FI68050C - Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner - Google Patents
Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner Download PDFInfo
- Publication number
- FI68050C FI68050C FI803988A FI803988A FI68050C FI 68050 C FI68050 C FI 68050C FI 803988 A FI803988 A FI 803988A FI 803988 A FI803988 A FI 803988A FI 68050 C FI68050 C FI 68050C
- Authority
- FI
- Finland
- Prior art keywords
- dihydro
- phenyl
- methyl
- benzodiazepine
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792952279 DE2952279A1 (de) | 1979-12-24 | 1979-12-24 | Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE2952279 | 1979-12-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803988L FI803988L (fi) | 1981-06-25 |
| FI68050B FI68050B (fi) | 1985-03-29 |
| FI68050C true FI68050C (fi) | 1985-07-10 |
Family
ID=6089628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803988A FI68050C (fi) | 1979-12-24 | 1980-12-19 | Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4325957A (nl) |
| EP (1) | EP0031080B1 (nl) |
| JP (1) | JPS5699477A (nl) |
| AU (1) | AU542701B2 (nl) |
| CA (1) | CA1169425A (nl) |
| DD (2) | DD155988A5 (nl) |
| DE (3) | DE2952279A1 (nl) |
| DK (1) | DK548080A (nl) |
| ES (2) | ES8201143A1 (nl) |
| FI (1) | FI68050C (nl) |
| GR (1) | GR73080B (nl) |
| HU (1) | HU185398B (nl) |
| IE (1) | IE50580B1 (nl) |
| IL (1) | IL61692A (nl) |
| NO (1) | NO154883C (nl) |
| NZ (1) | NZ195872A (nl) |
| PH (1) | PH17189A (nl) |
| PT (2) | PT72278B (nl) |
| SU (1) | SU1253430A3 (nl) |
| YU (1) | YU324780A (nl) |
| ZA (1) | ZA807704B (nl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3021107A1 (de) * | 1980-06-04 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel |
| DE3048264A1 (de) * | 1980-12-20 | 1982-09-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3124013A1 (de) * | 1981-06-19 | 1982-12-30 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3151597A1 (de) * | 1981-12-28 | 1983-07-07 | Kali-Chemie Pharma Gmbh, 3000 Hannover | (1,2)-anellierte 1,4-benzodiazepin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US4724237A (en) * | 1984-06-26 | 1988-02-09 | Merck & Co., Inc. | 2-substituted-aminomethyl-1,4-benzodiazepines |
| EP0170024A3 (en) * | 1984-06-26 | 1990-01-31 | Merck & Co. Inc. | Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions |
| US4684646A (en) * | 1984-06-26 | 1987-08-04 | Merck & Co., Inc. | 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists |
| JPH01314666A (ja) * | 1988-06-15 | 1989-12-19 | Kayaba Ind Co Ltd | パワーステアリング装置の操舵力制御装置 |
| GB8823042D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823041D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| US5380721A (en) * | 1990-09-10 | 1995-01-10 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| JPH0546660U (ja) * | 1991-12-03 | 1993-06-22 | カヤバ工業株式会社 | パワーステアリング装置 |
| US6825160B1 (en) | 1999-08-27 | 2004-11-30 | Procter & Gamble Company | Color safe laundry methods employing cationic formulation components |
| US6821935B1 (en) | 1999-08-27 | 2004-11-23 | Procter & Gamble Company | Color safe laundry methods employing zwitterionic formulation components |
| US6818607B1 (en) * | 1999-08-27 | 2004-11-16 | Procter & Gamble Company | Bleach boosting components, compositions and laundry methods |
| US7109156B1 (en) | 1999-08-27 | 2006-09-19 | Procter & Gamble Company | Controlled availability of formulation components, compositions and laundry methods employing same |
| CN1384867A (zh) | 1999-08-27 | 2002-12-11 | 宝洁公司 | 稳定性提高的配制组分、使用该组分的组合物和洗衣方法 |
| DE60028387T2 (de) * | 1999-08-27 | 2007-05-24 | The Procter & Gamble Company, Cincinnati | Bleichverstärkende verbindungen, zusammensetzungen und waschverfahren |
| US6903060B1 (en) | 1999-08-27 | 2005-06-07 | Procter & Gamble Company | Stable formulation components, compositions and laundry methods employing same |
| CN1382205A (zh) * | 1999-08-27 | 2002-11-27 | 宝洁公司 | 快速作用的制剂组分、使用该制剂组分的组合物和洗衣方法 |
| US7557076B2 (en) * | 2002-06-06 | 2009-07-07 | The Procter & Gamble Company | Organic catalyst with enhanced enzyme compatibility |
| US7169744B2 (en) * | 2002-06-06 | 2007-01-30 | Procter & Gamble Company | Organic catalyst with enhanced solubility |
| US20050113246A1 (en) * | 2003-11-06 | 2005-05-26 | The Procter & Gamble Company | Process of producing an organic catalyst |
| AR051659A1 (es) * | 2005-06-17 | 2007-01-31 | Procter & Gamble | Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada |
| KR100877824B1 (ko) | 2005-11-11 | 2009-01-12 | 한국생명공학연구원 | Ｅ2ｅｐｆ ｕｃｐ-ｖｈｌ 상호작용 및 그 용도 |
| CN113149914A (zh) * | 2021-01-15 | 2021-07-23 | 福安药业集团重庆礼邦药物开发有限公司 | 一种咪达唑仑中间体脱氟杂质的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681340A (en) * | 1968-02-12 | 1972-08-01 | Herman Robert Rodriguez | 1,3-benzodiazepines |
| US3738999A (en) * | 1970-05-28 | 1973-06-12 | Squibb & Sons Inc | 2,3,4,5-tetrahydro-2-phenyl-1,4-benzothiazepine, hydrochloride |
| DE2353160C2 (de) * | 1973-05-02 | 1986-07-17 | Kali-Chemie Ag, 3000 Hannover | 5-Phenyl-2,3-dihydro-1H-1,4-benzodiazepine, ihre Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel |
| DE2353187A1 (de) * | 1973-05-02 | 1974-11-14 | Kali Chemie Ag | Neue benzodiazepinderivate |
| US3925358A (en) * | 1973-07-27 | 1975-12-09 | Hoffmann La Roche | 1-Lower alkyl-2-substituted-1,4-benzodiazepines |
| US3947475A (en) * | 1975-04-28 | 1976-03-30 | Stauffer Chemical Company | 5-Furoyl-2,2,4-trimethyl-1,4-dihydro-1H-1,5-benzodiazepine as an anti-inflammatory agent |
| US4087421A (en) * | 1976-04-19 | 1978-05-02 | American Cyanamid Company | Substituted benzodiazepines and method of use |
-
1979
- 1979-12-24 DE DE19792952279 patent/DE2952279A1/de not_active Withdrawn
-
1980
- 1980-10-20 GR GR63733A patent/GR73080B/el unknown
- 1980-12-04 IE IE2531/80A patent/IE50580B1/en unknown
- 1980-12-09 ZA ZA00807704A patent/ZA807704B/xx unknown
- 1980-12-10 DE DE8282107036T patent/DE3070798D1/de not_active Expired
- 1980-12-10 EP EP80107779A patent/EP0031080B1/de not_active Expired
- 1980-12-10 DE DE8080107779T patent/DE3064983D1/de not_active Expired
- 1980-12-11 IL IL61692A patent/IL61692A/xx unknown
- 1980-12-16 PH PH24988A patent/PH17189A/en unknown
- 1980-12-17 HU HU803023A patent/HU185398B/hu unknown
- 1980-12-18 NZ NZ195872A patent/NZ195872A/xx unknown
- 1980-12-19 FI FI803988A patent/FI68050C/fi not_active IP Right Cessation
- 1980-12-22 YU YU03247/80A patent/YU324780A/xx unknown
- 1980-12-22 DD DD80226419A patent/DD155988A5/de unknown
- 1980-12-22 SU SU3220053A patent/SU1253430A3/ru active
- 1980-12-22 AU AU65664/80A patent/AU542701B2/en not_active Ceased
- 1980-12-22 DD DD80233407A patent/DD200274A5/de unknown
- 1980-12-22 DK DK548080A patent/DK548080A/da not_active Application Discontinuation
- 1980-12-23 US US06/219,487 patent/US4325957A/en not_active Expired - Lifetime
- 1980-12-23 PT PT72278A patent/PT72278B/pt unknown
- 1980-12-23 PT PT72279A patent/PT72279B/pt unknown
- 1980-12-23 NO NO803935A patent/NO154883C/no unknown
- 1980-12-23 ES ES498072A patent/ES8201143A1/es not_active Expired
- 1980-12-23 ES ES498071A patent/ES498071A0/es active Granted
- 1980-12-23 CA CA000367417A patent/CA1169425A/en not_active Expired
- 1980-12-24 JP JP18216980A patent/JPS5699477A/ja active Granted
-
1982
- 1982-01-12 US US06/338,883 patent/US4382030A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI68050C (fi) | Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner | |
| EP0492485B1 (en) | N-Acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same | |
| CA2012628C (fr) | Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| FI66604C (fi) | Foerfarande foer framstaellning av nya 5h-2,3-bensodiazepinderivat med inverkan pao det centrala nervsystemet | |
| FI57417B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-substituerad-oxazolo-(4,5-b)-pyridiner | |
| CA2325638A1 (en) | Amide derivatives and nociceptin antagonists | |
| JPH0647593B2 (ja) | 新規ピロロ―ベンズイミダゾール、これを含有する心臓―および循環器疾患の予防ないしは治療用医薬 | |
| CN103201270B (zh) | P2x4受体拮抗剂 | |
| CA1076572A (en) | Diazepine derivatives | |
| US4755508A (en) | Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin | |
| FI92486B (fi) | Menetelmä terapeuttisesti vaikuttavien 3-asyyliamino-2-okso-1H-2,3-dihydro-1,4-bentsodiatsepiiniyhdisteiden valmistamiseksi | |
| US5010074A (en) | Novel benzazepine derivatives | |
| DE3587556T2 (de) | 2-Substituierte Aminomethyl-1,4-benzodiazepine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen. | |
| Keshari et al. | Novel Mannich-bases as potential anticonvulsants: syntheses, characterization and biological evaluation | |
| FI68046B (fi) | Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-acylaminometyl-1,4-benzodiazepiner | |
| SU1331431A3 (ru) | Способ получени (1,2)-анеллированных 1,4-бензодиазепинов или их оптических изомеров или кислотно-аддитивных солей | |
| CA1162536A (en) | 2-azidomethyl-1,4-benzodiazepine derivatives and their salts, and process for their preparation | |
| Lucescu et al. | Studies on Pyrrolidinones: Chemistry of Dimethoxytriazines | |
| FI74004C (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara piperazinylpyrido/2,3-b/- och -/3,4-b/ pyrazinderivat. | |
| AT395155B (de) | Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen | |
| JP2005533866A (ja) | 抗コレシストキニン活性（抗−ｃｃｋ−１）を有するアントラニル酸誘導体、その製造法および医薬用途 | |
| CS241471B2 (cs) | Způsob výroby pyrimido-2-benzazepinů | |
| DE2741668A1 (de) | Veraetherte diazepinderivate | |
| GB2297750A (en) | 1-(2-Substituted vinyl)-5H-2,3-benzodiazepine derivatives | |
| JPH054986A (ja) | ピラゾロキノリン誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: KALI-CHEMIE PHARMA GMBH |