FI78389B - Vaginalring. - Google Patents
Vaginalring. Download PDFInfo
- Publication number
- FI78389B FI78389B FI813360A FI813360A FI78389B FI 78389 B FI78389 B FI 78389B FI 813360 A FI813360 A FI 813360A FI 813360 A FI813360 A FI 813360A FI 78389 B FI78389 B FI 78389B
- Authority
- FI
- Finland
- Prior art keywords
- weight
- active substance
- layer
- ring
- free
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Claims (2)
1. Vaginalring, bestäende av en stödring (1) som inte innehäller nägon verksam substans och ett pä 5 dess yttre kant anbringt steroidhaltigt skikt (2) som överdragits med ett skikt (3) som inte innehäller nägon verksam substans, kännetecknad därav, att stödringen (1) bestär av LTV-silikonelastomer med föl-jande sammansättning: 10 78,5-96,5 vikt-% polydimetylvinylsiloxan, 1- 10 vikt-% tetrametyl-tetravinyl-cyklotetra- siloxan, 2- 20 vikt-% polydimetylvätesiloxan, 0,5 - 10 vikt-% finfördelad kiselsyra och 15 10 - 100 ppm platinakatalysator, det steroidhaltiga skiktet (2) bestär av LTV-silikonelastomer med följande sammansättning: 75 - 97 vikt-% polydimetylvinylsiloxan, 1-10 vikt-% tetrametyl-tetravinyl-cyklotetra-20 siloxan, 1-10 vikt-% polydimetylvätesiloxan, 10 - 100 ppm platinakatalysator och 1-10 vikt-% av en verksam substans frän grupp-en noretisteronacetat, levonorgestrel och gestoden, 25 och skiktet (3) som inte innehäller nägon verksam substans bestär av LTV-silikonelastomer med följande sammansättning: 75 - 97 vikt-% polydimetylvinylsiloxan, 1- 10 vikt-% tetrametyl-tetravinyl-cyklotetra- 30 siloxan 2- 20 vikt-% polydimetylvätesiloxan, coh 10 - 100 ppm platinakatalysator, och skiktet (3) som inte innehäller nägon verksam substans har en tjocklek av 100 - 500 pm.
2. Vaginalring enligt patentkravet 1, känne tecknad därav, att stödringen (1) för upptagning av det steroidhaltiga skiktet (2) uppvisar en kringlö-pande skära.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3040978 | 1980-10-28 | ||
DE19803040978 DE3040978A1 (de) | 1980-10-28 | 1980-10-28 | Vaginalring |
Publications (3)
Publication Number | Publication Date |
---|---|
FI813360L FI813360L (fi) | 1982-04-29 |
FI78389B true FI78389B (fi) | 1989-04-28 |
FI78389C FI78389C (sv) | 1989-08-10 |
Family
ID=6115593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI813360A FI78389C (sv) | 1980-10-28 | 1981-10-27 | Vaginalring |
Country Status (26)
Country | Link |
---|---|
US (1) | US4822616A (sv) |
EP (1) | EP0050867B1 (sv) |
JP (2) | JPS5799954A (sv) |
AT (1) | ATE31875T1 (sv) |
AU (1) | AU7670981A (sv) |
BG (1) | BG42182A3 (sv) |
CA (1) | CA1165239A (sv) |
CS (1) | CS253564B2 (sv) |
DD (1) | DD201645A5 (sv) |
DE (2) | DE3040978A1 (sv) |
DK (1) | DK151529C (sv) |
EG (1) | EG15347A (sv) |
ES (2) | ES8505538A1 (sv) |
FI (1) | FI78389C (sv) |
GR (1) | GR75367B (sv) |
HU (1) | HU183646B (sv) |
IE (1) | IE54581B1 (sv) |
IL (1) | IL64139A (sv) |
NO (1) | NO153753C (sv) |
PL (1) | PL127941B1 (sv) |
PT (1) | PT73886B (sv) |
RO (1) | RO88674A (sv) |
SU (1) | SU1440326A3 (sv) |
YU (1) | YU252281A (sv) |
ZA (1) | ZA817477B (sv) |
ZW (1) | ZW26081A1 (sv) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3347125A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrstufenkombinationspraeparat und seine verwendung zur oralen kontrazeption |
GB8430703D0 (en) * | 1984-12-05 | 1985-01-16 | Lrc Products | Drug release devices |
FR2618329B1 (fr) * | 1987-07-22 | 1997-03-28 | Dow Corning Sa | Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede |
US5295984A (en) | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
US6264638B1 (en) * | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
AU1797592A (en) * | 1991-04-12 | 1992-11-17 | Upjohn Company, The | Vaginal drug delivery device |
FI95768C (sv) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Intravaginalt doseringssystem |
GB9326255D0 (en) * | 1993-12-23 | 1994-02-23 | Roussel Lab Ltd | Medical device for the prevention and treatment of cancer |
DE69616551T2 (de) * | 1995-07-04 | 2002-05-29 | Akzo Nobel Nv | Ringförmige vorrichtung |
GB9522403D0 (en) * | 1995-11-01 | 1996-01-03 | Hoechst Roussel Ltd | Intravaginal drug delivery device |
US5816248A (en) * | 1996-03-29 | 1998-10-06 | Iotek, Inc. | Channeled vaginal insert and method for treating urogenital disorders |
US5988169A (en) * | 1996-03-29 | 1999-11-23 | Iotek, Inc. | Vaginal insert and method for treating urogenital disorders |
US6030375A (en) * | 1996-03-29 | 2000-02-29 | Iotek, Inc. | Compressible vaginal insert and method for treating urogenital disorders |
CA2259506C (en) | 1996-07-03 | 2006-12-19 | Ultrafem, Inc. | Method and system for manufacturing elastomeric articles |
US5972372A (en) * | 1996-07-31 | 1999-10-26 | The Population Council, Inc. | Intravaginal rings with insertable drug-containing core |
IL123813A0 (en) * | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
US6039968A (en) * | 1997-06-24 | 2000-03-21 | Hoechst Marion Roussel | Intravaginal drug delivery device |
AU748653B2 (en) * | 1998-05-01 | 2002-06-06 | John F. Cline | Method for injection molding manufacture of controlled release devices |
ATE455526T1 (de) * | 2000-08-24 | 2010-02-15 | Sidney Lerner | Nicht-hormonales vaginales verhütungsmittel |
DE60116520T2 (de) * | 2000-10-10 | 2006-08-31 | Microchips, Inc., Bedford | Microchip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten |
KR20040036928A (ko) * | 2001-08-31 | 2004-05-03 | 쉐링 오와이 | 약물 전달 시스템 |
AU2003278766A1 (en) * | 2002-09-04 | 2004-03-29 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
US7357046B2 (en) | 2002-12-16 | 2008-04-15 | N. V. Organon | Method for dissolution testing of a pharmaceutical delivery device |
AU2004233997C1 (en) * | 2003-04-29 | 2014-01-30 | Massachusetts Institiute Of Technology | Methods and devices for the sustained release of multiple drugs |
TWI336627B (en) | 2003-05-23 | 2011-02-01 | Organon Nv | Drug delivery system,and use and manufacturing method thereof |
AU2005224056B2 (en) | 2004-03-24 | 2010-03-18 | Merck Sharp & Dohme B.V. | Drug delivery system based on polyethylene vinylacetate copolymers |
US20080076975A1 (en) * | 2005-01-25 | 2008-03-27 | Microchips, Inc. | Method and implantable device with reservoir array for pre-clinical in vivo testing |
AU2006208131A1 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
CN1899643B (zh) * | 2005-07-20 | 2010-12-29 | 上海市计划生育科学研究所 | 含有抗雌激素和抗孕激素复合制剂的阴道环或宫内释药装置及其制药用途 |
US8399012B2 (en) | 2006-04-17 | 2013-03-19 | Kimberly-Clark Worldwide, Inc. | Degradable therapeutic delivery device |
TW200930343A (en) | 2007-09-21 | 2009-07-16 | Organon Nv | Drug delivery system |
TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
JP5507467B2 (ja) * | 2008-02-04 | 2014-05-28 | テバ ウィメンズ ヘルス インコーポレイテッド | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
US20100040671A1 (en) * | 2008-08-12 | 2010-02-18 | Ahmed Salah U | Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof |
US8419793B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
US8420153B2 (en) * | 2008-09-19 | 2013-04-16 | Mentor Worldwide Llc | Coating with antimicrobial agents |
AU2010256558B2 (en) | 2009-06-03 | 2013-10-03 | Forsight Labs, Llc | Anterior segment drug delivery |
JP5690826B2 (ja) | 2009-07-21 | 2015-03-25 | ザ・ポピュレイション・カウンシル,インコーポレイテッド | 多層状勾配膣リング |
CN103154016A (zh) | 2010-05-05 | 2013-06-12 | 特卫华妇女健康有限公司 | 使用具有逐渐降低的释放速率的单剂型减轻对象症状的方法 |
US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
DE202012012713U1 (de) | 2011-03-04 | 2014-01-23 | Arstat, Inc. | Intravaginale Arzneimittelabgabevorrichtung |
WO2012121767A1 (en) | 2011-03-09 | 2012-09-13 | Arstat, Inc. | Treatment of uterine fibroids by intravaginal administration of a low dose of selective progesterone receptor modulator (sprm), anti-progestin, or anti-progestational agent |
DE202011110356U1 (de) | 2011-03-10 | 2014-01-15 | Arstat, Inc. | Behandlung von Endometriose durch intravaginale Verabreichung einer niedrigen Dosis eines selektiven Progesteronrezeptormodulators, eines Antigestagens oder eines Antigestagen-Wirkstoffes |
DE202012012761U1 (de) | 2011-04-07 | 2013-10-29 | Arstat, Inc. | Mit Arzneimittel versehene intravaginale Vorrichtung und pharmazeutische Zusammensetzung zur Behandlung von Menstruationsschmerzen und übermäßigem Menstruationsblutverlust |
KR102059698B1 (ko) * | 2011-06-06 | 2019-12-26 | 오크 크레스트 인스티튜트 오브 사이언스 | 심지 방출창을 도입한 약물 전달 장치 |
AU2012308317B2 (en) | 2011-09-14 | 2017-01-05 | Forsight Vision5, Inc. | Ocular insert apparatus and methods |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
JP6285866B2 (ja) | 2011-11-23 | 2018-02-28 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然複合ホルモン補充製剤および療法 |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
WO2014066775A1 (en) | 2012-10-26 | 2014-05-01 | Forsight Vision5, Inc. | Ophthalmic system for sustained release of drug to eye |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
WO2015055789A1 (en) | 2013-10-17 | 2015-04-23 | Bayer Pharma Aktiengesellschaft | INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION |
US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
US10413504B2 (en) | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
WO2015086489A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
DE102014004388A1 (de) * | 2014-03-26 | 2015-10-01 | Angela Kayser | Verfahren und System zum intravaginalen Verabreichen von Progesteron |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP3283004A4 (en) | 2015-04-13 | 2018-12-05 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
WO2016180764A1 (en) | 2015-05-13 | 2016-11-17 | Bayer Oy | A long acting drug delivery device and its use in contraception |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CA3018148C (en) * | 2016-03-23 | 2024-02-20 | The University Of North Carolina At Chapel Hill | Geometrically complex intravaginal rings, systems and methods of making the same |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
WO2018202574A1 (en) | 2017-05-04 | 2018-11-08 | Bayer Oy | Intravaginal drug delivery system, method for manufacturing such system and its use in gynecological therapies and contraception |
DE102017113166A1 (de) | 2017-06-14 | 2018-12-20 | Amw Gmbh | Depotform zur Abgabe eines Östrogen-Wirkstoffs |
BR112020008231A2 (pt) | 2017-10-27 | 2020-10-27 | Renovia, Inc. | dispositivos, sistemas e métodos para treinamento dos músculos do assoalho pélvico |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
CA988849A (en) * | 1969-06-16 | 1976-05-11 | Antonio Scommegna | Anti-fertility device |
GB1264731A (sv) * | 1969-11-10 | 1972-02-23 | ||
US3845761A (en) * | 1970-06-02 | 1974-11-05 | Alza Corp | Intrauterine contraceptive anti-fertility device for the management of reproduction |
US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
FR2270899A1 (en) * | 1974-05-16 | 1975-12-12 | Groves Harvey | Vaginal medicator with long medicament-carrying stem - having anchor to correctly position stem |
DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
IL48277A (en) * | 1974-10-18 | 1978-03-10 | Schering Ag | Vaginal ring |
US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
DE2450107A1 (de) * | 1974-10-18 | 1976-04-29 | Schering Ag | Vaginalring |
US4215691A (en) * | 1978-10-11 | 1980-08-05 | Alza Corporation | Vaginal contraceptive system made from block copolymer |
US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
-
1980
- 1980-10-28 DE DE19803040978 patent/DE3040978A1/de not_active Withdrawn
-
1981
- 1981-10-22 DD DD81234288A patent/DD201645A5/de not_active IP Right Cessation
- 1981-10-22 YU YU02522/81A patent/YU252281A/xx unknown
- 1981-10-22 AU AU76709/81A patent/AU7670981A/en not_active Abandoned
- 1981-10-23 GR GR66351A patent/GR75367B/el unknown
- 1981-10-24 DE DE8181108872T patent/DE3176606D1/de not_active Expired
- 1981-10-24 EP EP81108872A patent/EP0050867B1/en not_active Expired
- 1981-10-24 AT AT81108872T patent/ATE31875T1/de active
- 1981-10-26 DK DK471481A patent/DK151529C/da not_active IP Right Cessation
- 1981-10-26 JP JP56170262A patent/JPS5799954A/ja active Pending
- 1981-10-27 ES ES527301A patent/ES8505538A1/es not_active Expired
- 1981-10-27 EG EG81625A patent/EG15347A/xx active
- 1981-10-27 NO NO813625A patent/NO153753C/no unknown
- 1981-10-27 HU HU813156A patent/HU183646B/hu unknown
- 1981-10-27 CA CA000388832A patent/CA1165239A/en not_active Expired
- 1981-10-27 PT PT73886A patent/PT73886B/pt not_active IP Right Cessation
- 1981-10-27 FI FI813360A patent/FI78389C/sv not_active IP Right Cessation
- 1981-10-27 IE IE2503/81A patent/IE54581B1/en not_active IP Right Cessation
- 1981-10-27 SU SU813347855A patent/SU1440326A3/ru active
- 1981-10-27 ES ES1981261058U patent/ES261058U/es active Pending
- 1981-10-28 CS CS817905A patent/CS253564B2/cs unknown
- 1981-10-28 RO RO81105663A patent/RO88674A/ro unknown
- 1981-10-28 BG BG8153982A patent/BG42182A3/xx unknown
- 1981-10-28 ZW ZW260/81A patent/ZW26081A1/xx unknown
- 1981-10-28 PL PL1981233606A patent/PL127941B1/pl unknown
- 1981-10-28 IL IL64139A patent/IL64139A/xx not_active IP Right Cessation
- 1981-10-28 ZA ZA817477A patent/ZA817477B/xx unknown
-
1987
- 1987-02-13 US US07/014,316 patent/US4822616A/en not_active Expired - Fee Related
-
1990
- 1990-02-19 JP JP1990014821U patent/JPH048893Y2/ja not_active Expired
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: SCHERING AKTIENGESELLSCHAFT |