NL7605526A - Nieuwe tetracyclische derivaten. - Google Patents

Nieuwe tetracyclische derivaten.

Info

Publication number
NL7605526A
NL7605526A NL7605526A NL7605526A NL7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A
Authority
NL
Netherlands
Prior art keywords
tetracyclical
derivatives
new
tetracyclical derivatives
new tetracyclical
Prior art date
Application number
NL7605526A
Other languages
English (en)
Dutch (nl)
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Priority to NL7605526A priority Critical patent/NL7605526A/xx
Priority to ZA00772752A priority patent/ZA772752B/xx
Priority to GB20275/77A priority patent/GB1567862A/en
Priority to IE1013/77A priority patent/IE45419B1/en
Priority to US05/798,222 priority patent/US4145434A/en
Priority to FR7715413A priority patent/FR2352800A1/fr
Priority to CH626477A priority patent/CH633536A5/de
Priority to AU25331/77A priority patent/AU509073B2/en
Priority to JP5929577A priority patent/JPS532465A/ja
Priority to SE7705957A priority patent/SE436202B/xx
Priority to ES459024A priority patent/ES459024A1/es
Priority to FI771635A priority patent/FI65238C/fi
Priority to LU77387A priority patent/LU77387A1/xx
Priority to HU77AO447A priority patent/HU173795B/hu
Priority to BE177807A priority patent/BE854915A/fr
Priority to DE19772723209 priority patent/DE2723209A1/de
Priority to DE2760372A priority patent/DE2760372C2/de
Priority to DK227477A priority patent/DK157868C/da
Priority to CA279,010A priority patent/CA1122976A/fr
Publication of NL7605526A publication Critical patent/NL7605526A/xx
Priority to ES470408A priority patent/ES470408A1/es
Priority to ES470407A priority patent/ES470407A1/es
Priority to US05/918,219 priority patent/US4158059A/en
Priority to US05/918,217 priority patent/US4154836A/en
Priority to US05/923,606 priority patent/US4271179A/en
Priority to US05/918,883 priority patent/US4177275A/en
Priority to US05/919,196 priority patent/US4271178A/en
Priority to US05/918,981 priority patent/US4271177A/en
Priority to US05/919,110 priority patent/US4158058A/en
Priority to CH351282A priority patent/CH637382A5/de
Priority to FI832085A priority patent/FI67701C/fi
Priority to JP61007790A priority patent/JPS61178965A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NL7605526A 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten. NL7605526A (nl)

Priority Applications (31)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.
ZA00772752A ZA772752B (en) 1976-05-24 1977-05-09 Novel tetracyclic derivatives
GB20275/77A GB1567862A (en) 1976-05-24 1977-05-13 Tetracyclic derivatives
IE1013/77A IE45419B1 (en) 1976-05-24 1977-05-17 Novel tetracylic derivatives
US05/798,222 US4145434A (en) 1976-05-24 1977-05-18 Tetracyclic derivatives and pharmaceutical compositions of matter
FR7715413A FR2352800A1 (fr) 1976-05-24 1977-05-18 Nouveaux composes tetracycliques utiles comme depresseurs
CH626477A CH633536A5 (de) 1976-05-24 1977-05-20 Verfahren zur herstellung neuer tetracyclischer piperidin- oder pyrrolidinderivate.
AU25331/77A AU509073B2 (en) 1976-05-24 1977-05-20 Novel tetracyclic derivatives
JP5929577A JPS532465A (en) 1976-05-24 1977-05-20 Novel tetracyclic derivative* its preparation and formulations containing same
SE7705957A SE436202B (sv) 1976-05-24 1977-05-20 Analogiforfarande for framstellning av tetracykliska derivat
ES459024A ES459024A1 (es) 1976-05-24 1977-05-21 Procedimiento para la preparacion de un compuesto tetraci- clico.
DE19772723209 DE2723209A1 (de) 1976-05-24 1977-05-23 Tetracyclische pyridin- oder pyrrolderivate
LU77387A LU77387A1 (fr) 1976-05-24 1977-05-23
HU77AO447A HU173795B (hu) 1976-05-24 1977-05-23 Sposob poluchenija novykh tetraciklicheskikh soedinenij
BE177807A BE854915A (fr) 1976-05-24 1977-05-23 Nouveaux composes tetracycliques utiles comme depresseurs
FI771635A FI65238C (fi) 1976-05-24 1977-05-23 Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar
DE2760372A DE2760372C2 (fr) 1976-05-24 1977-05-23
DK227477A DK157868C (da) 1976-05-24 1977-05-24 Analogifremgangsmaade til fremstilling af tetracykliske forbindelser
CA279,010A CA1122976A (fr) 1976-05-24 1977-05-24 Composes tetracycliques
ES470408A ES470408A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico
ES470407A ES470407A1 (es) 1976-05-24 1978-06-01 Procedimiento para la preparacion de un compuesto tetraci- clico
US05/918,217 US4154836A (en) 1976-05-24 1978-06-23 Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenz[2,3;6,7]oxepino[4,5-c]pyridines
US05/918,219 US4158059A (en) 1976-05-24 1978-06-23 Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py
US05/923,606 US4271179A (en) 1976-05-24 1978-06-26 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof
US05/918,883 US4177275A (en) 1976-05-24 1978-06-26 Tension reducing 2,3,4,4a,9,13b-hexahydro-1H-dibenzo[b,f]pyrido[3,4-d]azepine derivatives
US05/919,196 US4271178A (en) 1976-05-24 1978-06-26 1,2,3,3a,8,12b-Hexahydro-dibenzo[b,f]pyrrolo[3,4-d]azepines and pharmaceutical use thereof
US05/918,981 US4271177A (en) 1976-05-24 1978-06-26 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof
US05/919,110 US4158058A (en) 1976-05-24 1978-06-26 Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenzo[2,3;6,7]thiepino[4,5-c]pyridines
CH351282A CH637382A5 (de) 1976-05-24 1982-06-07 Verfahren zur herstellung neuer tetracyclischer pyridin- oder pyrrolderivate.
FI832085A FI67701C (fi) 1976-05-24 1983-06-09 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetracykliska foereningar
JP61007790A JPS61178965A (ja) 1976-05-24 1986-01-17 新規な四環式誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Publications (1)

Publication Number Publication Date
NL7605526A true NL7605526A (nl) 1977-11-28

Family

ID=19826245

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7605526A NL7605526A (nl) 1976-05-24 1976-05-24 Nieuwe tetracyclische derivaten.

Country Status (18)

Country Link
US (1) US4145434A (fr)
JP (2) JPS532465A (fr)
AU (1) AU509073B2 (fr)
BE (1) BE854915A (fr)
CA (1) CA1122976A (fr)
CH (2) CH633536A5 (fr)
DE (2) DE2760372C2 (fr)
DK (1) DK157868C (fr)
ES (3) ES459024A1 (fr)
FI (1) FI65238C (fr)
FR (1) FR2352800A1 (fr)
GB (1) GB1567862A (fr)
HU (1) HU173795B (fr)
IE (1) IE45419B1 (fr)
LU (1) LU77387A1 (fr)
NL (1) NL7605526A (fr)
SE (1) SE436202B (fr)
ZA (1) ZA772752B (fr)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007450A1 (fr) * 1978-07-07 1980-02-06 Ciba-Geigy Ag Carbonitriles azatétracycliques, leur préparation, compositions pharmaceutiques les contenant et leur application
EP0030916B1 (fr) * 1979-12-10 1984-08-29 Ciba-Geigy Ag Carbonitriles azatétracycliques
FR2504140A1 (fr) * 1981-04-16 1982-10-22 Centre Nat Rech Scient Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
NZ204242A (en) * 1982-05-18 1986-08-08 Hoffmann La Roche 8-halo-6-phenyl-2,3-dihydro-1h,4h-pyrrolo(3,4-d)(2)benzazepine-(1-or 3-ones or 1,3-diones)
JPS62101941U (fr) * 1985-12-16 1987-06-29
IE62754B1 (en) * 1988-08-26 1995-02-22 Akzo Nv Tetracyclic antidepressants
EP0569096A1 (fr) * 1992-05-08 1993-11-10 Akzo Nobel N.V. Préparation de dépôt
JP2710695B2 (ja) * 1993-04-06 1998-02-10 アボツト・ラボラトリーズ ドーパミンアゴニストとしての四環式化合物
CA2182981C (fr) * 1994-03-02 2006-10-17 Leonardus Petrus Carla Delbressine Composition pharmaceutique sublinguale ou buccale
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
NZ329953A (en) * 1996-04-12 1999-06-29 Janssen Pharmaceutica Nv Substituted tetracyclic n-oxide tetrahydrofuran derivatives, salts and stereoisomeric forms thereof for the treatment of cns cardiovascular or gastrointestinal disorders
CA2290070A1 (fr) * 1997-05-26 1998-12-03 Akzo Nobel Nv Sels d'acides sulfoniques aromatiques
HRP20020305A8 (en) * 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en) * 2002-05-21 2003-12-31 Pliva D D 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20030160A2 (en) * 2003-03-06 2005-04-30 Pliva-Istra�iva�ki institut d.o.o. 1-thiadibenzoazulene derivatives and biological action thereof
CN1791430A (zh) * 2003-05-16 2006-06-21 辉瑞产品公司 非典型抗精神病药物和gaba调节剂、抗惊厥药物或苯并二氮杂䓬类的治疗性组合
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030954A2 (en) * 2003-11-21 2005-08-31 Pliva D.D. USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030955A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030959A2 (fr) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o.
HRP20030957A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030958A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
HRP20030956A2 (en) * 2003-11-21 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
HRP20040104A2 (en) * 2004-01-30 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
JP2007522200A (ja) * 2004-02-13 2007-08-09 ファイザー・プロダクツ・インク 非定型抗精神病薬とコルチコトロピン放出因子拮抗薬の治療的組合せ
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BRPI0516000A (pt) * 2004-10-15 2008-05-06 Pfizer uso de um composto ou de um sal, solvato, hidrato ou isÈmero óptico farmaceuticamente aceitável do mesmo, método para tratar distúrbio bipolar em um mamìfero em necessidade do mesmo, e, kit para uso no tratamento de distúrbios bipolares
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WO2009104080A2 (fr) 2008-02-20 2009-08-27 Targia Pharmaceuticals Compositions pharmaceutiques actives sur le snc et méthodes d'utilisation
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US8779161B2 (en) 2010-06-18 2014-07-15 Dr. Reddy's Laboratories Limited Asenapine maleate
CA2805542C (fr) 2010-07-29 2017-12-12 Laboratorios Lesvi, S.L. Nouveau procede de synthese de l'asenapine
JP5916746B2 (ja) 2010-11-15 2016-05-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのピリダジン誘導体、組成物、および方法
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SE436202B (sv) 1984-11-19
US4145434A (en) 1979-03-20
ES470408A1 (es) 1979-01-01
JPS6134426B2 (fr) 1986-08-07
IE45419L (en) 1977-11-24
DE2723209A1 (de) 1977-12-15
DK157868B (da) 1990-02-26
AU509073B2 (en) 1980-04-17
LU77387A1 (fr) 1977-08-29
CH633536A5 (de) 1982-12-15
DK157868C (da) 1990-07-30
JPS61178965A (ja) 1986-08-11
ES470407A1 (es) 1979-01-01
SE7705957L (sv) 1977-11-25
BE854915A (fr) 1977-11-23
ZA772752B (en) 1978-04-26
FR2352800B1 (fr) 1980-02-01
CH637382A5 (de) 1983-07-29
CA1122976A (fr) 1982-05-04
HU173795B (hu) 1979-08-28
GB1567862A (en) 1980-05-21
ES459024A1 (es) 1978-11-01
FI65238B (fi) 1983-12-30
DE2760372C2 (fr) 1991-05-29
FI771635A (fr) 1977-11-25
DK227477A (da) 1977-11-25
IE45419B1 (en) 1982-08-25
AU2533177A (en) 1978-11-23
FR2352800A1 (fr) 1977-12-23
JPS6238348B2 (fr) 1987-08-17
JPS532465A (en) 1978-01-11
FI65238C (fi) 1984-04-10

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