (en) | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
| CN101959412A (zh) | 2008-02-26 | 2011-01-26 | 萨利克斯药品有限公司 | 治疗肠病的方法 |
| US20090324736A1 (en) | 2008-05-07 | 2009-12-31 | Salix Pharmaceuticals, Ltd. | Methods of treating bowel diseases by administering a bowel cleanser and an antibiotic |
| CN101585843B (zh) * | 2008-05-21 | 2011-07-06 | 重庆赛诺生物药业股份有限公司 | 一种利福昔明的制备工艺 |
| US12285414B2 (en) | 2008-10-02 | 2025-04-29 | Salix Pharmaceuticals, Inc. | Methods of treating hepatic encephalopathy |
| LT2350096T (lt) | 2008-10-02 | 2020-03-10 | Salix Pharmaceuticals, Ltd. | Hepatinės encefalopatijos gydymo būdai |
| US20110035232A1 (en) | 2008-10-02 | 2011-02-10 | Salix Pharmaceuticals, Ltd. | Methods of treating hepatic encephalopathy |
| US7928115B2 (en) * | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| CA2745980C (en) | 2008-12-10 | 2017-10-31 | Cipla Limited | Rifaximin complexes |
| IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
| KR20120025578A (ko) | 2009-06-02 | 2012-03-15 | 샐릭스 파마슈티컬스 리미티드 | 간성 뇌병증의 치료방법 |
| BR112012005627A2 (pt) | 2009-09-13 | 2017-02-21 | Salix Pharmaceuticals Ltd | "uso de rifaximina para preparação de um medicamento para tratar síndrome do intestino irritável (ibs)" |
| WO2011061519A2 (en) | 2009-11-23 | 2011-05-26 | Cipla Limited | Topical foam composition |
| US8952159B2 (en) | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
| CA2789929C (en) | 2010-02-18 | 2019-11-26 | Salix Pharmaceuticals, Ltd. | Methods for treating infection |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| EP2582707A4 (en) * | 2010-06-16 | 2014-01-08 | Apotex Pharmachem Inc | POLYMORPHIC FORMS OF RIFAXIMINE |
| DK2593463T3 (da) | 2010-07-12 | 2020-08-10 | Salix Pharmaceuticals Inc | Formuleringer af rifaximin og anvendelser deraf |
| US8759513B2 (en) | 2010-09-13 | 2014-06-24 | Sequent Scientific Limited | Polymorphic form of rifaximin and process for its preparation |
| CN103827122B (zh) | 2011-02-11 | 2016-08-31 | 萨利克斯药品有限公司 | 利福昔明的形式及其用途 |
| CA2834829A1 (en) | 2011-05-02 | 2012-11-08 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
| WO2012155981A1 (en) | 2011-05-19 | 2012-11-22 | Friulchem Spa | New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby |
| ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
| ES2986825T3 (es) | 2011-11-02 | 2024-11-12 | Salix Pharmaceuticals Inc | Rifaximina para la repetición de tratamiento del síndrome del intestino irritable con predominio de diarrea |
| CA2876737A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| US20160038468A1 (en) | 2013-03-15 | 2016-02-11 | Alfa Wassermann S.P.A. | Rifaximin for use in the treating of vaginal infections |
| US20160047819A1 (en) | 2013-03-15 | 2016-02-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
| PL2983647T3 (pl) | 2013-04-12 | 2021-01-25 | Alfasigma S.P.A. | Podawanie nlpz oraz związane z tym składniki, sposoby i układy |
| US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
| ITMI20131307A1 (it) | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
| CN103509038B (zh) * | 2013-09-30 | 2016-01-20 | 浙江思贤制药有限公司 | 一种新晶型利福昔明ζ及其制备方法 |
| ES2621557T3 (es) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
| JP6693946B2 (ja) | 2014-05-04 | 2020-05-13 | サリックス ファーマスーティカルズ，インコーポレーテッド | Ｉｂｓ微生物叢及びその使用 |
| RS60576B1 (sr) | 2014-05-12 | 2020-08-31 | Alfasigma Spa | Priprema i upotreba tau kristalnog oblika rifaksimina solvatisanog sa degme |
| EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
| US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
| KR102494049B1 (ko) | 2016-09-30 | 2023-01-31 | 샐릭스 파마슈티컬스 인코포레이티드 | 리팍시민의 고체 분산물 형태 |
| DK3645539T3 (da) * | 2017-06-26 | 2021-05-10 | Biofer Spa | Pyrido-imidazo-rifamycin-derivater som antibakterielt middel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1154655B (it) | 1980-05-22 | 1987-01-21 | Alfa Farmaceutici Spa | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
-
1984
- 1984-05-15 IT IT03463/84A patent/IT1199374B/it active
-
1985
- 1985-04-19 DE DE8585104790T patent/DE3573120D1/de not_active Expired
- 1985-04-19 AT AT85104790T patent/ATE46512T1/de not_active IP Right Cessation
- 1985-04-19 EP EP85104790A patent/EP0161534B1/en not_active Expired
- 1985-04-19 ZA ZA852971A patent/ZA852971B/xx unknown
- 1985-04-25 PH PH32186A patent/PH22007A/en unknown
- 1985-04-26 US US06/727,521 patent/US4557866A/en not_active Expired - Lifetime
- 1985-04-29 CA CA000480321A patent/CA1215708A/en not_active Expired
- 1985-05-13 PT PT80446A patent/PT80446B/pt unknown
- 1985-05-13 GR GR851144A patent/GR851144B/el unknown
- 1985-05-14 IE IE119185A patent/IE58392B1/en not_active IP Right Cessation
- 1985-05-14 JP JP60102528A patent/JPS60252483A/ja active Granted
- 1985-05-14 ES ES543115A patent/ES8603489A1/es not_active Expired
- 1985-05-14 DK DK214685A patent/DK162647C/da not_active IP Right Cessation
- 1985-05-14 NO NO851921A patent/NO164242C/no not_active IP Right Cessation
- 1985-05-14 FI FI851907A patent/FI81101C/fi not_active IP Right Cessation
- 1985-05-15 AU AU42515/85A patent/AU568934B2/en not_active Expired
- 1985-05-15 AR AR85300385A patent/AR241913A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE46512T1 (de) | 1989-10-15 |
| FI851907A0 (fi) | 1985-05-14 |
| FI851907L (fi) | 1985-11-16 |
| DE3573120D1 (en) | 1989-10-26 |
| IT8403463A0 (it) | 1984-05-15 |
| FI81101C (fi) | 1990-09-10 |
| PT80446B (pt) | 1987-11-11 |
| DK162647B (da) | 1991-11-25 |
| JPH0469634B2 (en:Method) | 1992-11-06 |
| ZA852971B (en) | 1985-12-24 |
| GR851144B (en:Method) | 1985-11-25 |
| JPS60252483A (ja) | 1985-12-13 |
| AU4251585A (en) | 1985-11-21 |
| ES543115A0 (es) | 1986-01-01 |
| AR241913A1 (es) | 1993-01-29 |
| IT1199374B (it) | 1988-12-30 |
| NO851921L (no) | 1985-11-18 |
| EP0161534A2 (en) | 1985-11-21 |
| AU568934B2 (en) | 1988-01-14 |
| DK214685A (da) | 1985-11-16 |
| US4557866A (en) | 1985-12-10 |
| PH22007A (en) | 1988-05-02 |
| NO164242B (no) | 1990-06-05 |
| DK162647C (da) | 1992-04-13 |
| EP0161534B1 (en) | 1989-09-20 |
| IE58392B1 (en) | 1993-09-08 |
| NO164242C (no) | 1990-09-12 |
| PT80446A (en) | 1985-06-01 |
| EP0161534A3 (en) | 1987-03-04 |
| IE851191L (en) | 1985-11-15 |
| FI81101B (fi) | 1990-05-31 |
| CA1215708A (en) | 1986-12-23 |
| DK214685D0 (da) | 1985-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8603489A1 (es) | Un nuevo procedimiento para la preparacion de pirido-imidazorifamicinas | |
| EP0226225A3 (en) | Process for the preparation of (2,2)-paracyclophane and derivatives thereof | |
| GB1247370A (en) | Glyoxals and production thereof | |
| GB1477945A (en) | Method of protecting polyurethane resins from degradation by ultra violet radiation | |
| GB1476215A (en) | Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them | |
| GR3002689T3 (en) | Process for producing 2-methyl-1,4-naphthoquinone | |
| GB1481859A (en) | Halogen-substituted benzimidazolone compounds and a process for their manufacture | |
| ES2112433T3 (es) | Sintesis de derivados del acido n-acetil neuraminico. | |
| ES8302733A1 (es) | Un procedimiento para preparar nuevos derivados de antraci- clina | |
| NO173829C (no) | Fremgangsmaate for fremstilling av polyoksyalkylenforbindelser | |
| JPS6485953A (en) | Production of 7-amino-6-demethyl-6-deoxytetracycline | |
| FI932126A0 (fi) | Foerfarande foer framstaellning av 2-klor-5-klormetylpyridin | |
| GR3031922T3 (en) | Novel process. | |
| ES481264A1 (es) | Procedimiento para fabricar derivados del acido arilacetico. | |
| GB1464067A (en) | Process for preparing hydroxyphenol ethers | |
| ES8306021A1 (es) | Un metodo mejorado para concentrar una solucion de antibiotico de beta-lactama por medio de una membrana permeable. | |
| HUT58268A (en) | Process for producing benzaldehydes | |
| NO932952D0 (no) | Natriumhydrosulfittfremstilling med hoeyt utbytte | |
| HU9802495D0 (en) | Process for producing of formyl-imidazole-derivatives | |
| ES8307236A1 (es) | Un procedimiento para la preparacion de ranitidina. | |
| TW275061B (en:Method) | ||
| IE820659L (en) | Penicillinate compounds | |
| JPS56154480A (en) | Dioxolane derivative and manufacture | |
| GB1502275A (en) | Naphthoquinone derivatives | |
| GB1463850A (en) | 4-deoxy-4-oxoerythromycin b derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20051003 |