FI3685847T3 - Komplementtiaktiivisuuden modulaattoreita - Google Patents
Komplementtiaktiivisuuden modulaattoreita Download PDFInfo
- Publication number
- FI3685847T3 FI3685847T3 FIEP20157916.6T FI20157916T FI3685847T3 FI 3685847 T3 FI3685847 T3 FI 3685847T3 FI 20157916 T FI20157916 T FI 20157916T FI 3685847 T3 FI3685847 T3 FI 3685847T3
- Authority
- FI
- Finland
- Prior art keywords
- pharmaceutical composition
- composition according
- polypeptide
- concentration
- administered
- Prior art date
Links
- 230000024203 complement activation Effects 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 5
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 3
- 239000001488 sodium phosphate Substances 0.000 claims 3
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 3
- 201000009906 Meningitis Diseases 0.000 claims 2
- 241000588653 Neisseria Species 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 229960003405 ciprofloxacin Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229960002224 eculizumab Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268360P | 2015-12-16 | 2015-12-16 | |
| US201662331320P | 2016-05-03 | 2016-05-03 | |
| US201662347486P | 2016-06-08 | 2016-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3685847T3 true FI3685847T3 (fi) | 2023-04-03 |
Family
ID=57758701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP20157916.6T FI3685847T3 (fi) | 2015-12-16 | 2016-12-07 | Komplementtiaktiivisuuden modulaattoreita |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US10835574B2 (enExample) |
| EP (3) | EP3389692B1 (enExample) |
| JP (3) | JP7126940B2 (enExample) |
| KR (1) | KR20180094913A (enExample) |
| CN (2) | CN108697759B (enExample) |
| AU (1) | AU2016370210A1 (enExample) |
| BR (1) | BR112018012174A2 (enExample) |
| CA (1) | CA3007772A1 (enExample) |
| CY (1) | CY1123031T1 (enExample) |
| DK (2) | DK3685847T5 (enExample) |
| ES (2) | ES2941640T3 (enExample) |
| FI (1) | FI3685847T3 (enExample) |
| HR (2) | HRP20200508T1 (enExample) |
| HU (1) | HUE061759T2 (enExample) |
| IL (1) | IL259762B (enExample) |
| LT (2) | LT3389692T (enExample) |
| MX (2) | MX2018007352A (enExample) |
| PL (2) | PL3685847T3 (enExample) |
| PT (2) | PT3685847T (enExample) |
| RS (2) | RS64067B1 (enExample) |
| RU (2) | RU2733720C2 (enExample) |
| SG (1) | SG11201804721SA (enExample) |
| SI (2) | SI3389692T1 (enExample) |
| SM (1) | SMT202000213T1 (enExample) |
| TW (2) | TWI745320B (enExample) |
| WO (1) | WO2017105939A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101981532B1 (ko) | 2014-06-12 | 2019-09-02 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절 |
| PL3250230T3 (pl) | 2015-01-28 | 2022-02-14 | Ra Pharmaceuticals, Inc. | Modulatory aktywności dopełniacza |
| RU2733720C2 (ru) | 2015-12-16 | 2020-10-06 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
| MX2019006527A (es) * | 2016-12-07 | 2019-08-01 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
| TW201938184A (zh) | 2017-12-04 | 2019-10-01 | 美商Ｒａ製藥公司 | 補體活性之調節劑 |
| US12240893B2 (en) * | 2018-10-30 | 2025-03-04 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) |
| CN113543796A (zh) | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
| US20220211799A1 (en) | 2019-04-24 | 2022-07-07 | Ra Pharmaceuticals, Inc. | Compositions and methods for modulating complement activity |
| ES2973767T3 (es) * | 2019-06-04 | 2024-06-24 | Ra Pharmaceuticals Inc | Tratamiento de enfermedades inflamatorias con inhibidores del complemento |
| ES3013485T3 (en) | 2019-09-12 | 2025-04-14 | Ra Pharmaceuticals Inc | Treatment of a neurological disease with complement inhibitors |
| KR20230017789A (ko) | 2020-04-30 | 2023-02-06 | 알닐람 파마슈티칼스 인코포레이티드 | 보체 인자 B (CFB) iRNA 조성물 및 이의 사용 방법 |
| EP4423273A1 (en) | 2021-10-29 | 2024-09-04 | Alnylam Pharmaceuticals, Inc. | Complement factor b (cfb) irna compositions and methods of use thereof |
Family Cites Families (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271068A (en) | 1968-05-10 | 1981-06-02 | Ciba-Geigy Corporation | Process for the manufacture of cystine-containing peptides |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4033940A (en) | 1975-11-12 | 1977-07-05 | Armour Pharmaceutical Company | Cyclization of peptides |
| US4216141A (en) | 1978-07-19 | 1980-08-05 | The Salk Institute For Biological Studies | Method for cyclization of peptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5371109A (en) | 1986-07-01 | 1994-12-06 | Drilletten Ab | Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| CA2067194C (en) | 1989-10-05 | 2003-03-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
| US5585353A (en) | 1990-02-02 | 1996-12-17 | The Rockefeller University | Antibiotic peptides containing D-amino acids |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5843701A (en) | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| JPH08510325A (ja) | 1993-05-28 | 1996-10-29 | カイロン コーポレイション | 生物学的に活性なペプチド配列の選択方法 |
| EP0710243B1 (en) | 1993-06-29 | 2000-06-14 | Ferring B.V. | Synthesis of cyclic peptides |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5834318A (en) | 1995-05-10 | 1998-11-10 | Bayer Corporation | Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins |
| US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
| US6720472B2 (en) | 1996-07-12 | 2004-04-13 | University Of Medicine And Dentistry Of New Jersey | HMGI proteins in cancer and obesity |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| DE69739163D1 (de) | 1996-10-17 | 2009-01-22 | Mitsubishi Chem Corp | Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen |
| US6348584B1 (en) | 1996-10-17 | 2002-02-19 | John Edward Hodgson | Fibronectin binding protein compounds |
| US5922680A (en) | 1996-10-23 | 1999-07-13 | Ferring, B.V. | Stabilized composition for oral administration of peptides |
| PT971946E (pt) | 1997-01-21 | 2006-11-30 | Gen Hospital Corp | Selecção de proteínas utilizando fusões arn-proteína |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| EP0985039B1 (en) | 1997-06-12 | 2008-02-20 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| EP0896001A1 (en) | 1997-08-08 | 1999-02-10 | Daicel Chemical Industries, Ltd. | Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates |
| US6429301B1 (en) | 1998-04-17 | 2002-08-06 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
| WO2000007979A2 (en) | 1998-08-07 | 2000-02-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AU1705100A (en) | 1998-10-09 | 2000-05-01 | Musc Foundation For Research Development | Blocking factor b to treat complement-mediated immune disease |
| US6962781B1 (en) | 2000-05-19 | 2005-11-08 | Proteonova, Inc. | In vitro evolution of nucleic acids and encoded polypeptide |
| US7244701B2 (en) | 2000-06-16 | 2007-07-17 | Zealand Phama A/S | Diuretic peptide conjugate |
| JP4768620B2 (ja) | 2003-05-15 | 2011-09-07 | ジェネンテック， インコーポレイテッド | 敗血症の予防及び治療のための方法及び組成物 |
| WO2005023866A2 (en) | 2003-09-10 | 2005-03-17 | Baxter International Inc. | Peptides that inhibit complement activation |
| CA2537029C (en) | 2003-11-26 | 2013-03-12 | Likan Liang | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
| US7803931B2 (en) * | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| WO2006066258A2 (en) | 2004-12-17 | 2006-06-22 | Neose Technologies, Inc. | Lipoconjugation of peptides |
| SI1844337T1 (sl) | 2005-01-24 | 2013-11-29 | Pepscan Systems B.V. | Povezovalne spojine, imunogene spojine in peptidomimetiki |
| WO2006105214A2 (en) | 2005-03-29 | 2006-10-05 | Cardax Pharmaceuticals, Inc. | Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof |
| ES2548700T3 (es) | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
| ES2399645T3 (es) | 2005-06-06 | 2013-04-02 | Camurus Ab | Formulaciones de análogos de GLP-1 |
| ES2551202T5 (es) | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
| DK2359834T5 (en) | 2006-03-15 | 2017-02-06 | Alexion Pharma Inc | Treatment of paroxysmal nocturnal hemoglobinuria patients with a complement inhibitor |
| EP1876183A1 (en) | 2006-07-04 | 2008-01-09 | Technische Universität München | Minimized small peptides with high affinity for factor VIII and factor VIII-like proteins |
| EP3028716B1 (en) | 2006-10-10 | 2020-09-16 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
| US7736860B2 (en) | 2006-11-09 | 2010-06-15 | Univeristy Of Massachusetts | Methods of identifying compounds for the treatment of sterile inflammation |
| EP2129681A2 (en) | 2007-03-22 | 2009-12-09 | Novartis Ag | C5 antigens and uses thereof |
| US20100015139A1 (en) | 2008-07-10 | 2010-01-21 | Rekha Bansal | METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF |
| WO2008137236A2 (en) | 2007-04-30 | 2008-11-13 | Alcon Research, Ltd. | Treatment of age-related macular degeneration using inhibitors of complement factor d |
| AU2008262048B2 (en) | 2007-06-07 | 2013-09-26 | Genentech, Inc. | C3b antibodies and methods for the prevention and treatment of complement- associated disorders |
| US20110142837A1 (en) | 2007-07-20 | 2011-06-16 | Trustees Of The University Of Pennsylvania | Method Of Treating Acute Respiratory Distress Syndrome |
| MX2010003630A (es) | 2007-10-02 | 2010-04-21 | Potentia Pharmaceuticals Inc | Administracion sostenida de analogos de compstatina desde geles. |
| WO2009067191A2 (en) | 2007-11-16 | 2009-05-28 | The General Hospital Corporation | Methods and compositions for the treatment of hepatitis c virus (hcv) infection |
| US20110190221A1 (en) | 2008-03-28 | 2011-08-04 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
| US20100093624A1 (en) | 2008-07-30 | 2010-04-15 | Cosmix Therapeutics Llc | Peptide therapeutics that bind vegf and methods of use thereof |
| US20110172126A1 (en) | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
| RS64039B1 (sr) | 2008-11-10 | 2023-04-28 | Alexion Pharma Inc | Metode i kompozicije za lečenje poremećaja povezanih sa komplementom |
| AU2009230735B1 (en) | 2009-01-08 | 2010-01-21 | Shane Ramodien | Electronic equipment housing |
| CN106390117A (zh) | 2009-10-16 | 2017-02-15 | 奥默罗斯公司 | 通过抑制masp‑2依赖性补体活化治疗弥散性血管内凝血的方法 |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| JP6006118B2 (ja) | 2009-12-16 | 2016-10-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アナログ及び誘導体 |
| WO2011106635A1 (en) | 2010-02-25 | 2011-09-01 | The Trustees Of The University Of Pennsylvania | Treatment of sepsis using complement inhibitors |
| EP2563359A1 (en) | 2010-04-30 | 2013-03-06 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
| TW201241008A (en) | 2010-10-01 | 2012-10-16 | Alexion Pharma Inc | Polypeptides that bind to human complement component C5 |
| CN105413022A (zh) * | 2011-03-29 | 2016-03-23 | 艾伯维公司 | 自动注射装置中的改进的护罩展开 |
| KR20220044616A (ko) | 2011-04-08 | 2022-04-08 | 유니버시티 오브 레스터 | Ｍａｓｐ-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법 |
| CA2833931C (en) * | 2011-05-05 | 2021-05-04 | Wellstat Immunotherapeutics, Llc | Complement factor b analogs and their uses |
| WO2012162215A1 (en) | 2011-05-20 | 2012-11-29 | The Trustees Of The University Of Pennsylvania | Promotion of fracture healing using complement inhibitors |
| WO2012174055A1 (en) | 2011-06-13 | 2012-12-20 | The Trustees Of The University Of Pennsylvania | Wound healing using complement inhibitors |
| CN102321170B (zh) | 2011-09-14 | 2013-11-13 | 深圳翰宇药业股份有限公司 | 利拉鲁肽变构体及其缀合物 |
| WO2013052736A2 (en) | 2011-10-06 | 2013-04-11 | The Medicines Company | Methods of treating or preventing blood loss during surgery using the serine protease inhibitor mdco-2010 |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| US20130246083A1 (en) | 2012-03-16 | 2013-09-19 | Alexion Pharmaceuticals, Inc. | Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor |
| ES2755104T3 (es) * | 2012-05-17 | 2020-04-21 | Ra Pharmaceuticals Inc | Inhibidores peptídicos y peptidomiméticos |
| US9579360B2 (en) | 2012-06-20 | 2017-02-28 | The Trustees Of The University Of Pennsylvania | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| WO2014004733A1 (en) | 2012-06-26 | 2014-01-03 | The Regents Of The University Of California | Composition for lupus nephritis and methods of making and using the same |
| US20150330989A1 (en) | 2012-11-15 | 2015-11-19 | The Brigham And Women's Hospital, Inc. | Method and system for diagnosing and treating preeclampsia |
| US9700633B2 (en) | 2013-01-28 | 2017-07-11 | Jenkem Technology Co., Ltd., Tianjin Branch | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof |
| US20140234275A1 (en) | 2013-02-15 | 2014-08-21 | Jason Williams | Method for treating als via the increased production of factor h |
| US20150057342A1 (en) | 2013-08-21 | 2015-02-26 | Cannabics Pharmaceuticals Inc | Compositions for combined immediate and sustained release of cannabinoids, methods of manufacture and use thereof |
| CN104231085B (zh) * | 2013-09-05 | 2017-03-15 | 复旦大学附属肿瘤医院 | 靶向特异性补体系统抑制剂、其制备方法及应用 |
| EP3119802B1 (en) | 2014-03-20 | 2019-12-04 | InflaRx GmbH | Inhibitors of c5a for the treatment of viral pneumonia |
| KR101981532B1 (ko) * | 2014-06-12 | 2019-09-02 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절 |
| WO2016094834A2 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | A method for treating a complement mediated disorder caused by an infectious agent in a patient |
| CN107427482A (zh) | 2015-01-21 | 2017-12-01 | 帕西拉制药有限公司 | 凝血酸的多囊脂质体制剂 |
| PL3250230T3 (pl) * | 2015-01-28 | 2022-02-14 | Ra Pharmaceuticals, Inc. | Modulatory aktywności dopełniacza |
| WO2017035362A1 (en) | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses |
| RU2733720C2 (ru) * | 2015-12-16 | 2020-10-06 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
| MX2019006527A (es) * | 2016-12-07 | 2019-08-01 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| WO2019051436A1 (en) | 2017-09-11 | 2019-03-14 | Ra Pharmaceuticals, Inc. | FORMULATIONS FOR THE ADMINISTRATION OF COMPOUNDS |
| TW201938184A (zh) | 2017-12-04 | 2019-10-01 | 美商Ｒａ製藥公司 | 補體活性之調節劑 |
| CN113543796A (zh) | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
| US20220211799A1 (en) | 2019-04-24 | 2022-07-07 | Ra Pharmaceuticals, Inc. | Compositions and methods for modulating complement activity |
-
2016
- 2016-12-07 RU RU2018121615A patent/RU2733720C2/ru active
- 2016-12-07 SI SI201630688T patent/SI3389692T1/sl unknown
- 2016-12-07 RU RU2020131790A patent/RU2769701C2/ru active
- 2016-12-07 SI SI201631679T patent/SI3685847T1/sl unknown
- 2016-12-07 MX MX2018007352A patent/MX2018007352A/es unknown
- 2016-12-07 WO PCT/US2016/065228 patent/WO2017105939A1/en not_active Ceased
- 2016-12-07 SM SM20200213T patent/SMT202000213T1/it unknown
- 2016-12-07 CA CA3007772A patent/CA3007772A1/en active Pending
- 2016-12-07 BR BR112018012174-6A patent/BR112018012174A2/pt active Search and Examination
- 2016-12-07 CN CN201680081854.4A patent/CN108697759B/zh active Active
- 2016-12-07 EP EP16823378.1A patent/EP3389692B1/en active Active
- 2016-12-07 JP JP2018531393A patent/JP7126940B2/ja active Active
- 2016-12-07 RS RS20230218A patent/RS64067B1/sr unknown
- 2016-12-07 ES ES20157916T patent/ES2941640T3/es active Active
- 2016-12-07 KR KR1020187017156A patent/KR20180094913A/ko active Pending
- 2016-12-07 HR HRP20200508TT patent/HRP20200508T1/hr unknown
- 2016-12-07 LT LTEP16823378.1T patent/LT3389692T/lt unknown
- 2016-12-07 EP EP22216383.4A patent/EP4218790A1/en active Pending
- 2016-12-07 CN CN202210878127.8A patent/CN115920000B/zh active Active
- 2016-12-07 PT PT201579166T patent/PT3685847T/pt unknown
- 2016-12-07 US US16/062,653 patent/US10835574B2/en active Active
- 2016-12-07 AU AU2016370210A patent/AU2016370210A1/en not_active Abandoned
- 2016-12-07 TW TW105140483A patent/TWI745320B/zh active
- 2016-12-07 EP EP20157916.6A patent/EP3685847B1/en active Active
- 2016-12-07 HR HRP20230182TT patent/HRP20230182T1/hr unknown
- 2016-12-07 TW TW110131918A patent/TWI779805B/zh active
- 2016-12-07 PT PT168233781T patent/PT3389692T/pt unknown
- 2016-12-07 DK DK20157916.6T patent/DK3685847T5/da active
- 2016-12-07 HU HUE20157916A patent/HUE061759T2/hu unknown
- 2016-12-07 RS RS20200350A patent/RS60134B1/sr unknown
- 2016-12-07 SG SG11201804721SA patent/SG11201804721SA/en unknown
- 2016-12-07 PL PL20157916.6T patent/PL3685847T3/pl unknown
- 2016-12-07 DK DK16823378.1T patent/DK3389692T3/da active
- 2016-12-07 FI FIEP20157916.6T patent/FI3685847T3/fi active
- 2016-12-07 LT LTEP20157916.6T patent/LT3685847T/lt unknown
- 2016-12-07 ES ES16823378T patent/ES2781551T3/es active Active
- 2016-12-07 PL PL16823378T patent/PL3389692T3/pl unknown
-
2018
- 2018-06-03 IL IL259762A patent/IL259762B/en active IP Right Grant
- 2018-06-14 MX MX2022013454A patent/MX2022013454A/es unknown
-
2020
- 2020-03-27 CY CY20201100292T patent/CY1123031T1/el unknown
- 2020-10-08 US US17/065,560 patent/US11752190B2/en active Active
-
2022
- 2022-08-17 JP JP2022130131A patent/JP7379615B2/ja active Active
-
2023
- 2023-11-01 JP JP2023187363A patent/JP2024001300A/ja active Pending
-
2024
- 2024-03-07 US US18/599,164 patent/US20250090624A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI3685847T3 (fi) | Komplementtiaktiivisuuden modulaattoreita | |
| MX2024010140A (es) | Nuevos metodos. | |
| MX390627B (es) | Uso de pridopidina para el tratamiento de la disminucion funcional. | |
| FI3310809T3 (fi) | Anti-cgrp-vasta-aineformulaatio | |
| MA38399A1 (fr) | Formulation sous forme de comprimé, utile pour traiter l'insuffisance cardiaque aiguë et l'insuffisance cardiaque chronique | |
| MX384234B (es) | Uso de pridopidina para el tratamiento de enfermedad de huntington. | |
| MX2015016416A (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades. | |
| MX2015016344A (es) | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. | |
| EA201790726A1 (ru) | Фармацевтическая композиция для лечения язвенного колита | |
| EA201792566A1 (ru) | Замещенные фенилоксазолидиноны для антимикробной терапии | |
| JP2016515623A5 (enExample) | ||
| MX389336B (es) | Formulacion farmaceutica. | |
| EA201692032A1 (ru) | Антибактериальные соединения | |
| NZ700924A (en) | Dosage regimen for a pi-3 kinase inhibitor | |
| MA39447A1 (fr) | (s)-pirlindole ou ses sels pharmaceutiquement acceptables pour une utilisation en médecine | |
| PH12019500516A1 (en) | Pharmaceutical composition comprising mineralocorticoid receptor antagonist and use thereof | |
| MX381526B (es) | Agente para suprimir el progreso de o para mejorar la enfermedad renal crónica. | |
| MX2017015202A (es) | Formulaciones liquidas de celecoxib para administracion oral. | |
| MX388736B (es) | Tratamiento de rescate de nausea y vomito post operatorio. | |
| BR112019000509A2 (pt) | composto ou sal farmaceuticamente aceitável do mesmo e composição farmacêutica | |
| RU2014106575A (ru) | Способ профилактики кровотечения при миомэктомии | |
| MX2018011293A (es) | Composicion farmaceutica de liberacion prolongada que comprende cisteamina o sal de la misma. | |
| EA201790140A1 (ru) | Фармацевтические лекарственные формы | |
| JP2020040998A5 (enExample) | ||
| RU2013127881A (ru) | Применение фармацевтической композиции на основе соли четвертичного фосфония и замещенного динитробензофуроксана для лечения пироплазмоза у собак и способ лечения |