FI56389C - Foerfarande foer framstaellning av terapeutiskt anvaendbara 18-metyl-4,15-estradienderivat - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 18-metyl-4,15-estradienderivat Download PDF

Info

Publication number
FI56389C
FI56389C FI762876A FI762876A FI56389C FI 56389 C FI56389 C FI 56389C FI 762876 A FI762876 A FI 762876A FI 762876 A FI762876 A FI 762876A FI 56389 C FI56389 C FI 56389C
Authority
FI
Finland
Prior art keywords
methyl
estradien
ethynyl
group
hydroxy
Prior art date
Application number
FI762876A
Other languages
English (en)
Finnish (fi)
Other versions
FI762876A (da
FI56389B (fi
Inventor
Helmut Hofmeister
Rudolf Wiechert
Klaus Annen
Henry Laurent
Hermann Steinbeck
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752546062 external-priority patent/DE2546062A1/de
Priority claimed from DE19762636405 external-priority patent/DE2636405C2/de
Priority claimed from DE19762636404 external-priority patent/DE2636404C2/de
Priority claimed from DE19762636407 external-priority patent/DE2636407A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI762876A publication Critical patent/FI762876A/fi
Application granted granted Critical
Publication of FI56389B publication Critical patent/FI56389B/fi
Publication of FI56389C publication Critical patent/FI56389C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI762876A 1975-10-10 1976-10-08 Foerfarande foer framstaellning av terapeutiskt anvaendbara 18-metyl-4,15-estradienderivat FI56389C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DE2546062 1975-10-10
DE19752546062 DE2546062A1 (de) 1975-10-10 1975-10-10 Delta hoch 15 -steroide
DE19762636405 DE2636405C2 (de) 1976-08-12 1976-08-12 Δ↑1↑↑5↑-17α-Chloräthinyl- und -Propinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate
DE19762636404 DE2636404C2 (de) 1976-08-12 1976-08-12 Δ↑1↑↑5↑-17α-Äthinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate
DE2636407 1976-08-12
DE2636405 1976-08-12
DE19762636407 DE2636407A1 (de) 1976-08-12 1976-08-12 Delta hoch 15 -steroide
DE2636404 1976-08-12

Publications (3)

Publication Number Publication Date
FI762876A FI762876A (da) 1977-04-11
FI56389B FI56389B (fi) 1979-09-28
FI56389C true FI56389C (fi) 1980-01-10

Family

ID=27432034

Family Applications (1)

Application Number Title Priority Date Filing Date
FI762876A FI56389C (fi) 1975-10-10 1976-10-08 Foerfarande foer framstaellning av terapeutiskt anvaendbara 18-metyl-4,15-estradienderivat

Country Status (33)

Country Link
US (1) US4081537A (da)
JP (1) JPS5246060A (da)
AT (1) AT358199B (da)
AU (1) AU500942B2 (da)
BE (1) BE847090A (da)
BG (1) BG34187A3 (da)
CA (1) CA1069885A (da)
CH (2) CH630392A5 (da)
CY (1) CY1119A (da)
DD (1) DD126925B3 (da)
DK (2) DK138749C (da)
ES (1) ES452226A1 (da)
FI (1) FI56389C (da)
FR (1) FR2326927A1 (da)
GB (1) GB1569135A (da)
GR (1) GR60835B (da)
HK (1) HK41381A (da)
HU (1) HU176164B (da)
IE (1) IE43742B1 (da)
IT (1) IT1070580B (da)
KE (1) KE3153A (da)
LU (2) LU75961A1 (da)
MX (1) MX3847E (da)
MY (1) MY8200128A (da)
NL (2) NL187116C (da)
NO (2) NO144490C (da)
NZ (1) NZ182237A (da)
PH (1) PH12941A (da)
PL (1) PL103002B1 (da)
PT (1) PT65697B (da)
SE (2) SE415839B (da)
SU (1) SU671733A3 (da)
YU (1) YU39668B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3178784A (en) * 1963-03-27 1965-04-20 Krauthamer Charles Magnetic pocket pencil holder
DE3002746A1 (de) * 1980-01-23 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin 1-hydroxysteroide, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten
DE3005374A1 (de) * 1980-02-11 1981-08-20 Schering Ag Berlin Und Bergkamen, 1000 Berlin 3-desoxy-delta hoch 15 -steroide, verfahren zu ihrer herstellung sowie diese enthaltende pharmazeutische praeparate
DE3042529A1 (de) * 1980-11-07 1982-06-24 Schering Ag, 1000 Berlin Und 4619 Bergkamen 11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3214690A1 (de) * 1982-04-16 1983-10-27 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-chlor-(delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch)-steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CN1008820B (zh) * 1985-05-10 1990-07-18 施林工业产权保护股份公司 17α-乙炔基-17β-羟基-18-甲基-4，15-雌甾二烯-3-酮的制备方法
CA1317283C (en) * 1986-11-05 1993-05-04 Douglas Alan Livingston Steroidal 17–-silyl ethers and process to corticoids and progesterones
DE3710728A1 (de) * 1987-03-31 1988-10-13 Schering Ag Verfahren zur herstellung von 17(alpha)-ethinyl-17ss-hydroxy-18-methyl-4,15-estradien-3-on und die neuen zwischenprodukte fuer dieses verfahren
PT99338A (pt) * 1990-10-29 1992-10-30 Alza Corp Processo para a preparacao de composicoes de farmacos anticoncepcionais administradas transdermicamente contendo uma mistura dum estrogeno e gestodeno e dispositivos para a sua administracao transdermica
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
DE4329242A1 (de) * 1993-08-26 1995-03-02 Schering Ag Mittel zur transdermalen Applikation enthaltend Gestodenester
US5567830A (en) * 1994-02-14 1996-10-22 Cocensys, Inc. Process for synthesis of acetylenic carbinols
IT1271004B (it) 1994-09-09 1997-05-26 Ind Chimica Srl Processo per la preparazione del gestodene
EP1363669A2 (en) * 2001-02-02 2003-11-26 Pharmacia Corporation Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea
UA89766C2 (en) 2003-12-12 2010-03-10 Байер Шеринг Фарма Акциенгезельшафт Transdermal delivery system of gestodene
EP2354150A1 (en) 2010-02-09 2011-08-10 Laboratoire Theramex Process for the preparation of gestodene
HUE031326T2 (hu) 2010-09-06 2017-07-28 Bayer Ip Gmbh Alacsony dózisú transzdermális tapaszok magas hatóanyagleadással
CN105237605B (zh) * 2014-07-11 2019-01-25 上海迪赛诺生物医药有限公司 一种用于合成孕二烯酮的中间体及其制备方法和应用
CN115850359A (zh) * 2022-12-14 2023-03-28 梯尔希（南京）药物研发有限公司 一种孕二烯酮杂质i的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3433785A (en) * 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US3475463A (en) * 1966-07-11 1969-10-28 Sterling Drug Inc 15,16-unsaturated 19-norsteroids and their preparation
DE2439082A1 (de) * 1974-08-12 1976-02-26 Schering Ag 17 alpha-hydroxy-1,3,5(10),15-oestratetraene und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DK143604B (da) 1981-09-14
DD126925A5 (da) 1977-08-24
ES452226A1 (es) 1977-11-01
KE3153A (en) 1981-09-18
CH626636A5 (en) 1981-11-30
NL930071I1 (nl) 1993-09-01
NO763434L (da) 1977-04-13
MY8200128A (en) 1982-12-31
YU245276A (en) 1982-08-31
FI762876A (da) 1977-04-11
ATA748776A (de) 1980-01-15
HK41381A (en) 1981-08-28
SE7611145L (sv) 1977-04-11
AU500942B2 (en) 1979-06-07
GB1569135A (en) 1980-06-11
CY1119A (en) 1981-12-04
LU75961A1 (da) 1977-05-09
NL930071I2 (nl) 1994-02-16
DK143604C (da) 1982-02-22
IT1070580B (it) 1985-03-29
YU39668B (en) 1985-03-20
NO144490B (no) 1981-06-01
NO144490C (no) 1981-09-09
IE43742B1 (en) 1981-05-20
NL187116C (nl) 1991-06-03
DK138749C (da) 1979-04-02
NL7611073A (nl) 1977-04-13
DK77678A (da) 1978-02-21
PL103002B1 (pl) 1979-05-31
AT358199B (de) 1980-08-25
NO144967B (no) 1981-09-07
NO801013L (no) 1977-04-13
PT65697B (pt) 1978-04-17
IE43742L (en) 1977-04-10
JPS5246060A (en) 1977-04-12
CA1069885A (en) 1980-01-15
BE847090A (fr) 1977-04-08
NO144967C (no) 1981-12-16
US4081537A (en) 1978-03-28
FR2326927B1 (da) 1979-09-28
DK138749B (da) 1978-10-23
PH12941A (en) 1979-10-18
SE7907224L (sv) 1979-08-30
NZ182237A (en) 1978-09-20
DD126925B3 (de) 1990-06-06
HU176164B (en) 1980-12-28
SE428929B (sv) 1983-08-01
JPS6119640B2 (da) 1986-05-17
DK454376A (da) 1977-04-11
BG34187A3 (en) 1983-07-15
NL187116B (nl) 1991-01-02
SU671733A3 (ru) 1979-06-30
AU1851076A (en) 1978-04-13
CH630392A5 (de) 1982-06-15
LU88290I2 (de) 1994-05-04
GR60835B (en) 1978-08-31
FI56389B (fi) 1979-09-28
FR2326927A1 (fr) 1977-05-06
PT65697A (en) 1976-11-01
MX3847E (es) 1981-08-18
SE415839B (sv) 1980-11-03

Similar Documents

Publication Publication Date Title
FI56389C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 18-metyl-4,15-estradienderivat
JPH0826062B2 (ja) ９―α―ヒドロキシステロイド及びその製法
KR100287513B1 (ko) 17-스피로푸란-3'-일리덴 스테로이드
FI95711C (fi) Menetelmä terapeuttisesti käyttökelpoisten 4-substituoitujen 17 -(syklopropyylioksi)androst-5-eenijohdannaisten valmistamiseksi, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreina
EP0763541A1 (en) 11-(Substituted phenyl)-estra-4,9-diene derivatives
JPS6013796A (ja) １−アルキル−アンドロスタ−１，４−ジエン−３，１７−ジオン、その製法及び該化合物を含有するエストロゲン生合成を阻害する製薬的製剤
US4371529A (en) 11-Methylene-Δ15 -steroids, their preparation and use in pharmaceuticals
CS203912B2 (en) Process for preparing derivatives of estradiene
NO168892B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive 17beta-(cyclopropyloxy)androst-5-en-3beta-ol-derivater
RU2169153C2 (ru) 14,17-c2-мостиковые стероиды и фармацевтический препарат
JPS6137280B2 (da)
US4464365A (en) 11β-Chloro-Δ15 -steroids, a process for their preparation and pharmaceutical preparations containing them
US3461118A (en) 3beta-tetrahydrofuranyloxy - and 3beta-tetrahydropyranyloxyestra - 4,9(10) - dienes and -4,9(10),11-trienes,their preparation and intermediates thereof
CS203913B2 (en) Process for preparing derivatives of estradiene
US4390530A (en) 3-Deoxy-Δ15 -steroids
FI89053C (fi) Nya 11-metylenestr-15-ener och kompositioner innehaollande desamma foer anvaendning som preventivmedel
CA2120726A1 (en) Androst-4-eno¬4,5-b|pyrrole derivatives and process for their preparation
JPH0791312B2 (ja) 位置９（１１）が飽和され位置１０が三重結合を含む基により置換された新規なステロイド、その製造方法及び薬剤
Hofmeister et al. 3-Deoxy-Δ 15-steroids
HU186687B (en) Process for preparing 11beta-chloro-steroids and pharmaceutical compositions containing such compounds
MXPA96003476A (es) Derivados de 11-(fenilo sustituido)-estra-4,9-dieno
DE2636404A1 (de) Delta hoch 15 -steroide

Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: SCHERING AKTIENGESELLSCHAFT