EP1319067A2 - Varianten des menschlichen koagulationsfaktors vii - Google Patents

Varianten des menschlichen koagulationsfaktors vii

Info

Publication number
EP1319067A2
EP1319067A2 EP01967077A EP01967077A EP1319067A2 EP 1319067 A2 EP1319067 A2 EP 1319067A2 EP 01967077 A EP01967077 A EP 01967077A EP 01967077 A EP01967077 A EP 01967077A EP 1319067 A2 EP1319067 A2 EP 1319067A2
Authority
EP
European Patent Office
Prior art keywords
amino acid
seq
replaced
variant
factor vii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01967077A
Other languages
English (en)
French (fr)
Inventor
Egon Persson
Ole Hvilsted Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Novo Nordisk Health Care AG
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26068878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1319067(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk Health Care AG, Novo Nordisk AS filed Critical Novo Nordisk Health Care AG
Priority to EP10172126A priority Critical patent/EP2253703A1/de
Priority to EP10161855.1A priority patent/EP2226385B1/de
Publication of EP1319067A2 publication Critical patent/EP1319067A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Definitions

  • the invention provides a Factor VII polypeptide with the sequence of SEQ ID NO:1 , wherein five amino acids independently selected from the group consisting of the Lys at position 157, the Lys at position 337, the Asp at position 334, the Ser at position 336, the Val at position 158, the Glu at position 296 and the Met at position 298 of SEQ ID NO:1 have been replaced by different amino acids.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
EP01967077A 2000-09-13 2001-09-13 Varianten des menschlichen koagulationsfaktors vii Withdrawn EP1319067A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10172126A EP2253703A1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Gerinnungsfaktors VII
EP10161855.1A EP2226385B1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Koagulationsfaktors VII

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK200001361 2000-09-13
DKPA200001361 2000-09-13
US23645500P 2000-09-29 2000-09-29
PCT/DK2001/000596 WO2002022776A2 (en) 2000-09-13 2001-09-13 Human coagulation factor vii variants

Publications (1)

Publication Number Publication Date
EP1319067A2 true EP1319067A2 (de) 2003-06-18

Family

ID=26068878

Family Applications (3)

Application Number Title Priority Date Filing Date
EP10172126A Withdrawn EP2253703A1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Gerinnungsfaktors VII
EP10161855.1A Expired - Lifetime EP2226385B1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Koagulationsfaktors VII
EP01967077A Withdrawn EP1319067A2 (de) 2000-09-13 2001-09-13 Varianten des menschlichen koagulationsfaktors vii

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP10172126A Withdrawn EP2253703A1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Gerinnungsfaktors VII
EP10161855.1A Expired - Lifetime EP2226385B1 (de) 2000-09-13 2001-09-13 Varianten des menschlichen Koagulationsfaktors VII

Country Status (7)

Country Link
EP (3) EP2253703A1 (de)
JP (2) JP4361728B2 (de)
AU (2) AU2001287550B2 (de)
HU (1) HUP0301246A3 (de)
IL (4) IL154520A0 (de)
PL (1) PL204888B1 (de)
WO (1) WO2002022776A2 (de)

Families Citing this family (65)

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US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
EP2319541A1 (de) 2000-02-11 2011-05-11 Bayer HealthCare LLC Faktor VII- oder VIIA-ähnliche Konjugate
US7812132B2 (en) 2000-04-28 2010-10-12 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US7220837B1 (en) 2000-04-28 2007-05-22 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6905683B2 (en) 2000-05-03 2005-06-14 Novo Nordisk Healthcare A/G Human coagulation factor VII variants
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
RU2326126C2 (ru) 2000-09-13 2008-06-10 Ново Нордиск Хелт Кэр Аг Полипептид фактора vii свертывания крови, его получение и применение
WO2002038162A1 (en) 2000-11-09 2002-05-16 The Scripps Research Institute MODIFIED FACTOR VIIa
ES2432967T3 (es) * 2001-03-22 2013-12-05 Novo Nordisk Health Care Ag Derivados del Factor VII de coagulación
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US7052868B2 (en) 2001-09-27 2006-05-30 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
ES2490590T3 (es) * 2001-11-02 2014-09-04 Novo Nordisk Health Care Ag Polipéptidos de factor VII de coagulación humana
US6960657B2 (en) 2001-11-02 2005-11-01 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
US7125846B2 (en) 2001-11-09 2006-10-24 Novo Nordisk Healthcare A/G Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides
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AU2003266214A1 (en) 2002-09-25 2004-04-19 Novo Nordisk A/S Human coagulation factor vii polypeptides
US6911323B2 (en) 2002-09-25 2005-06-28 Novo Nordisk Healthcare A/G Human coagulation factor VII polypeptides
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Also Published As

Publication number Publication date
WO2002022776A2 (en) 2002-03-21
EP2226385A1 (de) 2010-09-08
PL204888B1 (pl) 2010-02-26
JP4361728B2 (ja) 2009-11-11
HUP0301246A2 (hu) 2003-08-28
JP2009278980A (ja) 2009-12-03
IL196482A (en) 2011-03-31
IL206229A (en) 2012-02-29
IL154520A0 (en) 2003-09-17
WO2002022776A3 (en) 2002-07-18
PL360384A1 (en) 2004-09-06
JP4814359B2 (ja) 2011-11-16
JP2004508822A (ja) 2004-03-25
IL154520A (en) 2010-06-16
AU2001287550B2 (en) 2007-03-22
AU8755001A (en) 2002-03-26
WO2002022776A9 (en) 2003-05-22
HUP0301246A3 (en) 2005-12-28
EP2253703A1 (de) 2010-11-24
EP2226385B1 (de) 2013-07-10

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