FI68050C - Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner - Google Patents
Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner Download PDFInfo
- Publication number
- FI68050C FI68050C FI803988A FI803988A FI68050C FI 68050 C FI68050 C FI 68050C FI 803988 A FI803988 A FI 803988A FI 803988 A FI803988 A FI 803988A FI 68050 C FI68050 C FI 68050C
- Authority
- FI
- Finland
- Prior art keywords
- dihydro
- phenyl
- methyl
- benzodiazepine
- general formula
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (4)
1. Förfarande för framställning av farmaceutiskt använd-bara 2-asYlaminometyl-lH-2,3-dihvdro-1,4-benzod iazepiner med den allmänna formeIn I i2 ?1 CH--N-C-FU « ό där Ri betecknar en väteatom eller en lägre alkyl- eller alkenylgrupp eller cyklopropylmetylgrupp, R2 betecknar en väteatom eller en lägre alkyl eller alkenylgrupp R3 betecknar en grupp enligt formeln -ζΤι h där R betecknar väteatom eller en Ci,..C3-alkyl, R4 betecknar väteatom, en halogenatom, speciellt klor-eller bromatom, en lägre alkyl, lägre alkoxi eller nitro, och R4' betecknar en väteatom eller en Cj...C4-alkyl A och B är oberoende av varandra osubstituerade eller substituerade med 1...3 substituenter valda ur följande grupp bestäende av halogen, lägre alkyltio, lägre alkoxi, lägre alkyl, hydroxi, nitro, och tr ifluormetyl, eller A och B utgörs av fenylrester i vilka tvä när-liggande C-atomer är forbundna med en metylendioxi- eller etylendioxigrupp, eller av optiska isomerer och syraadditionssalter av föreningar med den allmänna formeln I, känneteck- 48 6805 0 n a t därav, att man ρέ i och för sig känt sätt bringar en amin med formeln II |*1 gh2-nh-r2 mj 0 där A, B, och R2 betecknar samma som ovan, eller deras svraadditionssalter att reagera med en karbonsyra eller ett reaktivt karbonsyraderivat med den allmänna formeln III ^ 0 R3 - C (III) Y där R3 betecknar samma som ovan och Y betecknar hydroxi, halogen, eller en lägre alkoxigrupp eller O-CO-Z, där Z betecknar samma som R3 eller en lägre alkoxiqrupp, i ett inert lösningsmedel vid temperaturen mellan -30 °C och det använda lösningsmedels kokpunkt, vid normalt tryck eller förhöjt tryck varvid man erhäller en förening med den allmänna formeln I, där A, B, Rj_, R2 och P.3 betecknar samma som ovan, varefter man dä R2 betecknar en vätetom, eventuellt ersätter denna med en lägre alkvl, eventuellt inför pä i och för sig känt sätt en klor- eller bcomatom, eller en nitrogrupp i ringen A, eventuellt skiljer den racemiska blandningen i sinä optiska isomerer, och eventuellt överför den bildade basen i ett syraadditionssalt eller isolerar den fr ia basen ur ett syraadditionssalt.
2. 2-azidometyl-5-fenyl-lH-2,3-dihydro-l,4-benzo-diazepiner med den allmänna formeln X 49 68050 fl /'Vh 0C_> ά) där Ri betecknar en väteatom eller en lägre alkylgrupp, A och B är oberoende av varandra osubstituerade eller substituerade med 1...3 substituenter valda ur gruppen bestäende av halogen, lägre alkvltio, lägre alkoxi, lägre alkyl, hydroxi, nitro och tr ifluormetyl eller A och B utgörs av fenylrester, där tvä närliggande C-atomer är förbundna med en metylendioxi- eller etylen-dioxigrupp, samt deras syraadditionssalter.
3. R][-A- 2-az idometyl-5-B-lH-2,3-d ihydro-1,4-benzo-diazepin, där A utgörs av en väteatom, 7-fluor, 8-fluor, 7-klor, 7-brom, 7-metoxi, 8-metoxi, 7-metyl-, 7-trifluor-metyl eller 7-nitro, B utgörs av fenyl, 2-fluorfenyl, 2-klorfenvl, 2-bromfenyl eller 3,4,5-trimetoxifenyl och R^ utgörs av en väteatom, metyl eller etyl.
4. Förfarande för framställning av 2-azidometyl-5-fenyl-1H-2,3-dihydro-l,4-benzodiazepiner med den allmänna formeln X f 1 / C Vh -CH uC—/;H2 I (X) ό
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2952279 | 1979-12-24 | ||
| DE19792952279 DE2952279A1 (de) | 1979-12-24 | 1979-12-24 | Neue 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI803988L FI803988L (fi) | 1981-06-25 |
| FI68050B FI68050B (fi) | 1985-03-29 |
| FI68050C true FI68050C (fi) | 1985-07-10 |
Family
ID=6089628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI803988A FI68050C (fi) | 1979-12-24 | 1980-12-19 | Foerfarande foer framstaellning av farmaceutiskt anvaendbara 2-asylaminometyl-1h-2,3-dihydro-1,4-benzodiazepiner |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US4325957A (sv) |
| EP (1) | EP0031080B1 (sv) |
| JP (1) | JPS5699477A (sv) |
| AU (1) | AU542701B2 (sv) |
| CA (1) | CA1169425A (sv) |
| DD (2) | DD200274A5 (sv) |
| DE (3) | DE2952279A1 (sv) |
| DK (1) | DK548080A (sv) |
| ES (2) | ES498072A0 (sv) |
| FI (1) | FI68050C (sv) |
| GR (1) | GR73080B (sv) |
| HU (1) | HU185398B (sv) |
| IE (1) | IE50580B1 (sv) |
| IL (1) | IL61692A (sv) |
| NO (1) | NO154883C (sv) |
| NZ (1) | NZ195872A (sv) |
| PH (1) | PH17189A (sv) |
| PT (2) | PT72279B (sv) |
| SU (1) | SU1253430A3 (sv) |
| YU (1) | YU324780A (sv) |
| ZA (1) | ZA807704B (sv) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3021107A1 (de) * | 1980-06-04 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel |
| DE3048264A1 (de) * | 1980-12-20 | 1982-09-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2-acylaminomethyl-1,4-benzodiazepine und deren salze sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3124013A1 (de) * | 1981-06-19 | 1982-12-30 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3151597A1 (de) * | 1981-12-28 | 1983-07-07 | Kali-Chemie Pharma Gmbh, 3000 Hannover | (1,2)-anellierte 1,4-benzodiazepin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP0170024A3 (en) * | 1984-06-26 | 1990-01-31 | Merck & Co. Inc. | Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions |
| US4724237A (en) * | 1984-06-26 | 1988-02-09 | Merck & Co., Inc. | 2-substituted-aminomethyl-1,4-benzodiazepines |
| US4684646A (en) * | 1984-06-26 | 1987-08-04 | Merck & Co., Inc. | 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists |
| JPH01314666A (ja) * | 1988-06-15 | 1989-12-19 | Kayaba Ind Co Ltd | パワーステアリング装置の操舵力制御装置 |
| GB8823041D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823042D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| US5380721A (en) * | 1990-09-10 | 1995-01-10 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| JPH0546660U (ja) * | 1991-12-03 | 1993-06-22 | カヤバ工業株式会社 | パワーステアリング装置 |
| CN1384867A (zh) | 1999-08-27 | 2002-12-11 | 宝洁公司 | 稳定性提高的配制组分、使用该组分的组合物和洗衣方法 |
| US6825160B1 (en) | 1999-08-27 | 2004-11-30 | Procter & Gamble Company | Color safe laundry methods employing cationic formulation components |
| BR0014153A (pt) * | 1999-08-27 | 2002-05-07 | Procter & Gamble | Componentes de intensificação de branqueamento, composições e métodos de lavagem |
| JP2003508586A (ja) * | 1999-08-27 | 2003-03-04 | ザ、プロクター、エンド、ギャンブル、カンパニー | 迅速に作用する処方成分、それらの成分を使用する組成物および洗濯方法 |
| US6903060B1 (en) | 1999-08-27 | 2005-06-07 | Procter & Gamble Company | Stable formulation components, compositions and laundry methods employing same |
| US7109156B1 (en) | 1999-08-27 | 2006-09-19 | Procter & Gamble Company | Controlled availability of formulation components, compositions and laundry methods employing same |
| US6818607B1 (en) * | 1999-08-27 | 2004-11-16 | Procter & Gamble Company | Bleach boosting components, compositions and laundry methods |
| US6821935B1 (en) | 1999-08-27 | 2004-11-23 | Procter & Gamble Company | Color safe laundry methods employing zwitterionic formulation components |
| US7557076B2 (en) * | 2002-06-06 | 2009-07-07 | The Procter & Gamble Company | Organic catalyst with enhanced enzyme compatibility |
| US7169744B2 (en) * | 2002-06-06 | 2007-01-30 | Procter & Gamble Company | Organic catalyst with enhanced solubility |
| US20050113246A1 (en) * | 2003-11-06 | 2005-05-26 | The Procter & Gamble Company | Process of producing an organic catalyst |
| AR051659A1 (es) * | 2005-06-17 | 2007-01-31 | Procter & Gamble | Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada |
| KR100877824B1 (ko) | 2005-11-11 | 2009-01-12 | 한국생명공학연구원 | Ｅ2ｅｐｆ ｕｃｐ-ｖｈｌ 상호작용 및 그 용도 |
| CN113149914A (zh) * | 2021-01-15 | 2021-07-23 | 福安药业集团重庆礼邦药物开发有限公司 | 一种咪达唑仑中间体脱氟杂质的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3681340A (en) * | 1968-02-12 | 1972-08-01 | Herman Robert Rodriguez | 1,3-benzodiazepines |
| US3738999A (en) * | 1970-05-28 | 1973-06-12 | Squibb & Sons Inc | 2,3,4,5-tetrahydro-2-phenyl-1,4-benzothiazepine, hydrochloride |
| DE2353187A1 (de) * | 1973-05-02 | 1974-11-14 | Kali Chemie Ag | Neue benzodiazepinderivate |
| DE2353160C2 (de) * | 1973-05-02 | 1986-07-17 | Kali-Chemie Ag, 3000 Hannover | 5-Phenyl-2,3-dihydro-1H-1,4-benzodiazepine, ihre Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel |
| US3925358A (en) * | 1973-07-27 | 1975-12-09 | Hoffmann La Roche | 1-Lower alkyl-2-substituted-1,4-benzodiazepines |
| US3947475A (en) * | 1975-04-28 | 1976-03-30 | Stauffer Chemical Company | 5-Furoyl-2,2,4-trimethyl-1,4-dihydro-1H-1,5-benzodiazepine as an anti-inflammatory agent |
| US4087421A (en) * | 1976-04-19 | 1978-05-02 | American Cyanamid Company | Substituted benzodiazepines and method of use |
-
1979
- 1979-12-24 DE DE19792952279 patent/DE2952279A1/de not_active Withdrawn
-
1980
- 1980-10-20 GR GR63733A patent/GR73080B/el unknown
- 1980-12-04 IE IE2531/80A patent/IE50580B1/en unknown
- 1980-12-09 ZA ZA00807704A patent/ZA807704B/xx unknown
- 1980-12-10 EP EP80107779A patent/EP0031080B1/de not_active Expired
- 1980-12-10 DE DE8080107779T patent/DE3064983D1/de not_active Expired
- 1980-12-10 DE DE8282107036T patent/DE3070798D1/de not_active Expired
- 1980-12-11 IL IL61692A patent/IL61692A/xx unknown
- 1980-12-16 PH PH24988A patent/PH17189A/en unknown
- 1980-12-17 HU HU803023A patent/HU185398B/hu unknown
- 1980-12-18 NZ NZ195872A patent/NZ195872A/xx unknown
- 1980-12-19 FI FI803988A patent/FI68050C/fi not_active IP Right Cessation
- 1980-12-22 AU AU65664/80A patent/AU542701B2/en not_active Ceased
- 1980-12-22 DD DD80233407A patent/DD200274A5/de unknown
- 1980-12-22 SU SU3220053A patent/SU1253430A3/ru active
- 1980-12-22 DD DD80226419A patent/DD155988A5/de unknown
- 1980-12-22 DK DK548080A patent/DK548080A/da not_active Application Discontinuation
- 1980-12-22 YU YU03247/80A patent/YU324780A/xx unknown
- 1980-12-23 US US06/219,487 patent/US4325957A/en not_active Expired - Lifetime
- 1980-12-23 ES ES498072A patent/ES498072A0/es active Granted
- 1980-12-23 PT PT72279A patent/PT72279B/pt unknown
- 1980-12-23 NO NO803935A patent/NO154883C/no unknown
- 1980-12-23 CA CA000367417A patent/CA1169425A/en not_active Expired
- 1980-12-23 ES ES498071A patent/ES498071A0/es active Granted
- 1980-12-23 PT PT72278A patent/PT72278B/pt unknown
- 1980-12-24 JP JP18216980A patent/JPS5699477A/ja active Granted
-
1982
- 1982-01-12 US US06/338,883 patent/US4382030A/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: KALI-CHEMIE PHARMA GMBH |