DK144128C - Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner - Google Patents

Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Info

Publication number
DK144128C
DK144128C DK328978A DK328978A DK144128C DK 144128 C DK144128 C DK 144128C DK 328978 A DK328978 A DK 328978A DK 328978 A DK328978 A DK 328978A DK 144128 C DK144128 C DK 144128C
Authority
DK
Denmark
Prior art keywords
oner
quinazolin
analogy procedure
preparing imidazo
imidazo
Prior art date
Application number
DK328978A
Other languages
English (en)
Other versions
DK328978A (da
DK144128B (da
Inventor
M S Chodnekar
A Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK328978A publication Critical patent/DK328978A/da
Publication of DK144128B publication Critical patent/DK144128B/da
Application granted granted Critical
Publication of DK144128C publication Critical patent/DK144128C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK328978A 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner DK144128C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
LU77829 1977-07-25
CH577678 1978-05-26
CH577678 1978-05-26

Publications (3)

Publication Number Publication Date
DK328978A DK328978A (da) 1979-01-26
DK144128B DK144128B (da) 1981-12-14
DK144128C true DK144128C (da) 1982-05-17

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328978A DK144128C (da) 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Country Status (29)

Country Link
US (1) US4256748A (da)
EP (1) EP0000718B1 (da)
JP (1) JPS5441894A (da)
AR (1) AR218500A1 (da)
AT (1) AT363479B (da)
AU (1) AU519688B2 (da)
BR (1) BR7804763A (da)
CA (1) CA1094555A (da)
CS (1) CS203014B2 (da)
DE (2) DE2861688D1 (da)
DK (1) DK144128C (da)
ES (2) ES471981A1 (da)
FI (1) FI63409C (da)
FR (1) FR2398748A1 (da)
GB (1) GB2001638B (da)
GR (1) GR72968B (da)
HU (1) HU177643B (da)
IE (1) IE47280B1 (da)
IL (1) IL55183A (da)
IT (1) IT1097337B (da)
MC (1) MC1199A1 (da)
MY (1) MY8500249A (da)
NL (1) NL7807507A (da)
NO (1) NO150800C (da)
NZ (1) NZ187921A (da)
PH (1) PH14642A (da)
PT (1) PT68342A (da)
SE (1) SE7808111L (da)
YU (1) YU177578A (da)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
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EP0029559A3 (en) * 1979-11-24 1981-09-30 Sandoz Ag 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
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JPS57178234U (da) * 1981-05-06 1982-11-11
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US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
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JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
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CZ281628B6 (cs) * 1991-07-29 1996-11-13 Warner-Lambert Company Deriváty chinazolinu a farmaceutické přípravky na jejich bázi
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
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US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
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GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
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EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
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GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
PT3004138T (pt) 2013-06-05 2024-06-18 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
AU2014305843B2 (en) 2013-08-09 2019-08-29 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
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DE1445430A1 (de) 1962-10-26 1969-01-23 American Home Prod Verfahren zur Herstellung von 3-Acyloxy-1,3-dihydro-2 H-1-benzodiazepin-2-onen
GB1037375A (en) * 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
BE794964A (fr) 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
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NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
AU3812778A (en) 1980-01-24
GR72968B (da) 1984-01-20
US4256748A (en) 1981-03-17
DK328978A (da) 1979-01-26
FI63409C (fi) 1983-06-10
DE2861688D1 (en) 1982-04-29
NO150800B (no) 1984-09-10
FI63409B (fi) 1983-02-28
DE2832138A1 (de) 1979-02-08
FI782248A (fi) 1979-01-26
EP0000718B1 (de) 1982-03-24
MC1199A1 (fr) 1979-03-19
ES471981A1 (es) 1979-10-16
PT68342A (en) 1978-08-01
NZ187921A (en) 1981-03-16
SE7808111L (sv) 1979-01-26
ATA535178A (de) 1981-01-15
JPS5441894A (en) 1979-04-03
YU177578A (en) 1983-01-21
CS203014B2 (en) 1981-02-27
AR218500A1 (es) 1980-06-13
IT1097337B (it) 1985-08-31
EP0000718A2 (de) 1979-02-21
MY8500249A (en) 1985-12-31
DK144128B (da) 1981-12-14
IL55183A0 (en) 1978-09-29
NO782541L (no) 1979-01-26
NO150800C (no) 1984-12-27
CA1094555A (en) 1981-01-27
BR7804763A (pt) 1979-04-10
IL55183A (en) 1981-11-30
FR2398748A1 (fr) 1979-02-23
EP0000718A3 (en) 1979-06-13
IE47280B1 (en) 1984-02-08
IE781478L (en) 1979-01-25
PH14642A (en) 1981-10-12
IT7826019A0 (it) 1978-07-24
FR2398748B1 (da) 1981-09-04
AT363479B (de) 1981-08-10
HU177643B (en) 1981-11-28
NL7807507A (nl) 1979-01-29
GB2001638A (en) 1979-02-07
GB2001638B (en) 1982-02-10
ES476955A1 (es) 1979-10-16
AU519688B2 (en) 1981-12-17

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