JP2019504012A5 - - Google Patents

Download PDF

Info

Publication number
JP2019504012A5
JP2019504012A5 JP2018531393A JP2018531393A JP2019504012A5 JP 2019504012 A5 JP2019504012 A5 JP 2019504012A5 JP 2018531393 A JP2018531393 A JP 2018531393A JP 2018531393 A JP2018531393 A JP 2018531393A JP 2019504012 A5 JP2019504012 A5 JP 2019504012A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
administered
administration
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018531393A
Other languages
English (en)
Japanese (ja)
Other versions
JP7126940B2 (ja
JP2019504012A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/065228 external-priority patent/WO2017105939A1/en
Publication of JP2019504012A publication Critical patent/JP2019504012A/ja
Publication of JP2019504012A5 publication Critical patent/JP2019504012A5/ja
Priority to JP2022130131A priority Critical patent/JP7379615B2/ja
Application granted granted Critical
Publication of JP7126940B2 publication Critical patent/JP7126940B2/ja
Priority to JP2023187363A priority patent/JP2024001300A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018531393A 2015-12-16 2016-12-07 補体活性のモジュレーター Active JP7126940B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022130131A JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562268360P 2015-12-16 2015-12-16
US62/268,360 2015-12-16
US201662331320P 2016-05-03 2016-05-03
US62/331,320 2016-05-03
US201662347486P 2016-06-08 2016-06-08
US62/347,486 2016-06-08
PCT/US2016/065228 WO2017105939A1 (en) 2015-12-16 2016-12-07 Modulators of complement activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022130131A Division JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター

Publications (3)

Publication Number Publication Date
JP2019504012A JP2019504012A (ja) 2019-02-14
JP2019504012A5 true JP2019504012A5 (enExample) 2020-01-09
JP7126940B2 JP7126940B2 (ja) 2022-08-29

Family

ID=57758701

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018531393A Active JP7126940B2 (ja) 2015-12-16 2016-12-07 補体活性のモジュレーター
JP2022130131A Active JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A Pending JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022130131A Active JP7379615B2 (ja) 2015-12-16 2022-08-17 補体活性のモジュレーター
JP2023187363A Pending JP2024001300A (ja) 2015-12-16 2023-11-01 補体活性のモジュレーター

Country Status (26)

Country Link
US (3) US10835574B2 (enExample)
EP (3) EP3389692B1 (enExample)
JP (3) JP7126940B2 (enExample)
KR (1) KR20180094913A (enExample)
CN (2) CN115920000B (enExample)
AU (1) AU2016370210A1 (enExample)
BR (1) BR112018012174A2 (enExample)
CA (1) CA3007772A1 (enExample)
CY (1) CY1123031T1 (enExample)
DK (2) DK3685847T5 (enExample)
ES (2) ES2781551T3 (enExample)
FI (1) FI3685847T3 (enExample)
HR (2) HRP20200508T1 (enExample)
HU (1) HUE061759T2 (enExample)
IL (1) IL259762B (enExample)
LT (2) LT3389692T (enExample)
MX (2) MX2018007352A (enExample)
PL (2) PL3389692T3 (enExample)
PT (2) PT3685847T (enExample)
RS (2) RS60134B1 (enExample)
RU (2) RU2733720C2 (enExample)
SG (1) SG11201804721SA (enExample)
SI (2) SI3685847T1 (enExample)
SM (1) SMT202000213T1 (enExample)
TW (2) TWI779805B (enExample)
WO (1) WO2017105939A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6432954B2 (ja) 2014-06-12 2018-12-05 ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. 補体活性の変調
SI3250230T1 (sl) 2015-01-28 2022-01-31 Ra Pharmaceuticals, Inc. Modulatorji aktivnosti komplementa
AU2016370210A1 (en) 2015-12-16 2018-06-21 Ra Pharmaceuticals, Inc. Modulators of complement activity
JP7301741B2 (ja) 2016-12-07 2023-07-03 ラ ファーマシューティカルズ インコーポレイテッド 補体活性のモジュレータ
MX2020005547A (es) 2017-12-04 2020-08-20 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
EA202191189A1 (ru) * 2018-10-30 2021-08-06 Алексион Фармасьютикалс, Инк. Подкожное введение и дозировка антител к c5 для лечения пароксизмальной ночной гемоглобинурии (пнг)
CN113543796A (zh) 2019-03-08 2021-10-22 Ra制药公司 齐鲁考普作为深层组织穿透性c5抑制剂
US20220211799A1 (en) 2019-04-24 2022-07-07 Ra Pharmaceuticals, Inc. Compositions and methods for modulating complement activity
ES2973767T3 (es) 2019-06-04 2024-06-24 Ra Pharmaceuticals Inc Tratamiento de enfermedades inflamatorias con inhibidores del complemento
WO2021050885A1 (en) 2019-09-12 2021-03-18 Ra Pharmaceuticals, Inc. Neurological disease treatment with complement inhibitors
JP2023523790A (ja) 2020-04-30 2023-06-07 アルナイラム ファーマシューティカルズ, インコーポレイテッド 補体因子B(CFB)iRNA組成物およびその使用方法
AR127477A1 (es) 2021-10-29 2024-01-31 Alnylam Pharmaceuticals Inc COMPOSICIONES DE ARNi CONTRA EL FACTOR B DEL COMPLEMENTO (CFB) Y MÉTODOS DE USO DE LAS MISMAS

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271068A (en) 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4033940A (en) 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4216141A (en) 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5371109A (en) 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
JP3127158B2 (ja) 1989-10-05 2001-01-22 オプテイン,インコーポレイティド 新規の遺伝子及びポリペチドの無細胞合成並びに単離
US5585353A (en) 1990-02-02 1996-12-17 The Rockefeller University Antibiotic peptides containing D-amino acids
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
DK0617706T3 (da) 1991-11-25 2001-11-12 Enzon Inc Multivalente antigenbindende proteiner
AU684510B2 (en) 1993-05-28 1997-12-18 Chiron Corporation Method for selection of biologically active peptide sequences
DK0710243T3 (da) 1993-06-29 2000-10-16 Ferring Bv Syntese af cykliske peptider
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US6720472B2 (en) 1996-07-12 2004-04-13 University Of Medicine And Dentistry Of New Jersey HMGI proteins in cancer and obesity
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6348584B1 (en) 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
WO1998016636A1 (en) 1996-10-17 1998-04-23 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US5922680A (en) 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
PT1712623E (pt) 1997-01-21 2011-12-21 Gen Hospital Corp Selecção de proteínas utilizando fusões de arn-proteína
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
CA2293632C (en) 1997-06-12 2011-11-29 Research Corporation Technologies, Inc. Artificial antibody polypeptides
EP0896001A1 (en) 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates
US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
DE69931930T2 (de) 1998-08-07 2006-10-05 Emisphere Technologies, Inc. Verbindungen und zusammensetzungen zur verabreichung aktiven substanzen
WO2000021559A2 (en) 1998-10-09 2000-04-20 Musc Foundation For Research Development Blocking factor b to treat complement-mediated immune disease
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7244701B2 (en) 2000-06-16 2007-07-17 Zealand Phama A/S Diuretic peptide conjugate
CN102258784A (zh) 2003-05-15 2011-11-30 唐纳士公司 用于预防和治疗败血症的方法与组合物
EP1667702A2 (en) 2003-09-10 2006-06-14 Baxter International Inc., Baxter Healthcare Corp. Peptides that inhibit complement activation
JP4994039B2 (ja) 2003-11-26 2012-08-08 スパーナス ファーマシューティカルズ インコーポレイテッド 脂溶性または疎水性化合物の送達に有用なミセル系
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
US8951522B2 (en) 2011-04-08 2015-02-10 University Of Leicester Methods for treating conditions associated with MASP-2 dependent complement activation
WO2006066258A2 (en) 2004-12-17 2006-06-22 Neose Technologies, Inc. Lipoconjugation of peptides
PL1844337T3 (pl) 2005-01-24 2013-12-31 Pepscan Systems Bv Związki wiążące, związki immunogenne i peptydomimetyki
US20060270590A1 (en) 2005-03-29 2006-11-30 Lockwood Samuel F Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
ES2548700T3 (es) 2005-05-26 2015-10-20 The Regents Of The University Of Colorado, A Body Corporate Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas
JP5198261B2 (ja) 2005-06-06 2013-05-15 カムルス エービー Glp−1類似体製剤
KR20150055628A (ko) 2005-11-04 2015-05-21 제넨테크, 인크. 안질환 치료를 위한 보체 경로 억제제의 용도
BR122017024057B8 (pt) * 2006-03-15 2021-05-25 Alexion Pharma Inc anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável
EP1876183A1 (en) 2006-07-04 2008-01-09 Technische Universität München Minimized small peptides with high affinity for factor VIII and factor VIII-like proteins
DK3028716T3 (da) 2006-10-10 2020-11-23 Regenesance B V Komplementhæmning til forbedret nerveregeneration
US7736860B2 (en) 2006-11-09 2010-06-15 Univeristy Of Massachusetts Methods of identifying compounds for the treatment of sterile inflammation
US20100166748A1 (en) 2007-03-22 2010-07-01 Novartis Ag C5 Antigens and Uses Thereof
US20100015139A1 (en) 2008-07-10 2010-01-21 Rekha Bansal METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF
BRPI0811007A2 (pt) 2007-04-30 2015-01-27 Alcon Res Ltd Tratamento de degeneração macular relacionada à idade usando inibidores de fator de complemento d
BRPI0812767A2 (pt) 2007-06-07 2014-12-02 Genentech Inc Anticorpos para c3b e métodos para prevenção e tratamento de distúrbios associados ao complemento
US20110142837A1 (en) 2007-07-20 2011-06-16 Trustees Of The University Of Pennsylvania Method Of Treating Acute Respiratory Distress Syndrome
KR20100094453A (ko) 2007-10-02 2010-08-26 포텐시아 팔마큐티칼스, 인크. 겔로부터 콤스타틴 유사체의 지속적 운반
WO2009067191A2 (en) 2007-11-16 2009-05-28 The General Hospital Corporation Methods and compositions for the treatment of hepatitis c virus (hcv) infection
EP2278987A4 (en) 2008-03-28 2012-08-22 Apellis Ag MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM
EP2324048A2 (en) 2008-07-30 2011-05-25 Cosmix Therapeutics Llc Peptide therapeutics that bind vegf and methods of use thereof
AU2009290137A1 (en) 2008-09-03 2010-03-11 Xenome Ltd Libraries of peptide conjugates and methods for making them
FI2894165T3 (fi) 2008-11-10 2023-03-23 Alexion Pharma Inc Menetelmiä ja koostumuksia komplementtiin liityvien häiriöiden hoitamiseksi
AU2009230735B1 (en) 2009-01-08 2010-01-21 Shane Ramodien Electronic equipment housing
CA2777845C (en) 2009-10-16 2017-08-01 Omeros Corporation Methods for treating disseminated intravascular coagulation by inhibiting masp-2 dependent complement activation
NZ600393A (en) 2009-11-05 2014-08-29 Alexion Cambridge Corp Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
WO2011073328A1 (en) 2009-12-16 2011-06-23 Novo Nordisk A/S Glp-1 receptor agonist compounds with a modified n-terminus
US9358266B2 (en) 2010-02-25 2016-06-07 The Trustees Of The University Of Pennsylvania Treatment of sepsis using complement inhibitors
US20110269807A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
TW201241008A (en) * 2010-10-01 2012-10-16 Alexion Pharma Inc Polypeptides that bind to human complement component C5
CA2831563A1 (en) * 2011-03-29 2012-10-04 Abbvie Inc. Improved shroud deployment in automatic injection devices
RU2639521C2 (ru) * 2011-05-05 2017-12-21 ВЕЛЛСТАТ ИММЬЮНОТЕРАПЬЮТИКС, ЭлЭлСи Аналоги фактора комплемента в и их применения
WO2012162215A1 (en) 2011-05-20 2012-11-29 The Trustees Of The University Of Pennsylvania Promotion of fracture healing using complement inhibitors
WO2012174055A1 (en) 2011-06-13 2012-12-20 The Trustees Of The University Of Pennsylvania Wound healing using complement inhibitors
CN102321170B (zh) 2011-09-14 2013-11-13 深圳翰宇药业股份有限公司 利拉鲁肽变构体及其缀合物
WO2013052736A2 (en) 2011-10-06 2013-04-11 The Medicines Company Methods of treating or preventing blood loss during surgery using the serine protease inhibitor mdco-2010
SMT201900189T1 (it) 2012-02-20 2019-05-10 Swedish Orphan Biovitrum Ab Publ Polipeptidi che si legano al c5 del complemento umano
US20130246083A1 (en) 2012-03-16 2013-09-19 Alexion Pharmaceuticals, Inc. Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor
EP2850095B1 (en) 2012-05-17 2019-10-09 RA Pharmaceuticals, Inc. Peptide and peptidomimetic inhibitors
US9579360B2 (en) 2012-06-20 2017-02-28 The Trustees Of The University Of Pennsylvania Methods of treating or preventing periodontitis and diseases associated with periodontitis
WO2014004733A1 (en) 2012-06-26 2014-01-03 The Regents Of The University Of California Composition for lupus nephritis and methods of making and using the same
WO2014078622A1 (en) 2012-11-15 2014-05-22 The Brigham And Women's Hospital, Inc. Method and system for diagnosing and treating preeclampsia
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
US20140234275A1 (en) 2013-02-15 2014-08-21 Jason Williams Method for treating als via the increased production of factor h
US20150057342A1 (en) 2013-08-21 2015-02-26 Cannabics Pharmaceuticals Inc Compositions for combined immediate and sustained release of cannabinoids, methods of manufacture and use thereof
CN104231085B (zh) * 2013-09-05 2017-03-15 复旦大学附属肿瘤医院 靶向特异性补体系统抑制剂、其制备方法及应用
MX2016011862A (es) 2014-03-20 2016-12-05 Inflarx Gmbh Inhibidores de c5a para el tratamiento de la neumonia viral.
JP6432954B2 (ja) * 2014-06-12 2018-12-05 ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. 補体活性の変調
US20160168237A1 (en) 2014-12-12 2016-06-16 Alexion Pharmaceuticals, Inc. Method for treating a complement mediated disorder caused by an infectious agent in a patient
CN107427482A (zh) 2015-01-21 2017-12-01 帕西拉制药有限公司 凝血酸的多囊脂质体制剂
SI3250230T1 (sl) * 2015-01-28 2022-01-31 Ra Pharmaceuticals, Inc. Modulatorji aktivnosti komplementa
WO2017035362A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses
AU2016370210A1 (en) * 2015-12-16 2018-06-21 Ra Pharmaceuticals, Inc. Modulators of complement activity
JP7301741B2 (ja) * 2016-12-07 2023-07-03 ラ ファーマシューティカルズ インコーポレイテッド 補体活性のモジュレータ
US10376595B2 (en) 2017-04-03 2019-08-13 Inflarx Gmbh Treatment of inflammatory diseases with inhibitors of C5a activity
EP3682016A4 (en) 2017-09-11 2021-06-02 RA Pharmaceuticals, Inc. FORMULATIONS FOR THE ADMINISTRATION OF COMPOUNDS
MX2020005547A (es) 2017-12-04 2020-08-20 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
CN113543796A (zh) 2019-03-08 2021-10-22 Ra制药公司 齐鲁考普作为深层组织穿透性c5抑制剂
US20220211799A1 (en) 2019-04-24 2022-07-07 Ra Pharmaceuticals, Inc. Compositions and methods for modulating complement activity

Similar Documents

Publication Publication Date Title
JP2019504012A5 (enExample)
RU2018121615A (ru) Модуляторы активности комплемента
Putcha et al. Management of hyperkalemia in dialysis patients
Chermy et al. Cancer pain management current strategy
JP2022009125A5 (enExample)
Neutel et al. A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension
JP2016520573A5 (enExample)
CA2867343C (en) Method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration
TW200838545A (en) Therapeutic agent for painful disease
JP2011511072A5 (enExample)
JP2018507243A5 (enExample)
IL314873A (en) Compositions and methods for treating disorders ameliorated by muscarnic receptor activation
AU2011334617A2 (en) Folic acid - Ramipril combination: cellprotective, neuroprotective and retinoprotective ophtalmologic compositions
JP2014511365A5 (enExample)
JP2021046394A5 (enExample)
JP2019529570A5 (enExample)
Brdon et al. Comparison between early and delayed systemic treatment with candesartan of rats after ischaemic stroke
EP2988750B9 (en) Use of landiolol hydrochloride in the long-term treatment of tachyarrhythmias
WO2020072311A1 (en) Pharmaceutical compositions of r-(+)-propranolol in enantiomeric excess and therapeutic uses related thereto
JP2016505050A5 (enExample)
KR20120089623A (ko) 정맥내 투여용 이부프로펜을 이용한 환자의 치료
Li et al. Depressive effects of chronic intermittent hypobaric hypoxia on renal vascular hypertension through enhancing baroreflex
RU2412701C2 (ru) Способ снижения непереносимости противотуберкулезных препаратов
CN103239444A (zh) 右旋吲哚布芬与氯吡格雷的复方药物组合物
JPH0213644B2 (enExample)