EP2278987A4 - Modulation and repletion/enhancement of the complement system for treatment of trauma - Google Patents

Modulation and repletion/enhancement of the complement system for treatment of trauma

Info

Publication number
EP2278987A4
EP2278987A4 EP09724618A EP09724618A EP2278987A4 EP 2278987 A4 EP2278987 A4 EP 2278987A4 EP 09724618 A EP09724618 A EP 09724618A EP 09724618 A EP09724618 A EP 09724618A EP 2278987 A4 EP2278987 A4 EP 2278987A4
Authority
EP
European Patent Office
Prior art keywords
repletion
trauma
enhancement
modulation
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09724618A
Other languages
German (de)
French (fr)
Other versions
EP2278987A2 (en
Inventor
Cedric Francois
Pascal Deschatelets
Paul Olson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynatron AG
Original Assignee
Dynatron AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynatron AG filed Critical Dynatron AG
Publication of EP2278987A2 publication Critical patent/EP2278987A2/en
Publication of EP2278987A4 publication Critical patent/EP2278987A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1725—Complement proteins, e.g. anaphylatoxin, C3a or C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP09724618A 2008-03-28 2009-03-30 Modulation and repletion/enhancement of the complement system for treatment of trauma Withdrawn EP2278987A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4063408P 2008-03-28 2008-03-28
US4063708P 2008-03-28 2008-03-28
US4063508P 2008-03-28 2008-03-28
PCT/US2009/038807 WO2009121065A2 (en) 2008-03-28 2009-03-30 Modulation and repletion/enhancement of the complement system for treatment of trauma

Publications (2)

Publication Number Publication Date
EP2278987A2 EP2278987A2 (en) 2011-02-02
EP2278987A4 true EP2278987A4 (en) 2012-08-22

Family

ID=41114827

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09724618A Withdrawn EP2278987A4 (en) 2008-03-28 2009-03-30 Modulation and repletion/enhancement of the complement system for treatment of trauma

Country Status (3)

Country Link
US (1) US20110190221A1 (en)
EP (1) EP2278987A4 (en)
WO (1) WO2009121065A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
JP2010505946A (en) 2006-10-10 2010-02-25 アカデミシュ ジーケンハウス ビイ デ ユニヴェアズィテート ファン アムステルダム Complement inhibition to improve nerve regeneration
EP4105224A1 (en) 2011-05-11 2022-12-21 Apellis Pharmaceuticals, Inc. Long-acting compstatin analogs and uses thereof
WO2012162215A1 (en) * 2011-05-20 2012-11-29 The Trustees Of The University Of Pennsylvania Promotion of fracture healing using complement inhibitors
ES2728278T3 (en) 2011-12-21 2019-10-23 Novartis Ag Compositions comprising antibodies directed to factor P and C5
CA2889170C (en) 2012-10-25 2021-09-07 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
CN108610418B (en) 2012-11-02 2022-11-01 美国比奥维拉迪维股份有限公司 Anti-complement C1s antibodies and uses thereof
PT3660033T (en) 2012-11-15 2021-07-06 Apellis Pharmaceuticals Inc Long-acting compstatin analogs and related compositions and methods
US10308687B2 (en) 2013-03-15 2019-06-04 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10155983B2 (en) 2014-03-31 2018-12-18 Machaon Diagnostics, Inc. Method of diagnosis of complement-mediated thrombotic microangiopathies
US10106579B2 (en) 2014-06-12 2018-10-23 Ra Pharmaceuticals, Inc. Modulation of complement activity
US9937222B2 (en) 2015-01-28 2018-04-10 Ra Pharmaceuticals, Inc. Modulators of complement activity
HRP20230093T1 (en) 2015-04-06 2023-03-31 Bioverativ Usa Inc. Humanized anti-c1s antibodies and methods of use thereof
CN117503905A (en) 2015-10-07 2024-02-06 阿佩利斯制药有限公司 dosing regimen
TWI745320B (en) 2015-12-16 2021-11-11 美商Ｒａ製藥公司 Modulators of complement activity
JP2019506159A (en) 2016-01-20 2019-03-07 ヴィトリサ セラピューティクス， インコーポレイテッド Compositions and methods for inhibiting factor D
CN110249053A (en) * 2016-10-17 2019-09-17 阿佩利斯制药有限公司 The combination treatment inhibited for C3
CN110087668A (en) 2016-12-07 2019-08-02 Ra制药公司 The regulator of complement activity
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
CA3059304A1 (en) 2017-04-07 2018-10-11 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
WO2019006153A1 (en) * 2017-06-30 2019-01-03 Anthrobio Proteolytic cascade enhancement for the treatment of disease
US20200262879A1 (en) 2017-09-11 2020-08-20 Insideoutbio, Inc. Methods and compositions to enhance the immunogenicity of tumors
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
US11510939B1 (en) 2019-04-19 2022-11-29 Apellis Pharmaceuticals, Inc. RNAs for complement inhibition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006062716A2 (en) * 2004-11-18 2006-06-15 Yale University Methods and compositions for treating ocular disorders
WO2007062249A2 (en) * 2005-11-28 2007-05-31 The Trustees Of The University Of Pennsylvania Potent compstatin analogs

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981481A (en) * 1974-12-06 1999-11-09 The Johns Hopkins University Human C3b/C4b receptor (CR1)
EP1413587A2 (en) * 1991-05-03 2004-04-28 Washington University Modified complement system regulator
AUPO755097A0 (en) * 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US6197934B1 (en) * 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
US7084106B1 (en) * 1999-01-19 2006-08-01 University Of Louisville Research Foundation, Inc. Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease
US7108982B1 (en) * 1999-02-19 2006-09-19 University Of Iowa Research Foundation Diagnostics and the therapeutics for macular degeneration
WO2004026328A1 (en) * 2002-09-20 2004-04-01 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved activity
CN1787741B (en) * 2003-05-15 2011-08-17 唐纳士公司 Methods and compositions for the prevention and treatment of sepsis
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
JP2008512350A (en) * 2004-07-01 2008-04-24 イェール ユニバーシティ Polymeric substances that are targeted and loaded with drugs at high density
WO2006042252A2 (en) * 2004-10-08 2006-04-20 Potentia Pharmeceuticals, Inc. Viral complement control proteins for eye disorders
US8043609B2 (en) * 2004-10-08 2011-10-25 Potentia Pharmaceuticals, Inc. Viral complement control proteins for eye disorders
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
JP4438712B2 (en) * 2005-07-25 2010-03-24 トヨタ自動車株式会社 Control device for internal combustion engine
US8168584B2 (en) * 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
CN101346473A (en) * 2005-12-22 2009-01-14 爱尔康研究有限公司 C3-convertase inhibitors for the prevention and treatment of age-related macular degeneration in patients with at risk variants of complement factor H
US20070196367A1 (en) * 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
WO2009015087A2 (en) * 2007-07-20 2009-01-29 Potentia Pharmaceuticals, Inc. Compositions and methods for treatment of trauma
KR20150080007A (en) * 2007-10-02 2015-07-08 포텐시아 팔마큐티칼스, 인크. Sustained delivery of compstatin analogs from gels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006062716A2 (en) * 2004-11-18 2006-06-15 Yale University Methods and compositions for treating ocular disorders
WO2007062249A2 (en) * 2005-11-28 2007-05-31 The Trustees Of The University Of Pennsylvania Potent compstatin analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 11 June 2007 (2007-06-11), PILLAY NIRVANA S ET AL: "Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma.", XP002679788, Database accession no. NLM17467672 *
MOLLNES T E ET AL: "Strategies of therapeutic complement inhibition", MOLECULAR IMMUNOLOGY, PERGAMON, GB, vol. 43, no. 1-2, 1 January 2006 (2006-01-01), pages 107 - 121, XP027899184, ISSN: 0161-5890, [retrieved on 20060101] *
PILLAY NIRVANA S ET AL: "Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma.", BRAIN RESEARCH 11 JUN 2007 LNKD- PUBMED:17467672, vol. 1153, 11 June 2007 (2007-06-11), pages 158 - 165, ISSN: 0006-8993 *

Also Published As

Publication number Publication date
US20110190221A1 (en) 2011-08-04
EP2278987A2 (en) 2011-02-02
WO2009121065A2 (en) 2009-10-01
WO2009121065A3 (en) 2010-03-18

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