FI63409C - Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,5-dihydro-imidazo(2,1-b)kinazolin-2(3h)-onderivat - Google Patents
Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,5-dihydro-imidazo(2,1-b)kinazolin-2(3h)-onderivat Download PDFInfo
- Publication number
- FI63409C FI63409C FI782248A FI782248A FI63409C FI 63409 C FI63409 C FI 63409C FI 782248 A FI782248 A FI 782248A FI 782248 A FI782248 A FI 782248A FI 63409 C FI63409 C FI 63409C
- Authority
- FI
- Finland
- Prior art keywords
- quinazolin
- dihydro
- chloro
- formula
- ethyl ester
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 2
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- ZJYZQVSCSFKDPV-SNVBAGLBSA-N ethyl (2r)-2-[(2-amino-3-methylphenyl)methylamino]propanoate Chemical compound CCOC(=O)[C@@H](C)NCC1=CC=CC(C)=C1N ZJYZQVSCSFKDPV-SNVBAGLBSA-N 0.000 description 1
- AITNNCPPLYJMPW-SNVBAGLBSA-N ethyl (2r)-2-[(2-amino-5-methylphenyl)methylamino]propanoate Chemical compound CCOC(=O)[C@@H](C)NCC1=CC(C)=CC=C1N AITNNCPPLYJMPW-SNVBAGLBSA-N 0.000 description 1
- IHNPWXCCECFVGX-QGZVFWFLSA-N ethyl (2r)-2-[(2-amino-6-chlorophenyl)methylamino]-3-phenylpropanoate Chemical compound C([C@H](C(=O)OCC)NCC=1C(=CC=CC=1N)Cl)C1=CC=CC=C1 IHNPWXCCECFVGX-QGZVFWFLSA-N 0.000 description 1
- XTOYREDAYWBXOW-CQSZACIVSA-N ethyl (2r)-2-[(2-amino-6-chlorophenyl)methylamino]-4-methylpentanoate Chemical compound CCOC(=O)[C@@H](CC(C)C)NCC1=C(N)C=CC=C1Cl XTOYREDAYWBXOW-CQSZACIVSA-N 0.000 description 1
- JNKASCNGJPDNFK-SNVBAGLBSA-N ethyl (2r)-2-[(2-amino-6-methylphenyl)methylamino]propanoate Chemical compound CCOC(=O)[C@@H](C)NCC1=C(C)C=CC=C1N JNKASCNGJPDNFK-SNVBAGLBSA-N 0.000 description 1
- CSNSUUUPCIUOJV-SECBINFHSA-N ethyl (2r)-2-[(2-aminophenyl)methylamino]propanoate Chemical compound CCOC(=O)[C@@H](C)NCC1=CC=CC=C1N CSNSUUUPCIUOJV-SECBINFHSA-N 0.000 description 1
- QXGRINMHXDKSIY-SNVBAGLBSA-N ethyl (2r)-2-[(2-chloro-6-nitrophenyl)methylamino]-3-hydroxypropanoate Chemical compound CCOC(=O)[C@@H](CO)NCC1=C(Cl)C=CC=C1[N+]([O-])=O QXGRINMHXDKSIY-SNVBAGLBSA-N 0.000 description 1
- JICGZLATBHCWTA-MRXNPFEDSA-N ethyl (2r)-2-[(2-chloro-6-nitrophenyl)methylamino]-3-phenylpropanoate Chemical compound C([C@H](C(=O)OCC)NCC=1C(=CC=CC=1Cl)[N+]([O-])=O)C1=CC=CC=C1 JICGZLATBHCWTA-MRXNPFEDSA-N 0.000 description 1
- OSWAAOBYYDIABH-CYBMUJFWSA-N ethyl (2r)-2-[(2-chloro-6-nitrophenyl)methylamino]-4-methylpentanoate Chemical compound CCOC(=O)[C@@H](CC(C)C)NCC1=C(Cl)C=CC=C1[N+]([O-])=O OSWAAOBYYDIABH-CYBMUJFWSA-N 0.000 description 1
- ROBXZHNBBCHEIQ-SCSAIBSYSA-N ethyl (2r)-2-aminopropanoate Chemical compound CCOC(=O)[C@@H](C)N ROBXZHNBBCHEIQ-SCSAIBSYSA-N 0.000 description 1
- JCXLZWMDXJFOOI-PGMHMLKASA-N ethyl (2r)-2-aminopropanoate;hydrochloride Chemical compound Cl.CCOC(=O)[C@@H](C)N JCXLZWMDXJFOOI-PGMHMLKASA-N 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- FVGAJEWYPIQRJX-UHFFFAOYSA-N imidazo[4,5-h]quinazolin-2-one Chemical class N1=CN=C2C3=NC(=O)N=C3C=CC2=C1 FVGAJEWYPIQRJX-UHFFFAOYSA-N 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000009090 positive inotropic effect Effects 0.000 description 1
- 239000011591 potassium Chemical group 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000011734 sodium Chemical group 0.000 description 1
- 229910052708 sodium Chemical group 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU77829 | 1977-07-25 | ||
| LU77829 | 1977-07-25 | ||
| CH577678 | 1978-05-26 | ||
| CH577678 | 1978-05-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI782248A7 FI782248A7 (fi) | 1979-01-26 |
| FI63409B FI63409B (fi) | 1983-02-28 |
| FI63409C true FI63409C (fi) | 1983-06-10 |
Family
ID=25698353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI782248A FI63409C (fi) | 1977-07-25 | 1978-07-14 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,5-dihydro-imidazo(2,1-b)kinazolin-2(3h)-onderivat |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4256748A (es) |
| EP (1) | EP0000718B1 (es) |
| JP (1) | JPS5441894A (es) |
| AR (1) | AR218500A1 (es) |
| AT (1) | AT363479B (es) |
| AU (1) | AU519688B2 (es) |
| BR (1) | BR7804763A (es) |
| CA (1) | CA1094555A (es) |
| CS (1) | CS203014B2 (es) |
| DE (2) | DE2832138A1 (es) |
| DK (1) | DK144128C (es) |
| ES (2) | ES471981A1 (es) |
| FI (1) | FI63409C (es) |
| FR (1) | FR2398748A1 (es) |
| GB (1) | GB2001638B (es) |
| GR (1) | GR72968B (es) |
| HU (1) | HU177643B (es) |
| IE (1) | IE47280B1 (es) |
| IL (1) | IL55183A (es) |
| IT (1) | IT1097337B (es) |
| MC (1) | MC1199A1 (es) |
| MY (1) | MY8500249A (es) |
| NL (1) | NL7807507A (es) |
| NO (1) | NO150800C (es) |
| NZ (1) | NZ187921A (es) |
| PH (1) | PH14642A (es) |
| PT (1) | PT68342A (es) |
| SE (1) | SE7808111L (es) |
| YU (1) | YU177578A (es) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
| CA1131631A (en) * | 1979-06-20 | 1982-09-14 | Madhukar S. Chodnekar | Quinazoline derivatives and pharmaceutical preparations |
| EP0029559A3 (en) * | 1979-11-24 | 1981-09-30 | Sandoz Ag | 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them |
| US4444768A (en) * | 1980-03-04 | 1984-04-24 | Ciba-Geigy Corporation | Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them |
| ZW16481A1 (en) * | 1980-08-15 | 1982-03-10 | Hoffmann La Roche | Novel imidazoquinazoline derivatives |
| EP0054180A3 (de) * | 1980-12-16 | 1982-12-01 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung eines Imidazochinazolinonderivates |
| JPS57178234U (es) * | 1981-05-06 | 1982-11-11 | ||
| US4455311A (en) * | 1981-08-28 | 1984-06-19 | Hoffmann-La Roche Inc. | Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system |
| US4551459A (en) * | 1983-02-16 | 1985-11-05 | Syntex (U.S.A.) Inc. | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides |
| US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
| US4663320A (en) * | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
| JPS604186A (ja) * | 1983-06-21 | 1985-01-10 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン化合物 |
| JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
| ES8607299A1 (es) * | 1984-02-15 | 1986-06-01 | Syntex Inc | Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas |
| GB8514207D0 (en) * | 1985-06-05 | 1985-07-10 | Pfizer Ltd | Cardiac stimulants |
| US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
| US4837239A (en) * | 1985-08-23 | 1989-06-06 | Syntex (U.S.A.) Inc. | Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins |
| US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
| US4775674A (en) * | 1986-05-23 | 1988-10-04 | Bristol-Myers Company | Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors |
| US4701459A (en) * | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
| US5043327A (en) * | 1989-07-18 | 1991-08-27 | Janssen Pharmaceutica N.V. | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use |
| US4943573A (en) * | 1989-11-01 | 1990-07-24 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility |
| CA2113115A1 (en) * | 1991-07-29 | 1993-02-18 | Vlad E. Gregor | Quinazoline derivatives as acetylcholinesterase inhibitors |
| US5196428A (en) * | 1992-04-03 | 1993-03-23 | Bristol-Myers Squibb Company | Imidazo[4,5-b]qinolinyl oxy alkyl ureas |
| US5158958A (en) * | 1992-04-03 | 1992-10-27 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives |
| US5348960A (en) * | 1992-04-03 | 1994-09-20 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives |
| US5208237A (en) * | 1992-04-03 | 1993-05-04 | Bristol-Meyers Squibb Company | 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones |
| JPH06167328A (ja) * | 1992-05-26 | 1994-06-14 | Mayekawa Mfg Co Ltd | 氷厚測定装置 |
| EP1216037A2 (en) * | 1999-09-21 | 2002-06-26 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
| US6388073B1 (en) * | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
| BRPI0406634A (pt) * | 2003-01-23 | 2005-12-06 | Shire Holding Ag | Uso de um anagrelìdeo, anagrelìdeo na forma de base, ou um sal farmaceuticamente aceitável do anagrelìdeo, composição farmacêutica não-oral, e dispositivo médido para administração transdérmica |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
| US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
| US8426429B2 (en) | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US8383637B2 (en) | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
| US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
| GB0623750D0 (en) * | 2006-11-28 | 2007-01-10 | Shire Llc | Substituted quinazolines |
| US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| GB0808948D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808947D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808950D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808944D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808953D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | substituted quinazolines |
| GB0808951D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0808967D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substitute quinazolines |
| GB0808968D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substitute quinazolines |
| GB0808952D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
| GB0810005D0 (en) * | 2008-06-02 | 2008-07-09 | Shire Llc | Substituted quinazolines |
| WO2009149279A2 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| GB0822970D0 (en) | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
| GB201004495D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Subtituted quinazolines |
| GB201004491D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Quinazoline analogues |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP3366698A1 (en) | 2011-03-01 | 2018-08-29 | Synergy Pharmaceuticals Inc. | Guanylate cyclase c agonists |
| AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
| WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP3004138B1 (en) | 2013-06-05 | 2024-03-13 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| JP5935843B2 (ja) * | 2014-08-08 | 2016-06-15 | Ｊｆｅスチール株式会社 | スポット溶接性に優れた冷延鋼板およびその製造方法 |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1445430A1 (de) | 1962-10-26 | 1969-01-23 | American Home Prod | Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen |
| GB1037375A (en) * | 1964-08-07 | 1966-07-27 | Hoffmann La Roche | A process for the manufacture of benzodiazepine derivatives |
| US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| BE794964A (fr) | 1972-02-04 | 1973-08-02 | Bristol Myers Co | Nouveaux agents hypotenseurs et procede pour les preparer |
| US3983119A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
| US3988340A (en) * | 1975-01-23 | 1976-10-26 | Bristol-Myers Company | 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones |
| NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
-
1978
- 1978-07-12 NL NL7807507A patent/NL7807507A/xx not_active Application Discontinuation
- 1978-07-13 MC MC781312A patent/MC1199A1/fr unknown
- 1978-07-14 FI FI782248A patent/FI63409C/fi not_active IP Right Cessation
- 1978-07-18 AU AU38127/78A patent/AU519688B2/en not_active Expired
- 1978-07-19 FR FR7821396A patent/FR2398748A1/fr active Granted
- 1978-07-19 HU HU78HO2088A patent/HU177643B/hu unknown
- 1978-07-20 IL IL55183A patent/IL55183A/xx unknown
- 1978-07-20 CA CA307,767A patent/CA1094555A/en not_active Expired
- 1978-07-20 NZ NZ187921A patent/NZ187921A/xx unknown
- 1978-07-21 DE DE19782832138 patent/DE2832138A1/de not_active Withdrawn
- 1978-07-21 PH PH21412A patent/PH14642A/en unknown
- 1978-07-21 EP EP78100471A patent/EP0000718B1/de not_active Expired
- 1978-07-21 DE DE7878100471T patent/DE2861688D1/de not_active Expired
- 1978-07-24 NO NO782541A patent/NO150800C/no unknown
- 1978-07-24 GR GR56847A patent/GR72968B/el unknown
- 1978-07-24 IE IE1478/78A patent/IE47280B1/en unknown
- 1978-07-24 CS CS784914A patent/CS203014B2/cs unknown
- 1978-07-24 AT AT0535178A patent/AT363479B/de active
- 1978-07-24 BR BR7804763A patent/BR7804763A/pt unknown
- 1978-07-24 JP JP8953478A patent/JPS5441894A/ja active Pending
- 1978-07-24 DK DK328978A patent/DK144128C/da not_active IP Right Cessation
- 1978-07-24 PT PT68342A patent/PT68342A/pt unknown
- 1978-07-24 ES ES471981A patent/ES471981A1/es not_active Expired
- 1978-07-24 IT IT26019/78A patent/IT1097337B/it active
- 1978-07-24 GB GB787830868A patent/GB2001638B/en not_active Expired
- 1978-07-24 SE SE7808111A patent/SE7808111L/xx unknown
- 1978-07-25 YU YU01775/78A patent/YU177578A/xx unknown
- 1978-07-25 AR AR273064A patent/AR218500A1/es active
-
1979
- 1979-01-18 ES ES476955A patent/ES476955A1/es not_active Expired
- 1979-06-20 US US06/050,395 patent/US4256748A/en not_active Expired - Lifetime
-
1985
- 1985-12-30 MY MY249/85A patent/MY8500249A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE & CO. |