DK149749C - Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater - Google Patents

Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater

Info

Publication number
DK149749C
DK149749C DK269178A DK269178A DK149749C DK 149749 C DK149749 C DK 149749C DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A DK 149749 C DK149749 C DK 149749C
Authority
DK
Denmark
Prior art keywords
ingrediates
piperide
trihydroxy
hydroxy
alkyl
Prior art date
Application number
DK269178A
Other languages
English (en)
Other versions
DK269178A (da
DK149749B (da
Inventor
Hiromu Murai
Hiroshi Enomoto
Yoshiaki Aoyagi
Yoshiaki Yoshikuni
Masahiro Yagi
Ichiro Shirahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK269178A publication Critical patent/DK269178A/da
Publication of DK149749B publication Critical patent/DK149749B/da
Application granted granted Critical
Publication of DK149749C publication Critical patent/DK149749C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK269178A 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater DK149749C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7593677 1977-06-25
JP52075936A JPS5943459B2 (ja) 1977-06-25 1977-06-25 N−アルキルピペリジン誘導体

Publications (3)

Publication Number Publication Date
DK269178A DK269178A (da) 1978-12-26
DK149749B DK149749B (da) 1986-09-22
DK149749C true DK149749C (da) 1987-03-02

Family

ID=13590624

Family Applications (1)

Application Number Title Priority Date Filing Date
DK269178A DK149749C (da) 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater

Country Status (12)

Country Link
US (1) US4182767A (da)
JP (1) JPS5943459B2 (da)
AT (1) AT365576B (da)
BE (1) BE868329A (da)
CH (1) CH633264A5 (da)
DE (1) DE2824781C3 (da)
DK (1) DK149749C (da)
FR (1) FR2420529A1 (da)
GB (1) GB1555654A (da)
IT (1) IT1104743B (da)
NL (1) NL176071C (da)
SE (1) SE430333B (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2835069A1 (de) * 1978-08-10 1980-02-21 Bayer Ag N-amino-3,4,5-trihydroxypiperidine, ihre herstellung und verwendung
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus
US5089520A (en) * 1987-12-21 1992-02-18 Monsanto Company Method of inhibiting virus
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
US5043416A (en) * 1988-09-26 1991-08-27 Monsanto Company Method of inhibiting virus
US5144037A (en) * 1988-11-03 1992-09-01 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-d-glucitol derivatives
US5221746A (en) * 1988-11-03 1993-06-22 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4973602A (en) * 1988-11-03 1990-11-27 G. D. Searle & Co. Antiviral compounds and a method of use thereas
US5310745A (en) * 1988-11-03 1994-05-10 G. D. Searle & Co. Antiviral compounds
US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4876268A (en) * 1988-11-03 1989-10-24 G. D. Searle & Co. Antiviral compounds and use thereof
US4937357A (en) * 1988-11-03 1990-06-26 G. D. Searle & Co. Intermediates for antiviral compounds
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
US5103008A (en) * 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
EP0453692A1 (en) * 1990-04-27 1991-10-30 Merrell Dow Pharmaceuticals Inc. Novel nojirimycin derivatives
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US6291657B1 (en) * 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
DK0739205T3 (da) * 1994-01-13 2000-05-01 Searle & Co Anvendelse af N-alkylderivater af 1,5-didesoxy-1,5-imino-D-glucitol til behandling af hepatitis-B-virusinfektioner
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
WO1999024401A1 (en) 1997-11-10 1999-05-20 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ATE331515T1 (de) 1998-02-12 2006-07-15 Searle Llc Verwendung von n-substituirten-1,5-dideoxy-1,5- imino-d-glucitolen zur behandlung von hepatitis infektionen
ATE402701T1 (de) * 1999-02-12 2008-08-15 United Therapeutics Corp N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino- - glucitol zur behandlung von hepatitis-virus- infektionen
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
US20050032841A1 (en) * 1999-04-20 2005-02-10 Steven Walkley Therapeutic compositions and methods of treating glycolipid storage related disorders
GB9909066D0 (en) 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
UA82698C2 (uk) * 2003-05-30 2008-05-12 Ранбакси Лабораториз Лимитед Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co
US8003617B2 (en) * 2004-11-10 2011-08-23 Genzyme Corporation Methods of treating diabetes mellitus
WO2007054896A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
SI2032134T1 (sl) 2006-05-09 2015-10-30 Genzyme Corporation Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida
AR063469A1 (es) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
US20080131398A1 (en) * 2006-08-21 2008-06-05 United Therapeutics Corporation Combination therapy for treatment of viral infections
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594564B1 (en) * 2007-05-31 2016-09-28 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
MX337396B (es) 2007-10-05 2016-03-02 Genzyme Corp Metodo para el tratamiento de enfermedades del riñon poliquisticas con derivados de ceramica.
US8389517B2 (en) 2008-07-28 2013-03-05 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
CN107935983A (zh) 2008-10-03 2018-04-20 简詹姆公司 2‑酰胺基丙醇型葡糖神经酰胺合酶抑制剂
EP2398321B1 (en) * 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
EP2400843B1 (en) * 2009-02-24 2015-11-11 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
ES2524361T3 (es) 2009-06-12 2014-12-05 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
CN102625801B (zh) * 2009-09-04 2015-09-09 联合治疗公司 治疗痘病毒感染的方法
CN105748476A (zh) * 2009-09-04 2016-07-13 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
WO2011028775A1 (en) * 2009-09-04 2011-03-10 United Therapeutics Corporation Methods of treating orthomyxoviral infections
WO2017192599A1 (en) 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
US11369592B2 (en) 2020-02-21 2022-06-28 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
DE2656602C3 (de) * 1975-12-29 1981-11-26 Nippon Shinyaku Co., Ltd., Kyoto Verfahren zum Extrahieren von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin aus Maulbeerpflanzen

Also Published As

Publication number Publication date
SE430333B (sv) 1983-11-07
AT365576B (de) 1982-01-25
US4182767A (en) 1980-01-08
IT1104743B (it) 1985-10-28
NL7805253A (nl) 1978-12-28
FR2420529A1 (fr) 1979-10-19
GB1555654A (en) 1979-11-14
DK269178A (da) 1978-12-26
SE7805329L (sv) 1978-12-26
CH633264A5 (de) 1982-11-30
ATA451778A (de) 1981-06-15
JPS5412381A (en) 1979-01-30
NL176071B (nl) 1984-09-17
DK149749B (da) 1986-09-22
FR2420529B1 (da) 1984-10-12
IT7849760A0 (it) 1978-06-07
DE2824781C3 (de) 1980-09-18
DE2824781A1 (de) 1979-01-04
BE868329A (fr) 1978-10-16
JPS5943459B2 (ja) 1984-10-22
DE2824781B2 (da) 1980-01-31
NL176071C (nl) 1985-02-18

Similar Documents

Publication Publication Date Title
DK149749C (da) Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater
DK153552C (da) Analogifremgangsmaade til fremstilling af 1,8-naphthyridinderivater
DK13878A (da) Fremgangsmaade til fremstilling af 11beta-substituerede 4,9-diensteroider
DK155733C (da) Fremgangsmaade til fremstilling af 4-hydroxy-2-oxo-pyrrolidinderivater
DK349478A (da) Fremgangsmaade til fremstilling af oligoimider
DK155603C (da) Analogifremgangsmaade til fremstilling af benzimidazolderivater
DK155279C (da) Fremgangsmaade til fremstilling af 4-hydroxy-2-oxo-pyrrolidinderivater
DK153844C (da) Analogifremgangsmaade til fremstilling af 1,2,3,5-tetrahydroimidazothienopyrimidin-2-oner
DK13978A (da) Fremgangsmaade til fremstilling af 11betasubstituerede 1,3,5(,0)-triensteroider
DK465578A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner
DK483378A (da) Fremgangsmaade til fremstilling af 2,4-difluoranilin
DK156635C (da) Analogifremgangsmaade til fremstilling af 24,24-difluor-25-hydroxycholecalciferol
DK134978A (da) Fremgangsmaade til fremstilling af 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-oner
DK301277A (da) Fremgangsmade til fremstilling af substituerede 2,6-methano-2h-1-benzoxociner
DK67978A (da) Fremgangsmaade til fremstilling af 1,3,5-triazin2,6-dioner
DK142848C (da) Analogifremgangsmaade til fremstilling af 2-acylamido-4-amino-5-benzylpyrimidinforbindelser
DK548478A (da) Fremgangsmaade til fremstilling af 2,4,5-trichlorphenol
DK150299C (da) Analogifremgangsmaade til fremstilling af 8-aminoalkyl-tetracyclo(4,3,0,02,4,03,7)nonanderivater
DK153838C (da) Analogifremgangsmaade til fremstilling af 2,4-dichlor-alfa-(n-imidazolylmethyl)-dibenzylethere
DK73077A (da) Fremgangsmade til fremstilling af 2,9-dioxatricyclo (4,3,1,03,7) decaner
DK385478A (da) Fremgangsmaade til fremstilling af dibenzocycloocteniminer
DK147406C (da) Analogifremgangsmaade til fremstilling af 7alfa-acylthio-17beta-hydroxy-4-androsten-3-oner
DK146624C (da) Analogifremgangsmaade til fremstilling af 1-aminoalkyl-3,4-diphenyl-1h-pyrazoler
DK144418C (da) Analogifremgangsmaade til fremstilling af 2,4-diamino-5-benzylpyrimidiner
DK280376A (da) Fremgangsmade til fremstilling af 1-acyl-1,2,3,4-tetrahydro-6-quinoliner

Legal Events

Date Code Title Description
PBP Patent lapsed