DK3028716T3 - Komplementhæmning til forbedret nerveregeneration - Google Patents
Komplementhæmning til forbedret nerveregeneration Download PDFInfo
- Publication number
- DK3028716T3 DK3028716T3 DK15187453.4T DK15187453T DK3028716T3 DK 3028716 T3 DK3028716 T3 DK 3028716T3 DK 15187453 T DK15187453 T DK 15187453T DK 3028716 T3 DK3028716 T3 DK 3028716T3
- Authority
- DK
- Denmark
- Prior art keywords
- generation
- complementary inhibition
- nervous
- improved nervous
- improved
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85027706P | 2006-10-10 | 2006-10-10 | |
EP13181901.3A EP2698166B1 (en) | 2006-10-10 | 2007-10-10 | Complement inhibition for improved nerve regeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3028716T3 true DK3028716T3 (da) | 2020-11-23 |
Family
ID=38857887
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15187453.4T DK3028716T3 (da) | 2006-10-10 | 2007-10-10 | Komplementhæmning til forbedret nerveregeneration |
DK13181901.3T DK2698166T3 (da) | 2006-10-10 | 2007-10-10 | Komplementærhæmning for bedre nerveregeneration |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13181901.3T DK2698166T3 (da) | 2006-10-10 | 2007-10-10 | Komplementærhæmning for bedre nerveregeneration |
Country Status (16)
Country | Link |
---|---|
US (4) | US8703136B2 (da) |
EP (4) | EP3804755A1 (da) |
JP (2) | JP2010505946A (da) |
AU (1) | AU2007307375B2 (da) |
CA (3) | CA3154415A1 (da) |
CY (1) | CY1123734T1 (da) |
DK (2) | DK3028716T3 (da) |
ES (2) | ES2831325T3 (da) |
HK (2) | HK1194688A1 (da) |
HU (2) | HUE026042T2 (da) |
LT (1) | LT3028716T (da) |
NZ (1) | NZ576195A (da) |
PL (2) | PL2698166T3 (da) |
PT (2) | PT3028716T (da) |
SI (2) | SI3028716T1 (da) |
WO (1) | WO2008044928A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ576195A (en) | 2006-10-10 | 2012-04-27 | Az Univ Amsterdam | Complement inhibition for improved nerve regeneration |
AU2014200822B2 (en) * | 2006-10-10 | 2016-01-28 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
NZ591057A (en) * | 2008-07-10 | 2012-11-30 | Az Univ Amsterdam | Complement antagonists and uses thereof |
WO2010022149A1 (en) * | 2008-08-20 | 2010-02-25 | The Trustees Of The University Of Pennsylvania | Complement inhibitors for treatment of injury form intracerebral hemorrhage |
WO2011105902A2 (en) | 2010-02-23 | 2011-09-01 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Antagonists of complement component 8-beta (c8-beta) and uses thereof |
WO2011105901A2 (en) | 2010-02-23 | 2011-09-01 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Antagonists of complement component 9 (c9) and uses thereof |
WO2011105900A2 (en) | 2010-02-23 | 2011-09-01 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Antagonists of complement component 8-alpha (c8-alpha) and uses thereof |
JP6253578B2 (ja) | 2011-07-22 | 2017-12-27 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 阻害性抗第xii/xiia因子モノクローナル抗体及びそれらの使用 |
EP2623110A1 (en) * | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
WO2014066744A2 (en) | 2012-10-25 | 2014-05-01 | True North Therapeutics, Inc. | Anti-complement c1s antibodies and uses thereof |
US8945562B2 (en) | 2012-11-02 | 2015-02-03 | True North Therapeutics, Inc. | Anti-complement C1s antibodies |
AU2014224599B2 (en) | 2013-03-08 | 2018-11-08 | Csl Behring Gmbh | Treatment and prevention of remote ischemia-reperfusion injury |
DK3154561T3 (da) | 2014-06-12 | 2019-10-07 | Ra Pharmaceuticals Inc | Modulering af komplementaktivitet |
KR20230137502A (ko) * | 2014-12-19 | 2023-10-04 | 레제네상스 비.브이. | 인간 c6에 결합하는 항체 및 이의 용도 |
LT3250230T (lt) | 2015-01-28 | 2021-12-27 | Ra Pharmaceuticals, Inc. | Komplemento aktyvumo moduliatoriai |
LT3280440T (lt) | 2015-04-06 | 2023-02-27 | Bioverativ Usa Inc. | Humanizuoti antikūnai prieš c1s ir jų panaudojimo būdai |
SG11201804721SA (en) | 2015-12-16 | 2018-07-30 | Ra Pharmaceuticals Inc | Modulators of complement activity |
EP3405577B8 (en) | 2016-01-20 | 2023-02-15 | 396419 B.C. Ltd. | Compositions and methods for inhibiting factor d |
MA45235A (fr) | 2016-06-14 | 2019-04-17 | Regeneron Pharma | Anticorps anti-c5 et leurs utilisations |
JP7301741B2 (ja) | 2016-12-07 | 2023-07-03 | ラ ファーマシューティカルズ インコーポレイテッド | 補体活性のモジュレータ |
WO2018136827A1 (en) | 2017-01-20 | 2018-07-26 | Vitrisa Therapeutics, Inc. | Stem-loop compositions and methods for inhibiting factor d |
JP2021505565A (ja) | 2017-12-04 | 2021-02-18 | ラ ファーマシューティカルズ インコーポレイテッドRa Pharmaceuticals,Inc. | 補体活性のモジュレータ |
EP3724226A1 (en) | 2017-12-13 | 2020-10-21 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
US11161900B2 (en) | 2018-12-13 | 2021-11-02 | Argenx Bvba | Antibodies that specifically bind to human complement factor C2b |
TW202100179A (zh) | 2019-03-08 | 2021-01-01 | 美商Ra製藥公司 | 補體活性之調節劑 |
WO2020205501A1 (en) | 2019-03-29 | 2020-10-08 | Ra Pharmaceuticals, Inc. | Complement modulators and related methods |
JP2022530042A (ja) | 2019-04-24 | 2022-06-27 | ラ ファーマシューティカルズ インコーポレイテッド | 補体活性を調節するための組成物及び方法 |
GB2584105B (en) * | 2019-05-21 | 2023-08-02 | Argenx Bvba | Methods of treating neuropathy |
CN115605592A (zh) | 2020-05-11 | 2023-01-13 | 基因泰克公司(Us) | 用于治疗神经系统疾病的补体组分c1r抑制剂以及相关的组合物、系统和使用它们的方法 |
WO2021231204A1 (en) | 2020-05-11 | 2021-11-18 | Genentech, Inc. | Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same |
WO2021231211A1 (en) | 2020-05-11 | 2021-11-18 | Genentech, Inc. | Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same |
WO2024081954A2 (en) | 2022-10-14 | 2024-04-18 | Sanegene Bio Usa Inc. | Small interfering rna targeting c3 and uses thereof |
WO2024137590A2 (en) | 2022-12-19 | 2024-06-27 | Sanegene Bio Usa Inc. | Small interfering rna targeting cfb and uses thereof |
Family Cites Families (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
IL89790A (en) | 1988-04-01 | 2002-05-23 | Johns Hopking University | Sequences of nucleic acids encoding and cells producing CR1 protein and methods for its production and purification |
US5256642A (en) | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5177190A (en) | 1989-01-03 | 1993-01-05 | Merck & Co., Inc. | Purified C5a receptor from human polymorphonuclear leukocytes |
JPH05503001A (ja) | 1989-10-27 | 1993-05-27 | スティッチング セントラール ラボラトリウム ファン デ ブルートトランスフュジエディエンスト ファン ヘット ネデールランツェ ローデ クルイス | C1インヒビターミューティンおよびその利用 |
GB9007971D0 (en) | 1990-04-09 | 1990-06-06 | Imutran Ltd | Pharmaceutical formulations |
WO1992022320A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | C1 inhibitor variants and treating inflammatory response with c1 inhibitor |
DE4222534A1 (de) * | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
EP1621554B2 (en) | 1992-08-21 | 2012-08-29 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
DE4227762A1 (de) | 1992-08-24 | 1994-03-03 | Behringwerke Ag | Verwendung eines Kallikrein-Inhibitors zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie bestimmter Krankheiten |
US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
US5480974A (en) | 1993-06-18 | 1996-01-02 | The Scripps Research Institute | Antibodies to human C5a receptor |
FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
ES2171465T3 (es) | 1993-09-01 | 2002-09-16 | Sanquin Bloedvoorziening | Inhibidor de la esterasa de c1 para reducir lesiones de miocardio durante un infarto de miocardio agudo. |
US5627264A (en) | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
JPH09510088A (ja) | 1994-03-03 | 1997-10-14 | アレクション・ファーマシューティカル・インク | 最終補体インヒビター融合遺伝子およびタンパク質 |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
US5679345A (en) * | 1994-06-02 | 1997-10-21 | The Johns Hopkins University | Method for preventing complement-dependent rejection of organ or tissue transplants |
EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
US6267955B1 (en) | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
SE9503495L (sv) | 1995-10-09 | 1997-04-10 | Actinova Ltd | Nytt protein |
US5843884A (en) | 1995-11-15 | 1998-12-01 | Oklahoma Medical Research Foundation | C9 complement inhibitor |
US5922690A (en) | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
EP0937140B1 (en) | 1996-06-27 | 2007-09-26 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Antibody molecules which interact specifically with the active site or cleft of a target molecule |
DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
JP2001513576A (ja) | 1997-08-26 | 2001-09-04 | グリアテック インコーポレイテッド | 側副経路を介する補体活性化を阻害するためのプロセス |
AU748143B2 (en) | 1997-10-28 | 2002-05-30 | University Of British Columbia, The | Immunological compositions and methods of use to transiently alter mammalian central nervous system myelin to promote neuronal regeneration |
EP1051493A2 (en) | 1998-01-26 | 2000-11-15 | Unilever Plc | Method for producing antibody fragments |
WO1999037149A1 (en) | 1998-01-27 | 1999-07-29 | Brigham & Women's Hospital | Methods of treating cytotoxic damage |
AU3066699A (en) | 1998-03-03 | 1999-09-20 | Johns Hopkins University, The | Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation |
US20030096775A1 (en) | 2001-10-23 | 2003-05-22 | Isis Pharmaceuticals Inc. | Antisense modulation of complement component C3 expression |
WO2000029033A2 (en) * | 1998-11-17 | 2000-05-25 | The General Hospital Corporation | A method of genetic vector delivery |
CA2347734A1 (en) | 1998-12-15 | 2000-06-22 | Brigham And Women's Hospital, Inc. | Methods and products for regulating lectin complement pathway associated complement activation |
BR9916765A (pt) | 1999-01-05 | 2001-09-25 | Unilever Nv | Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico |
AU2291700A (en) | 1999-01-19 | 2000-08-07 | Unilever Plc | Method for producing antibody fragments |
EP1152759A2 (en) | 1999-02-09 | 2001-11-14 | 3-Dimensional Pharmaceuticals, Inc. | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR |
BR0009866A (pt) | 1999-04-22 | 2002-01-08 | Unilever Nv | Método de inibição de infecção viral, uso de uma proteìna de ligação de antìgeno monovalente, produto alimentìcio, composição farmacêutica ou cosmética, proteìna de ligação de antìgeno monovalente, sequência de nucleotìdeos, vetor de expressão, célula hospedeira, e, métodos de seleção e de indentificação de uma proteìna de ligação de antìgeno |
JP2002542299A (ja) | 1999-04-28 | 2002-12-10 | ユニバーシティ・オブ・ブリティッシュ・コロンビア | ミエリン特異性抗体および補体タンパク質を含むニューロン再生用組成物 |
US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
DE60042789D1 (de) | 1999-11-29 | 2009-10-01 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
DK1242460T3 (da) | 1999-11-29 | 2006-12-11 | Unilever Nv | Immobilisering af proteiner ved hjælp af et polypeptidsegment |
DE60132169T2 (de) | 2000-01-31 | 2008-12-11 | Pharming Intellectual Property Bv | Humaner c1 inhibitor hergestellt in der milch transgener säugetiere |
DE60138333D1 (de) | 2000-03-14 | 2009-05-28 | Unilever Nv | Variabele Domänen der schweren Kette eines Antikörpers gegen menschliche Ernährungslipasen und deren Verwendungen |
AU2001268855A1 (en) | 2000-05-26 | 2001-12-03 | National Research Council Of Canada | Single-domain antigen-binding antibody fragments derived from llama antibodies |
ES2368623T3 (es) | 2000-12-13 | 2011-11-18 | Bac Ip B.V. | Matrices de proteína de dominios variables de inmunoglobulina de cadena pesada de camilidae. |
DE10112617A1 (de) * | 2001-03-14 | 2002-10-02 | Aventis Behring Gmbh | Verwendung eines C1-Esterase-Inhibitors zur Verhinderung oder Verzögerung der Abstoßung von Xenotransplantaten in Säugetieren |
CA2454562A1 (en) * | 2001-07-26 | 2003-02-06 | Alexion Pharmaceuticals, Inc. | Method of improving cognitive function |
EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
US20050214857A1 (en) | 2001-12-11 | 2005-09-29 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
EP1456237A2 (en) | 2001-12-21 | 2004-09-15 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Method for cloning of variable domain sequences |
EP1461085A2 (en) | 2002-01-03 | 2004-09-29 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunoconjugates useful for treatment of tumours |
EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
CA2505326A1 (en) | 2002-11-08 | 2004-05-21 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
ES2392511T3 (es) | 2002-11-15 | 2012-12-11 | Musc Foundation For Research Development | Moduladores de complemento dianas sobre el receptor 2 de complemento |
MXPA05006043A (es) | 2003-01-10 | 2006-01-30 | Ablynx Nv | Polipeptidos terapeuticos, homologos de los mismos, fragmentos de los mismos y para uso al modular la agregacion mediada de plaquetas. |
AU2004216176B2 (en) | 2003-02-21 | 2008-04-03 | Genentech, Inc. | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
PL1626736T3 (pl) * | 2003-05-16 | 2021-05-04 | Pharming Intellectual Property B.V. | Inhibitor c1 o krótkim okresie półtrwania do leczenia przejściowego |
US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
WO2005016285A2 (en) * | 2003-08-13 | 2005-02-24 | New York University | Compositions and methods for inhibiting slit protein and glypican interactions |
US20060233776A1 (en) * | 2003-08-19 | 2006-10-19 | Norbert Heimburger | C1-inh as a drug for treating viruses pathogenic to humans |
US7923010B2 (en) | 2003-09-11 | 2011-04-12 | The Board Of Regents Of The University Of Texas System | Methods and materials for treating autoimmune diseases and conditions |
US20050169921A1 (en) | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
US20070116710A1 (en) | 2004-02-03 | 2007-05-24 | Leonard Bell | Methods of treating hemolytic anemia |
EP2340850A1 (en) | 2004-02-10 | 2011-07-06 | The Regents of the University of Colorado, a Body Corporate | Inhibition of factor B, the alternative complement pathway and methods related thereto |
CN1997384A (zh) | 2004-03-26 | 2007-07-11 | 普罗米克斯有限公司 | 使用补体C5a受体调节剂治疗神经系统病症 |
SI1755674T1 (sl) | 2004-05-14 | 2015-04-30 | Alexion Pharmaceuticals, Inc. | Podaljšanje preživetja alotransplantata z inhibiranjem aktivnosti komplementa |
EP1674580A1 (en) * | 2004-12-23 | 2006-06-28 | F. Hoffmann-La Roche Ag | Method for identifying activators and/or inhibitors of enzyme activity |
WO2006103118A2 (en) | 2005-04-01 | 2006-10-05 | Umc Utrecht Holding B.V. | Therapeutic use of scin, a staphylococcal complement inhibitor in inflammatory diseases |
AU2006249835B2 (en) * | 2005-05-26 | 2011-09-08 | Musc Foundation For Research Development | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
CA2654440C (en) | 2005-06-06 | 2013-09-03 | Girish J. Kotwal | Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury |
EP1738763A1 (en) * | 2005-06-30 | 2007-01-03 | AVANT Immunotherapeutics, Inc. | Use of complement inhibitory proteins to treat spinal cord injury |
JP2007008876A (ja) * | 2005-06-30 | 2007-01-18 | Avant Immunotherapeutics Inc | 脊髄損傷を治療するための補体阻害タンパク質の使用 |
US20070004625A1 (en) * | 2005-06-30 | 2007-01-04 | Li Liang-Man | Use of complement inhibitory proteins to treat spinal cord injury |
AU2005227420B2 (en) | 2005-10-14 | 2013-05-09 | Alltech, Inc. | Method and compositions for altering cell function |
WO2007047995A2 (en) | 2005-10-21 | 2007-04-26 | Catalyst Biosciences, Inc. | Modified proteases that inhibit complement activation |
WO2007056227A2 (en) | 2005-11-04 | 2007-05-18 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
ATE516043T1 (de) * | 2005-12-21 | 2011-07-15 | Pharming Intellectual Pty Bv | Verwendung von c1-inhibitor zur prävention von ischämischen reperfusionsschäden |
MX2008011054A (es) | 2006-03-02 | 2009-03-03 | Alexion Pharma Inc | Prolongacion de supervivencia de un aloinjerto, mediante la inhibicion de actividad de complemento. |
US8241843B2 (en) | 2006-06-15 | 2012-08-14 | Eastern Virginia Medical School | Methods for regulating complement cascade proteins using astrovirus coat protein and derivatives thereof |
GB0617734D0 (en) * | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
NZ576195A (en) | 2006-10-10 | 2012-04-27 | Az Univ Amsterdam | Complement inhibition for improved nerve regeneration |
US8580735B2 (en) | 2007-02-05 | 2013-11-12 | Apellis Pharmaceuticals, Inc. | Local complement inhibition for treatment of complement-mediated disorders |
JP2010521194A (ja) | 2007-03-22 | 2010-06-24 | ノバルティス アーゲー | C5抗原およびその使用 |
US8192742B2 (en) | 2007-03-23 | 2012-06-05 | NovelMed Therapeutics | Method of inhibiting complement activation with human anti-factor C3 antibodies and use thereof |
US20110008343A1 (en) | 2007-06-08 | 2011-01-13 | Lambris John D | Method Of Reducing Tissue Loss In Pancreatic Islet Cell Transplantation |
WO2009015087A2 (en) | 2007-07-20 | 2009-01-29 | Potentia Pharmaceuticals, Inc. | Compositions and methods for treatment of trauma |
WO2009014633A1 (en) | 2007-07-20 | 2009-01-29 | Trustees Of The University Of Pennsylvania | Method of treating acute respiratory distress syndrome |
JP5697027B2 (ja) | 2008-02-15 | 2015-04-08 | タフツ ユニバーシティー | マウス網膜上への細胞膜傷害複合体(mac)生成のヒト化モデル、並びに、黄斑変性の処置のための組成物とキットと方法 |
US10632170B2 (en) | 2008-02-19 | 2020-04-28 | The Trustees Of The University Of Pennsylvania | Administration of compstatin to an individual for the treatment of a tumor |
WO2009108153A1 (en) | 2008-02-29 | 2009-09-03 | The Brigham And Women's Hospital, Inc. | Methods and compositions for the regulation of lectin complement pathway (lcp)- associated complement activation in hyperglycemic myocardial damage |
WO2009121065A2 (en) | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
US20090324585A1 (en) | 2008-06-12 | 2009-12-31 | The Trustees of the Leland Standford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
WO2010022149A1 (en) | 2008-08-20 | 2010-02-25 | The Trustees Of The University Of Pennsylvania | Complement inhibitors for treatment of injury form intracerebral hemorrhage |
DE102008049136B4 (de) | 2008-09-26 | 2012-10-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. | Neue Regulatoren des angeborenen Immunsystems |
CA2738930C (en) | 2008-09-30 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Method of inhibiting biomaterial-induced procoagulant activity using complement inhibitors |
DK2894165T3 (da) | 2008-11-10 | 2023-03-20 | Alexion Pharma Inc | Fremgangsmåder og sammensætninger til behandling af komplementforbundne forstyrrelser |
WO2010057084A1 (en) | 2008-11-14 | 2010-05-20 | Novelmed Therapeutics, Inc. | Method of treating ischemia reperfusion injury |
GB0906779D0 (en) | 2009-04-20 | 2009-06-03 | Natural Environment Res Council | Composition |
JP5852021B2 (ja) | 2010-03-01 | 2016-02-03 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | ドゴー病を処置するための方法および組成物 |
WO2011107591A1 (en) | 2010-03-05 | 2011-09-09 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
US20130324482A1 (en) | 2010-07-09 | 2013-12-05 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of rhinosinusitis and nasal polyposis |
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