JP7126940B2 - 補体活性のモジュレーター - Google Patents

補体活性のモジュレーター Download PDF

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Publication number
JP7126940B2
JP7126940B2 JP2018531393A JP2018531393A JP7126940B2 JP 7126940 B2 JP7126940 B2 JP 7126940B2 JP 2018531393 A JP2018531393 A JP 2018531393A JP 2018531393 A JP2018531393 A JP 2018531393A JP 7126940 B2 JP7126940 B2 JP 7126940B2
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Japan
Prior art keywords
pharmaceutical composition
subject
complement
administration
polypeptide
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Active
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JP2018531393A
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English (en)
Japanese (ja)
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JP2019504012A5 (enExample
JP2019504012A (ja
Inventor
ジェームズ デマルコ、スティーブン
デニス ホアーティ、ミシェル
ビクトリア パーカー、グレース
リカルド、アロンソ
トビー、シルビア
エイ． トレコ、ダグラス
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UCB Inc
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Ra Pharmaceuticals Inc
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Publication of JP2019504012A publication Critical patent/JP2019504012A/ja
Publication of JP2019504012A5 publication Critical patent/JP2019504012A5/ja
Priority to JP2022130131A priority Critical patent/JP7379615B2/ja
Application granted granted Critical
Publication of JP7126940B2 publication Critical patent/JP7126940B2/ja
Priority to JP2023187363A priority patent/JP2024001300A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Steroid Compounds (AREA)
  • Amplifiers (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018531393A 2015-12-16 2016-12-07 補体活性のモジュレーター Active JP7126940B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022130131A JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562268360P 2015-12-16 2015-12-16
US62/268,360 2015-12-16
US201662331320P 2016-05-03 2016-05-03
US62/331,320 2016-05-03
US201662347486P 2016-06-08 2016-06-08
US62/347,486 2016-06-08
PCT/US2016/065228 WO2017105939A1 (en) 2015-12-16 2016-12-07 Modulators of complement activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022130131A Division JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター

Publications (3)

Publication Number Publication Date
JP2019504012A JP2019504012A (ja) 2019-02-14
JP2019504012A5 JP2019504012A5 (enExample) 2020-01-09
JP7126940B2 true JP7126940B2 (ja) 2022-08-29

Family

ID=57758701

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018531393A Active JP7126940B2 (ja) 2015-12-16 2016-12-07 補体活性のモジュレーター
JP2022130131A Active JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A Pending JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022130131A Active JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A Pending JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Country Status (26)

Country Link
US (3) US10835574B2 (enExample)
EP (3) EP3389692B1 (enExample)
JP (3) JP7126940B2 (enExample)
KR (1) KR20180094913A (enExample)
CN (2) CN115920000B (enExample)
AU (1) AU2016370210A1 (enExample)
BR (1) BR112018012174A2 (enExample)
CA (1) CA3007772A1 (enExample)
CY (1) CY1123031T1 (enExample)
DK (2) DK3685847T5 (enExample)
ES (2) ES2781551T3 (enExample)
FI (1) FI3685847T3 (enExample)
HR (2) HRP20200508T1 (enExample)
HU (1) HUE061759T2 (enExample)
IL (1) IL259762B (enExample)
LT (2) LT3389692T (enExample)
MX (2) MX2018007352A (enExample)
PL (2) PL3389692T3 (enExample)
PT (2) PT3685847T (enExample)
RS (2) RS60134B1 (enExample)
RU (2) RU2733720C2 (enExample)
SG (1) SG11201804721SA (enExample)
SI (2) SI3685847T1 (enExample)
SM (1) SMT202000213T1 (enExample)
TW (2) TWI779805B (enExample)
WO (1) WO2017105939A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6432954B2 (ja) 2014-06-12 2018-12-05 ラ ファーマシューティカルズ インコーポレイテッドＲａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 補体活性の変調
SI3250230T1 (sl) 2015-01-28 2022-01-31 Ra Pharmaceuticals, Inc. Modulatorji aktivnosti komplementa
AU2016370210A1 (en) 2015-12-16 2018-06-21 Ra Pharmaceuticals, Inc. Modulators of complement activity
JP7301741B2 (ja) 2016-12-07 2023-07-03 ラ ファーマシューティカルズ インコーポレイテッド 補体活性のモジュレータ
MX2020005547A (es) 2017-12-04 2020-08-20 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
EA202191189A1 (ru) * 2018-10-30 2021-08-06 Алексион Фармасьютикалс, Инк. Подкожное введение и дозировка антител к c5 для лечения пароксизмальной ночной гемоглобинурии (пнг)
CN113543796A (zh) 2019-03-08 2021-10-22 Ra制药公司 齐鲁考普作为深层组织穿透性c5抑制剂
US20220211799A1 (en) 2019-04-24 2022-07-07 Ra Pharmaceuticals, Inc. Compositions and methods for modulating complement activity
ES2973767T3 (es) 2019-06-04 2024-06-24 Ra Pharmaceuticals Inc Tratamiento de enfermedades inflamatorias con inhibidores del complemento
WO2021050885A1 (en) 2019-09-12 2021-03-18 Ra Pharmaceuticals, Inc. Neurological disease treatment with complement inhibitors
JP2023523790A (ja) 2020-04-30 2023-06-07 アルナイラム ファーマシューティカルズ， インコーポレイテッド 補体因子Ｂ（ＣＦＢ）ｉＲＮＡ組成物およびその使用方法
AR127477A1 (es) 2021-10-29 2024-01-31 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015508652A (ja) 2012-02-20 2015-03-23 スウェディッシュ・オーファン・バイオヴィトラム・アーベー（ペーウーベーエル） ヒト補体ｃ５に結合するポリペプチド

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