ES2139132T3 - Composiciones farmaceuticas activas en la terapia de desordenes del sueño. - Google Patents

Composiciones farmaceuticas activas en la terapia de desordenes del sueño.

Info

Publication number
ES2139132T3
ES2139132T3 ES95118386T ES95118386T ES2139132T3 ES 2139132 T3 ES2139132 T3 ES 2139132T3 ES 95118386 T ES95118386 T ES 95118386T ES 95118386 T ES95118386 T ES 95118386T ES 2139132 T3 ES2139132 T3 ES 2139132T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
sleep disorders
compositions active
therapy
disorders therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95118386T
Other languages
English (en)
Inventor
Gabriele Biella
Franco Fraschini
Bojidar Stanvok
Strambi Luigi Ferini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
I F L O ISTITUTO FARMACOLOGICO
Original Assignee
I F L O ISTITUTO FARMACOLOGICO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I F L O ISTITUTO FARMACOLOGICO filed Critical I F L O ISTITUTO FARMACOLOGICO
Application granted granted Critical
Publication of ES2139132T3 publication Critical patent/ES2139132T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN CANTIDADES EFECTIVAS TERAPEUTICAMENTE DE 2-BROMOMELATONINA PARA UTILIZACION EN LA TERAPIA DE LOS TRASTORNOS DEL SUEÑO Y EN LA MEDICACION PREANESTESICA.
ES95118386T 1991-05-13 1992-05-11 Composiciones farmaceuticas activas en la terapia de desordenes del sueño. Expired - Lifetime ES2139132T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI911299A IT1251544B (it) 1991-05-13 1991-05-13 Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
EP92107865A EP0513702B1 (en) 1991-05-13 1992-05-11 Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication

Publications (1)

Publication Number Publication Date
ES2139132T3 true ES2139132T3 (es) 2000-02-01

Family

ID=11359886

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95118386T Expired - Lifetime ES2139132T3 (es) 1991-05-13 1992-05-11 Composiciones farmaceuticas activas en la terapia de desordenes del sueño.
ES92107865T Expired - Lifetime ES2093735T3 (es) 1991-05-13 1992-05-11 Derivados de melatonina para uso en la terapia de trastornos del sueño y en medicacion preanestesica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES92107865T Expired - Lifetime ES2093735T3 (es) 1991-05-13 1992-05-11 Derivados de melatonina para uso en la terapia de trastornos del sueño y en medicacion preanestesica.

Country Status (9)

Country Link
US (1) US5430029A (es)
EP (2) EP0513702B1 (es)
JP (1) JPH05155769A (es)
AT (2) ATE184792T1 (es)
DE (2) DE69230046T2 (es)
DK (2) DK0713701T3 (es)
ES (2) ES2139132T3 (es)
GR (2) GR3022060T3 (es)
IT (1) IT1251544B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0641565B1 (en) * 1990-09-28 2000-03-15 I.F.L.O. S.a.s. di Giorgio e Aldo Laguzzi Contraceptive and menstrual cycle controlling drug having oncostatic properties
IT1255199B (it) * 1992-07-01 1995-10-20 Franco Fraschini Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin
IT1262912B (it) * 1992-12-30 1996-07-22 Impiego della melatonina nella terapia della sclerosi sistemica, della sarcoidosi ed altro
US5654325A (en) * 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
AU726758B2 (en) * 1993-11-18 2000-11-23 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US6180657B1 (en) 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
CN1047386C (zh) * 1994-04-07 1999-12-15 西玛夫公司 新型褪黑激素拮抗物螺旋[吲哚吡咯烷丁]衍生物,其制备方法及其作为药物产品的用途
EE03384B1 (et) * 1995-02-01 2001-04-16 Neurim Pharmaceuticals (1991) Ltd. Melatoniini kasutamine ravimi tootmiseks
US6469044B1 (en) 1995-02-01 2002-10-22 Neurim Pharmaceuticals (1991) Ltd. Method for treating patients suffering from drug dependencies which lead to plasma melationin deficiencies
WO1999063977A2 (en) * 1998-06-09 1999-12-16 Takeda Chemical Industries, Ltd. Pharmaceutical combination comprising a tricyclic compound and at least one of zolpidem, zopiclone, triazolam and brotizolam for treating or preventing sleep disorders
FR2787447B1 (fr) * 1998-12-18 2001-03-23 Centre Nat Rech Scient Nouveaux derives de melatonine et medicament comprenant de tels derives
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
JP2002536337A (ja) * 1999-02-05 2002-10-29 ザ・ビクトリア・ユニバーシテイ・オブ・マンチエスター 麻酔の調節
US6552064B2 (en) * 2000-09-19 2003-04-22 University Of Iowa Research Foundation Use of melatonin for induction of general anesthesia
US6638966B2 (en) 2000-09-19 2003-10-28 University Of Iowa Research Foundation Use of melatonin analogues for induction of general anesthesia
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
IL149377A (en) * 2002-04-28 2012-10-31 Neurim Pharma 1991 Pharmaceutical formulation comprising melatonin for the potentiation of the effect of hypnotic compounds
DK1691811T3 (da) * 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005063248A1 (en) * 2003-12-22 2005-07-14 Sepracor Inc. Modafinil combination therapy for improving sleep quality
CA2551637A1 (en) * 2003-12-24 2005-07-14 Sepracor Inc. Melatonin combination therapy for improving sleep quality
DE602005018763D1 (de) 2004-02-18 2010-02-25 Sepracor Inc Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität
WO2005084664A1 (ja) * 2004-03-08 2005-09-15 Kanazawa University Technology Licensing Organization Ltd. インドール誘導体及びその用途
JP3964417B2 (ja) 2004-09-27 2007-08-22 国立大学法人金沢大学 インドール誘導体を有効成分とするα２受容体遮断剤及び血管拡張剤
AR056076A1 (es) * 2005-09-20 2007-09-19 Takeda Pharmaceutical Agente profilactico o terapeutico para el desorden de sueno
BRPI0712206A2 (pt) * 2006-05-22 2012-03-13 Vanda Pharmaceuticals, Inc. tratamento do agonista de melatonina
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
EP2934509B1 (en) 2012-12-18 2020-05-27 Vanda Pharmaceuticals Inc. Tasimelteon for the treatment of circadian rhythm disorders
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11744833B2 (en) 2019-04-12 2023-09-05 LA PharmaTech Inc. Pharmaceutical compositions and methods for treatment of insomnia
US11938139B2 (en) 2019-04-12 2024-03-26 LA PharmaTech Inc. Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders
US11690849B2 (en) 2019-04-12 2023-07-04 LA PharmaTech Inc. Method of treating dementia
JP7088153B2 (ja) * 2019-09-19 2022-06-21 カシオ計算機株式会社 Ｃａｐ（周期性脳波活動）検出装置、ｃａｐ（周期性脳波活動）検出方法及びプログラム
WO2023158424A1 (en) * 2022-02-16 2023-08-24 La Pharma Tech Inc. Novel pharmaceutical compositions and methods for treatment of insomnia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3466215D1 (en) * 1983-05-18 1987-10-22 Univ Monash The use of melatonin for the manufacture of a medicament
KR910006124B1 (ko) * 1987-08-17 1991-08-13 넬슨 리써취 앤드 디벨럽먼트 캄파니 멜라토닌 동족체

Also Published As

Publication number Publication date
GR3032207T3 (en) 2000-04-27
ATE184792T1 (de) 1999-10-15
ITMI911299A1 (it) 1992-11-13
DK0513702T3 (da) 1996-12-30
ES2093735T3 (es) 1997-01-01
DE69230046D1 (de) 1999-10-28
EP0513702B1 (en) 1996-09-18
EP0713701B1 (en) 1999-09-22
DE69213814D1 (de) 1996-10-24
JPH05155769A (ja) 1993-06-22
EP0513702A2 (en) 1992-11-19
DE69230046T2 (de) 2000-05-31
ITMI911299A0 (it) 1991-05-13
ATE142877T1 (de) 1996-10-15
GR3022060T3 (en) 1997-03-31
EP0513702A3 (en) 1992-11-25
DE69213814T2 (de) 1997-04-03
US5430029A (en) 1995-07-04
EP0713701A1 (en) 1996-05-29
DK0713701T3 (da) 2000-04-03
IT1251544B (it) 1995-05-17

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