ATE420366T1 - ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN - Google Patents

ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Info

Publication number
ATE420366T1
ATE420366T1 AT01995216T AT01995216T ATE420366T1 AT E420366 T1 ATE420366 T1 AT E420366T1 AT 01995216 T AT01995216 T AT 01995216T AT 01995216 T AT01995216 T AT 01995216T AT E420366 T1 ATE420366 T1 AT E420366T1
Authority
AT
Austria
Prior art keywords
ßtethering
advanced
approach
quickly
finding ligands
Prior art date
Application number
AT01995216T
Other languages
English (en)
Inventor
Daniel Erlanson
Andrew Braisted
Robert Mcdowell
John Prescott
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE420366T1 publication Critical patent/ATE420366T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Structural Engineering (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Control And Safety Of Cranes (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
AT01995216T 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN ATE420366T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25229400P 2000-11-21 2000-11-21

Publications (1)

Publication Number Publication Date
ATE420366T1 true ATE420366T1 (de) 2009-01-15

Family

ID=22955415

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01995216T ATE420366T1 (de) 2000-11-21 2001-11-20 ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN

Country Status (13)

Country Link
EP (2) EP1441228B1 (de)
JP (2) JP3836791B2 (de)
AT (1) ATE420366T1 (de)
AU (2) AU2573102A (de)
CA (1) CA2430234C (de)
DE (1) DE60137356D1 (de)
DK (1) DK1337853T3 (de)
ES (1) ES2322796T3 (de)
IL (2) IL155926A0 (de)
MX (1) MXPA03004435A (de)
NZ (1) NZ525861A (de)
WO (1) WO2002042773A2 (de)
ZA (1) ZA200303772B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214487B2 (en) 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
EP1421063A1 (de) * 2001-08-07 2004-05-26 Sunesis Pharmaceuticals, Inc. Disulfid- und thiosulfonatliganden, und bibliotheken, die diese liganden umfassen
NZ532579A (en) * 2001-11-21 2006-11-30 Sunesis Pharmaceuticals Inc Methods for ligand discovery based on tethering process
EP1579186A4 (de) 2002-03-21 2008-10-08 Sunesis Pharmaceuticals Inc Identifizierung von kinase-inhibitoren
IL166450A0 (en) 2002-07-24 2006-01-15 Keddem Bio Science Ltd Drug discovery method
WO2004057340A1 (en) 2002-12-23 2004-07-08 Astex Technology Limited Synthesis and screening of ligands using x-ray crystallography
CA2539064A1 (en) * 2003-09-17 2005-04-21 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
JP5173193B2 (ja) * 2003-11-14 2013-03-27 スリーエム イノベイティブ プロパティズ カンパニー Ｎ−スルホニルアミノカルボニル含有化合物
US8053243B2 (en) 2004-04-12 2011-11-08 The University Of Vermont And State Agricultural College Detection of nitrosylated proteins
US20060234299A1 (en) * 2004-11-16 2006-10-19 Avidia Research Institute Protein scaffolds and uses thereof
US20080070802A1 (en) * 2006-08-23 2008-03-20 Moerschell Richard P Directed heterobifunctional linkers
WO2011131510A2 (en) 2010-04-21 2011-10-27 Novo Nordisk A/S Selective modification of proteins
ES2634490T3 (es) 2010-07-02 2017-09-28 Gilead Sciences, Inc. Derivados de ácido napht-2-ylacetico para tratar el sida
CA2802492C (en) 2010-07-02 2018-10-16 Gilead Sciences, Inc. 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
AP2013007249A0 (en) 2011-04-21 2013-11-30 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
PH12014500842A1 (en) 2012-04-20 2014-06-09 Gilead Sciences Inc Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
WO2015113476A1 (zh) * 2014-01-29 2015-08-06 上海恒瑞医药有限公司 配体-细胞毒性药物偶联物、其制备方法及其应用
AU2016218840A1 (en) * 2015-02-15 2017-08-31 Jiangsu Hengrui Medicine Co., Ltd. Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof
WO2017070611A1 (en) * 2015-10-22 2017-04-27 The Scripps Research Institute Cysteine reactive probes and uses thereof
GB201614152D0 (en) * 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
CA3050260A1 (en) 2017-01-18 2018-07-26 The Scripps Research Institute Photoreactive ligands and uses thereof
US20180372751A1 (en) * 2017-06-23 2018-12-27 The Scripps Research Institute Lysine reactive probes and uses thereof
JP7805983B2 (ja) 2022-03-22 2026-01-26 アッヴィ・インコーポレイテッド ブルトン型チロシンキナーゼを分解するためのピリミジン

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011436A1 (en) * 1996-09-13 1998-03-19 Whitehead Institute For Biomedical Research Non-specific affinity enhancement to identify combinatorial library members
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules

Also Published As

Publication number Publication date
IL155926A (en) 2009-06-15
DK1337853T3 (da) 2009-05-04
MXPA03004435A (es) 2005-01-25
EP1337853B1 (de) 2009-01-07
IL155926A0 (en) 2003-12-23
EP1441228A1 (de) 2004-07-28
WO2002042773A3 (en) 2002-11-14
AU2002225731B2 (en) 2005-04-14
NZ525861A (en) 2004-09-24
WO2002042773A2 (en) 2002-05-30
JP2006113077A (ja) 2006-04-27
JP2004514891A (ja) 2004-05-20
JP3836791B2 (ja) 2006-10-25
CA2430234C (en) 2008-02-12
CA2430234A1 (en) 2002-05-30
HK1063844A1 (en) 2005-01-14
ZA200303772B (en) 2004-05-17
WO2002042773B1 (en) 2002-12-12
EP1337853A2 (de) 2003-08-27
ES2322796T3 (es) 2009-06-29
AU2573102A (en) 2002-06-03
EP1441228B1 (de) 2006-06-28
DE60137356D1 (de) 2009-02-26

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