US10106579B2 - Modulation of complement activity
- Google Patents
Modulation of complement activity
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Publication number
US10106579B2
US10106579B2
US15/318,063
US201515318063A
US10106579B2
US 10106579 B2
US10106579 B2
US 10106579B2
US 201515318063 A
US201515318063 A
US 201515318063A
US 10106579 B2
US10106579 B2
US 10106579B2
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US
United States
Prior art keywords
polypeptide
nvl
amino acids
polypeptides
azatrp
Prior art date
2014-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US15/318,063
Other versions
US20170137468A1
(en
Inventor
Michelle Denise Hoarty
Ketki Ashok Dhamnaskar
Daniel Elbaum
Kristopher Josephson
Kelley Cronin Larson
Zhong Ma
Nathan Ezekiel Nims
Alonso Ricardo
Kathleen Seyb
Guo-Qing Tang
Douglas A. Treco
Zhaolin Wang
Ping Ye
Hong Zheng
Sarah Jacqueline Perlmutter
Robert Paul Hammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RA Pharmaceuticals Inc
Original Assignee
RA Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
2014-06-12
Filing date
2015-06-12
Publication date
2018-10-23
Family has litigation
First worldwide family litigation filed
litigation
Critical
https://patents.darts-ip.com/?family=54834568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US10106579(B2)
"Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
2015-06-12
Application filed by RA Pharmaceuticals Inc
filed
Critical
RA Pharmaceuticals Inc
2015-06-12
Priority to US15/318,063
priority
Critical
patent/US10106579B2/en
2017-01-09
Assigned to RA PHARMACEUTICALS, INC.
reassignment
RA PHARMACEUTICALS, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS).
Assignors: LARSON, Kelley Cronin, DHAMNASKAR, Ketki Ashok, ELBAUM, DANIEL, JOSEPHSON, Kristopher, NIMS, NATHAN EZEKIEL, WANG, ZHAOLIN, PERLMUTTER, Sarah Jacqueline, TANG, GUO-QING, ZHENG, HONG, ARATA, MICHELLE DENISE, RICARDO, Alonso, SEYB, KATHLEEN, YE, PING, MA, Zhong, TRECO, DOUGLAS A.
2017-05-18
Publication of US20170137468A1
publication
Critical
patent/US20170137468A1/en
2018-04-18
Assigned to RA PHARMACEUTICALS, INC.
reassignment
RA PHARMACEUTICALS, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS).
Assignors: HAMMER, ROBERT PAUL
2018-10-23
Application granted
granted
Critical
2018-10-23
Publication of US10106579B2
publication
Critical
patent/US10106579B2/en
2022-04-19
Priority to US17/724,304
priority
patent/US11535650B1/en
Status
Active
legal-status
Critical
Current
2035-06-12
Anticipated expiration
legal-status
Critical
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spermine
Chemical compound
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trityl group
Chemical group
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tyrosine
Natural products
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(2R,3S)-3-Hydroxy-2-pyrolidinecarboxylic acid
Natural products
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(2S)-2-amino-3-(1,2,4-oxadiazol-3-yl)butanoic acid
Chemical compound
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(2S)-2-amino-3-(1,3,4-oxadiazol-2-yl)butanoic acid
Chemical compound
N[C@H](C(=O)O)C(C)C=1OC=NN=1
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(2S)-2-amino-3-(1,3-oxazol-2-yl)butanoic acid
Chemical compound
N[C@H](C(=O)O)C(C)C=1OC=CN=1
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(2S)-2-amino-3-(1,3-oxazol-5-yl)butanoic acid
Chemical compound
N[C@H](C(=O)O)C(C)C1=CN=CO1
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(2S)-2-amino-3-(2H-indazol-3-yl)butanoic acid
Chemical compound
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(2S)-2-amino-3-(5-fluoro-2H-indazol-3-yl)butanoic acid
Chemical compound
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(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Chemical compound
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(2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane
Chemical compound
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(2s)-2-(9h-fluoren-9-ylmethoxycarbonylamino)-6-(prop-2-enoxycarbonylamino)hexanoic acid
Chemical compound
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(2s)-2-(naphthalen-1-ylamino)propanoic acid
Chemical compound
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(2s)-2-(naphthalen-2-ylamino)propanoic acid
Chemical compound
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(2s)-2-amino-2-methylbutanedioic acid
Chemical compound
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(3s)-3-(9h-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid
Chemical compound
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(3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid
Chemical compound
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Chemical group
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(Z)-2-aminobutenoic acid
Chemical group
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Natural products
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1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Chemical compound
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1,2,3,4-tetrakis(bromomethyl)benzene
Chemical compound
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1,2,3-tris(bromomethyl)benzene
Chemical compound
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1,4-dichloro-2-isothiocyanatobenzene
Chemical compound
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1,5-dibromo-5,6-dimethylcyclohexa-1,3-diene
Chemical group
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1-phenylethylamine
Chemical compound
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13-cis retinol
Natural products
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Chemical group
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2,5-dibromo-5,6-dimethylcyclohexa-1,3-diene
Chemical group
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2-(pentylazaniumyl)acetate
Chemical compound
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2-[methyl(pentyl)amino]acetic acid
Chemical compound
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2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride
Chemical compound
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2-methyltetrahydrofuran
Chemical compound
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Chemical group
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3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate
Chemical compound
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3-aminoadipic acid
Chemical compound
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3-cyanoalanine
Chemical compound
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3-mercaptopropanoic acid
Chemical compound
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4-[(2-hydroxy-4-methoxybenzoyl)amino]butanoic acid
Chemical compound
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4-[4-(4-carboxyphenyl)phenyl]benzoic acid
Chemical compound
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4-azaleucine
Chemical compound
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5,6-dibromo-5,6-dimethylcyclohexa-1,3-diene
Chemical group
CC1(Br)C=CC=CC1(C)Br
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5-aminohexanoic acid
Chemical compound
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6-aminohexanoic acid
Chemical compound
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Chemical compound
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Human genes
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Chemical compound
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D-erythro-ascorbic acid
Natural products
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Chemical compound
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Chemical compound
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Proteins
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Diseases
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Chemical compound
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Human genes
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Ethyl cellulose
Chemical compound
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Exenatide
Chemical compound
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Human genes
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Proteins
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Fibrin monomer
Chemical compound
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Human genes
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Human genes
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Chemical compound
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Natural products
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Chemical compound
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Human genes
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Natural products
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Chemical compound
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Chemical compound
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L-methionine sulphoxide
Natural products
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L-propargyl glycine
Natural products
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Chemical compound
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Chemical compound
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Chemical compound
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Chemical compound
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