JP2011511072A5 - - Google Patents
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- Publication number
- JP2011511072A5 JP2011511072A5 JP2010545883A JP2010545883A JP2011511072A5 JP 2011511072 A5 JP2011511072 A5 JP 2011511072A5 JP 2010545883 A JP2010545883 A JP 2010545883A JP 2010545883 A JP2010545883 A JP 2010545883A JP 2011511072 A5 JP2011511072 A5 JP 2011511072A5
- Authority
- JP
- Japan
- Prior art keywords
- administered
- picoplatin
- dose
- leucovorin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims description 112
- 229950005566 picoplatin Drugs 0.000 claims description 112
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims description 83
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims description 83
- 235000008191 folinic acid Nutrition 0.000 claims description 83
- 239000011672 folinic acid Substances 0.000 claims description 83
- 229960001691 leucovorin Drugs 0.000 claims description 83
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 73
- 229960002949 fluorouracil Drugs 0.000 claims description 73
- 229960000397 bevacizumab Drugs 0.000 claims description 59
- YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 claims description 25
- 206010009944 Colon cancer Diseases 0.000 claims description 23
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 23
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 23
- 229960004768 irinotecan Drugs 0.000 claims description 23
- 206010052358 Colorectal cancer metastatic Diseases 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 16
- 229960005395 cetuximab Drugs 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 8
- 238000001802 infusion Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 238000001990 intravenous administration Methods 0.000 claims description 6
- 239000000022 bacteriostatic agent Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000001186 cumulative effect Effects 0.000 claims description 4
- 239000000644 isotonic solution Substances 0.000 claims description 4
- 231100000682 maximum tolerated dose Toxicity 0.000 claims description 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000009098 adjuvant therapy Methods 0.000 claims description 2
- 229940120638 avastin Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 43
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 3
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 35
- 239000002464 receptor antagonist Substances 0.000 description 3
- 229940044551 receptor antagonist Drugs 0.000 description 3
- 230000003442 weekly effect Effects 0.000 description 3
- -1 bevacizumab Chemical compound 0.000 description 2
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2738708P | 2008-02-08 | 2008-02-08 | |
| US2738208P | 2008-02-08 | 2008-02-08 | |
| US2736008P | 2008-02-08 | 2008-02-08 | |
| PCT/US2009/000770 WO2009099649A1 (en) | 2008-02-08 | 2009-02-06 | Use of picoplatin and bevacizumab to treat colorectal cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511072A JP2011511072A (ja) | 2011-04-07 |
| JP2011511072A5 true JP2011511072A5 (enExample) | 2013-04-18 |
Family
ID=40952402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545878A Withdrawn JP2011511071A (ja) | 2008-02-08 | 2009-02-06 | 肺癌を治療するためのピコプラチンおよびアムルビシン |
| JP2010545883A Withdrawn JP2011511072A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用 |
| JP2010545885A Withdrawn JP2011511074A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびセツキシマブの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545878A Withdrawn JP2011511071A (ja) | 2008-02-08 | 2009-02-06 | 肺癌を治療するためのピコプラチンおよびアムルビシン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545885A Withdrawn JP2011511074A (ja) | 2008-02-08 | 2009-02-06 | 結腸直腸癌を治療するためのピコプラチンおよびセツキシマブの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110052581A1 (enExample) |
| EP (3) | EP2249644A4 (enExample) |
| JP (3) | JP2011511071A (enExample) |
| CN (3) | CN102014624A (enExample) |
| AU (3) | AU2009210654A1 (enExample) |
| CA (3) | CA2715329A1 (enExample) |
| WO (3) | WO2009099634A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
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| US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| RU2009133447A (ru) * | 2007-02-09 | 2011-03-20 | Пониард Фармасьютикалз, Инк. (Us) | Дозированная форма пикоплатина |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| WO2009011861A1 (en) * | 2007-07-16 | 2009-01-22 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| EP2249644A4 (en) * | 2008-02-08 | 2012-05-30 | Poniard Pharmaceuticals Inc | PICOPLATIN AND AMRUBICIN FOR THE TREATMENT OF LUNG CANCER |
| ES2354922B1 (es) | 2009-09-02 | 2012-02-07 | Fundacion Institut De Recerca De L'hospital Universitari Vall D'hebron | Marcadores para la selección de terapias personalizadas para el tratamiento del c�?ncer. |
| US9217032B2 (en) * | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
| EP2542699A4 (en) * | 2010-03-03 | 2013-10-02 | Targeted Molecular Diagnostics Llc | METHODS FOR DETERMINING REACTIVITY TO A MEDICINE BASED ON DETERMINATION OF RAS MUTATION AND / OR RAS AMPLIFICATION |
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| US8709419B2 (en) * | 2010-08-17 | 2014-04-29 | Hoffmann-La Roche, Inc. | Combination therapy |
| US8962804B2 (en) * | 2010-10-08 | 2015-02-24 | City Of Hope | Meditopes and meditope-binding antibodies and uses thereof |
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| WO2013067162A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| JP2014534228A (ja) | 2011-11-02 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 白金含有剤とｈｓｐ９０阻害剤の組合せ療法 |
| EP2780010A1 (en) | 2011-11-14 | 2014-09-24 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| EP2617421A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| US20130225529A1 (en) * | 2012-02-27 | 2013-08-29 | Basil Rigas | Phospho-ester derivatives and uses thereof |
| CN110507654A (zh) | 2012-04-03 | 2019-11-29 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
| NL2010276C2 (en) * | 2013-02-08 | 2014-08-11 | Stichting Vu Vumc | Biomarkers. |
| NL2008707C2 (en) * | 2012-04-26 | 2013-10-29 | Stichting Vu Vumc | Biomarkers. |
| EP2841947B1 (en) * | 2012-04-26 | 2019-10-09 | Stichting VUmc | Biomarkers |
| JP6312659B2 (ja) * | 2012-05-31 | 2018-04-18 | ジェネンテック， インコーポレイテッド | Ｐｄ−１系結合アンタゴニスト及びｖｅｇｆアンタゴニストを用いた癌の治療方法 |
| BR112015009134A2 (pt) * | 2012-10-25 | 2017-07-04 | Glaxosmithkline Llc | combinação |
| JP2018517892A (ja) | 2015-04-10 | 2018-07-05 | アプライド プロテオミクス，インク． | 結腸直腸癌と進行腺腫を検知するためのタンパク質バイオマーカーパネル |
| CN108136023B (zh) * | 2015-08-12 | 2021-07-27 | 北卡罗莱纳州立大学 | 血小板膜包覆的药物递送系统 |
| WO2021007512A1 (en) * | 2019-07-11 | 2021-01-14 | Emory University | Platinum-based chemotherapy, mast binding agents, glucocorticoid receptor (gr) binding agents, and/or hsp90 binding agents for uses in treating cancer |
| WO2025217467A1 (en) * | 2024-04-10 | 2025-10-16 | El Capitan Biosciences, Inc. | Occult blood mrna biomarkers paired with dna/rna mutations and dna methylation |
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-
2009
- 2009-02-06 EP EP09708292A patent/EP2249644A4/en not_active Withdrawn
- 2009-02-06 US US12/866,706 patent/US20110052581A1/en not_active Abandoned
- 2009-02-06 CA CA2715329A patent/CA2715329A1/en not_active Abandoned
- 2009-02-06 US US12/866,702 patent/US20110052580A1/en not_active Abandoned
- 2009-02-06 WO PCT/US2009/000750 patent/WO2009099634A2/en not_active Ceased
- 2009-02-06 EP EP09708527A patent/EP2244714A4/en not_active Withdrawn
- 2009-02-06 AU AU2009210654A patent/AU2009210654A1/en not_active Abandoned
- 2009-02-06 JP JP2010545878A patent/JP2011511071A/ja not_active Withdrawn
- 2009-02-06 AU AU2009210656A patent/AU2009210656A1/en not_active Abandoned
- 2009-02-06 WO PCT/US2009/000773 patent/WO2009099651A1/en not_active Ceased
- 2009-02-06 JP JP2010545883A patent/JP2011511072A/ja not_active Withdrawn
- 2009-02-06 AU AU2009210734A patent/AU2009210734A1/en not_active Abandoned
- 2009-02-06 JP JP2010545885A patent/JP2011511074A/ja not_active Withdrawn
- 2009-02-06 CN CN2009801101399A patent/CN102014624A/zh active Pending
- 2009-02-06 CA CA2715353A patent/CA2715353A1/en not_active Abandoned
- 2009-02-06 US US12/866,710 patent/US20110053879A1/en not_active Abandoned
- 2009-02-06 CN CN2009801110152A patent/CN101998851A/zh active Pending
- 2009-02-06 CA CA2715348A patent/CA2715348A1/en not_active Abandoned
- 2009-02-06 WO PCT/US2009/000770 patent/WO2009099649A1/en not_active Ceased
- 2009-02-06 EP EP09708387A patent/EP2249827A4/en not_active Withdrawn
- 2009-02-06 CN CN2009801097586A patent/CN102006875A/zh active Pending
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