NO150800C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser

Info

Publication number
NO150800C
NO150800C NO782541A NO782541A NO150800C NO 150800 C NO150800 C NO 150800C NO 782541 A NO782541 A NO 782541A NO 782541 A NO782541 A NO 782541A NO 150800 C NO150800 C NO 150800C
Authority
NO
Norway
Prior art keywords
preparation
therapeutic active
tricyclic compounds
analogy procedure
active tricyclic
Prior art date
Application number
NO782541A
Other languages
English (en)
Norwegian (no)
Other versions
NO782541L (no
NO150800B (no
Inventor
Madhukar Subraya Chodnekar
Ado Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO782541L publication Critical patent/NO782541L/no
Publication of NO150800B publication Critical patent/NO150800B/no
Publication of NO150800C publication Critical patent/NO150800C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO782541A 1977-07-25 1978-07-24 Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser NO150800C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
CH577678 1978-05-26

Publications (3)

Publication Number Publication Date
NO782541L NO782541L (no) 1979-01-26
NO150800B NO150800B (no) 1984-09-10
NO150800C true NO150800C (no) 1984-12-27

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
NO782541A NO150800C (no) 1977-07-25 1978-07-24 Analogifremgangsmaate ved fremstilling av terapeutisk aktive tricykliske forbindelser

Country Status (29)

Country Link
US (1) US4256748A (xx)
EP (1) EP0000718B1 (xx)
JP (1) JPS5441894A (xx)
AR (1) AR218500A1 (xx)
AT (1) AT363479B (xx)
AU (1) AU519688B2 (xx)
BR (1) BR7804763A (xx)
CA (1) CA1094555A (xx)
CS (1) CS203014B2 (xx)
DE (2) DE2861688D1 (xx)
DK (1) DK144128C (xx)
ES (2) ES471981A1 (xx)
FI (1) FI63409C (xx)
FR (1) FR2398748A1 (xx)
GB (1) GB2001638B (xx)
GR (1) GR72968B (xx)
HU (1) HU177643B (xx)
IE (1) IE47280B1 (xx)
IL (1) IL55183A (xx)
IT (1) IT1097337B (xx)
MC (1) MC1199A1 (xx)
MY (1) MY8500249A (xx)
NL (1) NL7807507A (xx)
NO (1) NO150800C (xx)
NZ (1) NZ187921A (xx)
PH (1) PH14642A (xx)
PT (1) PT68342A (xx)
SE (1) SE7808111L (xx)
YU (1) YU177578A (xx)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
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EP0029559A3 (en) * 1979-11-24 1981-09-30 Sandoz Ag 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (de) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung eines Imidazochinazolinonderivates
JPS57178234U (xx) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
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US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
HU193409B (en) * 1984-02-15 1987-10-28 Syntex Inc Process for producing 2-square bracket -n-cyclohexyl-4-bracket-oxo-1,2,3,5-tetrahydro-imidazo-square bracket-2,1-b-square bracket closed-quinazolin-7-yl-bracket closed-oxy-alkqne-carboxamidyl-square bracket closed-alkan-acides
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US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CA2113115A1 (en) * 1991-07-29 1993-02-18 Vlad E. Gregor Quinazoline derivatives as acetylcholinesterase inhibitors
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
EP1216037A2 (en) * 1999-09-21 2002-06-26 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
CA2513708C (en) * 2003-01-23 2011-01-04 Shire Holdings Ag Formulation and methods for the treatment of thrombocythemia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US7700608B2 (en) 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
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GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US9580471B2 (en) 2011-03-01 2017-02-28 Synergy Pharmaceuticals, Inc. Process of preparing guanylate cyclase C agonists
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
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Publication number Priority date Publication date Assignee Title
DE1445430A1 (de) 1962-10-26 1969-01-23 American Home Prod Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen
GB1037375A (en) 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
NO782541L (no) 1979-01-26
GB2001638B (en) 1982-02-10
ES476955A1 (es) 1979-10-16
IE781478L (en) 1979-01-25
IT1097337B (it) 1985-08-31
GR72968B (xx) 1984-01-20
DK144128B (da) 1981-12-14
IL55183A (en) 1981-11-30
FR2398748A1 (fr) 1979-02-23
YU177578A (en) 1983-01-21
ATA535178A (de) 1981-01-15
FR2398748B1 (xx) 1981-09-04
HU177643B (en) 1981-11-28
BR7804763A (pt) 1979-04-10
JPS5441894A (en) 1979-04-03
MY8500249A (en) 1985-12-31
EP0000718A2 (de) 1979-02-21
IE47280B1 (en) 1984-02-08
GB2001638A (en) 1979-02-07
IL55183A0 (en) 1978-09-29
EP0000718A3 (en) 1979-06-13
US4256748A (en) 1981-03-17
DE2832138A1 (de) 1979-02-08
ES471981A1 (es) 1979-10-16
DE2861688D1 (en) 1982-04-29
EP0000718B1 (de) 1982-03-24
NO150800B (no) 1984-09-10
AT363479B (de) 1981-08-10
AU3812778A (en) 1980-01-24
FI782248A (fi) 1979-01-26
IT7826019A0 (it) 1978-07-24
DK144128C (da) 1982-05-17
PH14642A (en) 1981-10-12
NL7807507A (nl) 1979-01-29
MC1199A1 (fr) 1979-03-19
CS203014B2 (en) 1981-02-27
NZ187921A (en) 1981-03-16
SE7808111L (sv) 1979-01-26
DK328978A (da) 1979-01-26
FI63409B (fi) 1983-02-28
AU519688B2 (en) 1981-12-17
FI63409C (fi) 1983-06-10
PT68342A (en) 1978-08-01
CA1094555A (en) 1981-01-27
AR218500A1 (es) 1980-06-13

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