DK269178A - Analogifremgangsmaade til fremstilling af n-alkylpiperidinderivater - Google Patents

Analogifremgangsmaade til fremstilling af n-alkylpiperidinderivater

Info

Publication number
DK269178A
DK269178A DK269178A DK269178A DK269178A DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A DK 269178 A DK269178 A DK 269178A
Authority
DK
Denmark
Prior art keywords
alkylpiperide
derivatives
preparing
analogical procedure
analogical
Prior art date
Application number
DK269178A
Other languages
English (en)
Other versions
DK149749B (da
DK149749C (da
Inventor
H Murai
H Enomoto
Y Aoygai
Y Yoshikuni
M Yagi
I Shitahase
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK269178A publication Critical patent/DK269178A/da
Publication of DK149749B publication Critical patent/DK149749B/da
Application granted granted Critical
Publication of DK149749C publication Critical patent/DK149749C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK269178A 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater DK149749C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7593677 1977-06-25
JP52075936A JPS5943459B2 (ja) 1977-06-25 1977-06-25 Ｎ−アルキルピペリジン誘導体

Publications (3)

Publication Number Publication Date
DK269178A true DK269178A (da) 1978-12-26
DK149749B DK149749B (da) 1986-09-22
DK149749C DK149749C (da) 1987-03-02

Family

ID=13590624

Family Applications (1)

Application Number Title Priority Date Filing Date
DK269178A DK149749C (da) 1977-06-25 1978-06-15 Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater

Country Status (12)

Country Link
US (1) US4182767A (da)
JP (1) JPS5943459B2 (da)
AT (1) AT365576B (da)
BE (1) BE868329A (da)
CH (1) CH633264A5 (da)
DE (1) DE2824781C3 (da)
DK (1) DK149749C (da)
FR (1) FR2420529A1 (da)
GB (1) GB1555654A (da)
IT (1) IT1104743B (da)
NL (1) NL176071C (da)
SE (1) SE430333B (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2835069A1 (de) * 1978-08-10 1980-02-21 Bayer Ag N-amino-3,4,5-trihydroxypiperidine, ihre herstellung und verwendung
DE2839309A1 (de) * 1978-09-09 1980-03-27 Bayer Ag 3,4,5-trihydroxypiperidin-derivate
DE2848117A1 (de) * 1978-11-06 1980-05-14 Bayer Ag Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
JPS55118415A (en) * 1979-02-28 1980-09-11 Pii Papahadojiyopo Dometoriosu Method of encapsulating biologically active substance in lipoid cell
DE2925943A1 (de) * 1979-06-27 1981-01-29 Bayer Ag 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2942365A1 (de) * 1979-10-19 1981-05-14 Bayer Ag, 5090 Leverkusen 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
JPS56108768A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Cinnamylmoranoline derivative
DE3007078A1 (de) * 1980-02-26 1981-09-10 Bayer Ag, 5090 Leverkusen Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
DE3620645A1 (de) * 1985-12-20 1987-07-02 Bayer Ag 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung
US5192772A (en) * 1987-12-09 1993-03-09 Nippon Shinyaku Co. Ltd. Therapeutic agents
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
US5089520A (en) * 1987-12-21 1992-02-18 Monsanto Company Method of inhibiting virus
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
US5043416A (en) * 1988-09-26 1991-08-27 Monsanto Company Method of inhibiting virus
US5003072A (en) * 1988-11-03 1991-03-26 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US5310745A (en) * 1988-11-03 1994-05-10 G. D. Searle & Co. Antiviral compounds
US4973602A (en) * 1988-11-03 1990-11-27 G. D. Searle & Co. Antiviral compounds and a method of use thereas
US5144037A (en) * 1988-11-03 1992-09-01 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-d-glucitol derivatives
US4876268A (en) * 1988-11-03 1989-10-24 G. D. Searle & Co. Antiviral compounds and use thereof
US4937357A (en) * 1988-11-03 1990-06-26 G. D. Searle & Co. Intermediates for antiviral compounds
US5221746A (en) * 1988-11-03 1993-06-22 G. D. Searle & Co. 1,5-dideoxy-1,5-imino-D-glucitol derivatives
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5103008A (en) * 1989-08-17 1992-04-07 Monsanto Company Compound, N-butyl-deoxynojirimycin-6-phosphate
US5043273A (en) * 1989-08-17 1991-08-27 Monsanto Company Phosphorylated glycosidase inhibitor prodrugs
EP0453692A1 (en) * 1990-04-27 1991-10-30 Merrell Dow Pharmaceuticals Inc. Novel nojirimycin derivatives
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5151519A (en) * 1990-05-07 1992-09-29 G. D. Searle & Co. Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5342951A (en) * 1992-04-01 1994-08-30 G.D. Searle & Co. 2- and 3-sulfur derivatives of 1,5-iminosugars
US5399567A (en) * 1993-05-13 1995-03-21 Monsanto Company Method of treating cholera
US6291657B1 (en) 1993-05-13 2001-09-18 Monsanto Company Deoxygalactonojirimycin derivatives
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
DE69421828T2 (de) * 1994-01-13 2000-04-20 Searle & Co Verwendung von 1,5-dideoxy-1,5-imino-d-glucitol n-alkylderivaten zur behandlung von hepatitis b infektionen
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
EP1030839B1 (en) 1997-11-10 2004-02-04 G.D. SEARLE & CO. Use of alkylated iminosugars to treat multidrug resistance
CA2319713C (en) 1998-02-12 2012-06-26 G.D. Searle & Co. Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
ES2311921T3 (es) * 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
AU3858600A (en) 1999-02-12 2001-02-19 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
GB9909066D0 (en) 1999-04-20 1999-06-16 Oxford Glycosciences Uk Ltd Therapies
US20050032841A1 (en) * 1999-04-20 2005-02-10 Steven Walkley Therapeutic compositions and methods of treating glycolipid storage related disorders
OA13174A (en) * 2003-05-30 2006-12-13 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as HMG-Co inhibitors.
CA2586761A1 (en) * 2004-11-10 2006-05-18 Genzyme Corporation Methods of treating diabetes mellitus
CA2627599A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
WO2008020314A2 (en) * 2006-03-14 2008-02-21 Ranbaxy Laboratories Limited Statin stabilizing dosage formulations
EP2032134B1 (en) 2006-05-09 2015-06-24 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
JP2009543773A (ja) * 2006-07-14 2009-12-10 ランバクシー ラボラトリーズ リミテッド ＨＭＧ−ＣｏＡレダクターゼ阻害剤の多形体及びその使用
EP2054076A2 (en) * 2006-08-21 2009-05-06 United Therapeutics Corporation Combination therapy for treatment of viral infections
US8097728B2 (en) * 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
EP2594565B1 (en) 2007-05-31 2018-10-24 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
KR20150085139A (ko) 2007-10-05 2015-07-22 젠자임 코포레이션 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법
EP2320886B1 (en) 2008-07-28 2017-06-28 Genzyme Corporation Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
WO2010039256A1 (en) 2008-10-03 2010-04-08 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
JP5600329B2 (ja) 2009-02-23 2014-10-01 ユナイテッド セラピューティクス コーポレーション イミノ糖およびウイルス性疾患を治療する方法
CA2753194A1 (en) * 2009-02-24 2010-09-02 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
US8426445B2 (en) * 2009-06-12 2013-04-23 United Therapeutics Corporation Iminosugars and methods of treating bunyaviral and togaviral diseases
CN105748476A (zh) * 2009-09-04 2016-07-13 联合治疗公司 亚氨基糖以及治疗丝状病毒性疾病的方法
KR101459530B1 (ko) * 2009-09-04 2014-11-07 유나이티드 세러퓨틱스 코오포레이션 폭스바이러스 감염의 치료 방법
ES2466027T3 (es) * 2009-09-04 2014-06-09 United Therapeutics Corporation Procedimiento para el tratamiento de infecciones por ortomixovirus
WO2017192599A1 (en) 2016-05-02 2017-11-09 Florida State University Research Foundation, Inc. Treatment of zika virus infections using alpha-glucosidase inhibitors
WO2021168483A2 (en) 2020-02-21 2021-08-26 Florida State University Research Foundation, Inc. Treatment of human coronavirus infections using alpha-glucosidase glycoprotein processing inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2660486C2 (de) * 1975-12-29 1984-03-08 Nippon Shinyaku Co., Ltd., Kyoto Verwendung von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin als Arzneimittel
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels

Also Published As

Publication number Publication date
IT7849760A0 (it) 1978-06-07
GB1555654A (en) 1979-11-14
FR2420529B1 (da) 1984-10-12
BE868329A (fr) 1978-10-16
JPS5412381A (en) 1979-01-30
NL176071C (nl) 1985-02-18
NL176071B (nl) 1984-09-17
CH633264A5 (de) 1982-11-30
DE2824781C3 (de) 1980-09-18
DE2824781A1 (de) 1979-01-04
NL7805253A (nl) 1978-12-28
DE2824781B2 (da) 1980-01-31
FR2420529A1 (fr) 1979-10-19
DK149749B (da) 1986-09-22
IT1104743B (it) 1985-10-28
AT365576B (de) 1982-01-25
JPS5943459B2 (ja) 1984-10-22
DK149749C (da) 1987-03-02
ATA451778A (de) 1981-06-15
SE7805329L (sv) 1978-12-26
SE430333B (sv) 1983-11-07
US4182767A (en) 1980-01-08

Similar Documents

Publication Publication Date Title
DK269178A (da) Analogifremgangsmaade til fremstilling af n-alkylpiperidinderivater
DK155733C (da) Fremgangsmaade til fremstilling af 4-hydroxy-2-oxo-pyrrolidinderivater
DK363179A (da) Fremgangsmaade til fremstilling af tetrazolylalkoxycarbostyrilderivater
DK457779A (da) Fremgangsmaade til fremstilling af 4-hydroxy-2-pyronderivater
DK349478A (da) Fremgangsmaade til fremstilling af oligoimider
DK494876A (da) Fremgangsmade til fremstilling af piperidinderivater
DK452178A (da) R fremgangsmaade til fremstilling af phenylethanolamin-derivate
DK539578A (da) Fremgangsmaade til fremstilling af pleuromutilinglycsid-derivater
DK155603C (da) Analogifremgangsmaade til fremstilling af benzimidazolderivater
DK155279C (da) Fremgangsmaade til fremstilling af 4-hydroxy-2-oxo-pyrrolidinderivater
DK531178A (da) Fremgangsmaade til fremstilling af phenylglycinderivater
DK562376A (da) Fremgangsmade til fremstilling af ergolinderivater
DK462376A (da) Fremgangsmade til fremstilling af 5-halogenpyrimidinderivater
DK581178A (da) Fremgangsmaade til fremstilling af peptidderivater
DK117677A (da) Fremgangsmade til fremstilling af piperidinderivater
DK138879A (da) Fremgangsmaade til fremstilling af lysergolderivater
DK470978A (da) R fremgangsmaade til fremstilling af pyrazinobenzoxapinderivate
DK329577A (da) Fremgangsmade til fremstilling af derivater af phenoxyhydroxypropylamin
DK152130C (da) Fremgangsmaade til fremstilling af benzooebaathienopyridinderivater
DK494978A (da) Fremgangsmaade til fremstilling af 2-iminoimidazolidinderivater
DK262678A (da) Fremgangsmaade til fremstilling af quinolinonderivater
DK547978A (da) Fremgangsmaade til fremstilling af pyrrolidinderivater
DK520178A (da) Fremgangsmaade til fremstilling af phenoxyalkanolamin-derivater
DK878A (da) Fremgangsmaade til fremstilling af chromonderivater
DK385478A (da) Fremgangsmaade til fremstilling af dibenzocycloocteniminer

Legal Events

Date Code Title Description
PBP Patent lapsed