FI66596C - Foerfarande foer framstaellning av terapeutiskt anvaendbara prolinderivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara prolinderivat. Download PDF

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Publication number
FI66596C
FI66596C FI770437A FI770437A FI66596C FI 66596 C FI66596 C FI 66596C FI 770437 A FI770437 A FI 770437A FI 770437 A FI770437 A FI 770437A FI 66596 C FI66596 C FI 66596C
Authority
FI
Finland
Prior art keywords
proline
acid
formula
phenyl
mixture
Prior art date
Application number
FI770437A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI770437A (fr
FI66596B (fi
Inventor
Miguel Angel Ondetti
David Wayne Cushman
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/657,792 external-priority patent/US4046889A/en
Priority claimed from US05/751,851 external-priority patent/US4105776A/en
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of FI770437A publication Critical patent/FI770437A/fi
Priority to FI832850A priority Critical patent/FI67694C/fi
Priority to FI832849A priority patent/FI68043B/fi
Priority to FI832851A priority patent/FI71553B/fi
Application granted granted Critical
Publication of FI66596B publication Critical patent/FI66596B/fi
Publication of FI66596C publication Critical patent/FI66596C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI770437A 1976-02-13 1977-02-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara prolinderivat. FI66596C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI832850A FI67694C (fi) 1976-02-13 1983-08-08 Foerfarande foer framstaellning av terapeutiskt anvaendbara bi-prolinderivat
FI832849A FI68043B (fi) 1976-02-13 1983-08-08 N-halogenacylprolinderivat vilka aer mellanprodukter vid framstaellning av terapeutiskt anvaendbara prolinderivat
FI832851A FI71553B (fi) 1976-02-13 1983-08-08 Analogifoerfarande foer framstaellning av nya inhibitorer foerett angiotensin omvandlande enzym

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US05/657,792 US4046889A (en) 1976-02-13 1976-02-13 Azetidine-2-carboxylic acid derivatives
US65779276 1976-02-13
US69843276A 1976-06-21 1976-06-21
US69843276 1976-06-21
US75185176 1976-12-22
US05/751,851 US4105776A (en) 1976-06-21 1976-12-22 Proline derivatives and related compounds

Publications (3)

Publication Number Publication Date
FI770437A FI770437A (fr) 1977-08-14
FI66596B FI66596B (fi) 1984-07-31
FI66596C true FI66596C (fi) 1987-03-18

Family

ID=27417986

Family Applications (1)

Application Number Title Priority Date Filing Date
FI770437A FI66596C (fi) 1976-02-13 1977-02-10 Foerfarande foer framstaellning av terapeutiskt anvaendbara prolinderivat.

Country Status (31)

Country Link
JP (1) JPS604815B2 (fr)
AR (4) AR222445A1 (fr)
AT (1) AT365569B (fr)
AU (1) AU509899B2 (fr)
BG (3) BG37075A3 (fr)
CA (1) CA1101864A (fr)
CH (3) CH622503A5 (fr)
DD (1) DD129442B3 (fr)
DE (2) DE2703828C2 (fr)
DK (1) DK157487C (fr)
ES (5) ES455803A1 (fr)
FI (1) FI66596C (fr)
FR (1) FR2340932A1 (fr)
GB (1) GB1576161A (fr)
GR (1) GR69811B (fr)
HK (1) HK20281A (fr)
HU (1) HU181965B (fr)
IE (1) IE44707B1 (fr)
IL (1) IL51297A (fr)
IT (1) IT1062293B (fr)
KE (1) KE3136A (fr)
MY (2) MY8200075A (fr)
NL (1) NL168509C (fr)
NO (1) NO146985C (fr)
NZ (1) NZ183130A (fr)
PH (1) PH12970A (fr)
PL (1) PL118161B1 (fr)
RO (1) RO69941A (fr)
SE (2) SE423812B (fr)
SU (1) SU747422A3 (fr)
YU (1) YU40664B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206122A (en) * 1978-04-14 1980-06-03 E. R. Squibb & Sons, Inc. Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
US4129566A (en) * 1978-02-15 1978-12-12 E. R. Squibb & Sons, Inc. Derivatives of dehydrocyclicimino acids
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
CA1120400A (fr) * 1977-12-27 1982-03-23 Zola P. Horovitz Traitement de l'hypertension et medicaments utilises a cette fin
PH15381A (en) * 1978-02-21 1982-12-17 Squibb & Sons Inc Halogen substituted mercaptoacylamino acids
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
CA1109475A (fr) * 1978-07-27 1981-09-22 Miguel A. Ondetti Derives d'acide thiopropanoylamine
CA1144930A (fr) * 1978-08-11 1983-04-19 Miguel A. Ondetti Derives mercaptoacyles de prolines substituees
NZ190995A (en) * 1978-09-05 1982-03-09 American Cyanamid Co Substituted omega propionyl or butyryl l-prolines and pharmaceutical compositions
NL7809120A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Werkwijze voor de bereiding van proline-derivaten.
NL7809121A (nl) * 1978-09-07 1980-03-11 Oce Andeno B V Grubbenvorsterw Optisch aktieve derivaten van mercapto-isoboterzuur.
GR73585B (fr) * 1978-09-11 1984-03-26 Univ Miami
US4690937A (en) * 1979-08-14 1987-09-01 University Of Miami Anti-hypertensive agents
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
JPS5540622A (en) * 1978-09-14 1980-03-22 Santen Pharmaceut Co Ltd Hypotensive agent
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
US4198515A (en) * 1978-12-08 1980-04-15 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
US4410542A (en) 1978-12-30 1983-10-18 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
CA1138452A (fr) * 1979-01-15 1982-12-28 John Krapcho Derives carbamate de mercaptoacyl hydroxyprolines
US4461896A (en) * 1979-02-07 1984-07-24 Norwich Eaton Pharmaceuticals, Inc. 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4220791A (en) * 1979-03-08 1980-09-02 E. R. Squibb & Sons, Inc. Mercaptoacylpyrazolidinone carboxylic acid derivatives
ZA802420B (en) * 1979-05-18 1981-04-29 Squibb & Sons Inc Aminoacyl derivatives of mercaptoacyl amino acids
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
JPS5629403U (fr) * 1979-08-13 1981-03-20
DE2937779A1 (de) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
GB2066240A (en) * 1979-12-10 1981-07-08 Squibb & Sons Inc Derivatives of mercaptoacyl amino acids
GB2065643B (en) * 1979-12-13 1983-08-24 Kanegafuchi Chemical Ind Optically active n-mercaptoalkanoylamino acids
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
GB2070586A (en) * 1980-03-21 1981-09-09 Squibb & Sons Inc Derivatives of Proline or Pipecolic Acid
DE3011239A1 (de) * 1980-03-22 1981-10-01 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte alkylthioacylaminosaeuren, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
SE8203245L (sv) * 1981-05-27 1982-11-28 Crc Ricerca Chim Forfarande for enantioselektiv framstellning av n-substituerade prolinderivat
KR860001391B1 (ko) * 1984-07-23 1986-09-22 보령제약 주식회사 피롤리딘 유도체의 제조방법
JPH06740B2 (ja) * 1984-08-16 1994-01-05 三菱レイヨン株式会社 光学活性カルボン酸アミドの製造法
HU196369B (en) * 1984-10-18 1988-11-28 Egyt Gyogyszervegyeszeti Gyar New process for producing n-acylized l-prolin derivatives
KR870001570B1 (ko) * 1984-12-19 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
KR870001569B1 (ko) * 1985-02-11 1987-09-04 보령제약 주식회사 피롤리딘 유도체의 제조방법
AT395012B (de) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
JP2863534B2 (ja) * 1988-10-24 1999-03-03 マリオン ラボラトリーズ，インコーポレイティド 医薬組成物
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
DE59306051D1 (de) * 1992-08-26 1997-05-07 Beiersdorf Ag Verwendung von radikalfängern als immunmodulierende agentien in kosmetischen und dermatologischen zubereitungen
DE4228455A1 (de) * 1992-08-26 1994-09-15 Beiersdorf Ag Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Thiolen und/oder Thiolderivaten
IT1266570B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9704522D0 (en) * 1997-03-05 1997-04-23 Smithkline Beecham Plc Compounds
ATE224366T1 (de) * 1997-10-31 2002-10-15 Hoffmann La Roche D-prolinderivate
IL159983A0 (en) * 2001-08-07 2004-06-20 Sunesis Pharmaceuticals Inc Disulfide and thiosulfonate ligands and libraries comprising these ligands
CN100361971C (zh) * 2005-09-19 2008-01-16 华中师范大学 催化活性可调的双官能团l-脯氨酸衍生物及制备
US8653131B2 (en) 2008-08-22 2014-02-18 Baxter Healthcare S.A. Polymeric benzyl carbonate-derivatives
RU2623233C2 (ru) 2012-04-27 2017-06-23 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и относящиеся к ним способы

Family Cites Families (1)

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CA946836A (en) * 1970-03-18 1974-05-07 Miguel A. Ondetti Enzyme inhibitor

Also Published As

Publication number Publication date
DE2759862C2 (fr) 1989-12-07
NZ183130A (en) 1979-08-31
NO146985C (no) 1983-01-12
AR222783A1 (es) 1981-06-30
HK20281A (en) 1981-05-22
GB1576161A (en) 1980-10-01
DK157487B (da) 1990-01-15
YU40664B (en) 1986-04-30
PL195965A1 (pl) 1978-02-27
YU33177A (en) 1983-01-21
IE44707B1 (en) 1982-03-10
IT1062293B (it) 1984-05-23
PH12970A (en) 1979-10-24
ES467053A1 (es) 1978-11-01
DE2703828A1 (de) 1977-08-18
DE2703828C2 (de) 1984-06-20
ES467052A1 (es) 1978-11-01
CH624932A5 (fr) 1981-08-31
ATA98977A (de) 1981-06-15
SE423812B (sv) 1982-06-07
SE426697B (sv) 1983-02-07
JPS604815B2 (ja) 1985-02-06
DK59677A (da) 1977-08-14
AU509899B2 (en) 1980-05-29
SE7701561L (sv) 1977-09-23
BG37074A3 (en) 1985-03-15
FR2340932A1 (fr) 1977-09-09
CA1101864A (fr) 1981-05-26
JPS52116457A (en) 1977-09-29
IL51297A0 (en) 1977-03-31
BG37375A3 (en) 1985-05-15
CH624931A5 (fr) 1981-08-31
NO770464L (no) 1977-08-16
SE8104660L (sv) 1981-08-03
IL51297A (en) 1980-03-31
AR214649A1 (es) 1979-07-13
FI770437A (fr) 1977-08-14
NO146985B (no) 1982-10-04
NL168509C (nl) 1982-04-16
FR2340932B1 (fr) 1981-02-06
DK157487C (da) 1990-06-11
ES467051A1 (es) 1978-11-01
PL118161B1 (en) 1981-09-30
AU2134777A (en) 1978-07-20
RO69941A (fr) 1980-05-15
AT365569B (de) 1982-01-25
NL7701457A (nl) 1977-08-16
SU747422A3 (ru) 1980-07-23
AR222445A1 (es) 1981-05-29
CH622503A5 (en) 1981-04-15
DD129442A5 (de) 1978-01-18
BG37075A3 (en) 1985-03-15
IE44707L (en) 1977-08-13
AR226290A1 (es) 1982-06-30
KE3136A (en) 1981-07-03
GR69811B (fr) 1982-07-13
ES455803A1 (es) 1978-06-16
HU181965B (en) 1983-11-28
MY102705A (en) 1992-09-30
FI66596B (fi) 1984-07-31
MY8200075A (en) 1982-12-31
DD129442B3 (de) 1990-01-10
ES467050A1 (es) 1978-11-01

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MA Patent expired
MA Patent expired

Owner name: E.R. SQUIBB & SONS, INC.