DK144128C - Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner - Google Patents

Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Info

Publication number
DK144128C
DK144128C DK328978A DK328978A DK144128C DK 144128 C DK144128 C DK 144128C DK 328978 A DK328978 A DK 328978A DK 328978 A DK328978 A DK 328978A DK 144128 C DK144128 C DK 144128C
Authority
DK
Denmark
Prior art keywords
oner
quinazolin
analogy procedure
preparing imidazo
imidazo
Prior art date
Application number
DK328978A
Other languages
Danish (da)
English (en)
Other versions
DK144128B (da
DK328978A (da
Inventor
M S Chodnekar
A Kaiser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK328978A publication Critical patent/DK328978A/da
Publication of DK144128B publication Critical patent/DK144128B/da
Application granted granted Critical
Publication of DK144128C publication Critical patent/DK144128C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
DK328978A 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner DK144128C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
LU77829 1977-07-25
LU77829 1977-07-25
CH577678 1978-05-26
CH577678 1978-05-26

Publications (3)

Publication Number Publication Date
DK328978A DK328978A (da) 1979-01-26
DK144128B DK144128B (da) 1981-12-14
DK144128C true DK144128C (da) 1982-05-17

Family

ID=25698353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK328978A DK144128C (da) 1977-07-25 1978-07-24 Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner

Country Status (29)

Country Link
US (1) US4256748A (xx)
EP (1) EP0000718B1 (xx)
JP (1) JPS5441894A (xx)
AR (1) AR218500A1 (xx)
AT (1) AT363479B (xx)
AU (1) AU519688B2 (xx)
BR (1) BR7804763A (xx)
CA (1) CA1094555A (xx)
CS (1) CS203014B2 (xx)
DE (2) DE2861688D1 (xx)
DK (1) DK144128C (xx)
ES (2) ES471981A1 (xx)
FI (1) FI63409C (xx)
FR (1) FR2398748A1 (xx)
GB (1) GB2001638B (xx)
GR (1) GR72968B (xx)
HU (1) HU177643B (xx)
IE (1) IE47280B1 (xx)
IL (1) IL55183A (xx)
IT (1) IT1097337B (xx)
MC (1) MC1199A1 (xx)
MY (1) MY8500249A (xx)
NL (1) NL7807507A (xx)
NO (1) NO150800C (xx)
NZ (1) NZ187921A (xx)
PH (1) PH14642A (xx)
PT (1) PT68342A (xx)
SE (1) SE7808111L (xx)
YU (1) YU177578A (xx)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
CA1131631A (en) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
EP0029559A3 (en) * 1979-11-24 1981-09-30 Sandoz Ag 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
US4444768A (en) * 1980-03-04 1984-04-24 Ciba-Geigy Corporation Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
EP0054180A3 (de) * 1980-12-16 1982-12-01 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung eines Imidazochinazolinonderivates
JPS57178234U (xx) * 1981-05-06 1982-11-11
US4455311A (en) * 1981-08-28 1984-06-19 Hoffmann-La Roche Inc. Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4551459A (en) * 1983-02-16 1985-11-05 Syntex (U.S.A.) Inc. Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
JPS604186A (ja) * 1983-06-21 1985-01-10 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン化合物
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
HU191316B (en) * 1984-02-15 1987-02-27 Syntex Usa Inc.,Us Process for producing (2-oxo-1,2,3,5-tetrahydro-imidazo /2,1-b/ quinazoline)-oxy-lakyl-amides and pharmacutical compositions containing them
GB8514207D0 (en) * 1985-06-05 1985-07-10 Pfizer Ltd Cardiac stimulants
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US5043327A (en) * 1989-07-18 1991-08-27 Janssen Pharmaceutica N.V. Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
CA2113115A1 (en) * 1991-07-29 1993-02-18 Vlad E. Gregor Quinazoline derivatives as acetylcholinesterase inhibitors
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
JPH06167328A (ja) * 1992-05-26 1994-06-14 Mayekawa Mfg Co Ltd 氷厚測定装置
AU7604400A (en) * 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
US6388073B1 (en) * 2000-07-26 2002-05-14 Shire Us Inc. Method for the manufacture of anagrelide
US20040209907A1 (en) * 2003-01-23 2004-10-21 Richard Franklin Formulation and methods for the treatment of thrombocythemia
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors
US8383637B2 (en) 2004-08-06 2013-02-26 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8426429B2 (en) 2004-08-06 2013-04-23 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en) * 2004-08-06 2013-05-07 Jansssen Pharmaceutica N.V. 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US7910597B2 (en) 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
GB0808953D0 (en) * 2008-05-16 2008-06-25 Shire Llc substituted quinazolines
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808952D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808951D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808967D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808948D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
GB0808950D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0810005D0 (en) * 2008-06-02 2008-07-09 Shire Llc Substituted quinazolines
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
GB0822970D0 (en) 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201004491D0 (en) 2010-03-18 2010-05-05 Shire Llc Quinazoline analogues
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (en) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylate cyclase c agonists
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CN105979959B (zh) 2013-08-09 2021-11-30 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
JP5935843B2 (ja) * 2014-08-08 2016-06-15 Ｊｆｅスチール株式会社 スポット溶接性に優れた冷延鋼板およびその製造方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
EP4201403A1 (en) 2021-12-21 2023-06-28 Som Innovation Biotech, S.L. Compounds tirapazamine and quazinone for use in the treatment of gm2 gangliosidoses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645917A1 (de) 1962-10-26 1970-09-24 American Home Prod Verfahren zur Herstellung von 5-Aryl-3-acyloxy-1,2-dihydro-3H-1,4-benzodiazepin-2-onen
GB1037375A (en) * 1964-08-07 1966-07-27 Hoffmann La Roche A process for the manufacture of benzodiazepine derivatives
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US3988340A (en) * 1975-01-23 1976-10-26 Bristol-Myers Company 6-Alkoxymethyl-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones and 7-alkoxymethyl-6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.

Also Published As

Publication number Publication date
BR7804763A (pt) 1979-04-10
NO150800C (no) 1984-12-27
AR218500A1 (es) 1980-06-13
YU177578A (en) 1983-01-21
NO150800B (no) 1984-09-10
PH14642A (en) 1981-10-12
IT1097337B (it) 1985-08-31
FI63409C (fi) 1983-06-10
GB2001638A (en) 1979-02-07
NO782541L (no) 1979-01-26
AU3812778A (en) 1980-01-24
GR72968B (xx) 1984-01-20
MC1199A1 (fr) 1979-03-19
DK144128B (da) 1981-12-14
ES471981A1 (es) 1979-10-16
MY8500249A (en) 1985-12-31
US4256748A (en) 1981-03-17
EP0000718A3 (en) 1979-06-13
FI782248A (fi) 1979-01-26
FR2398748A1 (fr) 1979-02-23
IT7826019A0 (it) 1978-07-24
DE2832138A1 (de) 1979-02-08
GB2001638B (en) 1982-02-10
DE2861688D1 (en) 1982-04-29
CS203014B2 (en) 1981-02-27
EP0000718B1 (de) 1982-03-24
IL55183A (en) 1981-11-30
IL55183A0 (en) 1978-09-29
FI63409B (fi) 1983-02-28
ATA535178A (de) 1981-01-15
JPS5441894A (en) 1979-04-03
IE781478L (en) 1979-01-25
SE7808111L (sv) 1979-01-26
HU177643B (en) 1981-11-28
NL7807507A (nl) 1979-01-29
IE47280B1 (en) 1984-02-08
ES476955A1 (es) 1979-10-16
FR2398748B1 (xx) 1981-09-04
AT363479B (de) 1981-08-10
AU519688B2 (en) 1981-12-17
CA1094555A (en) 1981-01-27
EP0000718A2 (de) 1979-02-21
PT68342A (en) 1978-08-01
NZ187921A (en) 1981-03-16
DK328978A (da) 1979-01-26

Similar Documents

Publication Publication Date Title
DK144128C (da) Analogifremgangsmaade til fremstilling af imidazo(2,1-b)quinazolin-2-oner
DK149749C (da) Analogifremgangsmaade til fremstilling af n-alkyl-2-hydroxy-metyl-3,4,5-trihydroxy-piperidinderivater
DK13878A (da) Fremgangsmaade til fremstilling af 11beta-substituerede 4,9-diensteroider
DK195378A (da) Fremgangsmaade til fremstilling af polyenforbindelser
DK144702C (da) Analogifremgangsmaade til fremstilling af 2,3-dihydro-imidazo(2,1-b)-thiazolderivater
DK467377A (da) Fremgangsmaade til fremstilling af 1,4,3,6-dianhydro-d-glucitol-2-nitrat.
DK364178A (da) Fremgangsmaade til fremstilling af antibiotikum
DK118277A (da) Fremgangsmade til fremstilling af n-5-tetrazololyl)-4-oxo-4h-pyrimido (2,1-b)benzothiazol-3-carboxamider
DK305578A (da) Fremgangsmaade til fremstilling af bicycliske thia-diaza-forbindelser isaer 1,3-diaza-cyclopent-2-eno(2,1-b) (1-thia-3-aza-cycloalkaner).
DK13978A (da) Fremgangsmaade til fremstilling af 11betasubstituerede 1,3,5(,0)-triensteroider
DK148538C (da) Analogifremgangsmaade til fremstilling af 2,3-substituerede 4-pyroner
DK465578A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner
DK483378A (da) Fremgangsmaade til fremstilling af 2,4-difluoranilin
DK134978A (da) Fremgangsmaade til fremstilling af 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-oner
DK156635C (da) Analogifremgangsmaade til fremstilling af 24,24-difluor-25-hydroxycholecalciferol
DK200280A (da) Fremgangsmaade til fremstilling af substituerede pyrido (1,2-a) pyrimidiner
DK185977A (da) Fremgangsmade til fremstilling af 1,3-dihydroheteroarylspiro (isobenzofuraner)
DK67978A (da) Fremgangsmaade til fremstilling af 1,3,5-triazin2,6-dioner
DK548478A (da) Fremgangsmaade til fremstilling af 2,4,5-trichlorphenol
DK142848C (da) Analogifremgangsmaade til fremstilling af 2-acylamido-4-amino-5-benzylpyrimidinforbindelser
DK150299C (da) Analogifremgangsmaade til fremstilling af 8-aminoalkyl-tetracyclo(4,3,0,02,4,03,7)nonanderivater
DK140758B (da) Analogifremgangsmåde til fremstilling af quinoxalin-2-carboxaldehyd-sulfonylhydrazoner.
DK73077A (da) Fremgangsmade til fremstilling af 2,9-dioxatricyclo (4,3,1,03,7) decaner
DK269478A (da) Fremgangsmaade til fremstilling af imidazo(1,2-a) pyridinforbindelser
DK328478A (da) Fremgangsmaade til fremstilling af pyrrolo (2,1-b) (3) benzazepiner

Legal Events

Date Code Title Description
PBP Patent lapsed