FI63937C - Foerfarande foer framstaellning av terapeutiskt anvaendbara feylpiperaziner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara feylpiperaziner Download PDF

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Publication number
FI63937C
FI63937C FI771287A FI771287A FI63937C FI 63937 C FI63937 C FI 63937C FI 771287 A FI771287 A FI 771287A FI 771287 A FI771287 A FI 771287A FI 63937 C FI63937 C FI 63937C
Authority
FI
Finland
Prior art keywords
phenyl
piperazine
ylmethyl
formula
alkyl
Prior art date
Application number
FI771287A
Other languages
English (en)
Finnish (fi)
Other versions
FI771287A (xx
FI63937B (fi
Inventor
John Pomfret Verge
William Boffey Jamieson
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of FI771287A publication Critical patent/FI771287A/fi
Application granted granted Critical
Publication of FI63937B publication Critical patent/FI63937B/fi
Publication of FI63937C publication Critical patent/FI63937C/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI771287A 1976-04-23 1977-04-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara feylpiperaziner FI63937C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB16526/76A GB1575904A (en) 1976-04-23 1976-04-23 Phenyl piperazines
GB1652676 1976-04-23

Publications (3)

Publication Number Publication Date
FI771287A FI771287A (xx) 1977-10-24
FI63937B FI63937B (fi) 1983-05-31
FI63937C true FI63937C (fi) 1983-09-12

Family

ID=10078930

Family Applications (1)

Application Number Title Priority Date Filing Date
FI771287A FI63937C (fi) 1976-04-23 1977-04-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara feylpiperaziner

Country Status (34)

Country Link
JP (1) JPS52151183A (xx)
AR (2) AR222003A1 (xx)
AT (1) AT355579B (xx)
AU (1) AU514822B2 (xx)
BE (1) BE853899A (xx)
BG (2) BG27746A3 (xx)
CA (1) CA1087617A (xx)
CH (2) CH633009A5 (xx)
CS (1) CS196360B2 (xx)
DD (1) DD129790A5 (xx)
DE (1) DE2717415A1 (xx)
DK (1) DK176177A (xx)
ES (2) ES457988A1 (xx)
FI (1) FI63937C (xx)
FR (1) FR2348925A1 (xx)
GB (1) GB1575904A (xx)
GR (1) GR64084B (xx)
HU (1) HU176820B (xx)
IE (1) IE44730B1 (xx)
IL (1) IL51787A (xx)
LU (1) LU77170A1 (xx)
MX (1) MX4596E (xx)
NL (1) NL7704456A (xx)
NO (1) NO146710C (xx)
NZ (1) NZ183715A (xx)
OA (1) OA05643A (xx)
PH (1) PH14124A (xx)
PL (1) PL117466B1 (xx)
PT (1) PT66452B (xx)
RO (1) RO72831A (xx)
SE (1) SE7704536L (xx)
SU (2) SU664564A3 (xx)
YU (1) YU104477A (xx)
ZA (1) ZA771849B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1601310A (en) * 1978-05-23 1981-10-28 Lilly Industries Ltd Aryl hydantoins
DE3142608A1 (de) * 1981-10-28 1983-05-05 Basf Ag, 6700 Ludwigshafen Polyazofarbstoffe
JPH07157477A (ja) * 1993-12-02 1995-06-20 Asahi Kagaku Kogyo Kk チアゾール誘導体の製造方法
KR970701705A (ko) * 1994-03-11 1997-04-12 오노다 마사요시 5-HT₃ 수용체 효능제, 신규한 티아졸 유도체 및 이의 중간체(5-HT₃receptor agonist, novel thiazole derivative, and intermediate therefor)
GB9517381D0 (en) * 1995-08-24 1995-10-25 Pharmacia Spa Aryl and heteroaryl piperazine derivatives
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
ES2462240T3 (es) * 2006-02-28 2014-05-22 Dart Neuroscience (Cayman) Ltd Piperazinas terapéuticas como inhibidores de PDE4

Also Published As

Publication number Publication date
MX4596E (es) 1982-06-25
HU176820B (en) 1981-05-28
PL197550A1 (pl) 1979-05-21
PL117466B1 (en) 1981-08-31
CH625802A5 (en) 1981-10-15
IL51787A0 (en) 1977-05-31
LU77170A1 (xx) 1979-01-18
CS196360B2 (en) 1980-03-31
CA1087617A (en) 1980-10-14
JPS52151183A (en) 1977-12-15
BG28055A3 (en) 1980-02-25
NO146710B (no) 1982-08-16
RO72831A (ro) 1983-08-03
PH14124A (en) 1981-02-26
ATA285177A (de) 1979-08-15
BE853899A (fr) 1977-10-24
AR222003A1 (es) 1981-04-15
CH633009A5 (en) 1982-11-15
GR64084B (en) 1980-01-21
AU514822B2 (en) 1981-02-26
NO771398L (no) 1977-10-25
NO146710C (no) 1982-11-24
FI771287A (xx) 1977-10-24
FR2348925A1 (fr) 1977-11-18
ES467948A1 (es) 1978-11-01
FR2348925B1 (xx) 1980-04-11
DE2717415A1 (de) 1977-11-10
RO72831B (ro) 1983-07-30
ZA771849B (en) 1978-11-29
OA05643A (fr) 1981-04-30
YU104477A (en) 1983-01-21
IE44730L (en) 1977-10-23
DK176177A (da) 1977-10-24
DD129790A5 (de) 1978-02-08
AR222635A1 (es) 1981-06-15
SU727146A3 (ru) 1980-04-05
NL7704456A (nl) 1977-10-25
AT355579B (de) 1980-03-10
SE7704536L (sv) 1977-10-24
NZ183715A (en) 1980-04-28
FI63937B (fi) 1983-05-31
ES457988A1 (es) 1978-07-16
AU2438677A (en) 1978-10-26
BG27746A3 (en) 1979-12-12
SU664564A3 (ru) 1979-05-25
GB1575904A (en) 1980-10-01
PT66452A (en) 1977-05-01
PT66452B (en) 1979-03-09
IL51787A (en) 1980-02-29
IE44730B1 (en) 1982-03-10

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MM Patent lapsed

Owner name: LILLY INDUSTRIES LIMITED