FI59103B - Mellanprodukter till anvaendning vid framstaellning av alfa-aminopenicillinestrar - Google Patents
Mellanprodukter till anvaendning vid framstaellning av alfa-aminopenicillinestrar Download PDFInfo
- Publication number
- FI59103B FI59103B FI791386A FI791386A FI59103B FI 59103 B FI59103 B FI 59103B FI 791386 A FI791386 A FI 791386A FI 791386 A FI791386 A FI 791386A FI 59103 B FI59103 B FI 59103B
- Authority
- FI
- Finland
- Prior art keywords
- penicillanate
- ester
- tai
- sodium
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (4)
- 43 591 03
- 1. Välituote a-amincpenisilliiniestereiden ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi, joilla on kaava /s\ /CH3 R - CH - CO - NH - CH - CH C I I I Pch3 , NH2 0=C — N -CH - COO - R jossa R on 2-7 hiiliatomia sisältävä alkyyli tai fenyyliryhmä, joka voi olla substituoitu halogeenilla, kuten kloorilla tai fluorilla, ja jossa R^ on CH- O • J "4 - CH - O - C - R tai R5 O I M A -CH-O-C-O-R 4 5 jossa R tarkoittaa 1-4 hiiliatomia sisältävää alkyyliä ja R on H, -CH^ tai -C^H^, tunnettu siitä, että sillä on kaava /CH3 R - CH - CONH - CH - CH C I I I I^ch3 N3 0=C — N - CH - COO - RX jossa R ja R^ tarkoittavat samaa kuin yllä.
- 2. Patenttivaatimuksen 1 mukainen välituote, tunnettu siitä, että R on fenyyli, ja R* on ryhmä R^ O I n a -CH-O-C-O-R, 5 4 jossa R on metyyli- ja R on etyyliryhmä.
- 1. Mellanprodukt för framställning av a-aminopenicillinest-rar med formeln
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1268870 | 1970-09-17 | ||
| SE7012688A SE374747B (fi) | 1970-09-17 | 1970-09-17 | |
| SE1572070 | 1970-11-20 | ||
| SE7015720A SE380806B (sv) | 1970-11-20 | 1970-11-20 | Forfarande for framstellning av nya estrar av alfa-aminopenicilliner |
| FI258071 | 1971-09-15 | ||
| FI2580/71A FI55203C (fi) | 1970-09-17 | 1971-09-15 | Analogifoerfarande foer framstaellning av estrar av alfa-aminopenicilliner |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI791386A FI791386A (fi) | 1979-04-27 |
| FI59103B true FI59103B (fi) | 1981-02-27 |
| FI59103C FI59103C (fi) | 1981-06-10 |
Family
ID=26655897
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI2580/71A FI55203C (fi) | 1970-09-17 | 1971-09-15 | Analogifoerfarande foer framstaellning av estrar av alfa-aminopenicilliner |
| FI3814/74A FI59600C (fi) | 1970-09-17 | 1974-12-31 | Mellanprodukt foer framstaellning av alfa-aminopenicillinestrar |
| FI773032A FI57951C (fi) | 1970-09-17 | 1977-10-13 | Mellanprodukter till anvaendning vid framstaellning av estrar av alfa-aminopenicilliner |
| FI791386A FI59103C (fi) | 1970-09-17 | 1979-04-27 | Mellanprodukter till anvaendning vid framstaellning av alfa-aminopenicillinestrar |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI2580/71A FI55203C (fi) | 1970-09-17 | 1971-09-15 | Analogifoerfarande foer framstaellning av estrar av alfa-aminopenicilliner |
| FI3814/74A FI59600C (fi) | 1970-09-17 | 1974-12-31 | Mellanprodukt foer framstaellning av alfa-aminopenicillinestrar |
| FI773032A FI57951C (fi) | 1970-09-17 | 1977-10-13 | Mellanprodukter till anvaendning vid framstaellning av estrar av alfa-aminopenicilliner |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US3873521A (fi) |
| JP (2) | JPS5317597B1 (fi) |
| AR (2) | AR201730A1 (fi) |
| AT (2) | AT309681B (fi) |
| BE (1) | BE772723A (fi) |
| BR (1) | BR7106116D0 (fi) |
| CA (2) | CA960211A (fi) |
| CH (5) | CH577513A5 (fi) |
| CS (2) | CS187316B2 (fi) |
| DD (1) | DD94815A5 (fi) |
| DK (6) | DK132759C (fi) |
| ES (3) | ES395145A1 (fi) |
| FI (4) | FI55203C (fi) |
| FR (1) | FR2106578B1 (fi) |
| GB (1) | GB1363506A (fi) |
| HU (1) | HU165868B (fi) |
| IE (1) | IE35642B1 (fi) |
| IT (1) | IT1049876B (fi) |
| NL (3) | NL164860C (fi) |
| NO (4) | NO140931C (fi) |
| SU (2) | SU553936A3 (fi) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1426869A (en) * | 1972-03-13 | 1976-03-03 | Astra Laekemedel Ab | Penicillins |
| US4089963A (en) * | 1972-03-13 | 1978-05-16 | Astra Pharmaceutical Products, Inc. | Esters of amidinopenicillanic acids, pharmaceutical preparations and method for treating infectious diseases |
| GB1425933A (en) * | 1972-03-13 | 1976-02-25 | Astra Laekemedel Ab | Cephalosporins |
| GB1437088A (en) * | 1972-05-25 | 1976-05-26 | Beecham Group Ltd | Esters of penicillins and cephalosporins |
| NL7401782A (fi) * | 1973-02-14 | 1974-08-16 | ||
| GB1550359A (en) * | 1975-08-07 | 1979-08-15 | Beecham Group Ltd | Antibiotic compositions for oral administration |
| US4247461A (en) * | 1979-11-16 | 1981-01-27 | Bristol-Myers Company | Esterification process using methoxymethyl-P-toluenesulfonate |
| US4340539A (en) * | 1980-01-21 | 1982-07-20 | Bristol-Myers Company | Derivatives of 6-bromo penicillanic acid |
| CA1212105A (en) | 1980-04-30 | 1986-09-30 | Shoji Ikeda | Ampicillin esters and production thereof |
| FR2482587A1 (fr) * | 1980-05-14 | 1981-11-20 | Poudres & Explosifs Ste Nale | Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores |
| US4321253A (en) * | 1980-08-22 | 1982-03-23 | Beatty Morgan L | Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration |
| US4479947A (en) * | 1981-07-13 | 1984-10-30 | Merck & Co., Inc. | Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group |
| CA1202617A (en) * | 1982-03-19 | 1986-04-01 | Norman B. Jones | Bacampicillin napsylate |
| IT1190897B (it) * | 1982-06-29 | 1988-02-24 | Opos Biochimica Srl | Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico |
| GB2123821B (en) * | 1982-06-29 | 1987-04-23 | Astra Laekemedel Ab | At-halogeno diethyl carbonates and their use in the preparation of antibiotics |
| SE454879B (sv) * | 1982-06-29 | 1988-06-06 | Astra Laekemedel Ab | Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g |
| FR2532933B1 (fr) * | 1982-06-29 | 1987-11-13 | Astra Laekemedel Ab | Perfectionnements apportes a la preparation d'antibiotiques |
| JPS5927900A (ja) * | 1982-08-09 | 1984-02-14 | Wakunaga Seiyaku Kk | 固定化オリゴヌクレオチド |
| US4606865A (en) * | 1982-09-20 | 1986-08-19 | Astra Lakemedel Aktiebolag | Methods for the preparation of α-bromodiethylcarbonate |
| DK149079C (da) * | 1982-10-06 | 1986-06-23 | Novo Industri As | Fremgangsmaade til fremstilling af et immobiliseret enzympraeparat |
| IL67177A (en) * | 1982-11-04 | 1985-08-30 | Orvet Bv | 1-bromoethyl ethyl carbonate,methods for its preparation and 1-bromoethylchloroformate and 1-bromoethylbromoformate obtained as intermediates |
| IL67637A0 (en) * | 1983-01-07 | 1983-05-15 | Orvet Bv | Preparation of 1'-ethoxycarbonyl-oxyethyl esters of penicillins and novel intermediates |
| IL67445A (en) * | 1982-12-09 | 1985-11-29 | Teva Pharma | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids |
| FR2551058B1 (fr) * | 1983-08-26 | 1986-09-26 | Poudres & Explosifs Ste Nale | Procede de preparation de chloroformiates a-chlores |
| SE8405611D0 (sv) * | 1984-11-09 | 1984-11-09 | Astra Laekemedel Ab | Process for stabilization of bacampicillin hydrochloride |
| US4855455A (en) * | 1988-01-22 | 1989-08-08 | W. R. Grace & Co.-Conn. | Preparation of amino acid derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1021654A (fr) * | 1949-07-07 | 1953-02-23 | Lphivens Kemiske Fabrik Ved A | Procédé de production d'éthers-sels aminés de pénicilline et de composés qui s'y rattachent |
| GB1241844A (en) * | 1968-08-23 | 1971-08-04 | Beecham Group Ltd | Penicillins |
| US3697507A (en) * | 1968-09-26 | 1972-10-10 | Leo Pharm Prod Ltd | Esters of {60 -aminobenzylpenicillin |
| US3660575A (en) * | 1968-09-26 | 1972-05-02 | Leo Pharm Prod Ltd | Esters of alpha-aminobenzylpenicillin in dosage unit form |
-
1971
- 1971-09-07 US US178426A patent/US3873521A/en not_active Expired - Lifetime
- 1971-09-14 AT AT795771A patent/AT309681B/de not_active IP Right Cessation
- 1971-09-14 SU SU1696133A patent/SU553936A3/ru active
- 1971-09-14 AT AT537872A patent/AT311557B/de not_active IP Right Cessation
- 1971-09-14 FR FR7133107A patent/FR2106578B1/fr not_active Expired
- 1971-09-15 CA CA122,881A patent/CA960211A/en not_active Expired
- 1971-09-15 GB GB4309071A patent/GB1363506A/en not_active Expired
- 1971-09-15 IE IE1167/71A patent/IE35642B1/xx unknown
- 1971-09-15 IT IT28678/71A patent/IT1049876B/it active
- 1971-09-15 FI FI2580/71A patent/FI55203C/fi active
- 1971-09-16 BR BR6116/71A patent/BR7106116D0/pt unknown
- 1971-09-16 HU HUAA684A patent/HU165868B/hu unknown
- 1971-09-16 CS CS71442A patent/CS187316B2/cs unknown
- 1971-09-16 NO NO3449/71A patent/NO140931C/no unknown
- 1971-09-16 CH CH859975A patent/CH577513A5/xx not_active IP Right Cessation
- 1971-09-16 DK DK453871A patent/DK132759C/da not_active IP Right Cessation
- 1971-09-16 CH CH1362371A patent/CH583239A5/xx not_active IP Right Cessation
- 1971-09-16 ES ES195145A patent/ES395145A1/es not_active Expired
- 1971-09-16 CS CS716617A patent/CS187312B2/cs unknown
- 1971-09-16 CH CH860075A patent/CH589654A5/xx not_active IP Right Cessation
- 1971-09-17 DD DD157795A patent/DD94815A5/xx unknown
- 1971-09-17 BE BE772723A patent/BE772723A/xx not_active IP Right Cessation
- 1971-09-17 JP JP7184971A patent/JPS5317597B1/ja active Pending
- 1971-09-17 NL NL7112789.A patent/NL164860C/xx not_active IP Right Cessation
-
1972
- 1972-01-31 NO NO236/72A patent/NO140930C/no unknown
- 1972-04-12 AR AR241427A patent/AR201730A1/es active
- 1972-04-14 ES ES401745A patent/ES401745A1/es not_active Expired
-
1973
- 1973-03-08 US US05/339,364 patent/US3939270A/en not_active Expired - Lifetime
- 1973-03-27 SU SU731899287A patent/SU1153830A3/ru active
- 1973-10-25 CA CA184,183A patent/CA1008447A/en not_active Expired
-
1974
- 1974-09-27 DK DK509774A patent/DK509774A/da unknown
- 1974-09-27 DK DK509674A patent/DK150200C/da not_active IP Right Cessation
- 1974-12-19 NO NO74744606A patent/NO142670C/no unknown
- 1974-12-31 FI FI3814/74A patent/FI59600C/fi active
-
1975
- 1975-01-08 ES ES433637A patent/ES433637A1/es not_active Expired
- 1975-04-08 AR AR258235A patent/AR210991A1/es active
- 1975-06-24 JP JP7921675A patent/JPS5537996B2/ja not_active Expired
- 1975-08-20 DK DK375975A patent/DK375975A/da unknown
-
1976
- 1976-04-20 CH CH493776A patent/CH613207A5/xx not_active IP Right Cessation
-
1977
- 1977-09-21 CH CH1155377A patent/CH602745A5/xx not_active IP Right Cessation
- 1977-10-13 FI FI773032A patent/FI57951C/fi not_active IP Right Cessation
-
1978
- 1978-01-31 NL NL7801086A patent/NL7801086A/xx active Search and Examination
- 1978-12-08 NO NO784144A patent/NO142671C/no unknown
-
1979
- 1979-04-27 FI FI791386A patent/FI59103C/fi not_active IP Right Cessation
-
1980
- 1980-03-17 NL NLAANVRAGE8001563,A patent/NL171160C/xx not_active IP Right Cessation
- 1980-03-27 DK DK133380A patent/DK150201C/da not_active IP Right Cessation
-
1982
- 1982-04-07 DK DK163482A patent/DK158519C/da not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: ASTRA LAEKEMEDEL AB |