CN103298483B - 具有增加的比活性的抗血友病因子viii的新型变体 - Google Patents
具有增加的比活性的抗血友病因子viii的新型变体 Download PDFInfo
- Publication number
- CN103298483B CN103298483B CN201180063748.0A CN201180063748A CN103298483B CN 103298483 B CN103298483 B CN 103298483B CN 201180063748 A CN201180063748 A CN 201180063748A CN 103298483 B CN103298483 B CN 103298483B
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- Prior art keywords
- fviii
- aminoacid
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- variants
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (12)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41043710P | 2010-11-05 | 2010-11-05 | |
US61/410,437 | 2010-11-05 | ||
PCT/US2011/059297 WO2012061689A2 (en) | 2010-11-05 | 2011-11-04 | A new variant of antihemophilic factor viii having increased specific activity |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103298483A CN103298483A (zh) | 2013-09-11 |
CN103298483B true CN103298483B (zh) | 2017-04-12 |
Family
ID=46025129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180063748.0A Active CN103298483B (zh) | 2010-11-05 | 2011-11-04 | 具有增加的比活性的抗血友病因子viii的新型变体 |
Country Status (18)
Country | Link |
---|---|
US (2) | US9150637B2 (zh) |
EP (1) | EP2635297B1 (zh) |
JP (1) | JP5922141B2 (zh) |
KR (1) | KR101948337B1 (zh) |
CN (1) | CN103298483B (zh) |
AU (1) | AU2011323236B2 (zh) |
BR (1) | BR112013011041B1 (zh) |
CA (1) | CA2816575C (zh) |
CO (1) | CO6720990A2 (zh) |
DK (1) | DK2635297T3 (zh) |
EA (1) | EA035447B1 (zh) |
ES (1) | ES2721478T3 (zh) |
IL (1) | IL226158B (zh) |
MX (2) | MX351220B (zh) |
MY (1) | MY165089A (zh) |
SG (2) | SG10201509149VA (zh) |
WO (1) | WO2012061689A2 (zh) |
ZA (1) | ZA201303816B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3250226B1 (en) | 2015-01-30 | 2020-07-15 | Emory University | Factor viii proteins having ancestral sequences, expression vectors, and uses related thereto |
WO2017222330A1 (ko) | 2016-06-24 | 2017-12-28 | 재단법인 목암생명과학연구소 | 재조합 단쇄 fviii 및 그 화학 접합물 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1416348A (zh) * | 2000-03-10 | 2003-05-07 | 埃默里大学 | 修饰的凝血因子ⅷ |
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US4348384A (en) | 1980-10-17 | 1982-09-07 | Dainippon Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
EP0182448A3 (en) | 1984-08-24 | 1987-10-28 | Genetics Institute, Inc. | Production of factor viii and related products |
AU5772886A (en) | 1985-04-12 | 1986-11-05 | Genetics Institute Inc. | Novel procoagulant proteins |
JPS6281327A (ja) | 1985-10-04 | 1987-04-14 | Green Cross Corp:The | 人トロンビン製剤の加熱処理方法 |
JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
JPS6485927A (en) | 1987-09-29 | 1989-03-30 | Green Cross Corp | Hepatitis b vaccine |
US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
JPH0626980Y2 (ja) | 1987-11-26 | 1994-07-20 | ソニー株式会社 | 誤消去防止機構 |
WO1989009784A1 (en) | 1988-04-08 | 1989-10-19 | Commonwealth Serum Laboratories Commission | Production of heat-stable factor viii concentrate |
DK162233C (da) | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
US5384132A (en) | 1990-03-20 | 1995-01-24 | Akzo N.V. | Stabilized gonadotropin containing preparations |
IE64738B1 (en) | 1990-03-20 | 1995-09-06 | Akzo Nv | Stabilized gonadotropin containing preparations |
DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
US5888974A (en) | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5744446A (en) | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US5663060A (en) | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
NZ256921A (en) | 1992-10-02 | 1996-05-28 | Pharmacia Ab | Formulations of coagulation factor viii and a non-ionic surfactant and their preparation |
US5563045A (en) * | 1992-11-13 | 1996-10-08 | Genetics Institute, Inc. | Chimeric procoagulant proteins |
SE9301581D0 (sv) | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
WO1994029471A1 (en) * | 1993-06-10 | 1994-12-22 | Genetic Therapy, Inc. | Adenoviral vectors for treatment of hemophilia |
SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
ZA955642B (en) | 1994-07-07 | 1997-05-06 | Ortho Pharma Corp | Lyophilized imaging agent formulation |
JPH0899999A (ja) | 1994-09-30 | 1996-04-16 | Chemo Sero Therapeut Res Inst | α1プロテアーゼインヒビターの製造方法 |
US6818439B1 (en) | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
AU6455896A (en) | 1995-07-11 | 1997-02-10 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered metal-binding properties |
AU6291896A (en) | 1995-07-11 | 1997-02-10 | Chiron Corporation | Novel factor viii:c polypeptide analogs comprising factor v domains or subdomains |
DE69740154D1 (de) * | 1996-04-24 | 2011-05-05 | Univ Michigan | Gegen Inaktivierung resistenter Faktor VIII |
US7560107B2 (en) * | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
AU735763B2 (en) | 1997-12-05 | 2001-07-12 | Immune Response Corporation, The | Novel vectors and genes exhibiting increased expression |
US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
US6759216B1 (en) | 1998-11-06 | 2004-07-06 | Emory University | Glycosylated, low antigenicity low immunogenicity factor VIII |
EP1820516B1 (en) | 1999-02-22 | 2013-07-24 | University of Connecticut | Novel albumin-free factor VIII formulations |
EP1194161B1 (en) | 1999-07-13 | 2005-11-23 | Biovitrum Ab | Stable factor viii compositions |
US6333192B1 (en) | 1999-08-09 | 2001-12-25 | North Carolina State University | Method of producing an undifferentiated avian cell culture using avian primordial germ cells |
US6586574B1 (en) | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
US7282562B2 (en) | 1999-08-31 | 2007-10-16 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
EP1319016A4 (en) | 2000-09-19 | 2006-05-10 | Univ Emory | MODIFIED FACTOR VIII |
WO2003031598A2 (en) * | 2001-10-05 | 2003-04-17 | Emory University | Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use |
CN1630666A (zh) | 2001-11-30 | 2005-06-22 | 埃默里大学 | 因子ⅷc2结构域变体 |
GB0207092D0 (en) | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
US7041635B2 (en) * | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
US20050123997A1 (en) | 2003-10-30 | 2005-06-09 | Lollar John S. | Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes |
WO2005072340A2 (en) | 2004-01-27 | 2005-08-11 | Compugen Ltd. | Novel polynucleotides encoding polypeptides and methods using same |
JP2007536230A (ja) | 2004-05-03 | 2007-12-13 | エモリー ユニバーシティ | ブタBドメイン欠損fVIIIの投与方法 |
SI3130601T1 (sl) * | 2004-11-12 | 2020-11-30 | Bayer Healthcare Llc | Usmerjena modifikacija FVIII |
JP5448839B2 (ja) | 2006-12-22 | 2014-03-19 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | インビボで長い半減期を有する修飾された凝固因子 |
US20090271163A1 (en) * | 2007-12-06 | 2009-10-29 | Wyeth | Crystal structure of human factor VIII and uses thereof |
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2011
- 2011-11-04 EP EP11838863.6A patent/EP2635297B1/en active Active
- 2011-11-04 EA EA201390654A patent/EA035447B1/ru not_active IP Right Cessation
- 2011-11-04 KR KR1020137014351A patent/KR101948337B1/ko active IP Right Grant
- 2011-11-04 SG SG10201509149VA patent/SG10201509149VA/en unknown
- 2011-11-04 MX MX2016015430A patent/MX351220B/es unknown
- 2011-11-04 CA CA2816575A patent/CA2816575C/en active Active
- 2011-11-04 DK DK11838863.6T patent/DK2635297T3/da active
- 2011-11-04 CN CN201180063748.0A patent/CN103298483B/zh active Active
- 2011-11-04 ES ES11838863T patent/ES2721478T3/es active Active
- 2011-11-04 AU AU2011323236A patent/AU2011323236B2/en active Active
- 2011-11-04 MX MX2013005047A patent/MX347503B/es active IP Right Grant
- 2011-11-04 SG SG2013034137A patent/SG190136A1/en unknown
- 2011-11-04 BR BR112013011041-4A patent/BR112013011041B1/pt active IP Right Grant
- 2011-11-04 WO PCT/US2011/059297 patent/WO2012061689A2/en active Application Filing
- 2011-11-04 MY MYPI2013001627A patent/MY165089A/en unknown
- 2011-11-04 JP JP2013537859A patent/JP5922141B2/ja not_active Expired - Fee Related
- 2011-11-04 US US13/883,244 patent/US9150637B2/en active Active
-
2013
- 2013-05-05 IL IL226158A patent/IL226158B/en active IP Right Grant
- 2013-05-24 ZA ZA2013/03816A patent/ZA201303816B/en unknown
- 2013-06-05 CO CO13136450A patent/CO6720990A2/es unknown
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2015
- 2015-08-25 US US14/834,769 patent/US10053500B2/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1416348A (zh) * | 2000-03-10 | 2003-05-07 | 埃默里大学 | 修饰的凝血因子ⅷ |
Non-Patent Citations (2)
Title |
---|
Biological activity of recombinant factor VIII variants lacking the central B-domain and the heavy-chain sequence Lys713-Arg740: discordant in vitro and in vivo activity;K Mertens et al.;《British Journal of Haematology》;19930930;134-136、140 * |
Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa A regulatory role of the factor VIII heavy-chain region Lys713-Arg740;Marie-Jose S. H. DONATH et al.;《Eur. J. Biochem》;19960930;365-372 * |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160811 Address after: Aupu, Switzerland Applicant after: Hundred deep limited liability company Applicant after: Hundred deep company Address before: Illinois State Applicant before: Baxter International Inc. Applicant before: Bakst Helth Co., Ltd. |
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GR01 | Patent grant | ||
CP02 | Change in the address of a patent holder |
Address after: Zug City Co-patentee after: Hundred deep company Patentee after: Hundred deep limited liability company Address before: Aupu, Switzerland Co-patentee before: Hundred deep company Patentee before: Hundred deep limited liability company |
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CP02 | Change in the address of a patent holder | ||
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Effective date of registration: 20210702 Address after: Osaka Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd. Address before: Zug City Patentee before: BAXALTA GmbH Patentee before: Baishen Co. |
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TR01 | Transfer of patent right |