MX351220B - Una variante nueva del factor viii antihemofilico que tiene actividad especifica incrementada. - Google Patents

Una variante nueva del factor viii antihemofilico que tiene actividad especifica incrementada.

Info

Publication number
MX351220B
MX351220B MX2016015430A MX2016015430A MX351220B MX 351220 B MX351220 B MX 351220B MX 2016015430 A MX2016015430 A MX 2016015430A MX 2016015430 A MX2016015430 A MX 2016015430A MX 351220 B MX351220 B MX 351220B
Authority
MX
Mexico
Prior art keywords
factor viii
specific activity
increased specific
new variant
antihemophilic factor
Prior art date
Application number
MX2016015430A
Other languages
English (en)
Inventor
Kong Lai Chee
Kevin Stafford Roddy
Original Assignee
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH filed Critical Baxalta GmbH
Publication of MX351220B publication Critical patent/MX351220B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invención se refiere a un polinucleótido que codifica una variante de factor VIII (FVIII) porcino con dominio B completa o parcialmente eliminando, la variante FVIII comprende una secuencia que es al menos 90% idéntica a la SEQ ID NO: 1; y desprovista de una secuencia de aminoácidos correspondiente a los aminoácidos 716 a 742 del factor VIII porcino como se representa en la Figura 2 o los aminoácidos 714 a 740 de la SEQ ID NO; 7.
MX2016015430A 2010-11-05 2011-11-04 Una variante nueva del factor viii antihemofilico que tiene actividad especifica incrementada. MX351220B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41043710P 2010-11-05 2010-11-05
PCT/US2011/059297 WO2012061689A2 (en) 2010-11-05 2011-11-04 A new variant of antihemophilic factor viii having increased specific activity

Publications (1)

Publication Number Publication Date
MX351220B true MX351220B (es) 2017-10-05

Family

ID=46025129

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016015430A MX351220B (es) 2010-11-05 2011-11-04 Una variante nueva del factor viii antihemofilico que tiene actividad especifica incrementada.
MX2013005047A MX347503B (es) 2010-11-05 2011-11-04 Una variante nueva del factor viii antihemofílico que tiene actividad específica incrementada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013005047A MX347503B (es) 2010-11-05 2011-11-04 Una variante nueva del factor viii antihemofílico que tiene actividad específica incrementada.

Country Status (18)

Country Link
US (2) US9150637B2 (es)
EP (1) EP2635297B1 (es)
JP (1) JP5922141B2 (es)
KR (1) KR101948337B1 (es)
CN (1) CN103298483B (es)
AU (1) AU2011323236B2 (es)
BR (1) BR112013011041B1 (es)
CA (1) CA2816575C (es)
CO (1) CO6720990A2 (es)
DK (1) DK2635297T3 (es)
EA (1) EA035447B1 (es)
ES (1) ES2721478T3 (es)
IL (1) IL226158B (es)
MX (2) MX351220B (es)
MY (1) MY165089A (es)
SG (2) SG10201509149VA (es)
WO (1) WO2012061689A2 (es)
ZA (1) ZA201303816B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10654910B2 (en) 2015-01-30 2020-05-19 Emory University Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto
CN109689683A (zh) 2016-06-24 2019-04-26 财团法人牧岩生命科学研究所 重组单链fvⅲ及其化学缀合物

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US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
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ZA955642B (en) 1994-07-07 1997-05-06 Ortho Pharma Corp Lyophilized imaging agent formulation
JPH0899999A (ja) 1994-09-30 1996-04-16 Chemo Sero Therapeut Res Inst α１プロテアーゼインヒビターの製造方法
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Also Published As

Publication number Publication date
CN103298483B (zh) 2017-04-12
MX2013005047A (es) 2013-12-06
AU2011323236B2 (en) 2017-03-30
CN103298483A (zh) 2013-09-11
WO2012061689A3 (en) 2012-10-04
BR112013011041B1 (pt) 2021-05-25
EP2635297A4 (en) 2014-06-25
IL226158B (en) 2019-08-29
CO6720990A2 (es) 2013-07-31
CA2816575C (en) 2019-06-11
MX347503B (es) 2017-04-26
KR20140114266A (ko) 2014-09-26
JP5922141B2 (ja) 2016-05-24
IL226158A0 (en) 2013-06-27
DK2635297T3 (da) 2019-05-06
BR112013011041A2 (pt) 2017-06-06
ES2721478T3 (es) 2019-07-31
KR101948337B1 (ko) 2019-02-14
EP2635297B1 (en) 2019-02-27
ZA201303816B (en) 2021-05-26
AU2011323236A1 (en) 2013-06-06
MY165089A (en) 2018-02-28
US9150637B2 (en) 2015-10-06
US10053500B2 (en) 2018-08-21
WO2012061689A2 (en) 2012-05-10
US20150353625A1 (en) 2015-12-10
JP2013545459A (ja) 2013-12-26
EA201390654A1 (ru) 2014-01-30
US20130296244A1 (en) 2013-11-07
SG190136A1 (en) 2013-07-31
EP2635297A2 (en) 2013-09-11
CA2816575A1 (en) 2012-05-10
EA035447B1 (ru) 2020-06-17
SG10201509149VA (en) 2015-12-30
AU2011323236A8 (en) 2013-07-25

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