ATE547114T1 - Flüssige zusammensetzungen von factor vii polypeptiden - Google Patents
Flüssige zusammensetzungen von factor vii polypeptidenInfo
- Publication number
- ATE547114T1 ATE547114T1 AT04738944T AT04738944T ATE547114T1 AT E547114 T1 ATE547114 T1 AT E547114T1 AT 04738944 T AT04738944 T AT 04738944T AT 04738944 T AT04738944 T AT 04738944T AT E547114 T1 ATE547114 T1 AT E547114T1
- Authority
- AT
- Austria
- Prior art keywords
- factor vii
- liquid compositions
- vii polypeptides
- iii
- ionic strength
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940012413 factor vii Drugs 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 102100023804 Coagulation factor VII Human genes 0.000 abstract 1
- 108010023321 Factor VII Proteins 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300959 | 2003-06-25 | ||
| US48433403P | 2003-07-02 | 2003-07-02 | |
| PCT/DK2004/000181 WO2004082708A2 (en) | 2003-03-18 | 2004-03-18 | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| PCT/DK2004/000447 WO2004112828A1 (en) | 2003-06-25 | 2004-06-24 | Liquid composition of factor vii polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE547114T1 true ATE547114T1 (de) | 2012-03-15 |
Family
ID=36816398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04738944T ATE547114T1 (de) | 2003-06-25 | 2004-06-24 | Flüssige zusammensetzungen von factor vii polypeptiden |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20060183683A1 (de) |
| EP (1) | EP1641487B1 (de) |
| JP (1) | JP4658041B2 (de) |
| AT (1) | ATE547114T1 (de) |
| ES (1) | ES2382157T3 (de) |
| WO (1) | WO2004112828A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004023848D1 (de) * | 2003-07-01 | 2009-12-10 | Novo Nordisk Healthcare Ag | Von factor vii polypeptiden |
| KR101159559B1 (ko) | 2003-08-05 | 2012-06-26 | 노보 노르디스크 에이/에스 | 신규의 인슐린 유도체 |
| AU2012213951B2 (en) * | 2005-04-28 | 2014-10-16 | Novo Nordisk Health Care Ag | A closed container comprising an activated factor VII polypeptide, processes for the preparation of the same, and a kit and a method for use of the kit |
| BRPI0608170A2 (pt) * | 2005-04-28 | 2010-11-09 | Novo Nordisk Healthcare Ag | recipiente fechado contendo uma composição de um polipeptìdeo do fator vii ativado, processo para a preparação de um recipiente fechado contendo um polipeptìdeo do fator vii ativado, kit, e, método para a preparação de uma composição farmacêutica |
| US20090060861A1 (en) * | 2005-05-25 | 2009-03-05 | Novo Nordisk A/S | Stabilized Polypeptide Formulations |
| EP1888118B1 (de) | 2005-05-25 | 2016-08-17 | Novo Nordisk A/S | Polypeptidformulierungen stabilisiert mittels ethylendiamin |
| US20090074882A1 (en) | 2005-12-28 | 2009-03-19 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| WO2008135500A1 (en) * | 2007-05-02 | 2008-11-13 | Novo Nordisk Health Care Ag | High concentration factor vii polypeptide formulations comprising an aromatic preservative and an antioxidant |
| WO2008152106A1 (en) | 2007-06-13 | 2008-12-18 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
| NL1034535C2 (nl) | 2007-10-17 | 2009-04-20 | Vanderlande Ind Nederland | Station voor het vanuit producthouders verzamelen van producten in verzamelhouders. |
| JP2011520999A (ja) * | 2008-05-23 | 2011-07-21 | ノボ ノルディスク ヘルス ケア アーゲー | 高濃度の芳香族保存料を有するペグ官能化セリンプロテアーゼの製剤 |
| US20110112029A1 (en) * | 2008-05-23 | 2011-05-12 | Novo Nordisk Health Care Ag | Low viscosity compositions comprising a pegylated gla-domain containing protein |
| CA2738615A1 (en) | 2008-10-30 | 2010-05-06 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
| US8795658B2 (en) * | 2010-09-17 | 2014-08-05 | Baxter International Inc. | Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH |
| JP6049625B2 (ja) | 2010-10-27 | 2016-12-21 | ノヴォ ノルディスク アー/エス | 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療 |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| WO2014177623A1 (en) | 2013-04-30 | 2014-11-06 | Novo Nordisk A/S | Novel administration regime |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
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|---|---|---|---|---|
| US115590A (en) * | 1871-06-06 | Lfxlproxeixie | ||
| DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| US4956386A (en) * | 1980-04-25 | 1990-09-11 | Gist-Brocades N.V. | Pharmaceutical compositions and process for their preparation |
| US4404132A (en) | 1980-05-27 | 1983-09-13 | Cutter Laboratories, Inc. | Blood coagulation promoting product |
| CA1182748A (en) | 1980-11-21 | 1985-02-19 | Gerard Marx | Method for synthesizing procoagulant factor viii activity |
| US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| GR860984B (en) * | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| EP0225160B1 (de) | 1985-11-26 | 1991-08-21 | Novo Nordisk A/S | Zubereitungen und Verfahren zur Behandlung von Blutungsstörungen |
| US5180583A (en) | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
| US5595886A (en) * | 1986-01-27 | 1997-01-21 | Chiron Corporation | Protein complexes having Factor VIII:C activity and production thereof |
| EP0272304B1 (de) | 1986-06-24 | 1994-01-26 | Novo Nordisk A/S | Verfahren zur herstellung eines koagulationsaktiven komplexes vom faktor viii-fragment |
| JP2824430B2 (ja) | 1989-08-02 | 1998-11-11 | 財団法人化学及血清療法研究所 | 血液凝固第▲vii▼因子または活性型血液凝固第▲vii▼因子の調製方法 |
| DE4001451A1 (de) * | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
| US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
| JP3459416B2 (ja) | 1991-02-28 | 2003-10-20 | ザイモジェネティクス,インコーポレイティド | 修飾されたファクター▲vii▼ |
| WO1993000807A1 (en) | 1991-07-03 | 1993-01-21 | Cryolife, Inc. | Method for stabilization of biomaterials |
| FR2684999A1 (fr) | 1991-12-16 | 1993-06-18 | Aquitaine Dev Transf Sanguine | Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag. |
| JP3155797B2 (ja) | 1991-12-26 | 2001-04-16 | 株式会社日立製作所 | 過電圧自己保護型半導体装置、及び、それを使用した半導体回路 |
| ES2152953T3 (es) | 1992-08-27 | 2001-02-16 | Sanquin Bloedvoorziening | Anticuerpos especificos para una proteina hemostatica, su utilizacion para aislar proteinas intactas, compuestos hemostaticos carentes de productos de segmentacion proteolitica de la proteina. |
| DK38293D0 (da) | 1993-03-31 | 1993-03-31 | Novo Nordisk As | Fremstilling af proteiner |
| SE9301581D0 (sv) | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| PT699075E (pt) | 1993-05-21 | 2002-05-31 | Novo Nordisk As | Factor vii modificado para inibicao de restenose vascular e de deposicao de plaquetas |
| WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
| US6277828B1 (en) * | 1993-08-20 | 2001-08-21 | Syntex (U.S.A.) Inc. | Pharmaceutical formulations of nerve growth factor |
| US5576291A (en) * | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| US5590109A (en) * | 1993-09-17 | 1996-12-31 | Matsushita Electric Industrial Co. | Disc apparatus |
| IL113010A0 (en) * | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| DE4435520A1 (de) | 1994-10-04 | 1996-04-11 | Immuno Ag | Verfahren zur Trennung von rekombinantem pro-Faktor IX von rekombinantem Faktor IX |
| SE9403915D0 (sv) * | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
| US5649959A (en) * | 1995-02-10 | 1997-07-22 | Sherwood Medical Company | Assembly for sealing a puncture in a vessel |
| US6255091B1 (en) | 1995-04-28 | 2001-07-03 | Axys Pharmaceuticals, Inc. | Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions |
| DE19531637A1 (de) | 1995-08-28 | 1997-03-06 | Immuno Ag | Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung |
| DE19538715A1 (de) | 1995-10-18 | 1997-04-30 | Behringwerke Ag | Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII |
| US5993795A (en) * | 1995-11-09 | 1999-11-30 | Takemoto Yushi Kabushiki Kaisha | Protein composition derived from sesame seed and use thereof |
| US6320029B1 (en) * | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5925738A (en) | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5830852A (en) * | 1995-12-19 | 1998-11-03 | Cobra Therapeutics, Ltd. | Compositions for insulin-receptor mediated nucleic acid delivery |
| US5770700A (en) | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| US5927739A (en) | 1996-10-07 | 1999-07-27 | Evling; Jens | Dual friction wheelchair hand rim |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| BR9809292A (pt) * | 1997-04-28 | 2000-07-04 | Lilly Co Eli | Métodos aperfeiçoados para o processamento de proteìna c ativada |
| US6310183B1 (en) * | 1997-09-10 | 2001-10-30 | Novo Nordisk A/S | Coagulation factor VIIa composition |
| AT409334B (de) | 1997-09-19 | 2002-07-25 | Immuno Ag | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
| AT408613B (de) | 1998-06-17 | 2002-01-25 | Immuno Ag | Pharmazeutisches faktor vii-präparat |
| CA2342606A1 (en) | 1998-10-07 | 2000-04-13 | Sigma-Aldrich Co. | Thromboplastin reagents and methods for preparing and using such reagents |
| PT2193809E (pt) * | 1999-02-22 | 2015-08-24 | Baxter Int | Formulações de fator viii livres de albumina |
| US20010031721A1 (en) * | 1999-05-05 | 2001-10-18 | Chandra Webb | Highly concentrated, lyophilized, and liquid factor IX formulations |
| JP4674021B2 (ja) | 1999-07-13 | 2011-04-20 | ビオヴィトルム・アクチボラゲット(プブリクト) | 安定第viii因子組成物 |
| AU6558400A (en) | 1999-08-17 | 2001-03-13 | Novo Nordisk A/S | Stabilisation of freeze-dried cake |
| US6586574B1 (en) * | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
| ATE389414T1 (de) * | 1999-09-08 | 2008-04-15 | Chugai Pharmaceutical Co Ltd | Stabile proteinlösung abgefüllt in einem behältnis aus hydrophobem harz und eine methode zur stabilisierung derselben |
| PL204285B1 (pl) | 2000-02-11 | 2009-12-31 | Bayer Healthcare Llc | Koniugat polipeptydowy, polipeptyd, sekwencja nukleotydowa, wektor ekspresyjny, komórka gospodarz, sposób wytwarzania koniugatu polipeptydowego, środek farmaceutyczny i zastosowanie koniugatu polipeptydowego |
| EP1282693B1 (de) * | 2000-05-03 | 2010-10-20 | Novo Nordisk Health Care AG | Varianten des menschlichen Koagulationsfaktors VII |
| JP5090605B2 (ja) | 2000-05-03 | 2012-12-05 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 凝固因子viiの皮下投与 |
| EP1593389A1 (de) | 2000-05-10 | 2005-11-09 | Novo Nordisk Health Care AG | Faktor VIIa und Factor XIII enthaltenden pharmazeutischen Verbindungen |
| IL154520A0 (en) | 2000-09-13 | 2003-09-17 | Novo Nordisk As | Human coagulation factor vii variants |
| AU9165201A (en) * | 2000-10-02 | 2002-04-15 | Novo Nordisk As | Factor vii glycoforms |
| DE50114021D1 (de) | 2001-01-08 | 2008-07-24 | Csl Behring Gmbh | Stabilisierte Flüssigzubereitung der den Blutgerinnungsfaktor VII aktivierenden Protease oder ihres Proenzyms |
| US6825323B2 (en) * | 2001-01-10 | 2004-11-30 | The United States Of America As Represented By The Secretary Of The Army | Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same |
| GB0117879D0 (en) | 2001-07-21 | 2001-09-12 | Common Services Agency | Storage of liquid compositions |
| KR20040065278A (ko) | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| ES2325653T3 (es) | 2001-12-21 | 2009-09-11 | Novo Nordisk Health Care Ag | Composicion liquida de polipeptidos del factor vii. |
| JP2005530682A (ja) * | 2001-12-21 | 2005-10-13 | ノボ ノルディスク アクティーゼルスカブ | 修飾第vii因子ポリペプチドの液体組成物 |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| AU2003223925A1 (en) | 2002-05-03 | 2003-11-17 | Novo Nordisk A/S | Stabilised solid compositions of modified factor vii |
| CA2490342C (en) | 2002-06-21 | 2015-06-16 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
| US6933808B2 (en) | 2002-07-17 | 2005-08-23 | Qing Ma | Microelectromechanical apparatus and methods for surface acoustic wave switching |
| EP1422309A1 (de) | 2002-11-22 | 2004-05-26 | Siemens Aktiengesellschaft | Verwendung einer Sprühkompaktierungsanlage zur Erzeugung einer Schicht und Schichtsystem hergestellt mittels einer Sprühkompaktierungsanlage und Schichtsystem |
| AT501088A2 (de) | 2002-12-18 | 2006-06-15 | Bio Prod & Bio Eng Ag | Stabile therapeutische proteine |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
-
2004
- 2004-06-24 AT AT04738944T patent/ATE547114T1/de active
- 2004-06-24 JP JP2006515730A patent/JP4658041B2/ja not_active Expired - Fee Related
- 2004-06-24 WO PCT/DK2004/000447 patent/WO2004112828A1/en not_active Ceased
- 2004-06-24 ES ES04738944T patent/ES2382157T3/es not_active Expired - Lifetime
- 2004-06-24 EP EP04738944A patent/EP1641487B1/de not_active Expired - Lifetime
-
2005
- 2005-12-15 US US11/304,429 patent/US20060183683A1/en not_active Abandoned
-
2008
- 2008-05-20 US US12/154,088 patent/US7790852B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1641487A1 (de) | 2006-04-05 |
| US7790852B2 (en) | 2010-09-07 |
| WO2004112828A1 (en) | 2004-12-29 |
| JP4658041B2 (ja) | 2011-03-23 |
| US20080227715A1 (en) | 2008-09-18 |
| ES2382157T3 (es) | 2012-06-05 |
| EP1641487B1 (de) | 2012-02-29 |
| JP2007508235A (ja) | 2007-04-05 |
| US20060183683A1 (en) | 2006-08-17 |
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