JP2011511072A5 - - Google Patents

Info

Publication number

JP2011511072A5

JP2011511072A5 JP2010545883A JP2010545883A JP2011511072A5 JP 2011511072 A5 JP2011511072 A5 JP 2011511072A5 JP 2010545883 A JP2010545883 A JP 2010545883A JP 2010545883 A JP2010545883 A JP 2010545883A JP 2011511072 A5 JP2011511072 A5 JP 2011511072A5

Authority

JP

Japan

Prior art keywords

administered

picoplatin

dose

leucovorin

composition

Prior art date

2009-02-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims description 112
• 229950005566 picoplatin Drugs 0.000 claims description 112
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 83
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 83
• 235000008191 folinic acid Nutrition 0.000 claims description 83
• 239000011672 folinic acid Substances 0.000 claims description 83
• 229960001691 leucovorin Drugs 0.000 claims description 83
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 73
• 229960002949 fluorouracil Drugs 0.000 claims description 73
• 229960000397 bevacizumab Drugs 0.000 claims description 59
• YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 claims description 25
• 206010009944 Colon cancer Diseases 0.000 claims description 23
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 23
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 23
• 229960004768 irinotecan Drugs 0.000 claims description 23
• 206010052358 Colorectal cancer metastatic Diseases 0.000 claims description 17
• 206010028980 Neoplasm Diseases 0.000 claims description 16
• 201000011510 cancer Diseases 0.000 claims description 16
• 229960005395 cetuximab Drugs 0.000 claims description 9
• 239000002552 dosage form Substances 0.000 claims description 8
• 238000001802 infusion Methods 0.000 claims description 8
• 239000000243 solution Substances 0.000 claims description 8
• 238000001990 intravenous administration Methods 0.000 claims description 6
• 239000000022 bacteriostatic agent Substances 0.000 claims description 4
• 239000003795 chemical substances by application Substances 0.000 claims description 4
• 230000001186 cumulative effect Effects 0.000 claims description 4
• 239000000644 isotonic solution Substances 0.000 claims description 4
• 231100000682 maximum tolerated dose Toxicity 0.000 claims description 4
• 206010061289 metastatic neoplasm Diseases 0.000 claims description 4
• 239000003755 preservative agent Substances 0.000 claims description 4
• 230000002335 preservative effect Effects 0.000 claims description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
• 238000009098 adjuvant therapy Methods 0.000 claims description 2
• 229940120638 avastin Drugs 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 43
• 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 3
• 239000013066 combination product Substances 0.000 claims 1
• 229940127555 combination product Drugs 0.000 claims 1
• 238000000034 method Methods 0.000 description 35
• 239000002464 receptor antagonist Substances 0.000 description 3
• 229940044551 receptor antagonist Drugs 0.000 description 3
• 230000003442 weekly effect Effects 0.000 description 3
• -1 bevacizumab Chemical compound 0.000 description 2
• 229940079593 drug Drugs 0.000 description 1
• 239000003814 drug Substances 0.000 description 1