FI118171B - Farmaseuttinen formulointi tekijän VIII antamiseksi ihonalaisesti, lihaksensisäisesti tai ihonsisäisesti - Google Patents

Farmaseuttinen formulointi tekijän VIII antamiseksi ihonalaisesti, lihaksensisäisesti tai ihonsisäisesti Download PDF

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Publication number
FI118171B
FI118171B FI963871A FI963871A FI118171B FI 118171 B FI118171 B FI 118171B FI 963871 A FI963871 A FI 963871A FI 963871 A FI963871 A FI 963871A FI 118171 B FI118171 B FI 118171B
Authority
FI
Finland
Prior art keywords
viii
factor
factor viii
formulation
administration
Prior art date
Application number
FI963871A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963871A0 (fi
FI963871A (fi
Inventor
Thomas Oesterberg
Jack Spira
Lars Widlund
Brita Sjoestroem
Marianne Mikaelsson
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26662019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI118171(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9401105A external-priority patent/SE9401105D0/
Priority claimed from SE9500036A external-priority patent/SE9500036D0/xx
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of FI963871A0 publication Critical patent/FI963871A0/fi
Publication of FI963871A publication Critical patent/FI963871A/fi
Application granted granted Critical
Publication of FI118171B publication Critical patent/FI118171B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI963871A 1994-03-31 1996-09-27 Farmaseuttinen formulointi tekijän VIII antamiseksi ihonalaisesti, lihaksensisäisesti tai ihonsisäisesti FI118171B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
SE9401105A SE9401105D0 (sv) 1993-07-05 1994-03-31 Formulation
SE9401105 1994-03-31
SE9500036 1995-01-05
SE9500036A SE9500036D0 (sv) 1995-01-05 1995-01-05 Formulation
SE9500348 1995-02-01
PCT/SE1995/000348 WO1995026750A1 (en) 1994-03-31 1995-03-31 Pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration of factor viii or factor ix

Publications (3)

Publication Number Publication Date
FI963871A0 FI963871A0 (fi) 1996-09-27
FI963871A FI963871A (fi) 1996-09-27
FI118171B true FI118171B (fi) 2007-08-15

Family

ID=26662019

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963871A FI118171B (fi) 1994-03-31 1996-09-27 Farmaseuttinen formulointi tekijän VIII antamiseksi ihonalaisesti, lihaksensisäisesti tai ihonsisäisesti

Country Status (19)

Country Link
US (1) US5925739A (da)
EP (1) EP0772452B1 (da)
JP (1) JP3939750B2 (da)
AT (1) ATE222770T1 (da)
AU (1) AU690666B2 (da)
BR (1) BRPI9507227B8 (da)
CA (1) CA2186126C (da)
DE (1) DE69527966T2 (da)
DK (1) DK0772452T3 (da)
ES (1) ES2182899T3 (da)
FI (1) FI118171B (da)
HU (1) HU223314B1 (da)
IL (2) IL113010A (da)
NO (1) NO321139B1 (da)
NZ (1) NZ283499A (da)
PL (1) PL180282B1 (da)
PT (1) PT772452E (da)
TW (1) TW400234B (da)
WO (1) WO1995026750A1 (da)

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SE9502285D0 (sv) * 1995-06-22 1995-06-22 Pharmacia Ab Improvements related to injections
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US5763401A (en) * 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
US20050032690A1 (en) * 1997-09-10 2005-02-10 Rojkjaer Lisa Payne Factor VII polypeptides for preventing formation of inhibitors in subjects with haemophilia
US6310183B1 (en) * 1997-09-10 2001-10-30 Novo Nordisk A/S Coagulation factor VIIa composition
US7786070B2 (en) * 1997-09-10 2010-08-31 Novo Nordisk Healthcare A/G Subcutaneous administration of coagulation factor VII
US6586573B1 (en) 1999-02-22 2003-07-01 Baxter International Inc. Albumin-free Factor VIII formulations
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
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US20020123093A1 (en) 2000-04-06 2002-09-05 Zannis Vassilis I. Compounds and methods for lowering cholesterol levels without inducing hypertrigylceridemia
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US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
JP4648002B2 (ja) 2002-06-21 2011-03-09 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの安定化された固体組成物
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US7977460B2 (en) * 2003-05-19 2011-07-12 National Institute For Biological Standards And Control Compositions comprising coagulation factors IXA and VIII for the treatment of haemophilia A or B
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ATE547114T1 (de) * 2003-06-25 2012-03-15 Novo Nordisk Healthcare Ag Flüssige zusammensetzungen von factor vii polypeptiden
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WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
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US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
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JP5401446B2 (ja) 2007-04-26 2014-01-29 バイエル ヘルスケア エルエルシー 凍結貯蔵を目的とした、組み換えタンパク質溶液の安定化
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CN102202684A (zh) * 2008-11-03 2011-09-28 拜耳医药保健有限公司 用于治疗血友病的方法
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KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 ｖｉｉｉ의 신규 변이체
JP6029674B2 (ja) 2011-10-18 2016-11-24 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 第ｖｉｉｉ因子のバイオアベイラビリティを改善するための、硫酸化グリコサミノグリカン及びヒアルロニダーゼの組み合わせ使用
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EA033469B1 (ru) * 2012-04-16 2019-10-31 Cantab Biopharmaceuticals Patents Ltd Подкожное введение конъюгатов факторов крови с полиэтиленгликолем
EP2841451A1 (en) 2012-04-24 2015-03-04 Novo Nordisk A/S Compounds suitable for treatment of haemophilia
AU2013203062C1 (en) 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
RS60003B1 (sr) * 2013-03-15 2020-04-30 Bioverativ Therapeutics Inc Formulacije polipeptida faktora viii
DK2796145T3 (da) 2013-04-22 2018-01-29 Csl Ltd Et kovalent kompleks af von Willebrand-faktor og faktor VIII linket af en disulfidbro
KR20170010895A (ko) 2014-06-06 2017-02-01 옥타파마 아게 인자 ⅷ 및 폰 빌레브란트 인자 펩티드를 포함하는 조제
GB201417589D0 (en) * 2014-10-06 2014-11-19 Cantab Biopharmaceuticals Patents Ltd Pharmaceutical Formulations
EP3733199A1 (en) 2016-07-08 2020-11-04 CSL Behring Lengnau AG Subcutaneous administration of long-acting factor ix in humans
CA3043397A1 (en) 2016-11-11 2018-05-17 CSL Behring Lengnau AG Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
CN114929261A (zh) 2020-02-17 2022-08-19 生物测试股份公司 凝血因子viii的皮下施用

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SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering

Also Published As

Publication number Publication date
ES2182899T3 (es) 2003-03-16
IL113010A0 (en) 1995-10-31
PL180282B1 (pl) 2001-01-31
NO964081D0 (no) 1996-09-27
EP0772452B1 (en) 2002-08-28
IL113010A (en) 1999-10-28
US5925739A (en) 1999-07-20
JPH10501522A (ja) 1998-02-10
AU690666B2 (en) 1998-04-30
HU9602693D0 (en) 1996-11-28
MX9604455A (es) 1997-07-31
FI963871A0 (fi) 1996-09-27
EP0772452A1 (en) 1997-05-14
FI963871A (fi) 1996-09-27
HUT74918A (en) 1997-03-28
NZ283499A (en) 1997-08-22
WO1995026750A1 (en) 1995-10-12
NO321139B1 (no) 2006-03-27
PT772452E (pt) 2003-01-31
ATE222770T1 (de) 2002-09-15
DE69527966T2 (de) 2003-05-28
HU223314B1 (hu) 2004-05-28
PL316618A1 (en) 1997-01-20
AU2156095A (en) 1995-10-23
JP3939750B2 (ja) 2007-07-04
DK0772452T3 (da) 2003-01-06
BR9507227A (pt) 1997-09-09
DE69527966D1 (de) 2002-10-02
TW400234B (en) 2000-08-01
CA2186126C (en) 2007-11-20
NO964081L (no) 1996-11-29
BRPI9507227B8 (pt) 2015-12-08
CA2186126A1 (en) 1995-10-12

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