IL55183A - 3-substituted-1,5-dihydroimidazo(2,1-b)quinazolin-2(3h)-one derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
3-substituted-1,5-dihydroimidazo(2,1-b)quinazolin-2(3h)-one derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL55183A IL55183A IL55183A IL5518378A IL55183A IL 55183 A IL55183 A IL 55183A IL 55183 A IL55183 A IL 55183A IL 5518378 A IL5518378 A IL 5518378A IL 55183 A IL55183 A IL 55183A
- Authority
- IL
- Israel
- Prior art keywords
- dihydroimidazo
- quinazolin
- derivatives
- substituted
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU77829 | 1977-07-25 | ||
CH577678 | 1978-05-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL55183A0 IL55183A0 (en) | 1978-09-29 |
IL55183A true IL55183A (en) | 1981-11-30 |
Family
ID=25698353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL55183A IL55183A (en) | 1977-07-25 | 1978-07-20 | 3-substituted-1,5-dihydroimidazo(2,1-b)quinazolin-2(3h)-one derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (29)
Country | Link |
---|---|
US (1) | US4256748A (xx) |
EP (1) | EP0000718B1 (xx) |
JP (1) | JPS5441894A (xx) |
AR (1) | AR218500A1 (xx) |
AT (1) | AT363479B (xx) |
AU (1) | AU519688B2 (xx) |
BR (1) | BR7804763A (xx) |
CA (1) | CA1094555A (xx) |
CS (1) | CS203014B2 (xx) |
DE (2) | DE2861688D1 (xx) |
DK (1) | DK144128C (xx) |
ES (2) | ES471981A1 (xx) |
FI (1) | FI63409C (xx) |
FR (1) | FR2398748A1 (xx) |
GB (1) | GB2001638B (xx) |
GR (1) | GR72968B (xx) |
HU (1) | HU177643B (xx) |
IE (1) | IE47280B1 (xx) |
IL (1) | IL55183A (xx) |
IT (1) | IT1097337B (xx) |
MC (1) | MC1199A1 (xx) |
MY (1) | MY8500249A (xx) |
NL (1) | NL7807507A (xx) |
NO (1) | NO150800C (xx) |
NZ (1) | NZ187921A (xx) |
PH (1) | PH14642A (xx) |
PT (1) | PT68342A (xx) |
SE (1) | SE7808111L (xx) |
YU (1) | YU177578A (xx) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
US4146718A (en) * | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
CA1131631A (en) * | 1979-06-20 | 1982-09-14 | Madhukar S. Chodnekar | Quinazoline derivatives and pharmaceutical preparations |
EP0029559A3 (en) * | 1979-11-24 | 1981-09-30 | Sandoz Ag | 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them |
US4444768A (en) * | 1980-03-04 | 1984-04-24 | Ciba-Geigy Corporation | Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them |
ZW16481A1 (en) * | 1980-08-15 | 1982-03-10 | Hoffmann La Roche | Novel imidazoquinazoline derivatives |
EP0054180A3 (de) * | 1980-12-16 | 1982-12-01 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung eines Imidazochinazolinonderivates |
JPS57178234U (xx) * | 1981-05-06 | 1982-11-11 | ||
US4455311A (en) * | 1981-08-28 | 1984-06-19 | Hoffmann-La Roche Inc. | Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system |
US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
US4663320A (en) * | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
US4551459A (en) * | 1983-02-16 | 1985-11-05 | Syntex (U.S.A.) Inc. | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides |
JPS604186A (ja) * | 1983-06-21 | 1985-01-10 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン化合物 |
JPS6028979A (ja) * | 1983-07-14 | 1985-02-14 | Dai Ichi Seiyaku Co Ltd | イミダゾキナゾリン類化合物 |
CA1254557A (en) * | 1984-02-15 | 1989-05-23 | Michael C. Venuti | (2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b) quinazolinyl) oxyalkylamides |
US4783467A (en) * | 1985-06-05 | 1988-11-08 | Pfizer Inc. | Tetrahydroimidazoquinazolinone inotropic agents |
GB8514207D0 (en) * | 1985-06-05 | 1985-07-10 | Pfizer Ltd | Cardiac stimulants |
US4837239A (en) * | 1985-08-23 | 1989-06-06 | Syntex (U.S.A.) Inc. | Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins |
US4670434A (en) * | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
US4775674A (en) * | 1986-05-23 | 1988-10-04 | Bristol-Myers Company | Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors |
US4701459A (en) * | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
US5043327A (en) * | 1989-07-18 | 1991-08-27 | Janssen Pharmaceutica N.V. | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use |
US4943573A (en) * | 1989-11-01 | 1990-07-24 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility |
EP0597956A1 (en) * | 1991-07-29 | 1994-05-25 | Warner-Lambert Company | Quinazoline derivatives as acetylcholinesterase inhibitors |
US5208237A (en) * | 1992-04-03 | 1993-05-04 | Bristol-Meyers Squibb Company | 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones |
US5196428A (en) * | 1992-04-03 | 1993-03-23 | Bristol-Myers Squibb Company | Imidazo[4,5-b]qinolinyl oxy alkyl ureas |
US5158958A (en) * | 1992-04-03 | 1992-10-27 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives |
US5348960A (en) * | 1992-04-03 | 1994-09-20 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives |
JPH06167328A (ja) * | 1992-05-26 | 1994-06-14 | Mayekawa Mfg Co Ltd | 氷厚測定装置 |
WO2001021259A2 (en) * | 1999-09-21 | 2001-03-29 | Emory University | Use and compositions for treating platelet-related disorders using anagrelide |
US6388073B1 (en) * | 2000-07-26 | 2002-05-14 | Shire Us Inc. | Method for the manufacture of anagrelide |
KR20050111317A (ko) * | 2003-01-23 | 2005-11-24 | 샤이어 홀딩스 아게 | 혈소판혈병의 치료를 위한 제형 및 방법 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20060030574A1 (en) * | 2004-08-04 | 2006-02-09 | Shire Holdings Ag | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors |
US7700608B2 (en) * | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
US8426429B2 (en) | 2004-08-06 | 2013-04-23 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8383637B2 (en) | 2004-08-06 | 2013-02-26 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8436006B2 (en) * | 2004-08-06 | 2013-05-07 | Jansssen Pharmaceutica N.V. | 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
GB0623750D0 (en) * | 2006-11-28 | 2007-01-10 | Shire Llc | Substituted quinazolines |
US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
GB0808944D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0808967D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substitute quinazolines |
GB0808968D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substitute quinazolines |
GB0808951D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0808948D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0808953D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | substituted quinazolines |
GB0808952D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0808947D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0808950D0 (en) * | 2008-05-16 | 2008-06-25 | Shire Llc | Substituted quinazolines |
GB0810005D0 (en) * | 2008-06-02 | 2008-07-09 | Shire Llc | Substituted quinazolines |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
GB0822970D0 (en) | 2008-12-17 | 2009-01-21 | Shire Llc | Process for the preparation of anagrelide and analogues |
GB201004491D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Quinazoline analogues |
GB201004495D0 (en) | 2010-03-18 | 2010-05-05 | Shire Llc | Subtituted quinazolines |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
ES2664873T3 (es) | 2011-03-01 | 2018-04-23 | Synergy Pharmaceuticals Inc. | Proceso de preparación de agonistas de guanilato ciclasa C |
EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
KR102272746B1 (ko) | 2013-06-05 | 2021-07-08 | 보슈 헬스 아일랜드 리미티드 | 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법 |
KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
JP5935843B2 (ja) * | 2014-08-08 | 2016-06-15 | Jfeスチール株式会社 | スポット溶接性に優れた冷延鋼板およびその製造方法 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
EP4201403A1 (en) | 2021-12-21 | 2023-06-28 | Som Innovation Biotech, S.L. | Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1445430A1 (de) | 1962-10-26 | 1969-01-23 | American Home Prod | Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen |
GB1037375A (en) * | 1964-08-07 | 1966-07-27 | Hoffmann La Roche | A process for the manufacture of benzodiazepine derivatives |
BE794964A (fr) * | 1972-02-04 | 1973-08-02 | Bristol Myers Co | Nouveaux agents hypotenseurs et procede pour les preparer |
US3932407A (en) * | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
US3983119A (en) * | 1974-11-06 | 1976-09-28 | Bristol-Myers Company | Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
US3988340A (en) * | 1975-01-23 | 1976-10-26 | Bristol-Myers Company | 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones |
NL7807507A (nl) | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
-
1978
- 1978-07-12 NL NL7807507A patent/NL7807507A/xx not_active Application Discontinuation
- 1978-07-13 MC MC781312A patent/MC1199A1/xx unknown
- 1978-07-14 FI FI782248A patent/FI63409C/fi not_active IP Right Cessation
- 1978-07-18 AU AU38127/78A patent/AU519688B2/en not_active Expired
- 1978-07-19 FR FR7821396A patent/FR2398748A1/fr active Granted
- 1978-07-19 HU HU78HO2088A patent/HU177643B/hu unknown
- 1978-07-20 NZ NZ187921A patent/NZ187921A/xx unknown
- 1978-07-20 CA CA307,767A patent/CA1094555A/en not_active Expired
- 1978-07-20 IL IL55183A patent/IL55183A/xx unknown
- 1978-07-21 EP EP78100471A patent/EP0000718B1/de not_active Expired
- 1978-07-21 DE DE7878100471T patent/DE2861688D1/de not_active Expired
- 1978-07-21 DE DE19782832138 patent/DE2832138A1/de not_active Withdrawn
- 1978-07-21 PH PH21412A patent/PH14642A/en unknown
- 1978-07-24 SE SE7808111A patent/SE7808111L/xx unknown
- 1978-07-24 BR BR7804763A patent/BR7804763A/pt unknown
- 1978-07-24 CS CS784914A patent/CS203014B2/cs unknown
- 1978-07-24 IE IE1478/78A patent/IE47280B1/en unknown
- 1978-07-24 JP JP8953478A patent/JPS5441894A/ja active Pending
- 1978-07-24 GR GR56847A patent/GR72968B/el unknown
- 1978-07-24 PT PT68342A patent/PT68342A/pt unknown
- 1978-07-24 AT AT0535178A patent/AT363479B/de active
- 1978-07-24 GB GB787830868A patent/GB2001638B/en not_active Expired
- 1978-07-24 IT IT26019/78A patent/IT1097337B/it active
- 1978-07-24 DK DK328978A patent/DK144128C/da not_active IP Right Cessation
- 1978-07-24 ES ES471981A patent/ES471981A1/es not_active Expired
- 1978-07-24 NO NO782541A patent/NO150800C/no unknown
- 1978-07-25 YU YU01775/78A patent/YU177578A/xx unknown
- 1978-07-25 AR AR273064A patent/AR218500A1/es active
-
1979
- 1979-01-18 ES ES476955A patent/ES476955A1/es not_active Expired
- 1979-06-20 US US06/050,395 patent/US4256748A/en not_active Expired - Lifetime
-
1985
- 1985-12-30 MY MY249/85A patent/MY8500249A/xx unknown
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