FI65238C - Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar - Google Patents
Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar Download PDFInfo
- Publication number
- FI65238C FI65238C FI771635A FI771635A FI65238C FI 65238 C FI65238 C FI 65238C FI 771635 A FI771635 A FI 771635A FI 771635 A FI771635 A FI 771635A FI 65238 C FI65238 C FI 65238C
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compounds
- alkyl
- compound
- test
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI832085A FI67701C (fi) | 1976-05-24 | 1983-06-09 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetracykliska foereningar |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7605526A NL7605526A (nl) | 1976-05-24 | 1976-05-24 | Nieuwe tetracyclische derivaten. |
NL7605526 | 1976-05-24 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI771635A FI771635A (fr) | 1977-11-25 |
FI65238B FI65238B (fi) | 1983-12-30 |
FI65238C true FI65238C (fi) | 1984-04-10 |
Family
ID=19826245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI771635A FI65238C (fi) | 1976-05-24 | 1977-05-23 | Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar |
Country Status (18)
Country | Link |
---|---|
US (1) | US4145434A (fr) |
JP (2) | JPS532465A (fr) |
AU (1) | AU509073B2 (fr) |
BE (1) | BE854915A (fr) |
CA (1) | CA1122976A (fr) |
CH (2) | CH633536A5 (fr) |
DE (2) | DE2760372C2 (fr) |
DK (1) | DK157868C (fr) |
ES (3) | ES459024A1 (fr) |
FI (1) | FI65238C (fr) |
FR (1) | FR2352800A1 (fr) |
GB (1) | GB1567862A (fr) |
HU (1) | HU173795B (fr) |
IE (1) | IE45419B1 (fr) |
LU (1) | LU77387A1 (fr) |
NL (1) | NL7605526A (fr) |
SE (1) | SE436202B (fr) |
ZA (1) | ZA772752B (fr) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007450A1 (fr) * | 1978-07-07 | 1980-02-06 | Ciba-Geigy Ag | Carbonitriles azatétracycliques, leur préparation, compositions pharmaceutiques les contenant et leur application |
EP0030916B1 (fr) * | 1979-12-10 | 1984-08-29 | Ciba-Geigy Ag | Carbonitriles azatétracycliques |
FR2504140A1 (fr) * | 1981-04-16 | 1982-10-22 | Centre Nat Rech Scient | Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant |
NZ204242A (en) * | 1982-05-18 | 1986-08-08 | Hoffmann La Roche | 8-halo-6-phenyl-2,3-dihydro-1h,4h-pyrrolo(3,4-d)(2)benzazepine-(1-or 3-ones or 1,3-diones) |
JPS62101941U (fr) * | 1985-12-16 | 1987-06-29 | ||
IE62754B1 (en) * | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
EP0569096A1 (fr) * | 1992-05-08 | 1993-11-10 | Akzo Nobel N.V. | Préparation de dépôt |
JP2710695B2 (ja) * | 1993-04-06 | 1998-02-10 | アボツト・ラボラトリーズ | ドーパミンアゴニストとしての四環式化合物 |
CA2182981C (fr) * | 1994-03-02 | 2006-10-17 | Leonardus Petrus Carla Delbressine | Composition pharmaceutique sublinguale ou buccale |
JP3274579B2 (ja) * | 1995-01-12 | 2002-04-15 | 住友製薬株式会社 | 脳血管障害に伴う精神症候治療剤 |
NZ329953A (en) * | 1996-04-12 | 1999-06-29 | Janssen Pharmaceutica Nv | Substituted tetracyclic n-oxide tetrahydrofuran derivatives, salts and stereoisomeric forms thereof for the treatment of cns cardiovascular or gastrointestinal disorders |
CA2290070A1 (fr) * | 1997-05-26 | 1998-12-03 | Akzo Nobel Nv | Sels d'acides sulfoniques aromatiques |
HRP20020305A8 (en) * | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
CN1791430A (zh) * | 2003-05-16 | 2006-06-21 | 辉瑞产品公司 | 非典型抗精神病药物和gaba调节剂、抗惊厥药物或苯并二氮杂䓬类的治疗性组合 |
HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030959A2 (fr) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
JP2007522200A (ja) * | 2004-02-13 | 2007-08-09 | ファイザー・プロダクツ・インク | 非定型抗精神病薬とコルチコトロピン放出因子拮抗薬の治療的組合せ |
CA2565996A1 (fr) * | 2004-05-11 | 2005-11-17 | Pfizer Products Inc. | Combinaison d'antipsychotiques atypiques et d'antagonistes du recepteur de 5-ht<sb>1b</sb> |
BRPI0516000A (pt) * | 2004-10-15 | 2008-05-06 | Pfizer | uso de um composto ou de um sal, solvato, hidrato ou isÈmero óptico farmaceuticamente aceitável do mesmo, método para tratar distúrbio bipolar em um mamìfero em necessidade do mesmo, e, kit para uso no tratamento de distúrbios bipolares |
US7872147B2 (en) | 2005-04-07 | 2011-01-18 | N. V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
PL1710241T3 (pl) * | 2005-04-07 | 2010-04-30 | Msd Oss Bv | Związki pośrednie do wytwarzania trans-5-chloro-2-metylo-2,3,3a,12b-tetrahydro-1H-dibenz-[2,3:6,7]oksepino[4,5-c]pirolu |
WO2006106135A1 (fr) * | 2005-04-07 | 2006-10-12 | N.V. Organon | Forme cristalline du maléate d'asenapine |
US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
WO2007046554A1 (fr) * | 2005-10-21 | 2007-04-26 | Sumitomo Chemical Company, Limited | Procédé pour la production d'un composé de dibenzoxépinopyrrole, intermédiaire pour la production du composé et procédé pour la production de l'intermédiaire |
US7750167B2 (en) * | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
TW200817414A (en) * | 2006-07-05 | 2008-04-16 | Organon Nv | Process for the preparation of asenapine and intermediate products used in said process |
US20080090892A1 (en) * | 2006-10-06 | 2008-04-17 | N.V. Organon | Amorphous asenapine and processes for preparing same |
US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
EP2170399A1 (fr) * | 2007-06-05 | 2010-04-07 | Synthon B.V. | Administration intranasale d'asénapine et compositions à cet usage |
JP5245428B2 (ja) * | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
US7964739B2 (en) * | 2008-01-04 | 2011-06-21 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
WO2009104080A2 (fr) | 2008-02-20 | 2009-08-27 | Targia Pharmaceuticals | Compositions pharmaceutiques actives sur le snc et méthodes d'utilisation |
EP2321011A1 (fr) * | 2008-06-25 | 2011-05-18 | Pfizer Inc. | Composés diaryle et leurs utilisations |
AU2010264670A1 (en) | 2009-06-24 | 2012-01-19 | Merck Sharp & Dohme B.V. | Injectable formulations containing asenapine and method of treatment using same |
TW201118102A (en) | 2009-07-29 | 2011-06-01 | Organon Nv | Hydroxyasenapine compounds, derivatives thereof and pharmaceutical compositions comprising same |
US8779161B2 (en) | 2010-06-18 | 2014-07-15 | Dr. Reddy's Laboratories Limited | Asenapine maleate |
CA2805542C (fr) | 2010-07-29 | 2017-12-12 | Laboratorios Lesvi, S.L. | Nouveau procede de synthese de l'asenapine |
JP5916746B2 (ja) | 2010-11-15 | 2016-05-11 | エージンバイオ, インコーポレイテッド | 認知障害を処置するためのピリダジン誘導体、組成物、および方法 |
WO2012066565A2 (fr) | 2010-11-16 | 2012-05-24 | Cadila Healthcare Limited | Maléate d'asénapine amorphe et forme cristalline et procédé pour leur préparation |
EP2468750A1 (fr) | 2010-12-13 | 2012-06-27 | Chemo Ibérica, S.A. | Formes polymorphiques de maléate d'asénapine et procédés de préparation |
EP2468751B1 (fr) | 2010-12-24 | 2016-03-16 | Medichem, S.A. | Procédé de préparation de 5-chloro-2-méthyl-2,3,3a,12b-tétrahydro-1H-dibenzo[2,3:6,7]oxépino[4,5-c]pyrrole |
WO2012123325A1 (fr) | 2011-03-11 | 2012-09-20 | Medichem S.A. | Nouvelles formes cristallines du sel de trans-5-chloro-2-méthyl-2,3,3a,12b-tétrahydro-1h-dibenzo[2,3:6,7] oxépino[4,5-c]pyrrole avec l'acide maléique |
ITMI20110734A1 (it) | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
EP2524921A1 (fr) * | 2011-05-17 | 2012-11-21 | Sandoz AG | Nouveaux sels cristallins d'asénapine |
EP2524919A1 (fr) * | 2011-05-17 | 2012-11-21 | Sandoz AG | Nouveaux sels cristallins d'asénapine avec des di-acides et des tri-acides cristallins |
EP2709615A1 (fr) | 2011-05-18 | 2014-03-26 | Laboratorios Lesvi, S.L. | Forme cristalline monoclinique de maléate d'asénapine présentant une granulométrie spécifique |
ES2665843T3 (es) | 2011-05-18 | 2018-04-27 | Laboratorios Lesvi, S.L. | Síntesis de una forma de maleato de asenapina monoclínica micronizada estable |
WO2013024492A2 (fr) | 2011-07-01 | 2013-02-21 | Megafine Pharma (P) Ltd. | Procédé de préparation d'asénapine et nouveaux sels de celle-ci |
WO2013011461A1 (fr) | 2011-07-20 | 2013-01-24 | Ranbaxy Laboratories Limited | Procédé de préparation de maléate d'asénapine |
WO2013035109A1 (fr) | 2011-09-08 | 2013-03-14 | Mylan Laboratories Ltd | Procédé amélioré de préparation de maléate d'asénapine |
EP2572703A1 (fr) | 2011-09-21 | 2013-03-27 | Hexal AG | Forme pharmaceutique orale compressée pour maléate d'asénapine |
WO2013041604A1 (fr) | 2011-09-21 | 2013-03-28 | Sandoz Ag | Forme cristalline de maléate d'asénapine |
US20140336391A1 (en) | 2011-11-28 | 2014-11-13 | Ranbaxy Laboratories Limited | Process for the preparation of asenapine intermediate |
CN103254201B (zh) * | 2012-02-21 | 2016-04-13 | 四川科伦药物研究有限公司 | 一种阿塞那平的制备方法 |
WO2013190481A1 (fr) * | 2012-06-21 | 2013-12-27 | Alembic Pharmaceuticals Limited | Procédé pour la préparation d'asénapine et sels d'intermédiaires de celle-ci |
ITMI20121810A1 (it) | 2012-10-24 | 2014-04-25 | Chemo Iberica Sa | Poliformi di maleato di asenapina e processo per la loro preparazione |
US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
WO2014127786A1 (fr) | 2013-02-22 | 2014-08-28 | Zentiva, K.S. | Composition pharmaceutique à désintégration orale comprenant de l'asénapine |
CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
CN103351393B (zh) * | 2013-07-03 | 2016-04-06 | 华裕(无锡)制药有限公司 | 用于制备阿森那平之还原剂及阿森那平之制备方法 |
CA2934553C (fr) | 2013-12-20 | 2023-10-31 | Agenebio, Inc. | Derives de benzodiazepine, compositions et procedes de traitement de la deficience cognitive |
CN103772400A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 反式-5-氯-2,3,3a,12b-四氢-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯的制备方法 |
CN103772401A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 11-氯-2,3,3a,12b-四氢-2-甲基-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯-1-酮的一种新精制方法 |
CA2987081C (fr) | 2015-06-11 | 2022-08-30 | Alrise Biosystems Gmbh | Procede pour la preparation de microparticules chargees de medicament |
IL256354B (en) | 2015-06-19 | 2022-09-01 | Agenebio Inc | History of benzodiazepines, preparations and their use for the treatment of cognitive impairment |
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CA3047451A1 (fr) | 2016-12-20 | 2018-06-28 | Lts Lohmann Therapie-Systeme Ag | Systeme therapeutique transdermique comportant de l'asenapine |
JP7149287B2 (ja) | 2016-12-20 | 2022-10-06 | エルテーエス ローマン テラピー-ジステーメ アーゲー | アセナピンおよびポリシロキサンまたはポリイソブチレンを含有する経皮治療システム |
EP3644973B1 (fr) | 2017-06-26 | 2021-03-24 | LTS LOHMANN Therapie-Systeme AG | Système thérapeutique transdermique contenant de l'asénapine et polymère hybride acrylique silicone |
BR112020026062B1 (pt) | 2018-06-19 | 2023-04-04 | Agenebio, Inc | Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson |
AU2019291060B2 (en) | 2018-06-20 | 2024-09-05 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
CN110183457A (zh) * | 2019-06-27 | 2019-08-30 | 浙江天顺药业有限公司 | 一种阿塞那平及其制备方法 |
CN112830931A (zh) | 2019-08-13 | 2021-05-25 | 浙江奥翔药业股份有限公司 | 制备阿塞那平的方法 |
US11679407B2 (en) * | 2020-06-26 | 2023-06-20 | Intel Corporation | Liquid metal thermal interface material application |
WO2023006954A1 (fr) | 2021-07-30 | 2023-02-02 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Asénapine pour une utilisation dans le cancer |
WO2024039886A1 (fr) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Dérivés de benzoazépine, compositions et méthodes de traitement de déficience cognitive |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH501007A (de) * | 1968-11-27 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten |
NL178593C (nl) * | 1974-01-31 | 1986-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen. |
AU469026B2 (en) * | 1974-11-07 | 1976-01-29 | Ciba-Geigy Ag | New azepine derivatives and process forthe production thereof |
-
1976
- 1976-05-24 NL NL7605526A patent/NL7605526A/xx not_active Application Discontinuation
-
1977
- 1977-05-09 ZA ZA00772752A patent/ZA772752B/xx unknown
- 1977-05-13 GB GB20275/77A patent/GB1567862A/en not_active Expired
- 1977-05-17 IE IE1013/77A patent/IE45419B1/en not_active IP Right Cessation
- 1977-05-18 FR FR7715413A patent/FR2352800A1/fr active Granted
- 1977-05-18 US US05/798,222 patent/US4145434A/en not_active Expired - Lifetime
- 1977-05-20 CH CH626477A patent/CH633536A5/de not_active IP Right Cessation
- 1977-05-20 JP JP5929577A patent/JPS532465A/ja active Granted
- 1977-05-20 SE SE7705957A patent/SE436202B/xx not_active IP Right Cessation
- 1977-05-20 AU AU25331/77A patent/AU509073B2/en not_active Expired
- 1977-05-21 ES ES459024A patent/ES459024A1/es not_active Expired
- 1977-05-23 FI FI771635A patent/FI65238C/fi not_active IP Right Cessation
- 1977-05-23 DE DE2760372A patent/DE2760372C2/de not_active Expired - Lifetime
- 1977-05-23 DE DE19772723209 patent/DE2723209A1/de not_active Withdrawn
- 1977-05-23 BE BE177807A patent/BE854915A/fr not_active IP Right Cessation
- 1977-05-23 HU HU77AO447A patent/HU173795B/hu unknown
- 1977-05-23 LU LU77387A patent/LU77387A1/xx unknown
- 1977-05-24 DK DK227477A patent/DK157868C/da not_active IP Right Cessation
- 1977-05-24 CA CA279,010A patent/CA1122976A/fr not_active Expired
-
1978
- 1978-06-01 ES ES470408A patent/ES470408A1/es not_active Expired
- 1978-06-01 ES ES470407A patent/ES470407A1/es not_active Expired
-
1982
- 1982-06-07 CH CH351282A patent/CH637382A5/de not_active IP Right Cessation
-
1986
- 1986-01-17 JP JP61007790A patent/JPS61178965A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
SE436202B (sv) | 1984-11-19 |
US4145434A (en) | 1979-03-20 |
ES470408A1 (es) | 1979-01-01 |
JPS6134426B2 (fr) | 1986-08-07 |
NL7605526A (nl) | 1977-11-28 |
IE45419L (en) | 1977-11-24 |
DE2723209A1 (de) | 1977-12-15 |
DK157868B (da) | 1990-02-26 |
AU509073B2 (en) | 1980-04-17 |
LU77387A1 (fr) | 1977-08-29 |
CH633536A5 (de) | 1982-12-15 |
DK157868C (da) | 1990-07-30 |
JPS61178965A (ja) | 1986-08-11 |
ES470407A1 (es) | 1979-01-01 |
SE7705957L (sv) | 1977-11-25 |
BE854915A (fr) | 1977-11-23 |
ZA772752B (en) | 1978-04-26 |
FR2352800B1 (fr) | 1980-02-01 |
CH637382A5 (de) | 1983-07-29 |
CA1122976A (fr) | 1982-05-04 |
HU173795B (hu) | 1979-08-28 |
GB1567862A (en) | 1980-05-21 |
ES459024A1 (es) | 1978-11-01 |
FI65238B (fi) | 1983-12-30 |
DE2760372C2 (fr) | 1991-05-29 |
FI771635A (fr) | 1977-11-25 |
DK227477A (da) | 1977-11-25 |
IE45419B1 (en) | 1982-08-25 |
AU2533177A (en) | 1978-11-23 |
FR2352800A1 (fr) | 1977-12-23 |
JPS6238348B2 (fr) | 1987-08-17 |
JPS532465A (en) | 1978-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired | ||
MA | Patent expired |
Owner name: AKZO N.V. |