CA2457814A1 - Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant - Google Patents

Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant Download PDF

Info

Publication number
CA2457814A1
CA2457814A1 CA002457814A CA2457814A CA2457814A1 CA 2457814 A1 CA2457814 A1 CA 2457814A1 CA 002457814 A CA002457814 A CA 002457814A CA 2457814 A CA2457814 A CA 2457814A CA 2457814 A1 CA2457814 A1 CA 2457814A1
Authority
CA
Canada
Prior art keywords
aryl
aliphatic
heteroaryl
heteroaliphatic
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002457814A
Other languages
English (en)
Inventor
Andrew C. Braisted
Daniel A. Erlanson
Jeffrey W. Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals, Inc.
Andrew C. Braisted
Daniel A. Erlanson
Jeffrey W. Jacobs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/990,421 external-priority patent/US6919178B2/en
Priority claimed from US10/121,216 external-priority patent/US6998233B2/en
Application filed by Sunesis Pharmaceuticals, Inc., Andrew C. Braisted, Daniel A. Erlanson, Jeffrey W. Jacobs filed Critical Sunesis Pharmaceuticals, Inc.
Publication of CA2457814A1 publication Critical patent/CA2457814A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'invention porte sur des composés et bibliothèques de composés de formule (I) dans laquelle: L et n sont tels que définis dans les revendications, et A est -S(CH¿2?)¿p?R?A1¿ ou -S(O)¿2?R?A2¿, où p, R?A1¿ et R?A2¿ sont tels que définis dans les revendications. Les bibliothèques de composés de formule (I) servent dans des procédés de découverte de médicaments.
CA002457814A 2001-08-07 2002-05-10 Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant Abandoned CA2457814A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31072501P 2001-08-07 2001-08-07
US60/310,725 2001-08-07
US09/990,421 US6919178B2 (en) 2000-11-21 2001-11-21 Extended tethering approach for rapid identification of ligands
US09/990,421 2001-11-21
US10/121,216 US6998233B2 (en) 1998-06-26 2002-04-10 Methods for ligand discovery
US10/121,216 2002-04-10
PCT/US2002/014778 WO2003014072A1 (fr) 2001-08-07 2002-05-10 Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant

Publications (1)

Publication Number Publication Date
CA2457814A1 true CA2457814A1 (fr) 2003-02-20

Family

ID=27382591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457814A Abandoned CA2457814A1 (fr) 2001-08-07 2002-05-10 Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant

Country Status (7)

Country Link
EP (1) EP1421063A1 (fr)
JP (1) JP2004537594A (fr)
CA (1) CA2457814A1 (fr)
IL (1) IL159983A0 (fr)
MX (1) MXPA04001074A (fr)
NZ (1) NZ530811A (fr)
WO (1) WO2003014072A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214487B2 (en) 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
WO2003081210A2 (fr) 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification d'inhibiteurs de kinase
EP2266622A3 (fr) * 2004-08-26 2012-06-20 Piramal Life Sciences Limited Promédicaments contenant de nouveaux liens bio-clivables
US7544756B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
JPH08201958A (ja) * 1995-01-24 1996-08-09 Konica Corp ハロゲン化銀写真感光材料及び画像形成方法
US6280760B1 (en) * 1997-05-22 2001-08-28 Merck Patent Gesellschaft Mit Beschraenkter Haftung Peptide-coated implants and methods for producing same
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
ATE420366T1 (de) * 2000-11-21 2009-01-15 Sunesis Pharmaceuticals Inc ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Also Published As

Publication number Publication date
NZ530811A (en) 2005-07-29
WO2003014072A1 (fr) 2003-02-20
MXPA04001074A (es) 2004-07-08
JP2004537594A (ja) 2004-12-16
IL159983A0 (en) 2004-06-20
EP1421063A1 (fr) 2004-05-26

Similar Documents

Publication Publication Date Title
US20120077711A1 (en) Novel Ligands and Libraries of Ligands
US8198218B2 (en) Heterocyclic compounds, combinatorial libraries thereof and methods of selecting drug leads
JP2021008507A (ja) イミド系タンパク質分解モジュレーター及び関連する使用方法
EP1789416B1 (fr) Dérivés amidés de 3-phényl dihydropyrimido[4,5-d]pyrimidinon, leur préparation et utilisation comme medicaments
CA2464094C (fr) Procedes de decouverte de ligands
MX2014008520A (es) Compuestos y metodos para degradacion mejorada de proteinas y otros polipeptidos elegidos como blanco mediante una ubiquitina ligasa e3.
JP2006113077A (ja) リガンドの迅速な同定のための拡張されたテザー化アプローチ
US20040043426A1 (en) Methods for ligand discovery
CA3032544A1 (fr) Inhibiteur de ido1, son procede de preparation et son application
CA3024071C (fr) Bibliotheques de divers composes macrocycliques, leurs procedes de fabrication et d'utilisation
CA3154079A1 (fr) Conjugues therapeutiques
CA3095211A1 (fr) Conjugue d'anticorps a base d'amanitine
CN111606970B (zh) 一种1，5-二氮杂双环[5,3,0]十烷酮氨基酸衍生物及其制备方法和应用
JP2019501188A (ja) ヘテロアリール含有大環状化合物のライブラリならびにその製造方法および使用方法
CA2457814A1 (fr) Ligands de bisulfure et de thiosulfonate, et bibliotheques les comprenant
CA2719579A1 (fr) Procedes d'evolution de chimiotype
AU2002316090A1 (en) Disulfide and thiosulfonate ligands and libraries comprising these ligands
Marciniak et al. Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template
CA3013829A1 (fr) Fonctionnalisation selective de site de proteines utilisant des marqueurs d'affinite sans trace
ZA200400745B (en) Disulfide and thiosulfonate ligands and libraries comprising these ligands.
Abdildinova et al. Traceless solid-phase synthesis and β-turn propensity of 1, 3-thiazole-based peptidomimetics
CN110483398A (zh) 一种含有生物可降解基团的光亲和链接体及制备方法和应用
JP2000502997A (ja) レトロウイルスプロテアーゼ抑制化合物
Jha The Design and Synthesis of β-Keto Vinyl Sultams and Macrocyclic β-Keto Vinyl Sultams: Novel Analogs of Tetramic Acids
EP3642399A1 (fr) Bibliothèques de composés macrocycliques contenant de la pyridine et leurs procédés de préparation et d'utilisation

Legal Events

Date Code Title Description
FZDE Discontinued