ES2322796T3 - Un procedimiento de anclaje extendido para la identificacion rapida de ligandos. - Google Patents
Un procedimiento de anclaje extendido para la identificacion rapida de ligandos. Download PDFInfo
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- ES2322796T3 ES2322796T3 ES01995216T ES01995216T ES2322796T3 ES 2322796 T3 ES2322796 T3 ES 2322796T3 ES 01995216 T ES01995216 T ES 01995216T ES 01995216 T ES01995216 T ES 01995216T ES 2322796 T3 ES2322796 T3 ES 2322796T3
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- 238000000926 separation method Methods 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 125000002653 sulfanylmethyl group Chemical group [H]SC([H])([H])[*] 0.000 description 1
- OORLZFUTLGXMEF-UHFFFAOYSA-N sulfentrazone Chemical compound O=C1N(C(F)F)C(C)=NN1C1=CC(NS(C)(=O)=O)=C(Cl)C=C1Cl OORLZFUTLGXMEF-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- GDQAOWSFAQASER-UHFFFAOYSA-N tert-butyl n-[2-(2-aminoethyldisulfanyl)ethyl]-n-[(2-methylpropan-2-yl)oxycarbonyl]carbamate Chemical compound CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)CCSSCCN GDQAOWSFAQASER-UHFFFAOYSA-N 0.000 description 1
- FQFILJKFZCVHNH-UHFFFAOYSA-N tert-butyl n-[3-[(5-bromo-2-chloropyrimidin-4-yl)amino]propyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCCNC1=NC(Cl)=NC=C1Br FQFILJKFZCVHNH-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Structural Engineering (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Peptides Or Proteins (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Control And Safety Of Cranes (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25229400P | 2000-11-21 | 2000-11-21 | |
| US252294P | 2000-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2322796T3 true ES2322796T3 (es) | 2009-06-29 |
Family
ID=22955415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01995216T Expired - Lifetime ES2322796T3 (es) | 2000-11-21 | 2001-11-20 | Un procedimiento de anclaje extendido para la identificacion rapida de ligandos. |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP1441228B1 (de) |
| JP (2) | JP3836791B2 (de) |
| AT (1) | ATE420366T1 (de) |
| AU (2) | AU2573102A (de) |
| CA (1) | CA2430234C (de) |
| DE (1) | DE60137356D1 (de) |
| DK (1) | DK1337853T3 (de) |
| ES (1) | ES2322796T3 (de) |
| IL (2) | IL155926A0 (de) |
| MX (1) | MXPA03004435A (de) |
| NZ (1) | NZ525861A (de) |
| WO (1) | WO2002042773A2 (de) |
| ZA (1) | ZA200303772B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214487B2 (en) | 1998-06-26 | 2007-05-08 | Sunesis Pharmaceuticals, Inc. | Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates |
| US6998233B2 (en) | 1998-06-26 | 2006-02-14 | Sunesis Pharmaceuticals, Inc. | Methods for ligand discovery |
| EP1421063A1 (de) * | 2001-08-07 | 2004-05-26 | Sunesis Pharmaceuticals, Inc. | Disulfid- und thiosulfonatliganden, und bibliotheken, die diese liganden umfassen |
| NZ532579A (en) * | 2001-11-21 | 2006-11-30 | Sunesis Pharmaceuticals Inc | Methods for ligand discovery based on tethering process |
| EP1579186A4 (de) | 2002-03-21 | 2008-10-08 | Sunesis Pharmaceuticals Inc | Identifizierung von kinase-inhibitoren |
| IL166450A0 (en) | 2002-07-24 | 2006-01-15 | Keddem Bio Science Ltd | Drug discovery method |
| WO2004057340A1 (en) | 2002-12-23 | 2004-07-08 | Astex Technology Limited | Synthesis and screening of ligands using x-ray crystallography |
| CA2539064A1 (en) * | 2003-09-17 | 2005-04-21 | Sunesis Pharmaceuticals, Inc. | Identification of kinase inhibitors |
| JP5173193B2 (ja) * | 2003-11-14 | 2013-03-27 | スリーエム イノベイティブ プロパティズ カンパニー | Ｎ−スルホニルアミノカルボニル含有化合物 |
| US8053243B2 (en) | 2004-04-12 | 2011-11-08 | The University Of Vermont And State Agricultural College | Detection of nitrosylated proteins |
| US20060234299A1 (en) * | 2004-11-16 | 2006-10-19 | Avidia Research Institute | Protein scaffolds and uses thereof |
| US20080070802A1 (en) * | 2006-08-23 | 2008-03-20 | Moerschell Richard P | Directed heterobifunctional linkers |
| WO2011131510A2 (en) | 2010-04-21 | 2011-10-27 | Novo Nordisk A/S | Selective modification of proteins |
| ES2634490T3 (es) | 2010-07-02 | 2017-09-28 | Gilead Sciences, Inc. | Derivados de ácido napht-2-ylacetico para tratar el sida |
| CA2802492C (en) | 2010-07-02 | 2018-10-16 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| AP2013007249A0 (en) | 2011-04-21 | 2013-11-30 | Gilead Sciences Inc | Benzothiazole compounds and their pharmaceutical use |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| PH12014500842A1 (en) | 2012-04-20 | 2014-06-09 | Gilead Sciences Inc | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
| US10782295B2 (en) | 2013-08-13 | 2020-09-22 | The Scripps Research Institute | Cysteine-reactive ligand discovery in proteomes |
| WO2015113476A1 (zh) * | 2014-01-29 | 2015-08-06 | 上海恒瑞医药有限公司 | 配体-细胞毒性药物偶联物、其制备方法及其应用 |
| AU2016218840A1 (en) * | 2015-02-15 | 2017-08-31 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof |
| WO2017070611A1 (en) * | 2015-10-22 | 2017-04-27 | The Scripps Research Institute | Cysteine reactive probes and uses thereof |
| GB201614152D0 (en) * | 2016-08-18 | 2016-10-05 | Imp Innovations Ltd | Assay |
| CA3050260A1 (en) | 2017-01-18 | 2018-07-26 | The Scripps Research Institute | Photoreactive ligands and uses thereof |
| US20180372751A1 (en) * | 2017-06-23 | 2018-12-27 | The Scripps Research Institute | Lysine reactive probes and uses thereof |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998011436A1 (en) * | 1996-09-13 | 1998-03-19 | Whitehead Institute For Biomedical Research | Non-specific affinity enhancement to identify combinatorial library members |
| US6344330B1 (en) * | 1998-03-27 | 2002-02-05 | The Regents Of The University Of California | Pharmacophore recombination for the identification of small molecule drug lead compounds |
| US6335155B1 (en) * | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
-
2001
- 2001-11-20 AT AT01995216T patent/ATE420366T1/de not_active IP Right Cessation
- 2001-11-20 MX MXPA03004435A patent/MXPA03004435A/es active IP Right Grant
- 2001-11-20 JP JP2002544662A patent/JP3836791B2/ja not_active Expired - Fee Related
- 2001-11-20 DE DE60137356T patent/DE60137356D1/de not_active Expired - Fee Related
- 2001-11-20 ES ES01995216T patent/ES2322796T3/es not_active Expired - Lifetime
- 2001-11-20 EP EP04008373A patent/EP1441228B1/de not_active Expired - Lifetime
- 2001-11-20 AU AU2573102A patent/AU2573102A/xx active Pending
- 2001-11-20 EP EP01995216A patent/EP1337853B1/de not_active Expired - Lifetime
- 2001-11-20 CA CA002430234A patent/CA2430234C/en not_active Expired - Fee Related
- 2001-11-20 IL IL15592601A patent/IL155926A0/xx unknown
- 2001-11-20 AU AU2002225731A patent/AU2002225731B2/en not_active Ceased
- 2001-11-20 NZ NZ525861A patent/NZ525861A/en not_active IP Right Cessation
- 2001-11-20 WO PCT/US2001/044036 patent/WO2002042773A2/en not_active Ceased
- 2001-11-20 DK DK01995216T patent/DK1337853T3/da active
-
2003
- 2003-05-15 IL IL155926A patent/IL155926A/en not_active IP Right Cessation
- 2003-05-15 ZA ZA200303772A patent/ZA200303772B/en unknown
-
2005
- 2005-12-13 JP JP2005359639A patent/JP2006113077A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL155926A (en) | 2009-06-15 |
| DK1337853T3 (da) | 2009-05-04 |
| MXPA03004435A (es) | 2005-01-25 |
| EP1337853B1 (de) | 2009-01-07 |
| IL155926A0 (en) | 2003-12-23 |
| EP1441228A1 (de) | 2004-07-28 |
| WO2002042773A3 (en) | 2002-11-14 |
| AU2002225731B2 (en) | 2005-04-14 |
| NZ525861A (en) | 2004-09-24 |
| WO2002042773A2 (en) | 2002-05-30 |
| JP2006113077A (ja) | 2006-04-27 |
| JP2004514891A (ja) | 2004-05-20 |
| JP3836791B2 (ja) | 2006-10-25 |
| CA2430234C (en) | 2008-02-12 |
| CA2430234A1 (en) | 2002-05-30 |
| HK1063844A1 (en) | 2005-01-14 |
| ATE420366T1 (de) | 2009-01-15 |
| ZA200303772B (en) | 2004-05-17 |
| WO2002042773B1 (en) | 2002-12-12 |
| EP1337853A2 (de) | 2003-08-27 |
| AU2573102A (en) | 2002-06-03 |
| EP1441228B1 (de) | 2006-06-28 |
| DE60137356D1 (de) | 2009-02-26 |
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