ES2182899T3 - Formulacion farmaceutica para la administracion subcutanea, intramuscular o intradermica de factor viii. - Google Patents

Formulacion farmaceutica para la administracion subcutanea, intramuscular o intradermica de factor viii.

Info

Publication number
ES2182899T3
ES2182899T3 ES95914669T ES95914669T ES2182899T3 ES 2182899 T3 ES2182899 T3 ES 2182899T3 ES 95914669 T ES95914669 T ES 95914669T ES 95914669 T ES95914669 T ES 95914669T ES 2182899 T3 ES2182899 T3 ES 2182899T3
Authority
ES
Spain
Prior art keywords
factor viii
subcutaneous
intramuscular
intradermal administration
pharmaceutical formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914669T
Other languages
English (en)
Inventor
Jack Spira
Lars Widlund
Thomas Osterberg
Brita Sjostrom
Marianne Mikaelsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26662019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2182899(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9401105A external-priority patent/SE9401105D0/
Priority claimed from SE9500036A external-priority patent/SE9500036D0/xx
Application filed by Biovitrum AB filed Critical Biovitrum AB
Application granted granted Critical
Publication of ES2182899T3 publication Critical patent/ES2182899T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA FORMULACION PARA LA ADMINISTRACION SUBCUTANEA, INTRAMUSCULAR O INTRADERMICA QUE INCLUYE FACTOR VIII O IX DE COAGULACION Y EL USO DE LOS MISMOS PARA LA FABRICACION DE UN MEDICAMENTO PARA TRATAR LA HEMOFILIA AO B. LA FORMULACION INCLUYE FACTOR VIII O IX DE COAGULACION CON UNA ACTIVIDAD DE AL MENOS 200 IU/ML Y UN ADITIVO QUE AUMENTA LA BIODISPONIBILIDAD DEL FACTOR VIII O IX. LAS PRUEBAS CON FACTOR VIII PROPORCIONA UN NIVEL TERAPEUTICO DE FACTOR VIII ACTIVO EN LA CIRCULACION SANGUINEA DURANTE UN PERIODO DE TIEMPO SORPRENDENTEMENTE LARGO DESPUES DE LA ADMINISTRACION SUBCUTANEA, INTRAMUSCULAR O INTRADERMICA. EL FACTOR VIII ES ADECUADAMENTE UN FACTOR VIII RECOMBINANTE ALTAMENTE PURIFICADO, Y PREFERIBLEMENTE UN DERIVADO DE ANULACION DEL MISMO , QUE PUEDE UTILIZARSE PARA LA FABRICACION DE UN MEDICAMENTO PARA LA ADMINISTRACION SUBCUTANEA.
ES95914669T 1994-03-31 1995-03-31 Formulacion farmaceutica para la administracion subcutanea, intramuscular o intradermica de factor viii. Expired - Lifetime ES2182899T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9401105A SE9401105D0 (sv) 1993-07-05 1994-03-31 Formulation
SE9500036A SE9500036D0 (sv) 1995-01-05 1995-01-05 Formulation

Publications (1)

Publication Number Publication Date
ES2182899T3 true ES2182899T3 (es) 2003-03-16

Family

ID=26662019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914669T Expired - Lifetime ES2182899T3 (es) 1994-03-31 1995-03-31 Formulacion farmaceutica para la administracion subcutanea, intramuscular o intradermica de factor viii.

Country Status (19)

Country Link
US (1) US5925739A (es)
EP (1) EP0772452B1 (es)
JP (1) JP3939750B2 (es)
AT (1) ATE222770T1 (es)
AU (1) AU690666B2 (es)
BR (1) BRPI9507227B8 (es)
CA (1) CA2186126C (es)
DE (1) DE69527966T2 (es)
DK (1) DK0772452T3 (es)
ES (1) ES2182899T3 (es)
FI (1) FI118171B (es)
HU (1) HU223314B1 (es)
IL (2) IL113010A (es)
NO (1) NO321139B1 (es)
NZ (1) NZ283499A (es)
PL (1) PL180282B1 (es)
PT (1) PT772452E (es)
TW (1) TW400234B (es)
WO (1) WO1995026750A1 (es)

Families Citing this family (69)

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US6310183B1 (en) * 1997-09-10 2001-10-30 Novo Nordisk A/S Coagulation factor VIIa composition
US7786070B2 (en) 1997-09-10 2010-08-31 Novo Nordisk Healthcare A/G Subcutaneous administration of coagulation factor VII
DE60035260T2 (de) 1999-02-22 2007-10-18 The University Of Connecticut, Farmington Neue albuminfreie faktor viii formulierungen
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
JP4663837B2 (ja) * 1999-12-24 2011-04-06 一般財団法人化学及血清療法研究所 第▲ｖｉｉｉ▼因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物
US20020123093A1 (en) 2000-04-06 2002-09-05 Zannis Vassilis I. Compounds and methods for lowering cholesterol levels without inducing hypertrigylceridemia
JP5090605B2 (ja) 2000-05-03 2012-12-05 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 凝固因子ｖｉｉの皮下投与
RU2185158C2 (ru) * 2000-06-14 2002-07-20 Нижегородский государственный научно-исследовательский институт травматологии и ортопедии Способ анестезиологического пособия при операциях на тазобедренном суставе
RU2163140C1 (ru) * 2000-07-05 2001-02-20 Гематологический научный центр РАМН Концентрат фактора ix системы свертывания крови и способ его получения
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KR20040065278A (ko) * 2001-12-21 2004-07-21 노보 노르디스크 에이/에스 변경된 인자 ⅶ 폴리펩티드의 액체 조성물
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
BRPI0311959B8 (pt) 2002-06-21 2021-05-25 Novo Nordisk Healthcare Ag composição, métodos para preparar um polipeptídeo estável do fator vii, e para tratar uma síndrome responsiva do fator vii, e, uso do polipeptídeo do fator vii
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US7897734B2 (en) * 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
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US7977460B2 (en) * 2003-05-19 2011-07-12 National Institute For Biological Standards And Control Compositions comprising coagulation factors IXA and VIII for the treatment of haemophilia A or B
WO2004103398A1 (en) * 2003-05-23 2004-12-02 Novo Nordisk Health Care Ag Protein stabilization in solution
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WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
KR101293503B1 (ko) 2003-08-14 2013-08-07 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인자 ｖｉｉ 폴리펩티드의 액상 수성 약학적 조성물
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KR20190073576A (ko) 2016-11-11 2019-06-26 체에스엘 베링 렝나우 아게 혈액 응고 장애의 치료 또는 예방에서 혈관외 투여를 위한 절단된 폰 빌레브란트 인자 폴리펩타이드
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Also Published As

Publication number Publication date
BRPI9507227B8 (pt) 2015-12-08
JPH10501522A (ja) 1998-02-10
DK0772452T3 (da) 2003-01-06
TW400234B (en) 2000-08-01
US5925739A (en) 1999-07-20
PL316618A1 (en) 1997-01-20
HU9602693D0 (en) 1996-11-28
HU223314B1 (hu) 2004-05-28
ATE222770T1 (de) 2002-09-15
IL113010A (en) 1999-10-28
AU690666B2 (en) 1998-04-30
NZ283499A (en) 1997-08-22
CA2186126C (en) 2007-11-20
IL113010A0 (en) 1995-10-31
DE69527966D1 (de) 2002-10-02
DE69527966T2 (de) 2003-05-28
FI118171B (fi) 2007-08-15
WO1995026750A1 (en) 1995-10-12
CA2186126A1 (en) 1995-10-12
NO964081L (no) 1996-11-29
FI963871L (fi) 1996-09-27
JP3939750B2 (ja) 2007-07-04
AU2156095A (en) 1995-10-23
EP0772452B1 (en) 2002-08-28
NO964081D0 (no) 1996-09-27
FI963871A0 (fi) 1996-09-27
HUT74918A (en) 1997-03-28
PT772452E (pt) 2003-01-31
PL180282B1 (pl) 2001-01-31
EP0772452A1 (en) 1997-05-14
BR9507227A (pt) 1997-09-09
MX9604455A (es) 1997-07-31
NO321139B1 (no) 2006-03-27

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